13196-1-AP

antibody from Proteintech Group

Targeting: AXL ARK, JTK11, Tyro7, UFO

Provider product page for 13196-1-AP

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Antibody data

Antibody Data
Antigen structure
References [43]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 13196-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13196-1-AP, RRID:AB_10642006
Product name: AXL antibody
Antibody type: Polyclonal
Description: AXL antibody (Cat. #13196-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AXL protein structure - 13196-1-AP shown in red.

Submitted references CD146(+) pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis.

Liu W, Duan W, Xia S, Liu Y, Chu H, Liang K, Fang S, Lin M, Wei S, You X, Hu Q, Qi J, Wang Q
Theranostics 2026;16(4):1905-1924

Cellular determinants of parvovirus B19 susceptibility in the human placenta.

Suter C, Küffer M, Bieri J, Fahmi A, Baud D, Alves MP, Ros C
PLoS pathogens 2026 Feb;22(2):e1013984

Synergistic overcoming of cisplatin resistance in ovarian cancer by combined Astragalus Membranaceus and cisplatin treatment: network pharmacology and experimental validation.

Wang F, Yue QF, Zhang Y, Lei FL
BMC complementary medicine and therapies 2025 Sep 30;25(1):337

Integrated single-cell and bulk transcriptome analysis revealed high plasticity subpopulation and promising diagnosis model for clear cell renal cell carcinoma.

Lu Z, Kong F, Sun J, Ge J, Wu J, Wang K
Hereditas 2025 Sep 30;162(1):198

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.

Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197

Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes.

Sun H, Yang Q, Zhang Y, Cui S, Zhou Z, Zhang P, Jia L, Zhang M, Wang Y, Chen X, Pei R
Journal of virology 2025 May 20;99(5):e0000225

Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia.

Zhang H, Bi F, Zhao P, Cui H, Tao X, Zhang J, Li C, Cao Y, Wang N, Li H
Journal of ethnopharmacology 2025 Mar 13;343:119464

A feeding-induced myokine modulates glucose homeostasis.

Shi X, Hu X, Fang X, Jia L, Wei F, Peng Y, Liu M, Gao A, Zhao K, Chen F, Hu X, Hong J, Ning G, Song Y, Wang J, Wang Y
Nature metabolism 2025 Jan;7(1):68-83

Ketogenic β-hydroxybutyrate regulates β-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice.

Han W, Zhang B, Zhao W, Zhao W, He J, Qiu X, Zhang L, Wang X, Wang Y, Lu H, Zhang Y, Xie Y, Geng Y, Zhao W, Huang Q, Zhang YW, Wang Z
Aging cell 2025 Jan;24(1):e14368

C1632 protects against LPS-induced acute lung injury by regulating AXL-mediated MAPK/NF-κB signaling pathway.

Mei Y, Wu Y, Zhai Y, Chen C, Han H, Wan L, Ma W, Ding M, Zheng X, Wu L
International immunopharmacology 2025 Apr 24;153:114542

The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines.

Diawara M, Martin LJ
Molecular biology reports 2024 Sep 14;51(1):982

BRAF-Mutated Melanoma Cell Lines Develop Distinct Molecular Signatures After Prolonged Exposure to AZ628 or Dabrafenib: Potential Benefits of the Antiretroviral Treatments Cabotegravir or Doravirine on BRAF-Inhibitor-Resistant Cells.

Zanrè V, Bellinato F, Cardile A, Passarini C, Di Bella S, Menegazzi M
International journal of molecular sciences 2024 Nov 6;25(22)

The AXL-mediated modulation of myeloid-derived suppressor cells (MDSC) in nasopharyngeal carcinoma.

Lv Y, Zhu J, Ge S, Jiang T, Xu Y, Yao W, Jiang C
Medical oncology (Northwood, London, England) 2024 Nov 27;42(1):17

Gas6/AXL Alleviates Hepatic Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the PI3K/AKT Pathway.

Zhan M, Liu D, Yao L, Wang W, Zhang R, Xu Y, Wang Z, Yan Q, Fang Q, Du J, Chen L
Transplantation 2024 Nov 1;108(11):e357-e369

Aberrant expressions of TAM receptors are associated with postoperative recurrence in chronic rhinosinusitis with nasal polyps.

Zhou Y, Feng Z, Wen J, Yang C, Jing Q
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2024 Jun;281(6):3005-3015

m(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation.

Wu H, Jiang W, Pang P, Si W, Kong X, Zhang X, Xiong Y, Wang C, Zhang F, Song J, Yang Y, Zeng L, Liu K, Jia Y, Wang Z, Ju J, Diao H, Bian Y, Yang B
Frontiers of medicine 2024 Jun;18(3):499-515

FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.

Tan Y, Xin L, Wang Q, Xu R, Tong X, Chen G, Ma L, Yang F, Jiang H, Zhang N, Wu J, Li X, Guo X, Wang C, Zhou H, Zhou F
Cancer letters 2024 Jun 28;592:216933

YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.

Chen H, Shang Y, Li X, Wang R
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91

MICA+ Tumor Cell Upregulated Macrophage-Secreted MMP9 via PROS1-AXL Axis to Induce Tumor Immune Escape in Advanced Hepatocellular Carcinoma (HCC).

Wu Q, Li X, Yang Y, Huang J, Yao M, Li J, Huang Y, Cai X, Geller DA, Yan Y
Cancers 2024 Jan 8;16(2)

Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk.

Liu Q, Niu Y, Pei Z, Yang Y, Xie Y, Wang M, Wang J, Wu M, Zheng J, Yang P, Hao H, Pang Y, Bao L, Dai Y, Niu Y, Zhang R
Journal of hazardous materials 2024 Aug 5;474:134786

Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α.

Han Y, Li G, Zhang Z, Zhang X, Zhao B, Yang H
Frontiers in immunology 2023;14:1158758

Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin.

Xin Y, Jiang Q, Liu C, Qiu J
Aging 2023 Nov 3;15(21):12225-12250

Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability.

Berico P, Nogaret M, Cigrang M, Lallement A, Vand-Rajabpour F, Flores-Yanke A, Gambi G, Davidson G, Seno L, Obid J, Vokshi BH, Le Gras S, Mengus G, Ye T, Cordero CF, Dalmasso M, Compe E, Bertolotto C, Hernando E, Davidson I, Coin F
Cell reports 2023 Nov 28;42(11):113363

Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers.

Cardile A, Passarini C, Zanrè V, Fiore A, Menegazzi M
Antioxidants (Basel, Switzerland) 2023 Jun 30;12(7)

NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression.

Zong G, Wang X, Guo X, Zhao Q, Wang C, Shen S, Xiao W, Yang Q, Jiang W, Shen J, Wan R
Experimental cell research 2023 Jul 15;428(2):113620

Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.

Tang J, Jin Y, Jia F, Lv T, Manaenko A, Zhang LF, Zhang Z, Qi X, Xue Y, Zhao B, Zhang X, Zhang JH, Lu J, Hu Q
Translational stroke research 2023 Dec;14(6):955-969

Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer.

Kim TH, Lee D, Oh HJ, Ham IH, Lee DM, Lee Y, Zhang Z, Ke D, Hur H
Life sciences 2023 Dec 15;335:122230

Combination of sunitinib and (177)Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer.

Oosterwijk-Wakka JC, de Weijert MCA, Franssen GM, Kolev DR, de Haan TAFJ, Boerman OC, Mulders PFA, Oosterwijk E
Neoplasia (New York, N.Y.) 2022 Oct;32:100826

SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.

Fang K, Du S, Shen D, Xiong Z, Jiang K, Liang D, Wang J, Xu H, Hu L, Zhai X, Jiang Y, Xia Z, Xie C, Jin D, Cheng W, Meng S, Wang Y
iScience 2022 Jul 15;25(7):104618

Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.

Wang Z, Liu D, Yan Q, Liu F, Zhan M, Qi S, Fang Q, Yao L, Wang W, Zhang R, Du J, Chen L
Transplantation 2022 Jul 1;106(7):1351-1364

Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins.

De Tomi E, Campagnari R, Orlandi E, Cardile A, Zanrè V, Menegazzi M, Gomez-Lira M, Gotte G
International journal of molecular sciences 2022 Jan 31;23(3)

Identification of an AXL kinase inhibitor in triple-negative breast cancer by structure-based virtual screening and bioactivity test.

Li P, Niu Y, Li S, Zu X, Xiao M, Yin L, Feng J, He J, Shen Y
Chemical biology & drug design 2022 Feb;99(2):222-232

GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.

Gao SS, Shi R, Sun J, Tang Y, Zheng Z, Li JF, Li H, Zhang J, Leng Q, Xu J, Chen X, Zhao J, Sy MS, Feng L, Li C
iScience 2022 Dec 22;25(12):105481

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.

Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749

Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5.

Yao ZW, Liu H, Zhou R, Feng MY, Wang F, Qin XJ, Chen XX, Zheng CB, Luo RH, Yang LM, Cen S, Xiong SD, Liu HY, Zheng YT
Bioorganic chemistry 2021 Nov;116:105303

Embryonic-Derived Myb(-) Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis.

Jerkic M, Litvack ML, Gagnon S, Otulakowski G, Zhang H, Rotstein O, Kavanagh BP, Post M, Laffey JG
International journal of molecular sciences 2021 Mar 20;22(6)

Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway.

Ke S, Wu L, Wang M, Liu D, Shi G, Zhu J, Qian X
Pharmaceutical biology 2021 Dec;59(1):1369-1377

Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.

Su S, Liu X, Tian RR, Qiao KX, Zheng CB, Gao WC, Yang LM, Kang QZ, Zheng YT
Virus research 2021 Dec;306:198593

A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.

Yu S, Wei S, Savani M, Lin X, Du K, Mender I, Siteni S, Vasilopoulos T, Reitman ZJ, Ku Y, Wu D, Liu H, Tian M, Chen Y, Labrie M, Charbonneau CM, Sugarman E, Bowie M, Hariharan S, Waitkus M, Jiang W, McLendon RE, Pan E, Khasraw M, Walsh KM, Lu Y, Herlyn M, Mills G, Herbig U, Wei Z, Keir ST, Flaherty K, Liu L, Wu K, Shay JW, Abdullah K, Zhang G, Ashley DM
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Dec 15;27(24):6800-6814

Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.

Dong M, Xiao Q, Hu J, Cheng F, Zhang P, Zong W, Tang Q, Li X, Mao F, He Y, Yu X, Wan F, Lei T, Guo D, Wang B
Cancer gene therapy 2020 Dec;27(12):878-897

Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET.

Shen Y, Zhang W, Liu J, He J, Cao R, Chen X, Peng X, Xu H, Zhao Q, Zhong J, Ding W, Lei X, Jiang Y, Zu X
International journal of cancer 2019 Feb 1;144(3):651-664

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.

Qiu C, Zheng H, Tao H, Yu W, Jiang X, Li A, Jin H, Lv A, Li H
Molecular and cellular biochemistry 2017 Sep;433(1-2):149-159

Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats.

Jiang X, Tao H, Qiu C, Ma X, Li S, Guo X, Lv A, Li H
European journal of pharmacology 2016 Sep 5;786:10-18

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 13196-1-AP(AXL antibody) at dilution of 1:1500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The AXL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AXL. This antibody recognizes human,mouse,rat antigen. The AXL antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 13196-1-AP.pdf

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