16750-1-AP

antibody from Proteintech Group

Targeting: SPOP BTBD32, TEF2

Provider product page for 16750-1-AP

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Product number: 16750-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16750-1-AP, RRID:AB_2756394
Product name: SPOP antibody
Antibody type: Polyclonal
Description: KD/KO validated SPOP antibody (Cat. #16750-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SPOP protein structure - 16750-1-AP shown in red.

Submitted references TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation.

Chen S, Lin J, Yang Z, Wang Y, Wang Q, Wang D, Qu Y, Lin Q, Liu J, Yan S, Wang Z, Qian X, Xiao Y, Li X, Chen Y, Fang W, Zhao J, Lu Z, Ren H, Zhu Y, Ma L
Cell death and differentiation 2026 Mar;33(3):480-495

Reduced YTHDF2 inhibits PD-L1 expression by stabilizing m(6)A-containing SPOP mRNA in colorectal cancer.

Xu X, Chen H, Zhao R, Xie J, Liu H, Xie B, Lou J, Wang H, Wu X, Han W, Pan H, Shen J
Cell death & disease 2026 Mar 24;17(1)

CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.

Yan P, Bu X, Hou T, Chen L, Zhong G, Huang D, Wang J, Qi Y, Jiang W, Li Z, Xue X, Gao Y, Liu J, Inuzuka H, Freeman GJ, Wei W, Dai X
Journal for immunotherapy of cancer 2026 Jan 14;14(1)

PINX1 inhibits proliferation and cisplatin resistance in nasopharyngeal carcinoma by promoting ILF3 ubiquitination.

Zhou N, Gong P, Wang S, He C, Hu L, Peng H
American journal of cancer research 2025;15(6):2518-2534

Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling.

Wierbiłowicz K, Yang CS, Almaghasilah A, Wesołowski PA, Pracht P, Dworak NM, Masur J, Wijngaarden S, Filippov DV, Wales DJ, Kelley JB, Ratan A, Paschal BM
The EMBO journal 2025 Sep;44(17):4720-4744

Germline-Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis.

Gasperini P, Alaimo A, Stringa B, Chung YM, Ciani Y, Lorenzin F, Fracassi G, Zekri Y, Orlando F, Quaini O, Gregoricchio S, Petris G, Casini A, Barbieri CE, Zwart W, Cereseto A, Sharifi N, Lunardi A, Demichelis F
Cancer discovery 2025 Oct 6;15(10):2166-2184

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression.

Wen H, Maheremu M, Zhang K, Bao L, Luo M, Zhang Y, Liao Y, Zhou M, Wu C, Lv S, Qiu X, Wei Q
Molecular biomedicine 2025 Nov 17;6(1):112

Sequence rules for a long SPOP-binding degron required for protein ubiquitylation.

Makhlouf L, Mishra M, Makhlouf H, Manfield I, Busino L, Zeqiraj E
The Biochemical journal 2025 May 21;482(10):583-600

CircXPO6 promotes breast cancer progression through competitively inhibiting the ubiquitination degradation of c-Myc.

Xu A, Li X, Cai Q, Yang C, Yang M, Gao H, Cheng M, Chen X, Ji F, Tang H, Wang K
Molecular and cellular biochemistry 2025 Mar;480(3):1731-1745

LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.

Li Y, Zhu J, Zhai F, Ge Y, Zhan Z, Wang S, Kong L, Zhao J, Hu L, Wang S, Shi J, Mao J, Yu Z, Wang H, Jin J, Zhao M, Li H, Jin X
Cell death discovery 2025 Jun 7;11(1):269

Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment.

Wang Z, Li L, Ye Q, Lei Y, Lu M, Ye L, Kang J, Huang W, Xu S, Wang K, Liu J, Gao Y, Wang C, Ma J, Li L
The Journal of clinical investigation 2025 Jul 15;135(14)

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer.

Tian S, Xu M, Geng X, Fang J, Xu H, Xue X, Hu H, Zhang Q, Yu D, Guo M, Zhang H, Lu J, Guo C, Wang Q, Liu S, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(1):e2410285

Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.

Liu C, Fan D, Sun J, Li G, Du R, Zuo X, Zhang K, Zhang W, Wang S, Li X, Du M, Wang D, Hao Q, Zhang Y, Li M, Zhang C, Gao Y
Journal of nanobiotechnology 2025 Jan 3;23(1):3

E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells.

Oguh AU, Haemmerle MW, Sen S, Rozo AV, Shrestha S, Cartailler JP, Fazelinia H, Ding H, Preza S, Yang J, Yang X, Sussel L, Alvarez-Dominguez JR, Doliba N, Spruce LA, Arrojo E Drigo R, Stoffers DA
Genes & development 2025 Feb 3;39(3-4):261-279

CircLRBA Promotes Epithelial-Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1.

Wang X, Yang X, Xing L, Chen H, Xie F, Wang B, Shi B, Yang Y, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e08918

SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway.

Deng Y, Xie C, Liu R, Ma K, Tang J, Zhou Z
Cell death & disease 2025 Dec 24;17(1):132

Harnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein.

Kirkiz E, Kaufmann G, Bergqvist S, Fernández-Pernas P, Eder T, Quell L, Allram M, Manhart G, Walter W, Haferlach T, Grebien F
Cell reports 2025 Dec 23;44(12):116602

Neural Stem Cell Extracellular Vesicles Carrying YBX1 Inhibited Neuronal Pyroptosis Through Increasing m6A-modified GPR30 Stability and Expression in Ischemic Stroke.

Peng J, He J, Lin L, Li Y, Xia Y
Translational stroke research 2025 Apr;16(2):262-279

The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer.

Ge Y, Kong L, Li Y, Yu Z, Zhai F, Zhan Z, Chen G, Wang S, Wang H, Wang Y, Zhao J, Hu L, Mao J, Wang S, Shi J, Zhao M, Lou P, Ye M, Jin X
Communications biology 2025 Apr 17;8(1):624

Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1.

Hong Y, Chen Q, Wang Z, Zhang Y, Li B, Guo H, Huang C, Kong X, Mo P, Xiao N, Xu J, Ye Y, Yu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2310037

SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death.

Lee GE, Bang G, Byun J, Chen W, Jeung D, Cho H, Lee JY, Kang HC, Lee HS, Kim JY, Kim KD, Wu J, Nam SB, Kwon YJ, Lee CJ, Cho YY
Cellular and molecular life sciences : CMLS 2024 Nov 14;81(1):451

Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.

Liu F, Zhang T, Sun X, Liu Z, Xu W, Dai X, Zhang X
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167032

TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer.

Dai X, Wu Z, Ruan R, Chen J, Huang C, Lei W, Yao Y, Li L, Tang X, Xiong J, Feng M, Deng J
Cell communication and signaling : CCS 2024 Mar 7;22(1):168

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis.

Zhang Y, Fong KW, Mao F, Wang R, Allison DB, Napier D, He D, Liu J, Zhang Y, Chen J, Kong Y, Li C, Li G, Liu J, Li Z, Zhu H, Wang C, Liu X
Cell reports 2024 Jul 23;43(7):114431

LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer.

Gan S, Qu F, Zhang X, Pan X, Xu D, Cui X, Hou J
Experimental cell research 2024 Jan 1;434(1):113857

SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.

Gong DA, Zhou P, Chang WY, Yang JY, Zhang YL, Huang AL, Tang N, Wang K
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119642

SPOP point mutations regulate substrate preference and affect its function.

Deng Y, Ding W, Ma K, Zhan M, Sun L, Zhou Z, Lu L
Cell death & disease 2024 Feb 26;15(2):172

BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma.

Yu Z, Wu X, Zhu J, Yan H, Li Y, Zhang H, Zhong Y, Lin M, Ye G, Li X, Jin J, Li K, Wang J, Zhuang H, Lin T, He J, Lu C, Xu Z, Zhang X, Li H, Jin X
Cellular and molecular life sciences : CMLS 2024 Feb 10;81(1):82

Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma.

Suvarna K, Jayabal P, Ma X, Wang H, Chen Y, Weintraub ST, Han X, Houghton PJ, Shiio Y
Cell reports 2024 Aug 27;43(8):114497

CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation.

Li K, Zhang J, Lyu H, Yang J, Wei W, Wang Y, Luo H, Zhang Y, Jiang X, Yi H, Wang M, Zhang C, Wu K, Xiao L, Wen W, Xu H, Li G, Wan Y, Yang F, Yang R, Fu X, Qin B, Zhou Z, Zhang H, Lee MH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2306827

ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.

Lee CJ, Lee H, Kim SR, Nam SB, Lee GE, Yang KE, Lee GJ, Chun SH, Kang HC, Lee JY, Lee HS, Cho SJ, Cho YY
Cell death & disease 2024 Apr 17;15(4):274

Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1.

Zhang Y, Zhang N, Song W, Yousuf S, Li W
Journal of Cancer 2023;14(17):3295-3308

Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis.

Ge Y, Jin J, Chen G, Li J, Ye M, Jin X
Cell communication and signaling : CCS 2023 Oct 30;21(1):303

Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.

Yang W, Zhuang Y, Wu H, Su S, Li Y, Wang C, Tian Z, Peng L, Zhang X, Liu J, Pei X, Yuan W, Hu X, Meng B, Li D, Zhang Y, Shan H, Pan Z, Lu Y
Cell chemical biology 2023 Oct 19;30(10):1248-1260.e4

O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.

Zhou P, Chang WY, Gong DA, Huang LY, Liu R, Liu Y, Xia J, Wang K, Tang N, Huang AL
Oncogene 2023 Mar;42(10):725-736

TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.

Ma J, Zhou Y, Pan P, Yu H, Wang Z, Li LL, Wang B, Yan Y, Pan Y, Ye Q, Liu T, Feng X, Xu S, Wang K, Wang X, Jian Y, Ma B, Fan Y, Gao Y, Huang H, Li L
Nature communications 2023 Mar 31;14(1):1810

Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.

Ding L, Chen X, Zhang W, Dai X, Guo H, Pan X, Xu Y, Feng J, Yuan M, Gao X, Wang J, Xu X, Li S, Wu H, Cao J, He Q, Yang B
The Journal of clinical investigation 2023 Jan 3;133(1)

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.

Gao K, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C, Wan X
Cell death and differentiation 2023 Feb;30(2):475-487

SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer.

Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, Mentucci FM, Grasso DH, Fernandez-Zapico ME
The Biochemical journal 2023 Aug 16;480(15):1199-1216

Additive Effect of CD73 Inhibitor in Colorectal Cancer Treatment With CDK4/6 Inhibitor Through Regulation of PD-L1.

Noh JY, Lee IP, Han NR, Kim M, Min YK, Lee SY, Yun SH, Kim SI, Park T, Chung H, Park D, Lee CH
Cellular and molecular gastroenterology and hepatology 2022;14(4):769-788

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein.

Dong M, Qian M, Ruan Z
Journal for immunotherapy of cancer 2022 Oct;10(10)

Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function.

Zhao X, Wei Y, Chu YY, Li Y, Hsu JM, Jiang Z, Liu C, Hsu JL, Chang WC, Yang R, Chan LC, Qu J, Zhang S, Ying H, Yu D, Hung MC
Cancer research 2022 Jun 6;82(11):2185-2195

A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.

Tawaratsumida K, Redecke V, Wu R, Kuriakose J, Bouchard JJ, Mittag T, Lohman BK, Mishra A, High AA, Häcker H
Science advances 2022 Jul 8;8(27):eabq0084

c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.

Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F
Clinical and translational medicine 2021 Sep;11(9):e464

SPOP mutation induces DNA methylation via stabilizing GLP/G9a.

Zhang J, Gao K, Xie H, Wang D, Zhang P, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H
Nature communications 2021 Sep 29;12(1):5716

Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.

Ghosh C, Xing Y, Li S, Hoyle RG, Sun M, Li J, Sun Y
FEBS letters 2021 Oct;595(20):2558-2569

SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.

Luo Z, Wang J, Zhu Y, Sun X, He C, Cai M, Ma J, Wang Y, Han S
Neoplasia (New York, N.Y.) 2021 Oct;23(10):1037-1047

The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.

Snoznik C, Medvedeva V, Mojsilovic-Petrovic J, Rudich P, Oosten J, Kalb RG, Lamitina T
Proceedings of the National Academy of Sciences of the United States of America 2021 Oct 5;118(40)

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.

Ma J, Shi Q, Cui G, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Mer G, Ye D, Wang C, Huang H
Nature communications 2021 Oct 1;12(1):5779

Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis.

He Y, Chen J, Peng X, Xia Y, Su Y
Cancer cell international 2021 Nov 27;21(1):626

Genetic fusions favor tumorigenesis through degron loss in oncogenes.

Liu J, Tokheim C, Lee JD, Gan W, North BJ, Liu XS, Pandolfi PP, Wei W
Nature communications 2021 Nov 18;12(1):6704

G3BP1 inhibits Cul3(SPOP) to amplify AR signaling and promote prostate cancer.

Mukhopadhyay C, Yang C, Xu L, Liu D, Wang Y, Huang D, Deonarine LD, Cyrta J, Davicioni E, Sboner A, Robinson BD, Chinnaiyan AM, Rubin MA, Barbieri CE, Zhou P
Nature communications 2021 Nov 18;12(1):6662

Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.

Zhang H, Xia Y, Wang F, Luo M, Yang K, Liang S, An S, Wu S, Yang C, Chen D, Xu M, Cai M, To KKW, Fu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(10):2003404

Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway.

Yuan D, Yang Z, Chen Y, Li S, Tan B, Yu Q
Cell biology international 2021 Mar;45(3):599-611

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.

Wang D, Ma J, Botuyan MV, Cui G, Yan Y, Ding D, Zhou Y, Krueger EW, Pei J, Wu X, Wang L, Pei H, McNiven MA, Ye D, Mer G, Huang H
Science advances 2021 Jun;7(25)

SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.

Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, Laggner C, Nguyen KT, Zhu Z, Prevatte AW, Barker NK, Herring LE, Davis IJ, Liu P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jul;8(14):e2004846

SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association.

Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX
Cellular & molecular immunology 2021 Jul;18(7):1708-1717

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.

Wang W, Tang YA, Xiao Q, Lee WC, Cheng B, Niu Z, Oguz G, Feng M, Lee PL, Li B, Yang ZH, Chen YF, Lan P, Wu XJ, Yu Q
Nature communications 2021 Jul 21;12(1):4441

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.

Jiang Q, Zheng N, Bu L, Zhang X, Zhang X, Wu Y, Su Y, Wang L, Zhang X, Ren S, Dai X, Wu D, Xie W, Wei W, Zhu Y, Guo J
Molecular cancer 2021 Aug 5;20(1):100

Loss of Speckle-Type POZ Protein Promotes Prostate Cancer Cell Migration and Invasion Through Upregulation of MCP-1.

Shi J, Cao J, Lu X, Fan L, Guo H, Fu J
Medical science monitor : international medical journal of experimental and clinical research 2021 Apr 19;27:e929199

DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1.

Hong Z, Zhang W, Ding D, Huang Z, Yan Y, Cao W, Pan Y, Hou X, Weroha SJ, Karnes RJ, Wang D, Wu Q, Wu D, Huang H
Molecular cell 2020 Sep 17;79(6):1008-1023.e4

SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.

Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S
Molecular biology of the cell 2020 Mar 15;31(6):478-490

SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression.

Wang L, Lin M, Chu M, Liu Y, Ma J, He Y, Wang ZW
EBioMedicine 2020 Jun;56:102795

BRD4 Levels Determine the Response of Human Lung Cancer Cells to BET Degraders That Potently Induce Apoptosis through Suppression of Mcl-1.

Zong D, Gu J, Cavalcante GC, Yao W, Zhang G, Wang S, Owonikoko TK, He X, Sun SY
Cancer research 2020 Jun 1;80(11):2380-2393

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.

Li K, Wu JL, Qin B, Fan Z, Tang Q, Lu W, Zhang H, Xing F, Meng M, Zou S, Wei W, Chen H, Cai J, Wang H, Zhang H, Cai J, Fang L, Bian X, Chen C, Lan P, Ghesquière B, Fang L, Lee MH
Cell research 2020 Feb;30(2):163-178

S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.

He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162

Snail promotes prostate cancer migration by facilitating SPOP ubiquitination and degradation.

Lv W, Huan M, Yang W, Gao Y, Wang K, Xu S, Zhang M, Ma J, Wang X, Chen Y, Li L
Biochemical and biophysical research communications 2020 Aug 27;529(3):799-804

SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation.

Dong Y, Zhang D, Cai M, Luo Z, Zhu Y, Gong L, Lei Y, Tan X, Zhu Q, Han S
American journal of cancer research 2019;9(7):1469-1483

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

Jin X, Wang J, Li Q, Zhuang H, Yang J, Lin Z, Lin T, Lv Z, Shen L, Yan C, Zheng J, Zhu J, Gong Z, Wang C, Gao K
American journal of cancer research 2019;9(12):2797-2812

SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway.

Li Y, Yu Q, Li R, Luo J, Yuan D, Song J, Sun Y, Long T, Yang Z
OncoTargets and therapy 2019;12:9239-9248

SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG.

Tan P, Xu Y, Du Y, Wu L, Guo B, Huang S, Zhu J, Li B, Lin F, Yao L
Cell death & disease 2019 Oct 17;10(11):794

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.

Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, Collins CC, Ye D, Wang Y, Huang H
EMBO molecular medicine 2019 Nov 7;11(11):e10659

SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.

Tan P, Wang A, Chen H, Du Y, Qian B, Shi H, Zhang Y, Xia X, Fu W
Experimental cell research 2019 Nov 1;384(1):111606

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L
Nature communications 2019 Jul 24;10(1):3304

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

Wang X, Jin J, Wan F, Zhao L, Chu H, Chen C, Liao G, Liu J, Yu Y, Teng H, Fang L, Jiang C, Pan W, Xie X, Li J, Lu X, Jiang X, Ge X, Ye D, Wang P
Developmental cell 2019 Feb 11;48(3):345-360.e7

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, Lu KP, Huang J, Zhao C, Sun Y, Gao X, Pandolfi PP, Wei W
Developmental cell 2019 Feb 11;48(3):329-344.e5

Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha.

Xiao X, Shen Y, Yin L, He J, Ni X, Luo G, Chen X, Zhu W, Zhong J, Liu J, Peng X, Zu X
Life sciences 2019 Dec 15;239:117042

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.

Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ
Genes & development 2019 Aug 1;33(15-16):1083-1094

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, Sigurðsson JO, Bartek J, Iglesias-Gato D, Olsen JV, Flores-Morales A
Nucleic acids research 2018 Oct 12;46(18):9891

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, Sigurðsson JO, Bartek J, Iglesias-Gato D, Olsen JV, Flores-Morales A
Nucleic acids research 2018 Oct 12;46(18):9484-9495

miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.

Wang LQ, Yu P, Li B, Guo YH, Liang ZR, Zheng LL, Yang JH, Xu H, Liu S, Zheng LS, Zhou H, Qu LH
Molecular oncology 2018 Nov;12(11):1949-1964

Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.

Ji P, Liang S, Li P, Xie C, Li J, Zhang K, Zheng X, Feng M, Li Q, Jiao H, Chi X, Zhao W, Zhang S, Wang X
Biochemical and biophysical research communications 2018 Jul 7;502(1):30-42

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.

Ma J, Chang K, Peng J, Shi Q, Gan H, Gao K, Feng K, Xu F, Zhang H, Dai B, Zhu Y, Shi G, Shen Y, Zhu Y, Qin X, Li Y, Zhang P, Ye D, Wang C
Journal of experimental & clinical cancer research : CR 2018 Jul 11;37(1):145

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.

Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W
Nature 2018 Jan 4;553(7686):91-95

The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.

Ding M, Lu X, Wang C, Zhao Q, Ge J, Xia Q, Wang J, Zen K, Zhang CY, Zhang C
Cancer research 2018 Dec 15;78(24):6771-6784

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.

Jin X, Yan Y, Wang D, Ding D, Ma T, Ye Z, Jimenez R, Wang L, Wu H, Huang H
Molecular cell 2018 Aug 16;71(4):592-605.e4

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.

Yan Y, An J, Yang Y, Wu D, Bai Y, Cao W, Ma L, Chen J, Yu Z, He Y, Jin X, Pan Y, Ma T, Wang S, Hou X, Weroha SJ, Karnes RJ, Zhang J, Westendorf JJ, Wang L, Chen Y, Xu W, Zhu R, Wang D, Huang H
EMBO molecular medicine 2018 Apr;10(4)

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W
Nature medicine 2017 Sep;23(9):1063-1071

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H
Nature medicine 2017 Sep;23(9):1055-1062

Identification of SPOP related metabolic pathways in prostate cancer.

Yan M, Qi H, Li J, Ye G, Shao Y, Li T, Liu J, Piao HL, Xu G
Oncotarget 2017 Nov 28;8(61):103032-103046

Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.

Tan Y, Ci Y, Dai X, Wu F, Guo J, Liu D, North BJ, Huo J, Zhang J
Oncotarget 2017 Jul 18;8(29):47890-47901

Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.

Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J
Cancer letters 2017 Jan 28;385:207-214

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.

Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, Tang L, Ma J, Xiao J, Zhang E, Zhu J, Zhang B, Zhao SM, Li Y, Ren S, Huang H, Yu L, Wang C
PLoS genetics 2017 Apr;13(4):e1006748

Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J
Cancer letters 2017 Apr 1;390:11-20

Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.

Gao K, Jin X, Tang Y, Ma J, Peng J, Yu L, Zhang P, Wang C
American journal of cancer research 2015;5(10):3210-20

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W
Molecular cell 2015 Sep 17;59(6):917-30

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.

An J, Ren S, Murphy SJ, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling GC, Cheng L, Sukov WR, Karnes RJ, Vasmatzis G, Zhang Q, Zhang J, Cheville JC, Yan J, Sun Y, Huang H
Molecular cell 2015 Sep 17;59(6):904-16

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.

Zeng C, Wang Y, Lu Q, Chen J, Zhang J, Liu T, Lv N, Luo S
Journal of experimental & clinical cancer research : CR 2014 Sep 11;33(1):75

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SPOP antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SPOP. This antibody recognizes human,mouse,rat antigen. The SPOP antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 16750-1-AP.pdf

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