Antibody data

Product number
11-3029 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-IMPDHII Antibody
Antibody type
Polyclonal
Description
IMPDH2 (Human type II inosine monophosphate dehydrogenase) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. The enzymatic reaction involves the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. It is increased more than 10-fold in activated peripheral blood T lymphocytes and is required for T cell activation. Type II isoform of the enzyme is selectively upregulated in neoplastic fast replicating lymphocytes and CML cancer cells. Thus, the IMPDH2 is an excellent target for antileukemic agent.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant IMPDHI
I protein (amino acids 48-351) was
used as the immunogen for this anti
body.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
IMPDH2 protein structure - 11-3029 shown in red.