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- Antibody Data
- Antigen structure
- References [22]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 15265-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15265-1-AP, RRID:AB_2146403
- Product name
- MLYCD antibody
- Antibody type
- Polyclonal
- Description
- MLYCD antibody (Cat. #15265-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction.
Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin.
Identification of mitochondrial-related signature and molecular subtype for the prognosis of osteosarcoma.
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.
Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension.
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
The Impact of Nicotine along with Oral Contraceptive Exposure on Brain Fatty Acid Metabolism in Female Rats.
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.
Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.
PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis.
c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction.
Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.
Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.
C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.
5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
Dafre AL, Zahid S, Probst JJ, Currais A, Yu J, Schubert D, Maher P
Aging 2024 Mar 20;16(6):4980-4999
Aging 2024 Mar 20;16(6):4980-4999
Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin.
Lai Q, Zhu X, Zhang L, Kou J, Liu F, Yu B, Li F
Translational research : the journal of laboratory and clinical medicine 2023 Nov;261:1-15
Translational research : the journal of laboratory and clinical medicine 2023 Nov;261:1-15
Identification of mitochondrial-related signature and molecular subtype for the prognosis of osteosarcoma.
Zhao X, Zhang J, Liu J, Chen Q, Cai C, Miao X, Wu T, Cheng X
Aging 2023 Nov 16;15(22):12794-12816
Aging 2023 Nov 16;15(22):12794-12816
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.
Guilherme A, Rowland LA, Wetoska N, Tsagkaraki E, Santos KB, Bedard AH, Henriques F, Kelly M, Munroe S, Pedersen DJ, Ilkayeva OR, Koves TR, Tauer L, Pan M, Han X, Kim JK, Newgard CB, Muoio DM, Czech MP
Cell reports 2023 May 30;42(5):112488
Cell reports 2023 May 30;42(5):112488
Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension.
Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA, Kudryashova TV
Frontiers in medicine 2022;9:886868
Frontiers in medicine 2022;9:886868
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Wang M, Zhao M, Yu J, Xu Y, Zhang J, Liu J, Zheng Z, Ye J, Wang Z, Ye D, Feng Y, Xu S, Pan W, Wei C, Wan J
Frontiers in cardiovascular medicine 2022;9:727474
Frontiers in cardiovascular medicine 2022;9:727474
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
Lin W, Zhang X, Zhang C, Li L, Zhang J, Xie P, Zhan Y, An W
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
Laboratory investigation; a journal of technical methods and pathology 2022 Oct;102(10):1075-1087
The Impact of Nicotine along with Oral Contraceptive Exposure on Brain Fatty Acid Metabolism in Female Rats.
Patel SH, Timón-Gómez A, Pradhyumnan H, Mankaliye B, Dave KR, Perez-Pinzon MA, Raval AP
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Zhuang L, Mao Y, Liu Z, Li C, Jin Q, Lu L, Tao R, Yan X, Chen K
Frontiers in cardiovascular medicine 2021;8:722908
Frontiers in cardiovascular medicine 2021;8:722908
Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.
Zhang L, Yang SY, Qi-Li FR, Liu XX, Zhang WT, Peng C, Wu P, Li P, Li P, Xu X
Phytotherapy research : PTR 2021 Jul;35(7):3898-3915
Phytotherapy research : PTR 2021 Jul;35(7):3898-3915
Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.
Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM
Cell reports 2019 Feb 5;26(6):1557-1572.e8
Cell reports 2019 Feb 5;26(6):1557-1572.e8
TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
Shah A, Melhuish TA, Fox TE, Frierson HF Jr, Wotton D
Genes & development 2019 Apr 1;33(7-8):388-402
Genes & development 2019 Apr 1;33(7-8):388-402
Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.
Sychev ZE, Hu A, DiMaio TA, Gitter A, Camp ND, Noble WS, Wolf-Yadlin A, Lagunoff M
PLoS pathogens 2017 Mar;13(3):e1006256
PLoS pathogens 2017 Mar;13(3):e1006256
PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis.
Standage SW, Bennion BG, Knowles TO, Ledee DR, Portman MA, McGuire JK, Liles WC, Olson AK
American journal of physiology. Heart and circulatory physiology 2017 Feb 1;312(2):H239-H249
American journal of physiology. Heart and circulatory physiology 2017 Feb 1;312(2):H239-H249
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis.
Zhang H, Li Y, Hu J, Shen WJ, Singh M, Hou X, Bittner A, Bittner S, Cortez Y, Tabassum J, Kraemer FB, Azhar S
PloS one 2015;10(9):e0138203
PloS one 2015;10(9):e0138203
c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction.
Ledee D, Smith L, Bruce M, Kajimoto M, Isern N, Portman MA, Olson AK
PloS one 2015;10(8):e0135262
PloS one 2015;10(8):e0135262
Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.
Polinati PP, Valanne L, Tyni T
Brain & development 2015 Jan;37(1):107-13
Brain & development 2015 Jan;37(1):107-13
Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.
Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 10;111(23):E2414-22
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 10;111(23):E2414-22
C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.
Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA
Journal of molecular and cellular cardiology 2013 Feb;55:156-64
Journal of molecular and cellular cardiology 2013 Feb;55:156-64
5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.
Stride N, Larsen S, Treebak JT, Hansen CN, Hey-Mogensen M, Speerschneider T, Jensen TE, Jeppesen J, Wojtaszewski JF, Richter EA, Køber L, Dela F
Frontiers in physiology 2012;3:33
Frontiers in physiology 2012;3:33
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
Hyyti OM, Ledee D, Ning XH, Ge M, Portman MA
American journal of physiology. Heart and circulatory physiology 2010 Sep;299(3):H868-75
American journal of physiology. Heart and circulatory physiology 2010 Sep;299(3):H868-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 15265-1-AP(MLYCD antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using MLYCD antibody 15265-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MLYCD (IP:15265-1-AP, 4ug; Detection:15265-1-AP 1:500) with mouse heart tissue lysate 5000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15265-1-AP(MLYCD antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15265-1-AP(MLYCD antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
