Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 13196-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13196-1-AP, RRID:AB_10642006
- Product name
- AXL antibody
- Antibody type
- Polyclonal
- Description
- AXL antibody (Cat. #13196-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Gas6/AXL Alleviates Hepatic Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the PI3K/AKT Pathway.
YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.
MICA+ Tumor Cell Upregulated Macrophage-Secreted MMP9 via PROS1-AXL Axis to Induce Tumor Immune Escape in Advanced Hepatocellular Carcinoma (HCC).
Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α.
Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin.
Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability.
Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers.
NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression.
Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer.
Combination of sunitinib and (177)Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer.
SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins.
Identification of an AXL kinase inhibitor in triple-negative breast cancer by structure-based virtual screening and bioactivity test.
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5.
Embryonic-Derived Myb(-) Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis.
Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway.
Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.
Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.
Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET.
Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats.
Zhan M, Liu D, Yao L, Wang W, Zhang R, Xu Y, Wang Z, Yan Q, Fang Q, Du J, Chen L
Transplantation 2024 Nov 1;108(11):e357-e369
Transplantation 2024 Nov 1;108(11):e357-e369
YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.
Chen H, Shang Y, Li X, Wang R
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91
MICA+ Tumor Cell Upregulated Macrophage-Secreted MMP9 via PROS1-AXL Axis to Induce Tumor Immune Escape in Advanced Hepatocellular Carcinoma (HCC).
Wu Q, Li X, Yang Y, Huang J, Yao M, Li J, Huang Y, Cai X, Geller DA, Yan Y
Cancers 2024 Jan 8;16(2)
Cancers 2024 Jan 8;16(2)
Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α.
Han Y, Li G, Zhang Z, Zhang X, Zhao B, Yang H
Frontiers in immunology 2023;14:1158758
Frontiers in immunology 2023;14:1158758
Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin.
Xin Y, Jiang Q, Liu C, Qiu J
Aging 2023 Nov 3;15(21):12225-12250
Aging 2023 Nov 3;15(21):12225-12250
Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability.
Berico P, Nogaret M, Cigrang M, Lallement A, Vand-Rajabpour F, Flores-Yanke A, Gambi G, Davidson G, Seno L, Obid J, Vokshi BH, Le Gras S, Mengus G, Ye T, Cordero CF, Dalmasso M, Compe E, Bertolotto C, Hernando E, Davidson I, Coin F
Cell reports 2023 Nov 28;42(11):113363
Cell reports 2023 Nov 28;42(11):113363
Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers.
Cardile A, Passarini C, Zanrè V, Fiore A, Menegazzi M
Antioxidants (Basel, Switzerland) 2023 Jun 30;12(7)
Antioxidants (Basel, Switzerland) 2023 Jun 30;12(7)
NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression.
Zong G, Wang X, Guo X, Zhao Q, Wang C, Shen S, Xiao W, Yang Q, Jiang W, Shen J, Wan R
Experimental cell research 2023 Jul 15;428(2):113620
Experimental cell research 2023 Jul 15;428(2):113620
Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Tang J, Jin Y, Jia F, Lv T, Manaenko A, Zhang LF, Zhang Z, Qi X, Xue Y, Zhao B, Zhang X, Zhang JH, Lu J, Hu Q
Translational stroke research 2023 Dec;14(6):955-969
Translational stroke research 2023 Dec;14(6):955-969
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer.
Kim TH, Lee D, Oh HJ, Ham IH, Lee DM, Lee Y, Zhang Z, Ke D, Hur H
Life sciences 2023 Dec 15;335:122230
Life sciences 2023 Dec 15;335:122230
Combination of sunitinib and (177)Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer.
Oosterwijk-Wakka JC, de Weijert MCA, Franssen GM, Kolev DR, de Haan TAFJ, Boerman OC, Mulders PFA, Oosterwijk E
Neoplasia (New York, N.Y.) 2022 Oct;32:100826
Neoplasia (New York, N.Y.) 2022 Oct;32:100826
SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway.
Fang K, Du S, Shen D, Xiong Z, Jiang K, Liang D, Wang J, Xu H, Hu L, Zhai X, Jiang Y, Xia Z, Xie C, Jin D, Cheng W, Meng S, Wang Y
iScience 2022 Jul 15;25(7):104618
iScience 2022 Jul 15;25(7):104618
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Wang Z, Liu D, Yan Q, Liu F, Zhan M, Qi S, Fang Q, Yao L, Wang W, Zhang R, Du J, Chen L
Transplantation 2022 Jul 1;106(7):1351-1364
Transplantation 2022 Jul 1;106(7):1351-1364
Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins.
De Tomi E, Campagnari R, Orlandi E, Cardile A, Zanrè V, Menegazzi M, Gomez-Lira M, Gotte G
International journal of molecular sciences 2022 Jan 31;23(3)
International journal of molecular sciences 2022 Jan 31;23(3)
Identification of an AXL kinase inhibitor in triple-negative breast cancer by structure-based virtual screening and bioactivity test.
Li P, Niu Y, Li S, Zu X, Xiao M, Yin L, Feng J, He J, Shen Y
Chemical biology & drug design 2022 Feb;99(2):222-232
Chemical biology & drug design 2022 Feb;99(2):222-232
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.
Gao SS, Shi R, Sun J, Tang Y, Zheng Z, Li JF, Li H, Zhang J, Leng Q, Xu J, Chen X, Zhao J, Sy MS, Feng L, Li C
iScience 2022 Dec 22;25(12):105481
iScience 2022 Dec 22;25(12):105481
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749
Cell death & disease 2022 Aug 30;13(8):749
Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5.
Yao ZW, Liu H, Zhou R, Feng MY, Wang F, Qin XJ, Chen XX, Zheng CB, Luo RH, Yang LM, Cen S, Xiong SD, Liu HY, Zheng YT
Bioorganic chemistry 2021 Nov;116:105303
Bioorganic chemistry 2021 Nov;116:105303
Embryonic-Derived Myb(-) Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis.
Jerkic M, Litvack ML, Gagnon S, Otulakowski G, Zhang H, Rotstein O, Kavanagh BP, Post M, Laffey JG
International journal of molecular sciences 2021 Mar 20;22(6)
International journal of molecular sciences 2021 Mar 20;22(6)
Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway.
Ke S, Wu L, Wang M, Liu D, Shi G, Zhu J, Qian X
Pharmaceutical biology 2021 Dec;59(1):1369-1377
Pharmaceutical biology 2021 Dec;59(1):1369-1377
Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.
Su S, Liu X, Tian RR, Qiao KX, Zheng CB, Gao WC, Yang LM, Kang QZ, Zheng YT
Virus research 2021 Dec;306:198593
Virus research 2021 Dec;306:198593
Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.
Dong M, Xiao Q, Hu J, Cheng F, Zhang P, Zong W, Tang Q, Li X, Mao F, He Y, Yu X, Wan F, Lei T, Guo D, Wang B
Cancer gene therapy 2020 Dec;27(12):878-897
Cancer gene therapy 2020 Dec;27(12):878-897
Therapeutic activity of DCC-2036, a novel tyrosine kinase inhibitor, against triple-negative breast cancer patient-derived xenografts by targeting AXL/MET.
Shen Y, Zhang W, Liu J, He J, Cao R, Chen X, Peng X, Xu H, Zhao Q, Zhong J, Ding W, Lei X, Jiang Y, Zu X
International journal of cancer 2019 Feb 1;144(3):651-664
International journal of cancer 2019 Feb 1;144(3):651-664
Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Qiu C, Zheng H, Tao H, Yu W, Jiang X, Li A, Jin H, Lv A, Li H
Molecular and cellular biochemistry 2017 Sep;433(1-2):149-159
Molecular and cellular biochemistry 2017 Sep;433(1-2):149-159
Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats.
Jiang X, Tao H, Qiu C, Ma X, Li S, Guo X, Lv A, Li H
European journal of pharmacology 2016 Sep 5;786:10-18
European journal of pharmacology 2016 Sep 5;786:10-18
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 13196-1-AP(AXL antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AXL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AXL. This antibody recognizes human,mouse,rat antigen. The AXL antibody has been validated for the following applications: ELISA, WB, IP analysis.
