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- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 21391-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ALDH1L2 antibody
- Antibody type
- Polyclonal
- Description
- ALDH1L2 antibody (Cat. #21391-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ALDH1L2 orchestrates redox-growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS-Akt/mTOR/S6K axis.
Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses.
Hypermethylation and suppression of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle.
Emerging variants, unique phenotypes, and transcriptomic signatures: an integrated study of COASY-associated diseases.
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil.
Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production.
Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis.
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Jiang C, Liu S, Zhang L, Li S, Wang J, Wang Y
Frontiers in immunology 2026;17:1768010
Frontiers in immunology 2026;17:1768010
Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses.
Meliton AY, Shin KWD, Cetin-Atalay R, Atalay MV, Tian Y, Houpy Szafran JC, Cho T, Sun KA, Woods PS, Shamaa OR, Chen B, Dulin NO, Husain AN, Muir A, Shah H, Mutlu GM, Hamanaka RB
Nature communications 2025 Oct 20;16(1):9250
Nature communications 2025 Oct 20;16(1):9250
Hypermethylation and suppression of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.
Wei Q, Xiao X, Huo E, Guo C, Zhou X, Hu X, Dong C, Shi H, Dong Z
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Jan 8;33(1):249-262
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Jan 8;33(1):249-262
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle.
Benzarti M, Neises L, Oudin A, Krötz C, Viry E, Gargiulo E, Pulido C, Schmoetten M, Pozdeev V, Lorenz NI, Ronellenfitsch MW, Sumpton D, Warmoes M, Jaeger C, Lesur A, Becker B, Moussay E, Paggetti J, Niclou SP, Letellier E, Meiser J
Cell reports 2024 Mar 26;43(3):113868
Cell reports 2024 Mar 26;43(3):113868
Emerging variants, unique phenotypes, and transcriptomic signatures: an integrated study of COASY-associated diseases.
Cavestro C, Morra F, Legati A, D'Amato M, Nasca A, Iuso A, Lubarr N, Morrison JL, Wheeler PG, Serra-Juhé C, Rodríguez-Santiago B, Turón-Viñas E, Prouteau C, Barth M, Hayflick SJ, Ghezzi D, Tiranti V, Di Meo I
Annals of clinical and translational neurology 2024 Jun;11(6):1615-1629
Annals of clinical and translational neurology 2024 Jun;11(6):1615-1629
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
Shashikadze B, Valla L, Lombardo SD, Prehn C, Haid M, Riols F, Stöckl JB, Elkhateib R, Renner S, Rathkolb B, Menche J, Hrabĕ de Angelis M, Wolf E, Kemter E, Fröhlich T
Molecular metabolism 2023 Sep;75:101768
Molecular metabolism 2023 Sep;75:101768
Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil.
Li C, Teng P, Sun S, Cui K, Yao S, Fei B, Ling F, Huang Z
The Journal of biological chemistry 2023 Sep;299(9):105090
The Journal of biological chemistry 2023 Sep;299(9):105090
Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production.
Meliton AY, Cetin-Atalay R, Tian Y, Szafran JCH, Shin KWD, Cho T, Sun KA, Woods PS, Shamaa OR, Chen B, Muir A, Mutlu GM, Hamanaka RB
bioRxiv : the preprint server for biology 2023 Nov 7;
bioRxiv : the preprint server for biology 2023 Nov 7;
Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.
Xiao X, Huo E, Guo C, Zhou X, Hu X, Dong C, Shi H, Dong Z, Wei Q
Research square 2023 Jun 5;
Research square 2023 Jun 5;
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ
Molecular cell 2022 Mar 3;82(5):920-932.e7
Molecular cell 2022 Mar 3;82(5):920-932.e7
G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis.
Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, Stanger BZ, Rabinowitz JD, Yang X
Science advances 2022 Jul 22;8(29):eabo0404
Science advances 2022 Jul 22;8(29):eabo0404
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
Yang Y, Liu S, Gao H, Wang P, Zhang Y, Zhang A, Jia Z, Huang S
Free radical biology & medicine 2020 May 20;152:821-837
Free radical biology & medicine 2020 May 20;152:821-837
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Balsa E, Perry EA, Bennett CF, Jedrychowski M, Gygi SP, Doench JG, Puigserver P
Nature communications 2020 Jun 1;11(1):2714
Nature communications 2020 Jun 1;11(1):2714
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 21391-1-AP(ALDH1L2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ALDH1L2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ALDH1L2. This antibody recognizes human, mouse antigen. The ALDH1L2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
