RA0675

antibody from Oursmab

Targeting: SEMA4D C9orf164, CD100, coll-4, FLJ39737, SEMAJ

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0675

Provider

Oursmab

Product name

Pepinemab (Biosimilar Reference Antibody) (SEMA4D)

Antibody type

Monoclonal

Description

Pepinemab (also known as VX-15/SA-4F) is an investigational, humanized monoclonal antibody that targets semaphorin 4D (SEMA4D, CD100), a transmembrane protein involved in immune regulation and neuronal guidance. SEMA4D is expressed on activated T cells, B cells, and dendritic cells, and its receptor plexin-B1 is found on endothelial cells, neurons, and immune cells. By binding to SEMA4D, pepinemab blocks its signaling, thereby inhibiting the negative regulatory effects of SEMA4D on immune cell infiltration and activation in the tumor microenvironment. This promotes the recruitment and function of cytotoxic T cells and reduces immunosuppressive cells. It is being developed as an immuno-oncology agent for the treatment of advanced solid tumors, including head and neck squamous cell carcinoma (HNSCC) and glioblastoma.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Pepinemab (Biosimilar Reference Antibody) (SEMA4D)-RA0675-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Pepinemab (Biosimilar Reference Antibody) (SEMA4D)-RA0675 in a linear range of 0.18¨C15 ng/mL.