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- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 22723-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ARK5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ARK5 antibody (Cat. #22723-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.
Plasmodium falciparum exploits NUAK1 to establish infection in human erythrocytes.
NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma.
NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer.
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression.
NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma.
Cancer susceptibility 18 positively regulates NUAK Family Kinase 1 expression to promote migration and invasion via sponging of miR-5586-5p in cervical cancer cells.
DKK1 promotes NUAK1 transcriptional expression through the activation Akt in hepatocellular carcinoma.
Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer.
Discovery of a novel NUAK1 inhibitor against pancreatic cancer.
High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5.
MiR-204 inhibits hepatocellular cancer drug resistance and metastasis through targeting NUAK1.
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Overexpression of ARK5 is associated with poor prognosis in hepatocellular carcinoma.
Zhuang Z, Guan B, Wang Y, Lin X, Cai H, Chen B, Li S, Liu X, Zhuang J, Guan G
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
Plasmodium falciparum exploits NUAK1 to establish infection in human erythrocytes.
Navarrete DJ, Kim CY, McLelland K, Ramirez MG, Baro B, Salinas ND, Tolia NH, Doerig C, Ong SE, Golkowski MG, Egan ES
bioRxiv : the preprint server for biology 2025 Oct 30;
bioRxiv : the preprint server for biology 2025 Oct 30;
NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma.
Yao CY, Tao HT, He JJ, Zhu FY, Xie CQ, Cheng YN, Li JQ, Liu ZZ, Hou CY, Liu XL, Fan YL, Fang D, Lv XR
Molecular medicine (Cambridge, Mass.) 2025 Feb 3;31(1):38
Molecular medicine (Cambridge, Mass.) 2025 Feb 3;31(1):38
NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer.
Cao L, Lin G, Fan D, Weng K, Chen Y, Wang J, Li P, Zheng C, Huang C, Xie J
Cell reports 2024 Jul 23;43(7):114446
Cell reports 2024 Jul 23;43(7):114446
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Taylor LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, McGeachan RI, Meftah S, Rose JL, Spires-Jones MP, Holt K, Catterson JH, Koch H, Liaquat I, Clarke JH, Skidmore J, Smith C, Booker SA, Brennan PM, Spires-Jones TL, Durrant CS
Acta neuropathologica 2024 Jan 4;147(1):7
Acta neuropathologica 2024 Jan 4;147(1):7
LncRNA HOTAIR Enhances Epithelial-to-mesenchymal Transition to Promote the Migration and Invasion of Liver Cancer by Regulating NUAK1 via Epigenetic Inhibition miR-145-5p Expression.
Chu DX, Jin Y, Wang BR, Jiao Y, Zhang CK, Guo ZH, Hu SZ, Li N
Journal of Cancer 2023;14(12):2329-2343
Journal of Cancer 2023;14(12):2329-2343
NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma.
Yang H, Wei Z, Song Y, Du K, Yin N, Lu H, Li B, Hou L, Xing P, Chen L, Wang C, Xie S
Cancer cell international 2023 Nov 2;23(1):258
Cancer cell international 2023 Nov 2;23(1):258
Cancer susceptibility 18 positively regulates NUAK Family Kinase 1 expression to promote migration and invasion via sponging of miR-5586-5p in cervical cancer cells.
Wang J, Zhang B, Gong S, Liu Y, Yi L, Long Y
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223310
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223310
DKK1 promotes NUAK1 transcriptional expression through the activation Akt in hepatocellular carcinoma.
Yao CY, Gao ZX, Hou LL, Fang D
Cell biology international 2023 Feb;47(2):383-393
Cell biology international 2023 Feb;47(2):383-393
Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer.
Zhou Y, Xiao L, Long G, Cao J, Liu S, Tao Y, Zhou L, Tang J
Frontiers in immunology 2022;13:921182
Frontiers in immunology 2022;13:921182
Discovery of a novel NUAK1 inhibitor against pancreatic cancer.
Seo MS, Jung KH, Kim K, Lee JE, Han BS, Ko S, Kim JH, Hong S, Lee SH, Hong SS
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113241
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113241
High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
Blazejewski SM, Bennison SA, Liu X, Toyo-Oka K
Scientific reports 2021 Apr 14;11(1):8156
Scientific reports 2021 Apr 14;11(1):8156
miR-424-5p represses the metastasis and invasion of intrahepatic cholangiocarcinoma by targeting ARK5.
Wu J, Yang B, Zhang Y, Feng X, He B, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2019;15(8):1591-1599
International journal of biological sciences 2019;15(8):1591-1599
MiR-204 inhibits hepatocellular cancer drug resistance and metastasis through targeting NUAK1.
Yu Y, Wang Y, Xiao X, Cheng W, Hu L, Yao W, Qian Z, Wu W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):563-570
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):563-570
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ
PLoS genetics 2014 Oct;10(10):e1004721
PLoS genetics 2014 Oct;10(10):e1004721
Overexpression of ARK5 is associated with poor prognosis in hepatocellular carcinoma.
Cui J, Yu Y, Lu GF, Liu C, Liu X, Xu YX, Zheng PY
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1913-8
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1913-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 22723-1-AP( NUAK1 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ARK5 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ARK5. This antibody recognizes human, mouse antigen. The ARK5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
