Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-3028 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-IMPDHII Antibody
- Antibody type
- Polyclonal
- Description
- Human type II inosine monophosphate dehydrogenase (IMPDHII) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. It is linked to cell growth, differentiation, and malignant transformation. IMPDHII also plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity. Indeed, IMPDHII increases the phosphatase activity of SHP1, which participates in the inactivation of PI3K. Enhanced expression of IMPDHII promotes the tumor metastasis and the advanced tumor progression in patients with prostate cancer.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant IMPDHI
I protein (amino acids 86-291) was
used as the immunogen for this anti
body.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of IMPDHII. Anti-IMPDHII antibody (11-3028) was used at 1 µg/ml on K562 lysate.