15201-1-AP

antibody from Proteintech Group

Targeting: IFIT3 CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, RIG-G

Provider product page for 15201-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 15201-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15201-1-AP, RRID:AB_2248738
Product name: IFIT3 antibody
Antibody type: Polyclonal
Description: KD/KO validated IFIT3 antibody (Cat. #15201-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IFIT3 protein structure - 15201-1-AP shown in red.

Submitted references ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication.

Espada CE, da Rocha EL, Ricciardi-Jorge T, Dos Santos AA, Soares ZG, Malaquias G, Patrício DO, Gonzalez Kozlova E, Dos Santos PF, Bordignon J, Sanford TJ, Fajardo T, Sweeney TR, Báfica A, Mansur DS
Frontiers in immunology 2024;15:1331731

CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection.

Lukoszek R, Inesta-Vaquera F, Brett NJM, Liang S, Hepburn LA, Hughes DJ, Pirillo C, Roberts EW, Cowling VH
Cell reports 2024 Jul 23;43(7):114405

Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.

Tajima Y, Shibasaki F, Masai H
Cancer gene therapy 2024 Jan;31(1):158-173

ETV7 promotes colorectal cancer progression through upregulation of IFIT3.

Chai B, Li Y, Guo Y, Zhang Z, Jia K, Chai X, Suo Y
Functional & integrative genomics 2024 Jan 10;24(1):8

Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.

Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A
PLoS pathogens 2024 Feb;20(2):e1012061

Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3.

Huang H, Lei X, Zhao C, Qin Y, Li Y, Zhang X, Li C, Lan T, Zhao B, Sun W, Lu H, Jin N
Journal of virology 2024 Feb 20;98(2):e0168223

Knockdown of IFIT3 ameliorates multiple sclerosis via selectively regulating M1 polarization of microglia in an experimental autoimmune encephalomyelitis model.

Sun R, Wang YF, Yang X
International immunopharmacology 2024 Feb 15;128:111501

Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.

He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.

Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
bioRxiv : the preprint server for biology 2024 Apr 12;

Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations.

Cai T, Xu J, Fang Y, Wu Y, Qin Q, Zhang JA
Immunobiology 2023 Sep;228(5):152726

Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity.

Zhang YG, Zhang HX, Chen HW, Lv P, Su J, Chen YR, Fu ZF, Cui M
Journal of neuroinflammation 2023 Sep 27;20(1):216

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8.

Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q
Journal of virology 2023 Oct 31;97(10):e0102823

Porcine Mx proteins inhibit pseudorabies virus replication through interfering with early gene synthesis.

Chen J, Hu JH, Sun RC, Li XH, Zhou J, Zhou B
Veterinary microbiology 2023 May;280:109706

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma.

Jia Y, Zhang B, Zhang C, Kwong DL, Chang Z, Li S, Wang Z, Han H, Li J, Zhong Y, Sui X, Fu L, Guan X, Qin Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Mar;10(7):e2204565

SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function.

Su J, Shen S, Hu Y, Chen S, Cheng L, Cai Y, Wei W, Wang Y, Rui Y, Yu XF
Journal of medical virology 2023 Jan;95(1):e28175

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79

Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors.

Pasquero S, Gugliesi F, Biolatti M, Dell'Oste V, Albano C, Bajetto G, Griffante G, Trifirò L, Brugo B, Raviola S, Lacarbonara D, Yang Q, Sudeshna S, Barasa L, Haniff H, Thompson PR, Landolfo S, De Andrea M
PLoS pathogens 2023 Dec;19(12):e1011849

The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures.

Wilson JL, Akin E, Zhou R, Jedlicka A, Dziedzic A, Liu H, Fenstermacher KZ, Rothman R, Pekosz A
bioRxiv : the preprint server for biology 2023 Aug 4;

Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.

Li H, Wan B, Jiang D, Ji P, Zhao M, Li X, Li R, Qiao S
Frontiers in veterinary science 2022;9:861137

Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.

Ke M
Oxidative medicine and cellular longevity 2022;2022:3124122

COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR Activation.

Zan X, Li S, Wei S, Gao L, Zhao L, Yan X, Zhao Y, Shi J, Wang Y, Liu R, Zhang Y, Wan Y, Zhou Y
Frontiers in oncology 2022;12:707525

DestVI identifies continuums of cell types in spatial transcriptomics data.

Lopez R, Li B, Keren-Shaul H, Boyeau P, Kedmi M, Pilzer D, Jelinski A, Yofe I, David E, Wagner A, Ergen C, Addadi Y, Golani O, Ronchese F, Jordan MI, Amit I, Yosef N
Nature biotechnology 2022 Sep;40(9):1360-1369

LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.

Guo B, Jiang T, Wu F, Ni H, Ye J, Wu X, Ni C, Jiang M, Ye L, Li Z, Zheng X, Li S, Yang Q, Wang Z, Huang X, Zhao C
Schizophrenia (Heidelberg, Germany) 2022 Mar 1;8(1):11

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse.

Maletzko A, Key J, Wittig I, Gispert S, Koepf G, Canet-Pons J, Torres-Odio S, West AP, Auburger G
Neurogenetics 2021 Oct;22(4):297-312

Murine Ifit3 restricts the replication of Rabies virus both in vitro and in vivo.

Chai B, Tian D, Zhou M, Tian B, Yuan Y, Sui B, Wang K, Pei J, Huang F, Wu Q, Lv L, Yang Y, Wang C, Fu Z, Zhao L
The Journal of general virology 2021 Jul;102(7)

Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi.

Xiong X, Wang Q, Wang S, Zhang J, Liu T, Guo L, Yu Y, Lin JD
Molecular metabolism 2019 Feb;20:128-137

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G
Journal of neuroinflammation 2017 Aug 2;14(1):154

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Jackson JD, Markert JM, Li L, Carroll SL, Cassady KA
Molecular cancer research : MCR 2016 May;14(5):482-92

Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity.

Jiang Z, Su C, Zheng C
Journal of virology 2016 Dec 15;90(24):11056-11061

MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection.

Huang Y, Liu H, Li S, Tang Y, Wei B, Yu H, Wang C
PLoS pathogens 2014 Mar;10(3):e1004020

Poly(I:C) inhibits porcine reproductive and respiratory syndrome virus replication in MARC-145 cells via activation of IFIT3.

Zhang L, Liu J, Bai J, Du Y, Wang X, Liu X, Jiang P
Antiviral research 2013 Sep;99(3):197-206

Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.

Lu Q, Bai J, Zhang L, Liu J, Jiang Z, Michal JJ, He Q, Jiang P
Journal of proteome research 2012 May 4;11(5):2890-903

Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses.

Zhao D, Liang L, Li Y, Liu L, Guan Y, Jiang Y, Chen H
Proteomics 2012 Jun;12(12):1970-82

IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

Liu XY, Chen W, Wei B, Shan YF, Wang C
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2559-68

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 15201-1-AP(IFIT3 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IFIT3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFIT3. This antibody recognizes human antigen. The IFIT3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 15201-1-AP.pdf

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