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- References [12]
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- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 13370-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13370-1-AP, RRID:AB_2271704
- Product name
- TDG antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TDG antibody (Cat. #13370-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.
Human HDAC6 senses valine abundancy to regulate DNA damage.
Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.
Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids.
TNC upregulation promotes glioma tumourigenesis through TDG-mediated active DNA demethylation.
Nucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription.
TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.
The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion.
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.
CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.
Zhu B, Pidugu LS, Cook ME, Nie XY, Amarasekara EAPT, Menet JS, Drohat AC, Sczepanski JT
The Journal of biological chemistry 2026 Apr;302(4):111308
The Journal of biological chemistry 2026 Apr;302(4):111308
Human HDAC6 senses valine abundancy to regulate DNA damage.
Jin J, Meng T, Yu Y, Wu S, Jiao CC, Song S, Li YX, Zhang Y, Zhao YY, Li X, Wang Z, Liu YF, Huang R, Qin J, Chen Y, Cao H, Tan X, Ge X, Jiang C, Xue J, Yuan J, Wu D, Wu W, Jiang CZ, Wang P
Nature 2025 Jan;637(8044):215-223
Nature 2025 Jan;637(8044):215-223
Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.
Chatterjee B, Majumder P, Chen CC, Wang JP, Su PH, Lai HC, Liu CC, Lin HN, Yu CA, Yuan HS, Shen CJ
Cellular & molecular biology letters 2025 Aug 5;30(1):95
Cellular & molecular biology letters 2025 Aug 5;30(1):95
Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids.
Zhu B, Pidugu LS, Cook ME, Nie XY, Amarasekara EAPT, Menet JS, Drohat AC, Sczepanski JT
bioRxiv : the preprint server for biology 2025 Aug 5;
bioRxiv : the preprint server for biology 2025 Aug 5;
TNC upregulation promotes glioma tumourigenesis through TDG-mediated active DNA demethylation.
Xu H, Long S, Xu C, Li Z, Chen J, Yang B, He Y, Xu Z, Li Z, Wei W, Li X
Cell death discovery 2024 Aug 1;10(1):347
Cell death discovery 2024 Aug 1;10(1):347
Nucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription.
Liu M, Lai M, Li D, Zhang R, Wang L, Peng W, Yang J, He W, Sheng Y, Xiao S, Nan A, Zeng X
Cancer science 2023 Oct;114(10):3884-3899
Cancer science 2023 Oct;114(10):3884-3899
TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.
Miao J, Zhao C, Tang K, Xiong X, Wu F, Xue W, Duan B, Zhang H, Jing X, Li W, Sun Y, Hou N, Huang C
International journal of biological sciences 2022;18(6):2527-2539
International journal of biological sciences 2022;18(6):2527-2539
The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion.
Li D, Chai L, Yu X, Song Y, Zhu X, Fan S, Jiang W, Qiao T, Tong J, Liu S, Fan L, Lv Z
Cell death & disease 2020 Apr 8;11(4):227
Cell death & disease 2020 Apr 8;11(4):227
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
Xu X, Yu T, Shi J, Chen X, Zhang W, Lin T, Liu Z, Wang Y, Zeng Z, Wang C, Li M, Liu C
The Journal of biological chemistry 2014 Mar 28;289(13):8881-90
The Journal of biological chemistry 2014 Mar 28;289(13):8881-90
Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.
Sahin U, Ferhi O, Jeanne M, Benhenda S, Berthier C, Jollivet F, Niwa-Kawakita M, Faklaris O, Setterblad N, de Thé H, Lallemand-Breitenbach V
The Journal of cell biology 2014 Mar 17;204(6):931-45
The Journal of cell biology 2014 Mar 17;204(6):931-45
CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
Shibata E, Dar A, Dutta A
The Journal of biological chemistry 2014 Aug 15;289(33):23056-23064
The Journal of biological chemistry 2014 Aug 15;289(33):23056-23064
Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.
Hu XV, Rodrigues TM, Tao H, Baker RK, Miraglia L, Orth AP, Lyons GE, Schultz PG, Wu X
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 24;107(34):15087-92
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 24;107(34):15087-92
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 13370-1-AP(TDG antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TDG antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TDG. This antibody recognizes human,mouse,rat antigen. The TDG antibody has been validated for the following applications: ELISA, WB, IP analysis.
