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Learn14119-1-AP
antibody from Proteintech Group
Targeting: MARCHF8
c-MIR, CMIR, MARCH-VIII, MARCH8, MIR, RNF178
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
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- Validations
- Western blot [1]
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- Product number
- 14119-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14119-1-AP, RRID:AB_2140168
- Product name
- MARCH8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MARCH8 antibody (Cat. #14119-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references O-GlcNAcylation regulates the stability of transferrin receptor (TFRC) to control the ferroptosis in hepatocellular carcinoma cells.
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation.
N protein of PEDV plays chess game with host proteins by selective autophagy.
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon.
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8.
The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction.
EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein.
Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells.
Elucidating the Antiviral Mechanism of Different MARCH Factors.
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.
BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy.
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Cell adhesion in zebrafish embryos is modulated by March 8.
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
Zhou X, Wang Y, Li X, Zhou J, Yang W, Wang X, Jiao S, Zuo W, You Z, Ying W, Wu C, Bao J
Redox biology 2024 Jul;73:103182
Redox biology 2024 Jul;73:103182
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D
Journal of virology 2024 Feb 20;98(2):e0172623
Journal of virology 2024 Feb 20;98(2):e0172623
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D
bioRxiv : the preprint server for biology 2023 Nov 4;
bioRxiv : the preprint server for biology 2023 Nov 4;
MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation.
Guo X, Adeyanju O, Olajuyin AM, Mandlem V, Sunil C, Adewumi J, Huang S, Tucker TA, Idell S, Qian G
American journal of physiology. Cell physiology 2023 Nov 1;325(5):C1190-C1200
American journal of physiology. Cell physiology 2023 Nov 1;325(5):C1190-C1200
N protein of PEDV plays chess game with host proteins by selective autophagy.
Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352
Autophagy 2023 Aug;19(8):2338-2352
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Dong S, Kong N, Zhang Y, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2022 May 25;96(10):e0007022
Journal of virology 2022 May 25;96(10):e0007022
FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon.
Dong S, Kong N, Wang C, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Journal of virology 2022 Jul 13;96(13):e0061822
Journal of virology 2022 Jul 13;96(13):e0061822
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Feng L, Li C, Zeng LW, Gao D, Sun YH, Zhong L, Lin H, Shu HB, Li S
Signal transduction and targeted therapy 2022 Jan 24;7(1):21
Signal transduction and targeted therapy 2022 Jan 24;7(1):21
2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8.
Sun D, Kong N, Dong S, Chen X, Qin W, Wang H, Jiao Y, Zhai H, Li L, Gao F, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Autophagy 2022 Aug;18(8):1969-1981
Autophagy 2022 Aug;18(8):1969-1981
The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction.
Xu F, Liu X, Zhang D, Zhao F, Fan Z, Hu S, Mei S, Huang Y, Sun H, Wei L, Guo L, Wang J, Cen S, Liang C, Guo F
Human gene therapy 2021 Sep;32(17-18):936-948
Human gene therapy 2021 Sep;32(17-18):936-948
EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein.
Wang H, Kong N, Jiao Y, Dong S, Sun D, Chen X, Zheng H, Tong W, Yu H, Yu L, Zhang W, Tong G, Shan T
Journal of virology 2021 Sep 9;95(19):e0064521
Journal of virology 2021 Sep 9;95(19):e0064521
Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
Qian G, Guo J, Vallega KA, Hu C, Chen Z, Deng Y, Wang Q, Fan S, Ramalingam SS, Owonikoko TK, Wei W, Sun SY
Molecular cancer research : MCR 2021 Oct;19(10):1622-1634
Molecular cancer research : MCR 2021 Oct;19(10):1622-1634
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
Jiao Y, Kong N, Wang H, Sun D, Dong S, Chen X, Zheng H, Tong W, Yu H, Yu L, Huang Y, Wang H, Sui B, Zhao L, Liao Y, Zhang W, Tong G, Shan T
Microbiology spectrum 2021 Oct 31;9(2):e0090821
Microbiology spectrum 2021 Oct 31;9(2):e0090821
MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells.
Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H
Cancers 2021 May 22;13(11)
Cancers 2021 May 22;13(11)
Elucidating the Antiviral Mechanism of Different MARCH Factors.
Umthong S, Lynch B, Timilsina U, Waxman B, Ivey EB, Stavrou S
mBio 2021 Mar 2;12(2)
mBio 2021 Mar 2;12(2)
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F
Nature communications 2021 Jul 20;12(1):4427
Nature communications 2021 Jul 20;12(1):4427
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.
Yu C, Li S, Zhang X, Khan I, Ahmad I, Zhou Y, Li S, Shi J, Wang Y, Zheng YH
mBio 2020 Sep 15;11(5)
mBio 2020 Sep 15;11(5)
BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy.
Kong N, Shan T, Wang H, Jiao Y, Zuo Y, Li L, Tong W, Yu L, Jiang Y, Zhou Y, Li G, Gao F, Yu H, Zheng H, Tong G
Autophagy 2020 Oct;16(10):1737-1752
Autophagy 2020 Oct;16(10):1737-1752
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J
Molecular cell 2017 Oct 19;68(2):308-322.e4
Molecular cell 2017 Oct 19;68(2):308-322.e4
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Wang Q, Chen Q, Zhu L, Chen M, Xu W, Panday S, Wang Z, Li A, Røe OD, Chen R, Wang S, Zhang R, Zhou J
Oncogenesis 2017 Jul 3;6(7):e353
Oncogenesis 2017 Jul 3;6(7):e353
Cell adhesion in zebrafish embryos is modulated by March 8.
Kim MH, Rebbert ML, Ro H, Won M, Dawid IB
PloS one 2014;9(4):e94873
PloS one 2014;9(4):e94873
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
Chen R, Li M, Zhang Y, Zhou Q, Shu HB
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14128-33
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14128-33
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MARCH8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MARCH8. This antibody recognizes human, mouse antigen. The MARCH8 antibody has been validated for the following applications: ELISA, WB, IP analysis.
