23247-1-AP

antibody from Proteintech Group

Targeting: IFIT1 G10P1, GARG-16, IFI56, IFNAI1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

23247-1-AP

Provider

Proteintech Group

Product name

IFIT1 antibody

Antibody type

Polyclonal

Description

IFIT1 antibody (Cat. #23247-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.

Weindel CG, Coleman AK, Ellzey LM, Kumar S, Chaisson SL, Davis JR, Patrick KL, Watson RO
Journal of immunology (Baltimore, Md. : 1950) 2026 Jan 21;215(1)

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Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation.

Wu M, Wang P, Wang R, Zhan M, Wang J, Cai H, Zha L, Zhou N, Luo Q, Chen L, Du J
PLoS neglected tropical diseases 2026 Feb;20(2):e0014035

---

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity.

Song J, Liu T, Yang J, Zhao L, Su J, Li Z, Ma R, Wen X, Cheng P
Journal of virology 2026 Feb 17;100(2):e0165625

---

Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection.

Jin S, He X, Wang Z, Zhou T, Wang J, Pan G, Zhang Y, Ma L, Yang S, Wang L, Wu Y, Zou Y, Qi N, Cui J
Nature microbiology 2025 Oct;10(10):2521-2536

---

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders.

McDougal MB, Boys IN, De Maria AM, Nakahara E, Schoggins JW
eLife 2025 Oct 22;13

---

Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection.

Liu CC, Chu LJ, Yeh YM, Lin HC, Chen LC, Huang CY, Chiu SF, Cheng FW, Lin WN, Huang KY
International immunopharmacology 2025 May 16;155:114643

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A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.

Xie S, Fang Y, Liao Z, Cui L, Niu K, Ren S, Zhu J, Wu W, Jing Z, Peng C
PLoS pathogens 2025 Mar;21(3):e1012994

---

Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses.

Li J, Zhang S, Wang B, Dai Y, Wu J, Liu D, Liang Y, Xiao S, Wang Z, Wu J, Zheng D, Chen X, Shi F, Tan K, Ding X, Song H, Zhang S, Lu M
Cell reports. Medicine 2025 Mar 18;6(3):101976

---

N-acetyltransferase 10 promotes mRNA stability of immune response factors to modulate Zika virus infection.

Gianola S, Lane N, Kaytes K, Pager CT
bioRxiv : the preprint server for biology 2025 Jul 17;

---

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders.

McDougal MB, Boys IN, De Maria AM, Nakahara E, Schoggins JW
bioRxiv : the preprint server for biology 2025 Jul 1;

---

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

He J, Kuang Y, Xu K, Huang R, Yang X, Deng L, Feng X, Ren Y, Yang J, Yuan L
Viruses 2025 Jan 30;17(2)

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Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.

Xue M, Huang C, Jiang X, Zhou S, Yan Y, Dong C, Chen Z, Dai J
Virulence 2025 Dec;16(1):2570000

---

Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.

Hao H, Zhang F, Chen Z, Tan Z, Zhang H, Feng X, Zhang X, Deng T, Zhan G, Luo T, Zhang K, Ding S, Liu H, Zheng Z, Wang Y, Huang F, Guan W
iScience 2024 Nov 15;27(11):111071

---

IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.

Cruz-Rivera PC, Eitson JL, Schoggins JW
bioRxiv : the preprint server for biology 2024 May 5;

---

Novel mutation N588 residue in the NS1 protein of feline parvovirus greatly augments viral replication.

Li L, Liu Z, Liang R, Yang M, Yan Y, Jiao Y, Jiao Z, Hu X, Li M, Shen Z, Peng G
Journal of virology 2024 May 14;98(5):e0009324

---

Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.

Lin Y, Wang D, Li B, Wang J, Xu L, Sun X, Ji K, Yan C, Liu F, Zhao Y
JCI insight 2024 Jun 25;9(15)

---

LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.

Weindel CG, Ellzey LM, Coleman AK, Patrick KL, Watson RO
bioRxiv : the preprint server for biology 2024 Jul 13;

---

IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling.

Li TH, Zhao BB, Qin C, Wang YY, Li ZR, Cao HT, Yang XY, Zhou XT, Wang WB
Cellular oncology (Dordrecht, Netherlands) 2024 Aug;47(4):1253-1265

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Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.

He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797

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Interferon inhibits a model RNA virus via a limited set of inducible effector genes.

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW
EMBO reports 2023 Sep 6;24(9):e56901

---

Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity.

Zhang YG, Zhang HX, Chen HW, Lv P, Su J, Chen YR, Fu ZF, Cui M
Journal of neuroinflammation 2023 Sep 27;20(1):216

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Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1.

Liu Y, Song Y, He Y, Kong Z, Li H, Zhu Y, Liu S
Biology direct 2023 Oct 10;18(1):65

---

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma.

Jia Y, Zhang B, Zhang C, Kwong DL, Chang Z, Li S, Wang Z, Han H, Li J, Zhong Y, Sui X, Fu L, Guan X, Qin Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Mar;10(7):e2204565

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Long noncoding RNA RFPL1S-202 inhibits ovarian cancer progression by downregulating the IFN-β/STAT1 signaling.

Liu S, Chen X, Huang K, Xiong X, Shi Y, Wang X, Pan X, Cong Y, Sun Y, Ge L, Xu J, Jia X
Experimental cell research 2023 Jan 15;422(2):113438

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The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.

Luo H, Hu X, Li Y, Lei D, Tan G, Zeng Y, Qin B
Virology 2023 Feb;579:84-93

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TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79

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The role of IBV PL1pro in virus replication and suppression of host innate immune responses.

Liu W, Mu G, Jia Y, Yu M, Zhang S, Wang Z, Fang S
BMC veterinary research 2023 Dec 13;19(1):270

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COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR Activation.

Zan X, Li S, Wei S, Gao L, Zhao L, Yan X, Zhao Y, Shi J, Wang Y, Liu R, Zhang Y, Wan Y, Zhou Y
Frontiers in oncology 2022;12:707525

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Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.

Luo Y, Li J, Huang C, Wang X, Long D, Cao Y
Molecular omics 2022 Sep 26;18(8):779-790

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Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.

Tang X, Song F, Zhao W, Zhang Z, Cao Y
Journal of applied toxicology : JAT 2022 Nov;42(11):1822-1831

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Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Yang T, Ma X, Wang R, Liu H, Wei S, Jing M, Li H, Zhao Y
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2022 Jun;30(6):764-778

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Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production.

Sakuragi S, Liao H, Yajima K, Fujiwara S, Nakamura H
International journal of molecular sciences 2022 Aug 29;23(17)

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Murine Ifit3 restricts the replication of Rabies virus both in vitro and in vivo.

Chai B, Tian D, Zhou M, Tian B, Yuan Y, Sui B, Wang K, Pei J, Huang F, Wu Q, Lv L, Yang Y, Wang C, Fu Z, Zhao L
The Journal of general virology 2021 Jul;102(7)

---

IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling.

Li TH, Zhao BB, Qin C, Wang YY, Li ZR, Cao HT, Yang XY, Zhou XT, Wang WB
Cellular oncology (Dordrecht, Netherlands) 2021 Dec;44(6):1425-1437

---

Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.

Chikhalya A, Dittmann M, Zheng Y, Sohn SY, Rice CM, Hearing P
mBio 2021 Dec 21;12(6):e0282921

---

Interferon-Lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 Infection.

Sohn SY, Hearing J, Mugavero J, Kirillov V, Gorbunova E, Helminiak L, Mishra S, Mackow E, Hearing P, Reich NC, Kim HK
mBio 2021 Dec 21;12(6):e0275621

---

Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.

Yang T, Wang R, Zhang J, Bao C, Zhang J, Li R, Chen X, Wu S, Wen J, Wei S, Li H, Cai H, Yang X, Zhao Y
Life sciences 2020 May 1;248:117456

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A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.

Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711

---

Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance.

Scott ML, Woodby BL, Ulicny J, Raikhy G, Orr AW, Songock WK, Bodily JM
Journal of virology 2020 Jan 6;94(2)

---

Suppression of Stromal Interferon Signaling by Human Papillomavirus 16.

Raikhy G, Woodby BL, Scott ML, Shin G, Myers JE, Scott RS, Bodily JM
Journal of virology 2019 Oct 1;93(19)

---

Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.

Yao Z, Jia X, Megger DA, Chen J, Liu Y, Li J, Sitek B, Yuan Z
Journal of proteome research 2019 Mar 1;18(3):855-864

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Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection.

Wei J, Ma Y, Wang L, Chi X, Yan R, Wang S, Li X, Chen X, Shao W, Chen JL
Veterinary microbiology 2017 May;203:234-244

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Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G
Journal of neuroinflammation 2017 Aug 2;14(1):154

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Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity.

Jiang Z, Su C, Zheng C
Journal of virology 2016 Dec 15;90(24):11056-11061

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 23247-1-AP( IFIT1 Antibody) at dilution of 1:600

Sample type

cell line

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

LPS treated RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 23247-1-AP( IFIT1 Antibody) at dilution of 1:600

Sample type

cell line

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

U-937 cells were subjected to SDS PAGE followed by western blot with 23247-1-AP( IFIT1 Antibody) at dilution of 1:600

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The IFIT1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IFIT1. This antibody recognizes human antigen. The IFIT1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.

Appendix

23247-1-AP.pdf

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