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- Antibody Data
- Antigen structure
- References [4]
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- Western blot [1]
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- Product number
- ABIN1881336 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Fanconi Anemia, Complementation Group L (FANCL) (C-Term), (AA 274-302) antibody
- Antibody type
- Polyclonal
- Antigen
- This FANCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the C-terminal region of human FANCL.
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- C-Term,AA 274-302
- Antibody clone number
- RB23901
- Vial size
- 400 μL
- Concentration
- 0.5 mg/mL
Submitted references FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth.
Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.
Zhang J, Zhao D, Park HK, Wang H, Dyer RB, Liu W, Klee GG, McNiven MA, Tindall DJ, Molina JR, Fei P
The Journal of clinical investigation 2010 May;120(5):1524-34
The Journal of clinical investigation 2010 May;120(5):1524-34
Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.
García MJ, Fernández V, Osorio A, Barroso A, Fernández F, Urioste M, Benítez J
Carcinogenesis 2009 Nov;30(11):1898-902
Carcinogenesis 2009 Nov;30(11):1898-902
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
Longerich S, San Filippo J, Liu D, Sung P
The Journal of biological chemistry 2009 Aug 28;284(35):23182-6
The Journal of biological chemistry 2009 Aug 28;284(35):23182-6
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.
Hess CJ, Ameziane N, Schuurhuis GJ, Errami A, Denkers F, Kaspers GJ, Cloos J, Joenje H, Reinhardt D, Ossenkoppele GJ, Zwaan CM, Waisfisz Q
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(4):299-306
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(4):299-306
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FANCL Antibody (C-term) (ABIN1881336) western blot analysis in 293 cell line lysates (35 μg/lane). This demonstrates the FANCL antibody detected the FANCL protein (arrow).
