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- Antigen structure
- References [5]
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- Product number
- 15852-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15852-1-AP, RRID:AB_2168894
- Product name
- PPP6C antibody
- Antibody type
- Polyclonal
- Description
- PPP6C antibody (Cat. #15852-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells.
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death.
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Yamamoto M, Fujiwara N
The Journal of veterinary medical science 2023 Sep 7;85(9):977-984
The Journal of veterinary medical science 2023 Sep 7;85(9):977-984
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death.
Wu G, Li D, Liang W, Sun W, Xie X, Tong Y, Shan B, Zhang M, Lu X, Yuan J, Li Y
Cell death & disease 2022 Sep 7;13(9):773
Cell death & disease 2022 Sep 7;13(9):773
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.
Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH, Tan M, Zhao B
Molecular cell 2022 Dec 15;82(24):4700-4711.e12
Molecular cell 2022 Dec 15;82(24):4700-4711.e12
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Li M, Shu HB
Protein & cell 2020 Aug;11(8):584-599
Protein & cell 2020 Aug;11(8):584-599
Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Hwang J, Lee JA, Pallas DC
The Journal of biological chemistry 2016 Sep 30;291(40):21008-21019
The Journal of biological chemistry 2016 Sep 30;291(40):21008-21019
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPP6C antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPP6C. This antibody recognizes human, mouse, rat antigen. The PPP6C antibody has been validated for the following applications: ELISA, WB analysis.
