Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 657802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#657802, RRID:AB_2562650
- Product name
- Purified anti-Lin28A
- Antibody type
- Monoclonal
- Antigen
- Recombinant human Lin28A from E. coli
- Description
- LIN28A is a highly conserved RNA-binding protein and reprogramming factor that plays important roles in development, self-renewal of stem cells, glucose metabolism and tumorigenesis. Lin28A modulates not only miRNAs, particularly the let-7 family miRNAs, but also the translation of mRNAs that are important for cell growth and metabolism. LIN28A/B has been observed to be overexpressed in a wide range of solid tumors and hematological malignancies, and has emerged as a new therapeutic target candidate for cancer.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 14E6-4E6
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Immunoprecipitation/Western blot analysis of extracts from NTERA-2 cells. Lane 1 contains lysate input (5%), lane 2 was immunoprecipitated with mouse IgG2a isotype control antibody and lane 3 was immunoprecipitated with Lin28A antibody (14E6-4E6). Western blot analysis was performed using rabbit anti-Lin28A antibody (clone D9F5).
- Conjugate
- Unconjugated