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- References [15]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14487-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14487-1-AP, RRID:AB_2165820
- Product name
- PNPT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PNPT1 antibody (Cat. #14487-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.
Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages.
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance.
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
RNA triggers chronic stress during neuronal aging.
Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1.
Blockade of pan-viral propagation by inhibition of host cell PNPT1.
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages.
Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice.
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
Wynne M, Zlatic SA, Park AS, Crocker A, Mendez-Vazquez H, Liporace E, Gokhale A, Tower-Gilchrist C, Robinette M, Purcell RH, Bassell GJ, Werner E, Kwong JQ, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 9;
bioRxiv : the preprint server for biology 2026 Jan 9;
Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages.
Li YP, Niu XJ, Zhang G, Chan OK, Sun N, Hu B, Shi ZJ, Ouyang DY, He XH, Zha QB
Frontiers in immunology 2025;16:1726408
Frontiers in immunology 2025;16:1726408
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance.
Singh G, Singh S, Mohapatra I, Kim S, Sharma M, Akers J, Nguyen T, Wong E, Moreno MM, Kokkoli E, Vasudevan S, Lawler SE, El-Deiry WS, Gokaslan Z, Chen CC
Cell reports 2025 Nov 25;44(11):116516
Cell reports 2025 Nov 25;44(11):116516
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
He J, Zhu Y, Tian Z, Liu M, Gao A, Fu W, Lu F, Sun Y, Guo Y, Pan R, Ji Y, Chen J, Lu H, Lin J, Liang X, Kim C, Zhou C, Jiao H
Molecular cell 2025 May 1;85(9):1790-1805.e7
Molecular cell 2025 May 1;85(9):1790-1805.e7
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Li J, Bai R, Zhou Y, Song X, Li L
PLoS genetics 2025 Jan;21(1):e1011580
PLoS genetics 2025 Jan;21(1):e1011580
RNA triggers chronic stress during neuronal aging.
Rhine K, Epstein E, Carlson NM, Ge X, Mizrahi O, Kamat A, Hermann A, Brothers WR, Ravits J, Bennett EJ, Pekkurnaz G, Yeo GW
bioRxiv : the preprint server for biology 2025 Aug 5;
bioRxiv : the preprint server for biology 2025 Aug 5;
Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1.
Zhang Y, Cao Y, Wu X, Chen Z, Chen B, Wang A, Guo Y, Chen W, Xue R, Liu Z, Li Y, Li T, Cheng R, Zhou N, Li J, Liu Y, Zhao X, Luo H, Xu M, Li H, Geng Y
Nature communications 2024 Oct 16;15(1):8936
Nature communications 2024 Oct 16;15(1):8936
Blockade of pan-viral propagation by inhibition of host cell PNPT1.
Qu S, Yang C, Sun X, Huang H, Li J, Zhu Y, Zhang Y, Li L, Liang H, Zen K
International journal of antimicrobial agents 2024 May;63(5):107124
International journal of antimicrobial agents 2024 May;63(5):107124
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J
Immunity 2023 Nov 14;56(11):2523-2541.e8
Immunity 2023 Nov 14;56(11):2523-2541.e8
Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages.
Hsu CG, Li W, Sowden M, Chávez CL, Berk BC
Cellular & molecular immunology 2023 Feb;20(2):131-142
Cellular & molecular immunology 2023 Feb;20(2):131-142
Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice.
Liu H, Peng H, Wang L, Xu P, Wang Z, Liu H, Wu H
Frontiers in cell and developmental biology 2020;8:635201
Frontiers in cell and developmental biology 2020;8:635201
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
Majumder M, Palanisamy V
PLoS genetics 2020 Jan;16(1):e1008580
PLoS genetics 2020 Jan;16(1):e1008580
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A
The EMBO journal 2016 Dec 1;35(23):2566-2583
The EMBO journal 2016 Dec 1;35(23):2566-2583
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
Pangršič T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E1028-37
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E1028-37
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C
American journal of human genetics 2012 Nov 2;91(5):919-27
American journal of human genetics 2012 Nov 2;91(5):919-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 14487-1-AP(PNPT1 antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14487-1-AP(PNPT1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PNPT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PNPT1. This antibody recognizes human, mouse, rat antigen. The PNPT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
