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- Antibody Data
- Antigen structure
- References [137]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 55456-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55456-1-AP, RRID:AB_11232209
- Product name
- TRIM63 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM63 antibody (Cat. #55456-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses.
Chronic hypoxia induces skeletal muscle atrophy in mice: Potential roles of antioxidant imbalance and FOXO1.
Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.
Canine Adipose MSC-Derived Exosomes Ameliorate Skeletal Muscle Injury in Mice.
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway.
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Targeting the mTOR-mitochondrial function axis: Calcitriol attenuates sarcopenic obesity with lipid dysregulation etiology.
Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism.
Duck-egg white hydrolysate supplementation enhances muscle endurance and fatigue resistance during high-intensity exercise.
Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in mice.
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
3,3'-Diindolylmethane ameliorate obesity-related skeletal muscle atrophy via regulating mitochondrial function.
Sesn2 is Associated with Attenuated Muscle Atrophy and Altered Expression of Key Myogenic and Autophagy Markers in Mdx Mice.
Protective effects of Salubrinal against H(2)O(2)-induced muscle wasting via eIF2α/ATF4 signaling pathway.
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.
Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.
TRIM63/IRF-8 axis promotes tumor progression and immunosuppression of melanoma with BRAF mutation.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Daurisoline inhibits pancreatic cancer progression by direct binding to PPARα and blocking its ubiquitination-mediated degradation.
Influence of Neonatal Exposure to Hyperoxia on Skeletal Muscle in a Rat Model.
The Alleviative Effect of Sodium Butyrate on Dexamethasone-Induced Skeletal Muscle Atrophy.
Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway.
Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.
Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
E3 ligase Trim63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of Myh11.
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial.
Anemarrhena asphodeloides fructan attenuates cigarette smoke-induced muscle atrophy by activating the Akt/mTOR pathway and inhibiting the ubiquitin-proteasome pathway.
Glucocorticoid-Induced Muscle Satellite Cell-Derived Extracellular Vesicles Mediate Skeletal Muscle Atrophy via the miR-335-5p/MAPK11/iNOS Pathway.
Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy.
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.
SESN2 mediates resistance training-induced improvements in exercise performance and energy metabolism in C57BL/6J mice.
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3-Mediated Pyroptosis.
Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice.
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
Electroacupuncture Improves Anorectal Function in Neurogenic Fecal Incontinence Rats, Related to Reversing Anal Sphincter Atrophy and Enhancing Muscle Satellite Cell Activity.
DR8 (DHNNPQIR), a rapeseed-derived peptide, mitigates fibrosis and muscle atrophy in chronic kidney disease by targeting CNR1-ERK/ELK-1 signaling.
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
HDAC11 deficiency regulates age-related muscle decline and sarcopenia.
Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.
An Animal Model of Liuzijue Based on Kinematic Features Exploration: A Pilot Study Conducting in COPD.
Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Lambertianic Acid from Platycladus orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells.
Ginsenoside Rg1 Attenuates Muscle Atrophy in Hyperglycemic Conditions, Inactivity and Protein Deprivation Models via AKT/mTOR Pathway Activation.
Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.
PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection.
Vagus nerve stimulation (VNS) inhibits cardiac mast cells activation and improves myocardial atrophy after ischemic stroke.
Pharmacological activation of pyruvate dehydrogenase by dichloroacetate protects against obesity-induced muscle atrophy in vitro and in vivo.
Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress.
A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats.
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice.
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes.
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy.
The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.
The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota.
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.
Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome.
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy.
N-acetylcysteine alleviates oxidative stress and apoptosis and prevents skeletal muscle atrophy in type 1 diabetes mellitus through the NRF2/HO-1 pathway.
Unraveling the gut microbiota and short-chain fatty acids characteristics and associations in a cancer cachexia mouse model.
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia.
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
Effects of millimeter-wave for preventing joint stiffness in the immobilized knee rat model.
Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons.
An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy.
Fish Protein Promotes Skeletal Muscle Hypertrophy via the Akt/mTOR Signaling Pathways.
An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.
A missense mutation in ISPD contributes to maintain muscle fiber stability.
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle.
A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Serum IL-35 levels is a new candidate biomarker of cancer-related cachexia in stage IV non-small cell lung cancer.
Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish.
Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice.
Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway.
miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles.
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting.
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia.
Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching.
Heat stress during late pregnancy of sows influences offspring longissimus dorsi muscle growth at weaning.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia.
Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα(+) mesenchymal progenitors.
FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway.
Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways.
Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten/Akt pathway.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Fucoxanthinol attenuates oxidative stress-induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes.
A novel oncogene TRIM63 promotes cell proliferation and migration via activating Wnt/β-catenin signaling pathway in breast cancer.
Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.
Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis.
Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades.
Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles.
Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.
Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge.
Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.
Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis.
Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.
Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.
Chen R, Dai X, Wang H, Zhang T, Zhang Z, Liu Y, Fan Z
Frontiers in aging 2026;7:1736069
Frontiers in aging 2026;7:1736069
Chronic hypoxia induces skeletal muscle atrophy in mice: Potential roles of antioxidant imbalance and FOXO1.
Luo X, Tang S, Luo X, Wangmo S, Xia R, Wang X
Biochimica et biophysica acta. General subjects 2026 May;1870(5):130922
Biochimica et biophysica acta. General subjects 2026 May;1870(5):130922
Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.
Yang X, Zou Y, Wang H, Niu Y, Fu L
Sports medicine and health science 2026 Mar;8(2):197-209
Sports medicine and health science 2026 Mar;8(2):197-209
Canine Adipose MSC-Derived Exosomes Ameliorate Skeletal Muscle Injury in Mice.
Gao J, Li Y, Zhong Y
Animals : an open access journal from MDPI 2026 Mar 9;16(5)
Animals : an open access journal from MDPI 2026 Mar 9;16(5)
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
Han L, Jing L, Zhu X, Li C, Bai L, Fang Y, Zhou Y, Bai D, Lu J, Han Y, Guo C, Zhou S, Yang Q
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70295
Journal of cachexia, sarcopenia and muscle 2026 Jun;17(3):e70295
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway.
Nie D, Zhang Y, Jia R, Fang Z, Zhu G, Xu B, Guo T, Zhang H
Journal of ethnopharmacology 2026 Jun 12;364:121500
Journal of ethnopharmacology 2026 Jun 12;364:121500
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Yang X, Peng J, Huang Y, Liu S, Niu Y, Fu L
Sports medicine and health science 2026 Jan;8(1):50-60
Sports medicine and health science 2026 Jan;8(1):50-60
Targeting the mTOR-mitochondrial function axis: Calcitriol attenuates sarcopenic obesity with lipid dysregulation etiology.
Fan S, Yu Y, Wei Y, An J, Wang Q, Yang Y
Free radical biology & medicine 2026 Jan;242:305-319
Free radical biology & medicine 2026 Jan;242:305-319
Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism.
Zhang Y, Pan Z, Shi J, Zhang J, Chai Y, Zhao Y, Liu W, Yuan W
Experimental gerontology 2026 Jan;213:113001
Experimental gerontology 2026 Jan;213:113001
Duck-egg white hydrolysate supplementation enhances muscle endurance and fatigue resistance during high-intensity exercise.
Shang KL, Lin YL, Sutopo CCY, Chen JW, Chen YC
Poultry science 2026 Jan;105(1):106088
Poultry science 2026 Jan;105(1):106088
Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in mice.
Xie Y, Deng D, Wang S, Li Z, Mo T, Wang Y, Guo H
NPJ science of food 2026 Jan 9;10(1):49
NPJ science of food 2026 Jan 9;10(1):49
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Song CY, Yang Y, Hong K
Tissue & cell 2026 Aug;101:103487
Tissue & cell 2026 Aug;101:103487
3,3'-Diindolylmethane ameliorate obesity-related skeletal muscle atrophy via regulating mitochondrial function.
Zhong Y, Chen S, Pan J, Niu R, Du J, Dong Q, Liu Y, Yao Y, Lin Y, Fang H, Su J, Li X, Zhang Y, Yang G, Wu J, Li J, Liu W, Huang B, Tang J, Zhu W
The Journal of nutritional biochemistry 2026 Apr;150:110223
The Journal of nutritional biochemistry 2026 Apr;150:110223
Sesn2 is Associated with Attenuated Muscle Atrophy and Altered Expression of Key Myogenic and Autophagy Markers in Mdx Mice.
Song Z, Lin Q, Liang J, He J, Zhang W
Journal of molecular neuroscience : MN 2026 Apr 22;76(2)
Journal of molecular neuroscience : MN 2026 Apr 22;76(2)
Protective effects of Salubrinal against H(2)O(2)-induced muscle wasting via eIF2α/ATF4 signaling pathway.
Lin S, Wu J, Lian G, Wu W, Chen W, Chen A, Luo L, Xie L
Frontiers in pharmacology 2025;16:1607606
Frontiers in pharmacology 2025;16:1607606
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Zhu M, Yang Y, Fang H, Chen R
Genomics 2025 Sep;117(5):111087
Genomics 2025 Sep;117(5):111087
Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.
Hosny N, Cohen H, Elafany MW, Schreifels J, Bauer J, Gulati R, Thompson BR, Liu JC, Metzger JM
bioRxiv : the preprint server for biology 2025 Sep 4;
bioRxiv : the preprint server for biology 2025 Sep 4;
Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.
Zhang J, Xue C, Lang J, Pei C, Liu Q
Meat science 2025 Oct;228:109889
Meat science 2025 Oct;228:109889
TRIM63/IRF-8 axis promotes tumor progression and immunosuppression of melanoma with BRAF mutation.
Yi F, Liu S, Ma Y, Li Y, Chen B, Yu B
Cell death & disease 2025 Nov 28;16(1):869
Cell death & disease 2025 Nov 28;16(1):869
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Daurisoline inhibits pancreatic cancer progression by direct binding to PPARα and blocking its ubiquitination-mediated degradation.
Xu D, Zhu Y, Ye W, Yu Y, Wang X, Xu C, Jiang K, Chen W, Zhang X, Shen H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157245
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157245
Influence of Neonatal Exposure to Hyperoxia on Skeletal Muscle in a Rat Model.
Awata K, Santosa I, Arai Y, Nakagawa M, Suganuma H, Shoji H
Pediatric reports 2025 Nov 14;17(6)
Pediatric reports 2025 Nov 14;17(6)
The Alleviative Effect of Sodium Butyrate on Dexamethasone-Induced Skeletal Muscle Atrophy.
Zhao X, Zhu M, Wang Z, Gao M, Long Y, Zhou S, Wang W
Cell biology international 2025 May;49(5):508-521
Cell biology international 2025 May;49(5):508-521
Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway.
Liang D, Wang D, Zheng X, Xiang H, Liu S, Yu C, Tian J, Ma J, Niu Y
Cellular signalling 2025 Mar;127:111581
Cellular signalling 2025 Mar;127:111581
Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.
Akhter A, Md Sheikh A, Yoshino J, Kanda T, Nagai A, Matsuo M, Yano S
International journal of molecular sciences 2025 Mar 27;26(7)
International journal of molecular sciences 2025 Mar 27;26(7)
Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.
Shi S, Li R, Han Y, Xie J, Wang S, Liu J, Wan F, Hou G, Liu Z, Sun X, Zuo B, Jia Z, Mei Z, Song T
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13853
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13853
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Zhao M, Liu S, Wang Y, Lou P, Lv K, Wu T, Li L, Wu Q, Zhu J, Lu Y, Wan M, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
E3 ligase Trim63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of Myh11.
Ye S, Wang Y, Luo Z, Liu A, Li X, Guo J, Zhao W, Chen D, Yang L, Liu H
Stem cells (Dayton, Ohio) 2025 Jun 24;43(7)
Stem cells (Dayton, Ohio) 2025 Jun 24;43(7)
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Wang H, Zhang C, He J, He Z, Yan S, Zhang Y, Huang S, Yan Y, Chen Y, Xian Z, Hu R, Wang Y, Xiao W, Wang M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial.
Kawahara T, Inazu T, Mizuno S, Tominaga N, Toda M, Toyama N, Kawahara C, Suzuki G, DPVD Research Group
Metabolism: clinical and experimental 2025 Jul;168:156240
Metabolism: clinical and experimental 2025 Jul;168:156240
Anemarrhena asphodeloides fructan attenuates cigarette smoke-induced muscle atrophy by activating the Akt/mTOR pathway and inhibiting the ubiquitin-proteasome pathway.
Wang L, Pan Y, Lin B, Zhang F, Xu L, Huang F, Wang N
Journal of ethnopharmacology 2025 Jul 24;351:120116
Journal of ethnopharmacology 2025 Jul 24;351:120116
Glucocorticoid-Induced Muscle Satellite Cell-Derived Extracellular Vesicles Mediate Skeletal Muscle Atrophy via the miR-335-5p/MAPK11/iNOS Pathway.
Ma P, Wu J, Zhou R, Xue L, Luo X, Yan Y, Lu J, Dong Y, Geng J, Wang H
Biomolecules 2025 Jul 24;15(8)
Biomolecules 2025 Jul 24;15(8)
Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy.
Tian Z, Wang Y, Liu X, Xin X, Liu S, Qu Y, Li Z, Su X, Ma D
Scientific reports 2025 Jul 19;15(1):26224
Scientific reports 2025 Jul 19;15(1):26224
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.
Liu X, Chen Y, Zhang L, Qi Z, Yang L, Huang C, Wang L, Lin D
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)
SESN2 mediates resistance training-induced improvements in exercise performance and energy metabolism in C57BL/6J mice.
Huang Y, Sun S, Yang X, Li X, Zhou Y, Liu S, Niu Y, Fu L
Experimental cell research 2025 Jul 1;450(1):114617
Experimental cell research 2025 Jul 1;450(1):114617
HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.
Qi H, Gao Y, Zhang Z, Zhang X, Tian D, Jiang Y, Zhang L, Zeng N, Yang R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917
Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.
Hu H, Yin Y, Zhou H, Jiang B, Cai T, Wu S, Guo S
Experimental cell research 2025 Jan 15;444(2):114396
Experimental cell research 2025 Jan 15;444(2):114396
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Song J, Yang M, Xia L, Wang L, Wang K, Xiang Y, Cheng J, Chen J, Liu J, Zhao R, Liu F, Sun Z, Hou X, Zang N, Chen L
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3-Mediated Pyroptosis.
Yang J, Wang M, Shi L, Fang X, Gao C, Ma L, Wang Y, Ying S, Yang Y
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13649
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13649
Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice.
Zheng L, Lan C, Gao X, Zhu A, Chen Y, Lin J, Yan S, Shen X
Heliyon 2025 Feb 15;11(3):e42123
Heliyon 2025 Feb 15;11(3):e42123
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
Wu Y, Yang Y, Du C, Peng X, Fan W, Chang B, Shan C
Scientific reports 2025 Feb 10;15(1):4918
Scientific reports 2025 Feb 10;15(1):4918
Electroacupuncture Improves Anorectal Function in Neurogenic Fecal Incontinence Rats, Related to Reversing Anal Sphincter Atrophy and Enhancing Muscle Satellite Cell Activity.
He J, Wan Q, Du L, Qin Q, Zhao L, Dong Q
Neurogastroenterology and motility 2025 Dec;37(12):e70138
Neurogastroenterology and motility 2025 Dec;37(12):e70138
DR8 (DHNNPQIR), a rapeseed-derived peptide, mitigates fibrosis and muscle atrophy in chronic kidney disease by targeting CNR1-ERK/ELK-1 signaling.
Zhang W, Zuo Y, Xu D, Lin Y, Zang Y, Chen R, Chen M, Su Z
Peptides 2025 Dec;194:171456
Peptides 2025 Dec;194:171456
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Song J, Sun Y, Zang N, Liu X, Chen J, Wang K, Xia L, Chen J, Zhao R, Liu F, Hou X, Chen L, Cheng J, Zhang W
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Upregulation of E3 ligase UBR2 in acetaldehyde-treated C2C12 myotubes and its potential involvement in fast-twitch muscle atrophy in alcohol-fed rats.
Shintani-Ishida K, Ikegaya H
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
Alcohol, clinical & experimental research 2025 Aug;49(8):1667-1677
HDAC11 deficiency regulates age-related muscle decline and sarcopenia.
Odria R, Cardús A, Gomis-Coloma C, Balanyà-Segura M, Mercado-Amarilla A, Maestre-Mora P, Poveda-Sabuco A, Domingo JC, Nogales-Gadea G, Gomez-Sanchez JA, Hurtado E, Suelves M
GeroScience 2025 Aug;47(4):5843-5868
GeroScience 2025 Aug;47(4):5843-5868
Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.
Wu X, Liu R, Zhu N, Wang X, Wei C, An X, Xu M, Li Y
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70002
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70002
An Animal Model of Liuzijue Based on Kinematic Features Exploration: A Pilot Study Conducting in COPD.
Li J, Ji X, Li K, Cao M, Sun Y, Cao C, Yin Z, Wang X, Fang F, Chen CT, Gu W
Immunity, inflammation and disease 2025 Aug;13(8):e70233
Immunity, inflammation and disease 2025 Aug;13(8):e70233
Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Ren Y, Wang K, Wu Y, Li J, Ma J, Wang L, Zhang C, Li J, Wei Y, Yang Y
International journal of biological macromolecules 2025 Apr;301:140488
International journal of biological macromolecules 2025 Apr;301:140488
Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.
An X, Ma L, Bai Y, Chen C, Liu J, Dawuti A, Zeng K, Yang B, Han B, Abulizi A
Journal of cachexia, sarcopenia and muscle 2025 Apr;16(2):e13777
Journal of cachexia, sarcopenia and muscle 2025 Apr;16(2):e13777
Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.
Gao S, Leng Y, Qiu Z, Li K, Li J, Peng J, Xie W, Lei S, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296
Lambertianic Acid from Platycladus orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells.
Cho CH, Chae SH, Thi NHL, Um SH, Lee S, Yu JS, Kang KS, Kim KH
Plants (Basel, Switzerland) 2025 Apr 30;14(9)
Plants (Basel, Switzerland) 2025 Apr 30;14(9)
Ginsenoside Rg1 Attenuates Muscle Atrophy in Hyperglycemic Conditions, Inactivity and Protein Deprivation Models via AKT/mTOR Pathway Activation.
He X, Li Y, Chen J, Zhang L, Huang Y, Zhou Y, Li J
Current molecular medicine 2025 Apr 23;
Current molecular medicine 2025 Apr 23;
Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.
Sasaki A, Takeda D, Kawai H, Tadokoro Y, Murakami A, Yatagai N, Arimoto S, Nagatsuka H, Akashi M, Hasegawa T
PloS one 2024;19(4):e0302194
PloS one 2024;19(4):e0302194
PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection.
Wang Y, Xu Y, Zhao T, Ma YJ, Qin W, Hu WL
Open life sciences 2024;19(1):20220952
Open life sciences 2024;19(1):20220952
Vagus nerve stimulation (VNS) inhibits cardiac mast cells activation and improves myocardial atrophy after ischemic stroke.
Tan Q, Ruan Y, Wu S, Jiang Y, Fu R, Gu X, Yu J, Wu Q, Li M, Jiang S
International immunopharmacology 2024 Sep 30;139:112714
International immunopharmacology 2024 Sep 30;139:112714
Pharmacological activation of pyruvate dehydrogenase by dichloroacetate protects against obesity-induced muscle atrophy in vitro and in vivo.
Yang JM, Han IS, Chen TH, Hsieh PS, Tsai MC, Chien HC
European journal of pharmacology 2024 Sep 15;979:176854
European journal of pharmacology 2024 Sep 15;979:176854
Exogenous hydrogen sulfide enhances myogenic differentiation of C2C12 myoblasts under high palmitate stress.
Lu F, Zhang S, Dong S, Wang M, Pang K, Zhao Y, Huang J, Kang J, Liu N, Zhang X, Zhao D, Lu F, Zhang W
Heliyon 2024 Oct 15;10(19):e38661
Heliyon 2024 Oct 15;10(19):e38661
A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats.
Ye H, Li ZQ, Yang JM, Long Y, Zhong YB, Wu Y, Wang MY
European journal of pharmacology 2024 Nov 5;982:176910
European journal of pharmacology 2024 Nov 5;982:176910
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice.
Li T, Hu X, Fan L, Yang Y, He K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116557
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116557
Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.
He J, He Z, Wang H, Zhang C, Pei T, Yan S, Yan Y, Wang F, Chen Y, Yuan N, Wang M, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116556
A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes.
Tawara W, Morisasa M, Mukai R, Suo R, Itoi S, Mori T, Goto-Inoue N
Lipids 2024 Mar;59(2):55-63
Lipids 2024 Mar;59(2):55-63
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy.
Mora S, Adegoke OAJ
American journal of physiology. Cell physiology 2024 Mar 1;326(3):C866-C879
American journal of physiology. Cell physiology 2024 Mar 1;326(3):C866-C879
The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.
She Y, Ma Y, Zou P, Peng Y, An Y, Chen H, Luo P, Wei S
Life (Basel, Switzerland) 2024 Jun 21;14(7)
Life (Basel, Switzerland) 2024 Jun 21;14(7)
The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota.
Zhang Y, Wang C, Lang H, Yu H, Zhou M, Rao X, Zhang Q, Yi L, Zhu J, Mi M
International journal of molecular sciences 2024 Jul 17;25(14)
International journal of molecular sciences 2024 Jul 17;25(14)
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.
Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49
Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.
Gao S, Zhao X, Leng Y, Xia Z
Scientific reports 2024 Jan 28;14(1):2328
Scientific reports 2024 Jan 28;14(1):2328
Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome.
Xiang M, Yuan X, Zhang N, Zhang L, Liu Y, Liu J, Gao Y, Xu Y, Sun W, Tang Q, Zhang Y, Lu J
Journal of physiology and biochemistry 2024 Feb;80(1):235-247
Journal of physiology and biochemistry 2024 Feb;80(1):235-247
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Cao X, Xue L, Yu X, Yan Y, Lu J, Luo X, Wang H, Wang J
Aging 2024 Feb 29;16(5):4609-4630
Aging 2024 Feb 29;16(5):4609-4630
Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.
Han D, Chen YB, Zhao K, Li HZ, Chen XY, Zhu GZ, Tu C, Gao JW, Zhuang JS, Wu ZY, Zhong ZM
Archives of biochemistry and biophysics 2024 Dec;762:110215
Archives of biochemistry and biophysics 2024 Dec;762:110215
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.
Wang K, Zeng H, Yang H
Chinese medicine 2024 Dec 31;19(1):180
Chinese medicine 2024 Dec 31;19(1):180
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Oleanolic acid alleviates obesity-induced skeletal muscle atrophy via the PI3K/Akt signaling pathway.
Sun Y, Wei X, Zhao T, Shi H, Hao X, Wang Y, Zhang H, Yao Z, Zheng M, Ma T, Fu T, Lu J, Luo X, Yan Y, Wang H
FEBS open bio 2024 Apr;14(4):584-597
FEBS open bio 2024 Apr;14(4):584-597
Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.
Cao Y, Li Y, Han W, Jia X, Zhu P, Wei B, Cong X, Wang Z
Journal of inflammation research 2023;16:343-358
Journal of inflammation research 2023;16:343-358
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Hu BA, Li YL, Han HT, Lu B, Jia X, Han L, Ma WX, Zhu P, Wang ZH, Zhang W, Zhong M, Zhang L
Frontiers in pharmacology 2023;14:1112123
Frontiers in pharmacology 2023;14:1112123
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy.
Martin TG, Juarros MA, Cleveland JC Jr, Bristow MR, Ambardekar AV, Buttrick PM, Leinwand LA
JACC. Basic to translational science 2023 Sep;8(9):1043-1056
JACC. Basic to translational science 2023 Sep;8(9):1043-1056
N-acetylcysteine alleviates oxidative stress and apoptosis and prevents skeletal muscle atrophy in type 1 diabetes mellitus through the NRF2/HO-1 pathway.
Ding Q, Sun B, Wang M, Li T, Li H, Han Q, Liao J, Tang Z
Life sciences 2023 Sep 15;329:121975
Life sciences 2023 Sep 15;329:121975
Unraveling the gut microbiota and short-chain fatty acids characteristics and associations in a cancer cachexia mouse model.
Liu H, Cheng Y, Qu Y, Wu G
Microbial pathogenesis 2023 Oct;183:106332
Microbial pathogenesis 2023 Oct;183:106332
An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia.
Huang XC, Huang YL, Guo YT, Li SY, Gao C, Chen JX, Ma JY, He B
Experimental gerontology 2023 Nov;183:112322
Experimental gerontology 2023 Nov;183:112322
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001
International immunopharmacology 2023 Nov;124(Pt B):111001
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
Yang Y, Yang X, Huang Y, Liu S, Niu Y, Fu L
Experimental cell research 2023 Nov 1;432(1):113779
Experimental cell research 2023 Nov 1;432(1):113779
Effects of millimeter-wave for preventing joint stiffness in the immobilized knee rat model.
Shui XP, Ye F, Li CY, Zhang X, Wang MJ, Li B, Chen K, Liao YY
The Knee 2023 Jun;42:236-245
The Knee 2023 Jun;42:236-245
Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons.
Zhang Y, Xi Q, Zhong M, Jiang Y, Zhuang Q, Ding Z, Tan S, Wang J, Liu H, Zhang Z, Zhou B, Wu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jun;37(6):e22980
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jun;37(6):e22980
An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.
Martin RA, Keeler SP, Wu K, Shearon WJ, Patel D, Li J, Hoang M, Hoffmann CM, Hughes ME, Holtzman MJ
American journal of physiology. Lung cellular and molecular physiology 2023 Jun 1;324(6):L870-L878
American journal of physiology. Lung cellular and molecular physiology 2023 Jun 1;324(6):L870-L878
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
Yang X, Wang L, Zhang L, Zhai X, Sheng X, Quan H, Lin H
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951
EMBO molecular medicine 2023 Jul 10;15(7):e16951
Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.
Huang KC, Chiang YF, Huang TC, Chen HY, Lin PH, Ali M, Hsia SM
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Shi Y, Zhang ZW, Du MM, Wu J, Li JX
Journal of ethnopharmacology 2023 Aug 10;312:116458
Journal of ethnopharmacology 2023 Aug 10;312:116458
Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy.
Song J, Liu J, Cui C, Hu H, Zang N, Yang M, Yang J, Zou Y, Li J, Wang L, He Q, Guo X, Zhao R, Yan F, Liu F, Hou X, Sun Z, Chen L
Journal of cachexia, sarcopenia and muscle 2023 Apr;14(2):915-929
Journal of cachexia, sarcopenia and muscle 2023 Apr;14(2):915-929
Fish Protein Promotes Skeletal Muscle Hypertrophy via the Akt/mTOR Signaling Pathways.
Morisasa M, Yoshida E, Fujitani M, Kimura K, Uchida K, Kishida T, Mori T, Goto-Inoue N
Journal of nutritional science and vitaminology 2022;68(1):23-31
Journal of nutritional science and vitaminology 2022;68(1):23-31
An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.
Martin RA, Keeler SP, Wu K, Shearon WJ, Patel D, Hoang M, Hoffmann CM, Hughes ME, Holtzman MJ
bioRxiv : the preprint server for biology 2022 Oct 8;
bioRxiv : the preprint server for biology 2022 Oct 8;
A missense mutation in ISPD contributes to maintain muscle fiber stability.
Guo L, Zhang S, Xu Y, Huang Y, Luo W, Wen Q, Liu G, Huang W, Xu H, Chen B, Nie Q
Poultry science 2022 Nov;101(11):102143
Poultry science 2022 Nov;101(11):102143
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle.
Huang S, Zheng X, Zhang X, Jin Z, Liu S, Fu L, Niu Y
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Nov 1;47(11):1062-1074
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Nov 1;47(11):1062-1074
A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity.
Zou YY, Chen ZL, Sun CC, Yang D, Zhou ZQ, Xiao Q, Peng XY, Tang CF
Nutrients 2022 May 9;14(9)
Nutrients 2022 May 9;14(9)
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Xiang G, Ying K, Jiang P, Jia M, Sun Y, Li S, Wu X, Hao S
Skeletal muscle 2022 May 6;12(1):10
Skeletal muscle 2022 May 6;12(1):10
Serum IL-35 levels is a new candidate biomarker of cancer-related cachexia in stage IV non-small cell lung cancer.
Li Z, Zhu L, Zheng H, Jiang W, Wang Y, Jiang Z, Xu J
Thoracic cancer 2022 Mar;13(5):716-723
Thoracic cancer 2022 Mar;13(5):716-723
Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish.
Tamai S, Fujita SI, Komine R, Kanki Y, Aoki K, Watanabe K, Takekoshi K, Sugasawa T
Biochemical and biophysical research communications 2022 Jun 11;608:59-65
Biochemical and biophysical research communications 2022 Jun 11;608:59-65
Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice.
Shimizu J, Kawano F
The Journal of physiology 2022 Jul;600(14):3331-3353
The Journal of physiology 2022 Jul;600(14):3331-3353
Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway.
Shen Q, Kuang JX, Miao CX, Zhang WL, Li YW, Zhang XW, Liu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153858
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153858
miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles.
Yang X, Li Z, Wang Z, Yu J, Ma M, Nie Q
Biomolecules 2022 Jan 23;12(2)
Biomolecules 2022 Jan 23;12(2)
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)
Metabolites 2022 Aug 25;12(9)
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting.
Li L, Liu H, Tao W, Wen S, Fu X, Yu S
Frontiers in pharmacology 2021;12:731386
Frontiers in pharmacology 2021;12:731386
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Zhang W, You B, Qi D, Qiu L, Ripley-Gonzalez JW, Zheng F, Fu S, Li C, Dun Y, Liu S
Scientific reports 2021 Sep 27;11(1):19116
Scientific reports 2021 Sep 27;11(1):19116
Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia.
Xie K, Xiong H, Xiao W, Xiong Z, Hu W, Ye J, Xu N, Shi J, Yuan C, Chen Z, Miao D, Zhang X, Yang H
Cancer cell international 2021 Nov 27;21(1):627
Cancer cell international 2021 Nov 27;21(1):627
Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching.
Deprez A, Orfi Z, Radu A, He Y, Ravizzoni Dartora D, Dort J, Dumont NA, Nuyt AM
Clinical science (London, England : 1979) 2021 Nov 26;135(22):2589-2605
Clinical science (London, England : 1979) 2021 Nov 26;135(22):2589-2605
Heat stress during late pregnancy of sows influences offspring longissimus dorsi muscle growth at weaning.
Li Y, Fan G, Liu Y, Yao W, Albrecht E, Zhao R, Yang X
Research in veterinary science 2021 May;136:336-342
Research in veterinary science 2021 May;136:336-342
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
Yoshikawa M, Hosokawa M, Miyashita K, Nishino H, Hashimoto T
Nutrients 2021 Mar 26;13(4)
Nutrients 2021 Mar 26;13(4)
Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.
Wang L, Zheng ZG, Meng L, Zhu L, Li P, Chen J, Yang H
Cell biology and toxicology 2021 Jun;37(3):441-460
Cell biology and toxicology 2021 Jun;37(3):441-460
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Dong J, Yu J, Li Z, Gao S, Wang H, Yang S, Wu L, Lan C, Zhao T, Gao C, Liu Z, Wang X, Hao J
Journal of cachexia, sarcopenia and muscle 2021 Jun;12(3):704-716
Journal of cachexia, sarcopenia and muscle 2021 Jun;12(3):704-716
Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia.
Miao C, Zhang W, Feng L, Gu X, Shen Q, Lu S, Fan M, Li Y, Guo X, Ma Y, Liu X, Wang H, Zhang X
Molecular therapy. Nucleic acids 2021 Jun 4;24:923-938
Molecular therapy. Nucleic acids 2021 Jun 4;24:923-938
Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Zhang L, Zhang Y, Zhou M, Wang S, Li T, Hu Z, Jin C
International journal of molecular medicine 2021 Jul;48(1)
International journal of molecular medicine 2021 Jul;48(1)
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα(+) mesenchymal progenitors.
Shang GK, Han L, Wang ZH, Song M, Wang D, Tan YM, Li YH, Li YL, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway.
Guo A, Li K, Tian HC, Fan Z, Chen QN, Yang YF, Yu J, Wu YX, Xiao Q
Journal of cellular and molecular medicine 2021 Apr;25(7):3585-3600
Journal of cellular and molecular medicine 2021 Apr;25(7):3585-3600
Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways.
Wei X, Yang B, Chen X, Wen L, Kan J
Food & function 2021 Apr 21;12(8):3740-3753
Food & function 2021 Apr 21;12(8):3740-3753
Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.
Wen C, Li F, Guo Q, Zhang L, Duan Y, Wang W, Li J, He S, Chen W, Yin Y
Journal of animal science and biotechnology 2020;11:56
Journal of animal science and biotechnology 2020;11:56
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten/Akt pathway.
Wang M, Wu X, Gan L, Teng Z, Zhang H, Zhang Y
Experimental physiology 2020 Nov;105(11):1918-1927
Experimental physiology 2020 Nov;105(11):1918-1927
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, Li Q, Shu F, Sun Y, Liu N, Peng S, Zhao Y, Dong S, Zhao D, Lu F, Zhang W
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Fucoxanthinol attenuates oxidative stress-induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes.
Yoshikawa M, Hosokawa M, Miyashita K, Fujita T, Nishino H, Hashimoto T
Molecular biology reports 2020 Apr;47(4):2703-2711
Molecular biology reports 2020 Apr;47(4):2703-2711
A novel oncogene TRIM63 promotes cell proliferation and migration via activating Wnt/β-catenin signaling pathway in breast cancer.
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Pathology, research and practice 2019 Oct;215(10):152573
Pathology, research and practice 2019 Oct;215(10):152573
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Life sciences 2019 Oct 15;235:116800
Life sciences 2019 Oct 15;235:116800
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BMC complementary and alternative medicine 2019 Oct 15;19(1):267
BMC complementary and alternative medicine 2019 Oct 15;19(1):267
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Chemico-biological interactions 2019 May 1;304:43-51
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GeroScience 2019 Dec;41(6):871-880
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3547-3559
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Cell reports 2018 Jul 3;24(1):197-208
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Frontiers in pharmacology 2017;8:915
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The British journal of nutrition 2016 Oct;116(7):1188-1198
The British journal of nutrition 2016 Oct;116(7):1188-1198
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 55456-1-AP(TRIM63 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM63 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TRIM63. This antibody recognizes human,mouse,rat antigen. The TRIM63 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55456-1-AP(TRIM63 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55456-1-AP(TRIM63 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
