Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB17892-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-28A/B (IFN-lambda 2/3) Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-28B/IFN-lambda 3 in ELISAs. In sandwich immunoassays, 100% cross-reactivity with recombinant mouse IL-28A/IFN-lambda 2 and no cross-reactivity with recombinant human (rh) IL-28A or rhIL-29 is observed.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
Q8CGK6
- Isotype
- IgG
- Antibody clone number
- 244716
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia.
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
Crotta S, Davidson S, Mahlakoiv T, Desmet CJ, Buckwalter MR, Albert ML, Staeheli P, Wack A
PLoS pathogens 2013;9(11):e1003773
PLoS pathogens 2013;9(11):e1003773
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
Rynda A, Maddaloni M, Ochoa-Repáraz J, Callis G, Pascual DW
PloS one 2010 Jan 14;5(1):e8720
PloS one 2010 Jan 14;5(1):e8720
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- IL-28B/IFN-lambda 3 Inhibition of EMCV-induced Cytopathy and Neutralization by Mouse IL-28B/IFN-lambda 3 Antibody. Recombinant Mouse IL-28B/IFN-lambda 3 (Catalog # 1789-ML) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IL-28B/IFN-lambda 3 (400 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-28B/IFN-lambda 3 Monoclonal Antibody (Catalog # MAB17892). The ND50 is typically 3-9 µg/mL.