MARCHF11

MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]). [supplied by OMIM, Apr 2010]

Description

membrane associated ring-CH-type finger 11

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

5:p15.1 (16067139 - 16180762)

Ensembl ID

ENSG00000183654  (ver. 99.38)

Orthologs

Mouse March11: ENSMUSG00000022269

UniProt

A6NNE9

neXtProt

NX_A6NNE9

Human splice variants
Mouse splice variants