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- Product number
- 13048-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13048-1-AP, RRID:AB_10640157
- Product name
- Glypican 4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Glypican 4 antibody (Cat. #13048-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references From multi-omics discovery to experimental validation: GPC4 mediates the anti-neuroinflammatory effects of Buyang Huanwu decoction via TLR4/NF-κB signaling in ischemic stroke with Qi deficiency and blood stasis syndrome.
The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling.
β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.
Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure.
Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection.
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle.
mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.
Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.
Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice.
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
Activity-dependent modulation of synapse-regulating genes in astrocytes.
LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.
Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.
Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Zhang C, Wu X, Yu Z, Xu G, Yang J, Shao C, Wan H
Journal of ethnopharmacology 2026 May 23;363:121375
Journal of ethnopharmacology 2026 May 23;363:121375
The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling.
Depret N, Gleizes M, Moreau MM, Poirault-Chassac S, Quiedeville A, Carvalho SDS, Venugopal V, Abed ASA, Ezan J, Barthet G, Mulle C, Desmedt A, Marighetto A, Racca C, Montcouquiol M, Sans N
Progress in neurobiology 2025 Mar;246:102728
Progress in neurobiology 2025 Mar;246:102728
β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.
Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA
bioRxiv : the preprint server for biology 2025 Feb 25;
bioRxiv : the preprint server for biology 2025 Feb 25;
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.
Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Miller BL, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA
Molecular neurodegeneration 2025 Aug 29;20(1):96
Molecular neurodegeneration 2025 Aug 29;20(1):96
Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure.
Niebergall EB, Weekley D, Mazur A, Olszewski NA, DeSchepper KM, Radant N, Vijay AS, Risher WC
Cells 2024 May 14;13(10)
Cells 2024 May 14;13(10)
Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Tatenhorst L, Maass F, Paul H, Dambeck V, Bähr M, Dono R, Lingor P
Scientific reports 2024 Feb 29;14(1):5005
Scientific reports 2024 Feb 29;14(1):5005
Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection.
Loffredo LF, Surpur A, Ringham OR, Li F, de Los Santos-Alexis K, Arpaia N
bioRxiv : the preprint server for biology 2024 Apr 28;
bioRxiv : the preprint server for biology 2024 Apr 28;
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle.
Colin-Pierre C, Untereiner V, Sockalingum GD, Ramont L, Brézillon S
International journal of molecular sciences 2023 Feb 21;24(5)
International journal of molecular sciences 2023 Feb 21;24(5)
mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Meng A, Ameroso D, Rios M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Aug 16;43(33):5918-5935
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Aug 16;43(33):5918-5935
Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.
Shelkar GP, Gandhi PJ, Liu J, Dravid SM
Science advances 2022 Jul 22;8(29):eabo6574
Science advances 2022 Jul 22;8(29):eabo6574
Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.
Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G
Cell reports 2022 Jul 19;40(3):111085
Cell reports 2022 Jul 19;40(3):111085
Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice.
Ma KG, Hu HB, Zhou JS, Ji C, Yan QS, Peng SM, Ren LD, Yang BN, Xiao XL, Ma YB, Wu F, Si KW, Wu XL, Liu JX
Experimental neurology 2022 Jan;347:113918
Experimental neurology 2022 Jan;347:113918
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J, Koizumi S
The Journal of experimental medicine 2022 Apr 4;219(4)
The Journal of experimental medicine 2022 Apr 4;219(4)
Activity-dependent modulation of synapse-regulating genes in astrocytes.
Farhy-Tselnicker I, Boisvert MM, Liu H, Dowling C, Erikson GA, Blanco-Suarez E, Farhy C, Shokhirev MN, Ecker JR, Allen NJ
eLife 2021 Sep 8;10
eLife 2021 Sep 8;10
LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MF, Siddiqui TJ
Neuron 2020 Apr 8;106(1):108-125.e12
Neuron 2020 Apr 8;106(1):108-125.e12
CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.
Fang Y, Shen ZY, Zhan YZ, Feng XC, Chen KL, Li YS, Deng HJ, Pan SM, Wu DH, Ding Y
Nature communications 2019 Sep 4;10(1):3981
Nature communications 2019 Sep 4;10(1):3981
Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.
Lu IL, Chen C, Tung CY, Chen HH, Pan JP, Chang CH, Cheng JS, Chen YA, Wang CH, Huang CW, Kang YN, Chang HY, Li LL, Chang KP, Shih YH, Lin CH, Kwan SY, Tsai JW
Nature communications 2018 Jun 27;9(1):2498
Nature communications 2018 Jun 27;9(1):2498
Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Farhy-Tselnicker I, van Casteren ACM, Lee A, Chang VT, Aricescu AR, Allen NJ
Neuron 2017 Oct 11;96(2):428-445.e13
Neuron 2017 Oct 11;96(2):428-445.e13
Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Xiong Y, Zhang Y, Zheng F, Yang Y, Xu X, Wang W, Zhu B, Wang X
Biochemical and biophysical research communications 2016 Sep 9;478(1):241-246
Biochemical and biophysical research communications 2016 Sep 9;478(1):241-246
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Allen NJ, Bennett ML, Foo LC, Wang GX, Chakraborty C, Smith SJ, Barres BA
Nature 2012 May 27;486(7403):410-4
Nature 2012 May 27;486(7403):410-4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Glypican 4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Glypican 4. This antibody recognizes human,mouse,rat antigen. The Glypican 4 antibody has been validated for the following applications: ELISA, WB analysis.
