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- Antibody Data
- Antigen structure
- References [41]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11238-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11238-1-AP, RRID:AB_2149040
- Product name
- NDUFV1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NDUFV1 antibody (Cat. #11238-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references N-acetylcysteine modulates rotenone-induced mitochondrial Complex I dysfunction in THP-1 cells.
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation.
The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration.
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis.
Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain.
Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch.
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells.
Gene Expression Changes by Diallyl Trisulfide Administration in Chemically-induced Mammary Tumors in Rats.
CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis.
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.
Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.
GABA regulates IL-1β production in macrophages.
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Novel MT-ND Gene Variants Causing Adult-Onset Mitochondrial Disease and Isolated Complex I Deficiency.
Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I.
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly.
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.
A salvage pathway maintains highly functional respiratory complex I.
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference.
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Quantitative temporal analysis of protein dynamics in cardiac remodeling.
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.
Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Beneficial effects of resveratrol on respiratory chain defects in patients' fibroblasts involve estrogen receptor and estrogen-related receptor alpha signaling.
GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models.
Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria.
Kwok WT, Kwak HA, Andreazza AC
Mitochondrion 2023 Sep;72:1-10
Mitochondrion 2023 Sep;72:1-10
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.
Milenkovic D, Misic J, Hevler JF, Molinié T, Chung I, Atanassov I, Li X, Filograna R, Mesaros A, Mourier A, Heck AJR, Hirst J, Larsson NG
Cell metabolism 2023 Oct 3;35(10):1799-1813.e7
Cell metabolism 2023 Oct 3;35(10):1799-1813.e7
Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.
Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
Signal transduction and targeted therapy 2023 Jun 16;8(1):229
PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation.
Ren L, Meng L, Gao J, Lu M, Guo C, Li Y, Rong Z, Ye Y
Cell death & disease 2023 Jan 20;14(1):44
Cell death & disease 2023 Jan 20;14(1):44
The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA
Cell metabolism 2023 Aug 8;35(8):1441-1456.e9
Cell metabolism 2023 Aug 8;35(8):1441-1456.e9
Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration.
Bastin J, Sroussi M, Nemazanyy I, Laurent-Puig P, Mouillet-Richard S, Djouadi F
Journal of translational medicine 2023 Aug 3;21(1):522
Journal of translational medicine 2023 Aug 3;21(1):522
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis.
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, Ju W, Li Y, Sun Z, Xu M, Li Z, Andrews RK, Gardiner EE, Zeng L, Xu K, Qiao J
Nature communications 2023 Aug 10;14(1):4829
Nature communications 2023 Aug 10;14(1):4829
Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain.
Robinson DRL, Hock DH, Muellner-Wong L, Kugapreethan R, Reljic B, Surgenor EE, Rodrigues CHM, Caruana NJ, Stroud DA
Frontiers in cell and developmental biology 2022;10:786268
Frontiers in cell and developmental biology 2022;10:786268
Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells.
Xu X, Liu Y, Luan J, Liu R, Wang Y, Liu Y, Xu A, Zhou B, Han F, Shang W
Proteome science 2022 Sep 7;20(1):14
Proteome science 2022 Sep 7;20(1):14
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609
Circulation 2022 Nov 22;146(21):1591-1609
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch.
Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C
Cell metabolism 2022 Nov 1;34(11):1792-1808.e6
Cell metabolism 2022 Nov 1;34(11):1792-1808.e6
The FoxQ1 transcription factor is a novel regulator of electron transport chain complex I subunits in human breast cancer cells.
Kim SH, Singh SV
Molecular carcinogenesis 2022 Mar;61(3):372-381
Molecular carcinogenesis 2022 Mar;61(3):372-381
Gene Expression Changes by Diallyl Trisulfide Administration in Chemically-induced Mammary Tumors in Rats.
Hahm ER, Singh SV
Journal of cancer prevention 2022 Mar 30;27(1):22-30
Journal of cancer prevention 2022 Mar 30;27(1):22-30
CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis.
Rumyantseva A, Popovic M, Trifunovic A
Brain : a journal of neurology 2022 Mar 29;145(1):92-104
Brain : a journal of neurology 2022 Mar 29;145(1):92-104
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B
Developmental cell 2022 Jan 24;57(2):260-276.e9
Developmental cell 2022 Jan 24;57(2):260-276.e9
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.
Xue W, Li X, Li W, Wang Y, Jiang C, Zhou L, Gao J, Yu Y, Shen Y, Xu Q
Signal transduction and targeted therapy 2022 Feb 4;7(1):35
Signal transduction and targeted therapy 2022 Feb 4;7(1):35
Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.
Hermeling JC, Herholz M, Baumann L, Cores EC, Zečić A, Hoppe T, Riemer J, Trifunovic A
Redox biology 2022 Dec;58:102533
Redox biology 2022 Dec;58:102533
GABA regulates IL-1β production in macrophages.
Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770
Cell reports 2022 Dec 6;41(10):111770
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Jiang L, Yin X, Chen YH, Chen Y, Jiang W, Zheng H, Huang FQ, Liu B, Zhou W, Qi LW, Li J
Theranostics 2021;11(4):1703-1720
Theranostics 2021;11(4):1703-1720
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Novel MT-ND Gene Variants Causing Adult-Onset Mitochondrial Disease and Isolated Complex I Deficiency.
Ng YS, Thompson K, Loher D, Hopton S, Falkous G, Hardy SA, Schaefer AM, Shaunak S, Roberts ME, Lilleker JB, Taylor RW
Frontiers in genetics 2020;11:24
Frontiers in genetics 2020;11:24
Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I.
Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW
EMBO molecular medicine 2020 Nov 6;12(11):e12619
EMBO molecular medicine 2020 Nov 6;12(11):e12619
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly.
Dibley MG, Formosa LE, Lyu B, Reljic B, McGann D, Muellner-Wong L, Kraus F, Sharpe AJ, Stroud DA, Ryan MT
Molecular & cellular proteomics : MCP 2020 Jan;19(1):65-77
Molecular & cellular proteomics : MCP 2020 Jan;19(1):65-77
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
Zhang X, Wang Q, Li Y, Ruan C, Wang S, Hu L, Ye M
Analytical chemistry 2020 Jan 7;92(1):1363-1371
Analytical chemistry 2020 Jan 7;92(1):1363-1371
Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.
Wen J, Wang GL, Yuan HJ, Zhang J, Xie HL, Gong S, Han X, Tan JH
Scientific reports 2020 Feb 17;10(1):2782
Scientific reports 2020 Feb 17;10(1):2782
A salvage pathway maintains highly functional respiratory complex I.
Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A
Nature communications 2020 Apr 2;11(1):1643
Nature communications 2020 Apr 2;11(1):1643
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB
Nature 2019 Nov;575(7782):380-384
Nature 2019 Nov;575(7782):380-384
Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference.
Xie HL, Zhu S, Zhang J, Wen J, Yuan HJ, Pan LZ, Luo MJ, Tan JH
Journal of cellular physiology 2018 Sep;233(9):6952-6964
Journal of cellular physiology 2018 Sep;233(9):6952-6964
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
Quantitative temporal analysis of protein dynamics in cardiac remodeling.
McClatchy DB, Ma Y, Liem DA, Ng DCM, Ping P, Yates JR 3rd
Journal of molecular and cellular cardiology 2018 Aug;121:163-172
Journal of molecular and cellular cardiology 2018 Aug;121:163-172
Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex.
Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT, Stojanovski D
Molecular cell 2017 Aug 3;67(3):457-470.e5
Molecular cell 2017 Aug 3;67(3):457-470.e5
Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature 2016 Oct 6;538(7623):123-126
Nature 2016 Oct 6;538(7623):123-126
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Tang H, Li J, Liu X, Wang G, Luo M, Deng H
Scientific reports 2016 Jun 21;6:28388
Scientific reports 2016 Jun 21;6:28388
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531
Cell reports 2016 Dec 6;17(10):2522-2531
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
eLife 2016 Aug 24;5
eLife 2016 Aug 24;5
Beneficial effects of resveratrol on respiratory chain defects in patients' fibroblasts involve estrogen receptor and estrogen-related receptor alpha signaling.
Lopes Costa A, Le Bachelier C, Mathieu L, Rotig A, Boneh A, De Lonlay P, Tarnopolsky MA, Thorburn DR, Bastin J, Djouadi F
Human molecular genetics 2014 Apr 15;23(8):2106-19
Human molecular genetics 2014 Apr 15;23(8):2106-19
GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models.
Kelly-Aubert M, Trudel S, Fritsch J, Nguyen-Khoa T, Baudouin-Legros M, Moriceau S, Jeanson L, Djouadi F, Matar C, Conti M, Ollero M, Brouillard F, Edelman A
Human molecular genetics 2011 Jul 15;20(14):2745-59
Human molecular genetics 2011 Jul 15;20(14):2745-59
Complex I specific increase in superoxide formation and respiration rate by PrP-null mouse brain mitochondria.
Paterson AW, Curtis JC, Macleod NK
Journal of neurochemistry 2008 Apr;105(1):177-91
Journal of neurochemistry 2008 Apr;105(1):177-91
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 11238-1-AP(NDUFV1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NDUFV1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NDUFV1. This antibody recognizes human,mouse,rat antigen. The NDUFV1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
