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- Antibody Data
- Antigen structure
- References [4]
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- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- NBP1-86177 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-86177, RRID:AB_11022985
- Product name
- Rabbit Polyclonal IMP Dehydrogenase 2/IMPDH2 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human IMP Dehydrogenase 2/IMPDH2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.
A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.
Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells.
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Barfeld SJ, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi KM, Rennie PS, Ceder Y, Chabes A, Visakorpi T, Mills IG
Oncotarget 2015 May 20;6(14):12587-602
Oncotarget 2015 May 20;6(14):12587-602
A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.
Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA
Cell reports 2013 Oct 31;5(2):493-507
Cell reports 2013 Oct 31;5(2):493-507
Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells.
Floryk D, Thompson TC
International journal of cancer 2008 Nov 15;123(10):2294-302
International journal of cancer 2008 Nov 15;123(10):2294-302
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA
Cell cycle (Georgetown, Tex.) 2008 Aug;7(15):2392-400
Cell cycle (Georgetown, Tex.) 2008 Aug;7(15):2392-400
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP1-86177] - Analysis in human cell line U-251 MG.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP1-86177] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1, using Anti-IMPDH2 antibody. Remaining relative intensity is presented. Loading control: Anti-PPIB
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: IMP Dehydrogenase 2/IMPDH2 Antibody [NBP1-86177] - Staining of human breast shows moderate cytoplasmic and nuclear positivity in glandular cells.
