AP0762

antibody from Bioworld Technology, Inc
Targeting: MAP1LC3B ATG8F
Provider product page for AP0762
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
AP0762 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#AP0762, RRID:AB_2797423
Product name
MAP1LC3B (D23) polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human MAP1LC3B.
Description
MAP1LC3B, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3ÉÇ , the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3ÉÇ , followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3£ª untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3ÉÇ may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MAP1LC3B protein structure - AP0762 shown in red.