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Western blot
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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NB110-40424 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB110-40424, RRID:AB_670002
- Product name
- Rabbit Polyclonal Sin1/MAPKAP1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 ul
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades.
Uncoupling TORC2 from AGC kinases inhibits tumour growth.
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Huang Y, Feng G, Cai J, Peng Q, Yang Z, Yan C, Yang L, Wang Z
Life sciences 2020 May 1;248:117449
Life sciences 2020 May 1;248:117449
Uncoupling TORC2 from AGC kinases inhibits tumour growth.
Cameron AJM, Veeriah S, Marshall JJT, Murray ER, Larijani B, Parker PJ
Oncotarget 2017 Oct 17;8(49):84685-84696
Oncotarget 2017 Oct 17;8(49):84685-84696
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
Misra UK, Pizzo SV
Journal of cellular biochemistry 2012 May;113(5):1488-500
Journal of cellular biochemistry 2012 May;113(5):1488-500
Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.
Das F, Ghosh-Choudhury N, Dey N, Mandal CC, Mahimainathan L, Kasinath BS, Abboud HE, Choudhury GG
The Journal of biological chemistry 2012 Feb 3;287(6):3808-22
The Journal of biological chemistry 2012 Feb 3;287(6):3808-22
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Lu M, Wang J, Ives HE, Pearce D
The Journal of biological chemistry 2011 Sep 2;286(35):30647-54
The Journal of biological chemistry 2011 Sep 2;286(35):30647-54
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Huang J, Wu S, Wu CL, Manning BD
Cancer research 2009 Aug 1;69(15):6107-14
Cancer research 2009 Aug 1;69(15):6107-14
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Sin1/MAPKAP1 Antibody [NB110-40424] - Detection of Human Sin1 on HeLa whole cell lysate.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NB110-40424] - FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:100. Detection: DAB staining using Immunohistochemistry Accessory Kit.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NB110-40424] - FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:500. Detection: DAB staining using Immunohistochemistry Accessory Kit.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NB110-40424] - Section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- Sin1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
