25768-1-AP

antibody from Proteintech Group

Targeting: USP19 KIAA0891, ZMYND9

Provider product page for 25768-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]

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Product number: 25768-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#25768-1-AP, RRID:AB_2713918
Product name: USP19 antibody
Antibody type: Polyclonal
Description: USP19 antibody (Cat. #25768-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP19 protein structure - 25768-1-AP shown in red.

Submitted references ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation.

Shao S, Li W, Hong Y, Zeng R, Zhu L, Yi L, Li Y, Wang Y, Huang H, Jiang X, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14077

Targeting USP11 counteracts SFTPC(I73T) -associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models.

Karapurkar JK, Rajkumar S, Jung JH, Kim JY, Birappa G, Gowda DAA, Colaco JC, Suresh B, Choi JY, Woo SH, Jo WJ, Lee JH, Kim KS, Hong SH, Ramakrishna S
Theranostics 2025;15(10):4526-4549

Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19.

Picard F, Nonaka T, Belotti E, Osseni A, Errazuriz-Cerda E, Jost-Mousseau C, Bernard E, Conjard-Duplany A, Bohl D, Hasegawa M, Raoul C, Galli T, Schaeffer L, Leblanc P
Cellular and molecular life sciences : CMLS 2025 Feb 13;82(1):76

USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.

Wang G, Dai S, Chen J, Zhang K, Huang C, Zhang J, Xie K, Lin F, Wang H, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Cell death and differentiation 2025 Apr;32(4):702-713

Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein.

Yu W, Zhuang S, Zhan M, Chen Y, Zhang J, Chen L, Tu C, Zheng L, Chen S
Journal of Alzheimer's disease : JAD 2024;100(3):799-808

USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression.

Tyagi A, Karapurkar JK, Colaco JC, Sarodaya N, Antao AM, Kaushal K, Haq S, Chandrasekaran AP, Das S, Singh V, Hong SH, Suresh B, Kim KS, Ramakrishna S
Molecular biotechnology 2024 Aug;66(8):2032-2045

USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells.

Yan XH, Zhu YN, Zhu YT
Current medical science 2024 Aug;44(4):707-717

Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1.

You Y, Wang H, Wang Q, Yu Z, Zhao Z, Zhuang L, Zeng S, Zheng J, Wen W
Open medicine (Warsaw, Poland) 2023;18(1):20230798

Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer.

Zhang X, Chen X, Qian F, Zhu Y, He G, Yang J, Wu X, Zhang H, Yu X, Liu X
Clinical and translational medicine 2023 Sep;13(9):e1398

Deubiquitinase USP19 enhances phenylalanine hydroxylase protein stability and its enzymatic activity.

Sarodaya N, Tyagi A, Kim HJ, Colaco JC, Kang JS, Kim WJ, Kim KS, Ramakrishna S
Cell biology and toxicology 2023 Oct;39(5):2295-2310

The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.

Tian Z, Xu C, He W, Lin Z, Zhang W, Tao K, Ding R, Zhang X, Dou K
Cancer letters 2023 Nov 28;577:216439

Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin.

Chandrasekaran AP, Tyagi A, Poondla N, Sarodaya N, Karapurkar JK, Kaushal K, Park CH, Hong SH, Kim KS, Ramakrishna S
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Nov 2;30(11):3414-3429

Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants.

Sarodaya N, Tyagi A, Kim HJ, Kang JS, Singh V, Hong SH, Kim WJ, Kim KS, Ramakrishna S
Scientific reports 2022 Aug 20;12(1):14243

USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.

Chandrasekaran AP, Kaushal K, Park CH, Kim KS, Ramakrishna S
Theranostics 2021;11(20):9752-9771

USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.

Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)

USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.

Dong Z, Guo S, Wang Y, Zhang J, Luo H, Zheng G, Yang D, Zhang T, Yan L, Song L, Liu K, Sun Z, Meng X, Zheng Z, Zhang J, Zhao Y
OncoTargets and therapy 2020;13:8495-8510

An Interaction Landscape of Ubiquitin Signaling.

Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 25768-1-AP( USP19 Antibody) at dilution of 1:600
Other comments: WB
Appendix: 25768-1-AP.pdf

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