Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 16588-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16588-1-AP, RRID:AB_1851513
- Product name
- Pyruvate Carboxylase antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Pyruvate Carboxylase antibody (Cat. #16588-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer.
Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Proteomic Analysis Reveals the Renoprotective Effect of Tribulus terrestris against Obesity-Related Glomerulopathy in Rats.
High salt diet induces metabolic alterations in multiple biological processes of Dahl salt-sensitive rats.
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.
Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase.
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Liu WL, Guan Q, Wen D, Ma B, Xu WB, Hu JQ, Wei WJ, Li DS, Wang Y, Xiang J, Liao T, Ji QH
Frontiers in cell and developmental biology 2021;9:723777
Frontiers in cell and developmental biology 2021;9:723777
Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.
Zhang L, Liu T, Hu C, Zhang X, Zhang Q, Shi K
BMC genomics 2021 Sep 4;22(1):640
BMC genomics 2021 Sep 4;22(1):640
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR
Nature communications 2021 Mar 25;12(1):1876
Nature communications 2021 Mar 25;12(1):1876
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.
Beręsewicz-Haller M, Krupska O, Bochomulski P, Dudzik D, Chęcińska A, Hilgier W, Barbas C, Zablocki K, Zablocka B
International journal of molecular sciences 2021 Aug 7;22(16)
International journal of molecular sciences 2021 Aug 7;22(16)
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G
Journal of proteome research 2019 Mar 1;18(3):960-969
Journal of proteome research 2019 Mar 1;18(3):960-969
Proteomic Analysis Reveals the Renoprotective Effect of Tribulus terrestris against Obesity-Related Glomerulopathy in Rats.
Jiang YH, Jiang LY, Wu S, Jiang WJ, Xie L, Li W, Yang CH
Biological & pharmaceutical bulletin 2018 Sep 1;41(9):1430-1439
Biological & pharmaceutical bulletin 2018 Sep 1;41(9):1430-1439
High salt diet induces metabolic alterations in multiple biological processes of Dahl salt-sensitive rats.
Wang Y, Liu X, Zhang C, Wang Z
The Journal of nutritional biochemistry 2018 Jun;56:133-141
The Journal of nutritional biochemistry 2018 Jun;56:133-141
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291
Scientific reports 2017 Mar 27;7:45291
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343
Oncotarget 2017 Dec 26;8(69):114328-114343
Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.
Hernandez JL, Davda D, Majmudar JD, Won SJ, Prakash A, Choi AI, Martin BR
Molecular bioSystems 2016 May;12(6):1799-808
Molecular bioSystems 2016 May;12(6):1799-808
Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase.
Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E, Taferner A, Unterluggauer H, Kramer C, Liedl KR, Jansen-Dürr P
The Journal of biological chemistry 2015 Mar 13;290(11):6755-62
The Journal of biological chemistry 2015 Mar 13;290(11):6755-62
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R
PloS one 2014;9(8):e105504
PloS one 2014;9(8):e105504
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo HK, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB
PloS one 2014;9(12):e115144
PloS one 2014;9(12):e115144
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 16588-1-AP(PC antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PC antibody 16588-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16588-1-AP(PC antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16588-1-AP(PC antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue