BS8347

antibody from Bioworld Technology, Inc
Targeting: NUDC
Provider product page for BS8347
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8347 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NUDC polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NUDC.
Description
NUDC (nuclear distribution gene C homolog, A. nidulans) is a ubiquitously expressed protein that is conserved from fungus to human. Highly expressed in proliferating cells, NUDC localizes to the cytoplasm and nucleus, contains a CS domain and participates in neurogenesis, mitosis, nuclear migration and cytokinesis. At the onset of mitosis, NUDC is phosphorylated by Plk. This modification of NUDC is required for proper mitotic spindle formation, chromosome separation during mitosis, cytokinesis and cell proliferation. In neurons and fibroblasts, NUDC forms a complex with LIS1 that localizes to the microtubule network and microtubule-organizing center and facilitates nuclear movement and transport in migrating neurons. In addition, the NUDC/LIS1 complex can associate with the minus-end directed Dynein/Dynactin motor complex and, together, these complexes cooperate in the regulation of cytokinesis. NUDCD3 is a 361 amino acid protein that contains one CS domain and is phosphorylated upon DNA damage by either ATR or ATM.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NUDC protein structure - BS8347 shown in red.