23024-1-AP

antibody from Proteintech Group

Targeting: SYCP3

Provider product page for 23024-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [41]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 23024-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#23024-1-AP, RRID:AB_11232426
Product name: SCP3 antibody
Antibody type: Polyclonal
Description: SCP3 antibody (Cat. #23024-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SYCP3 protein structure - 23024-1-AP shown in red.

Submitted references MCM8-9 helicase activity protects primordial germ cell development to prevent premature ovarian insufficiency.

Jiao X, Li Z, Tang Z, Xu J, Lu LY, Liu Y
Proceedings of the National Academy of Sciences of the United States of America 2026 May 12;123(19):e2535910123

Dissecting the development of bovine testicular tissue using spatial transcriptomics.

Jin H, Ma Y, Xie Y, Yang S, Chen X, Wang N, Zhang L, Ma Y
Journal of animal science and biotechnology 2026 Feb 5;17(1):21

Combinatorial tagging generates a multi-purpose knock-in mouse model revealing phase separation-dependent germ granules in RNA homeostasis and germline development.

Meng L, Xu C, Cao Y, Wu L, Zhu Y, Zou J, Uddin I, Zafar I, Muhammad A, Xing X, Jin RT, He L, Liu H, Li W, Bao J
Cell death and differentiation 2025 Sep;32(9):1595-1612

Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring.

Zhang W, Liu J, Wang Y, Wang J, Zhu P, Wang W, Song Z, Li J, Song D, Wang Y, Liu X
Scientific reports 2025 Mar 21;15(1):9810

Chronic exposure to liquid crystal monomer EBCN at environmentally relevant concentrations induces testicular dysfunction via the gut-testis axis.

Wu J, Lv D, Lin W, Mao Y, Xia Y, Feng L, Zhao T, Mao X, Shu F, Guo H
Journal of hazardous materials 2025 Mar 15;486:137033

Melatonin ameliorates heat stress-induced oxidative apoptosis in mouse spermatocytes via autophagy and ferroptosis pathways.

Lei YP, Wang J, Yin PL, Jia H, Ma WZ
Cell stress & chaperones 2025 Jul;30(4):100078

The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis.

Guo Y, Xia P, Tian Y, Fu D, Hu X, Xie K, Dong W, Zhang W, Liu D, Shen R, Wang D
Cell death discovery 2025 Jul 24;11(1):339

Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction.

Zhou H, Xu Z, Jiang C, Wu Q, Zhang C, Liu Z, Zhang X, Li W, Pang Y, Zhang J, Pan W, Chen M, Xia X
Cell communication and signaling : CCS 2025 Jan 31;23(1):58

Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.

Li Z, Xiang YJ, Zou ZC, Feng YM, Wang H, Chen WQ, Ge X, Ma JZ, Jing J, Yao B
Zoological research 2025 Jan 18;46(1):177-192

Duck Tembusu virus induced mitophagy in vacuolate spermatogenic cells is mediated by PINK1-Parkin pathway.

Huang Y, Yan X, Chu X, Shi Y, Xiang J, Yang S
Poultry science 2025 Feb;104(2):104795

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors.

Wang W, Xing J, Zhang X, Liu H, Liu X, Jiang H, Xu C, Zhao X, Hu Z
eLife 2025 Feb 26;13

Eugenol Nanoparticles Ameliorate Doxorubicin-Induced Spermatogenic Dysfunction by Inhibiting the PINK1/Parkin and BNIP3/NIX Signaling Pathways.

Fu Y, Yuan P, Wang M, Zheng Y, Zhang Y, Zhao L, Ma Q, Wang P, Sun X, Zheng X, Feng W
International journal of nanomedicine 2024;19:13287-13300

MRE11 is essential for the long-term viability of undifferentiated spermatogonia.

Tang Z, Liang Z, Zhang B, Xu X, Li P, Li L, Lu LY, Liu Y
Cell proliferation 2024 Sep;57(9):e13685

Flaxseed oil attenuates PFOS-induced testicular damage by regulating RNA alternative splicing.

Ren J, Liu J, Zuo J, Zhang Z, Huang D, Liu X, Lu M, Zhang Y, Su Y, Ma Y
Food & function 2024 Sep 30;15(19):10007-10019

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality.

Niu CX, Li JW, Li XL, Zhang LL, Lang Y, Song ZB, Yu CL, Yang XG, Zhao HF, Sun JL, Zheng LH, Wang X, Sun Y, Han XH, Wang GN, Bao YL
Zoological research 2024 Sep 18;45(5):1037-1047

Bazi Bushen alleviates reproductive aging in aged male mice.

Ma K, Li M, Song Y, Mao X, Zhang S, Zhang Y, Jiang Y, Ji C, Niu K, Li H, Hou Y, Wei C
Chinese journal of natural medicines 2024 May;22(5):416-425

Inhibition of p38MAPK signalling pathway alleviates radiation-induced testicular damage through improving spermatogenesis.

Yang J, Ou X, Shu M, Wang J, Zhang X, Wu Z, Hao W, Zeng H, Shao L
British journal of pharmacology 2024 Feb;181(3):393-412

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.

Chotiner JY, Leu NA, Yang F, Cossu IG, Guan Y, Lin H, Wang PJ
eLife 2024 Aug 29;12

Reproductive effects of pubertal exposure to neonicotinoid thiacloprid in immature male mice.

Zou Y, Zhang L, Yue M, Zou Z, Wu X, Zhang Q, Huang Y, Zeng S, Chen C, Gao J
Toxicology and applied pharmacology 2023 Sep 1;474:116629

Exposure to elevated temperature affects the expression of PIWI-interacting RNAs and associated transcripts in mouse testes.

Chen W, Zhao Z, Cen S, Lv D, Wu J, Zhou X, Yang T, Zhao T, Hou L, Mao X
Andrology 2023 May;11(4):724-737

The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.

Lin H, Cossu IG, Leu NA, Deshpande AJ, Bernt KM, Luo M, Wang PJ
Development (Cambridge, England) 2023 May 1;150(9)

Transcriptome Analysis in High Temperature Inhibiting Spermatogonial Stem Cell Differentiation In Vitro.

Gao WJ, Li HX, Feng J, Lu XR, Yin PL, Jia H, Ma WZ
Reproductive sciences (Thousand Oaks, Calif.) 2023 Jun;30(6):1938-1951

Systematic assessment of hexavalent chromium-induced damage to male fertility and the preventive role of melatonin: a longitudinal study from the translational point of view.

Li T, Lv Y, Wu Z, Guo M, Liu R, Zeng W, Zheng Y
Molecular human reproduction 2023 Jun 30;29(7)

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.

Jiang X, Cheng Y, Zhu Y, Xu C, Li Q, Xing X, Li W, Zou J, Meng L, Azhar M, Cao Y, Tong X, Qin W, Zhu X, Bao J
Nature communications 2023 Jun 22;14(1):3729

Acrylamide-induced meiotic arrest of spermatocytes in adolescent mice by triggering excessive DNA strand breaks: Potential therapeutic effects of resveratrol.

Gao Y, Zhang D, Wang P, Qu X, Xu J, Yu Y, Zhou X
Human & experimental toxicology 2023 Jan-Dec;42:9603271231188293

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.

Chotiner JY, Leu NA, Yang F, Cossu IG, Guan Y, Lin H, Wang PJ
bioRxiv : the preprint server for biology 2023 Dec 15;

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566

Optimized protocol for isolation of germ cells from mouse testis by centrifugal elutriation.

Cao Y, Meng L, Cheng Y, Azhar M, Jiang X, Xing X, Bao J
STAR protocols 2022 Sep 16;3(3):101540

SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.

Guan Y, Lin H, Leu NA, Ruthel G, Fuchs SY, Busino L, Luo M, Wang PJ
Nucleic acids research 2022 May 20;50(9):5129-5144

Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.

Fu Y, Yuan P, Zheng Y, Gao L, Wei Y, Chen Y, Li P, Ruan Y, Zheng X, Feng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061

Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability.

Min Z, Xin H, Liu X, Wan J, Fan Z, Rao X, Fan J, Yang L, Li D
iScience 2022 Dec 22;25(12):105552

Studying the nature of ascending-descending-floating-sinking of Chinese medicines based on gonadotropin-releasing hormone.

Yang FU, Peipei Y, Mengnan Z, Ying H, Liyuan G, Yaxin W, Xiaoke Z, Weisheng F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Aug;42(4):546-555

Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.

Li H, Chen H, Zhang X, Qi Y, Wang B, Cui Y, Ren J, Zhao Y, Chen Y, Zhu T, Wang Y, Yao L, Guo Y, Zhu H, Li Y, Situ C, Guo X
Cellular and molecular life sciences : CMLS 2022 Aug 5;79(8):467

YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.

Liu R, Kasowitz SD, Homolka D, Leu NA, Shaked JT, Ruthel G, Jain D, Lin H, Keeney S, Luo M, Pillai RS, Wang PJ
Cell reports 2021 Dec 14;37(11):110110

SKP1 drives the prophase I to metaphase I transition during male meiosis.

Guan Y, Leu NA, Ma J, Chmátal L, Ruthel G, Bloom JC, Lampson MA, Schimenti JC, Luo M, Wang PJ
Science advances 2020 Mar;6(13):eaaz2129

NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.

Zhang B, Tang Z, Li L, Lu LY
Cell death and differentiation 2020 Jul;27(7):2176-2190

Melatonin protects the mouse testis against heat-induced damage.

Zhang P, Zheng Y, Lv Y, Li F, Su L, Qin Y, Zeng W
Molecular human reproduction 2020 Feb 29;26(2):65-79

The testis-specifically expressed gene Trim69 is not essential for fertility in mice.

He X, Xie W, Li H, Cui Y, Wang Y, Guo X, Sha J
Journal of biomedical research 2020 Aug 21;35(1):47-60

Control of homologous recombination by the HROB-MCM8-MCM9 pathway.

Hustedt N, Saito Y, Zimmermann M, Álvarez-Quilón A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D
Genes & development 2019 Oct 1;33(19-20):1397-1415

The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.

Serra N, Velte EK, Niedenberger BA, Kirsanov O, Geyer CB
Biology of reproduction 2019 Feb 1;100(2):429-439

Abnormal synapses, recombination, and impaired double-strand break repair in a man with nonobstructive azoospermia.

Luo XY, Yang QL, Xin H, Zhao FF, Bai R, Li FY, Zhu J, Sun YP
Asian journal of andrology 2018 Jul-Aug;20(4):409-411

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse testis tissue were subjected to SDS PAGE followed by western blot with 23024-1-AP(SYCP3 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SCP3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SCP3. This antibody recognizes human,mouse,rat antigen. The SCP3 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 23024-1-AP.pdf

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