Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12946-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12946-1-AP, RRID:AB_2215681
- Product name
- VRK2 antibody
- Antibody type
- Polyclonal
- Description
- VRK2 antibody (Cat. #12946-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lin XT, Zhang J, Liu ZY, Wu D, Fang L, Li CM, Yu HQ, Xie CM
Cell reports 2023 Jul 25;42(7):112812
Cell reports 2023 Jul 25;42(7):112812
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.
Yin MY, Guo L, Zhao LJ, Zhang C, Liu WP, Zhang CY, Huo JH, Wang L, Li SW, Zheng CB, Xiao X, Li M, Wang C, Chang H
BMC medicine 2023 Jul 14;21(1):256
BMC medicine 2023 Jul 14;21(1):256
VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer.
Chen J, Qiao K, Zhang C, Zhou X, Du Q, Deng Y, Cao L
International journal of biological sciences 2022;18(3):1288-1302
International journal of biological sciences 2022;18(3):1288-1302
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The VRK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VRK2. This antibody recognizes human, mouse, rat antigen. The VRK2 antibody has been validated for the following applications: ELISA, WB analysis.