Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 11938-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11938-1-AP, RRID:AB_2083542
- Product name
- COMMD1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COMMD1 antibody (Cat. #11938-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements.
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity.
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.
Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes.
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.
HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.
COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking.
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.
Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells.
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
A cell-type-specific role for murine Commd1 in liver inflammation.
COMMD1 modulates noxious inflammation in cystic fibrosis.
The alteration of copper homeostasis in inflammation induced by lipopolysaccharides.
COMMD1-mediated ubiquitination regulates CFTR trafficking.
Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.
Shang J, Jiao J, Yan M, Wang J, Li Q, Shabuerjiang L, Lu Y, Song Q, Bi L, Huang G, Zhang X, Wen Y, Cui Y, Wu K, Li G, Wang P, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114534
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114534
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Healy MD, McNally KE, Butkovič R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ
Cell 2023 May 11;186(10):2219-2237.e29
Cell 2023 May 11;186(10):2219-2237.e29
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K
Science immunology 2023 Mar 31;8(81):eadc9324
Science immunology 2023 Mar 31;8(81):eadc9324
Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity.
Rivero-Ríos P, Tsukahara T, Uygun T, Chen A, Chavis GD, Giridharan SSP, Iwase S, Sutton MA, Weisman LS
The Journal of cell biology 2023 Jul 3;222(7)
The Journal of cell biology 2023 Jul 3;222(7)
Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.
Yang L, Fye MA, Yang B, Tang Z, Zhang Y, Haigh S, Covington BA, Bracey K, Taraska JW, Kaverina I, Qu S, Chen W
Molecular metabolism 2022 Sep;63:101541
Molecular metabolism 2022 Sep;63:101541
Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes.
Giridharan SSP, Luo G, Rivero-Rios P, Steinfeld N, Tronchere H, Singla A, Burstein E, Billadeau DD, Sutton MA, Weisman LS
eLife 2022 Jan 18;11
eLife 2022 Jan 18;11
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
Chen Y, Wu X, Zhang J, Pan G, Wang X, Guo X, Wang J, Cui X, Gao H, Cheng M, Yang J, Zhang C, Jiang F
EMBO reports 2022 Feb 3;23(3):e53373
EMBO reports 2022 Feb 3;23(3):e53373
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250
Theranostics 2021;11(9):4232-4250
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
Bakkar N, Starr A, Rabichow BE, Lorenzini I, McEachin ZT, Kraft R, Chaung M, Macklin-Isquierdo S, Wingfield T, Carhart B, Zahler N, Chang WH, Bassell GJ, Betourne A, Boulis N, Alworth SV, Ichida JK, August PR, Zarnescu DC, Sattler R, Bowser R
Neurobiology of disease 2021 Feb;149:105228
Neurobiology of disease 2021 Feb;149:105228
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R
Nature communications 2021 Feb 11;12(1):961
Nature communications 2021 Feb 11;12(1):961
The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.
Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B
Circulation research 2018 Jun 8;122(12):1648-1660
Circulation research 2018 Jun 8;122(12):1648-1660
HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.
MacDonald E, Brown L, Selvais A, Liu H, Waring T, Newman D, Bithell J, Grimes D, Urbé S, Clague MJ, Zech T
The Journal of cell biology 2018 Jul 2;217(7):2549-2564
The Journal of cell biology 2018 Jul 2;217(7):2549-2564
COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking.
Campion CG, Zaoui K, Verissimo T, Cossette S, Matsuda H, Solban N, Hamet P, Tremblay J
Cell reports 2018 Jul 17;24(3):670-684.e7
Cell reports 2018 Jul 17;24(3):670-684.e7
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K
Oncogene 2017 Oct 12;36(41):5745-5756
Oncogene 2017 Oct 12;36(41):5745-5756
Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer.
Fedoseienko A, Wieringa HW, Wisman GB, Duiker E, Reyners AK, Hofker MH, van der Zee AG, van de Sluis B, van Vugt MA
PloS one 2016;11(10):e0165385
PloS one 2016;11(10):e0165385
Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells.
Yeh DW, Chen YS, Lai CY, Liu YL, Lu CH, Lo JF, Chen L, Hsu LC, Luo Y, Xiang R, Chuang TH
Cell death and differentiation 2016 May;23(5):841-52
Cell death and differentiation 2016 May;23(5):841-52
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B
Nature communications 2016 Mar 11;7:10961
Nature communications 2016 Mar 11;7:10961
A cell-type-specific role for murine Commd1 in liver inflammation.
Bartuzi P, Wijshake T, Dekker DC, Fedoseienko A, Kloosterhuis NJ, Youssef SA, Li H, Shiri-Sverdlov R, Kuivenhoven JA, de Bruin A, Burstein E, Hofker MH, van de Sluis B
Biochimica et biophysica acta 2014 Nov;1842(11):2257-65
Biochimica et biophysica acta 2014 Nov;1842(11):2257-65
COMMD1 modulates noxious inflammation in cystic fibrosis.
de Becdelièvre A, Rocca J, Aissat A, Drévillon L, Moutereau S, Le Gouvello S, Hinzpeter A, Tarze A, Fanen P
The international journal of biochemistry & cell biology 2013 Nov;45(11):2402-9
The international journal of biochemistry & cell biology 2013 Nov;45(11):2402-9
The alteration of copper homeostasis in inflammation induced by lipopolysaccharides.
Han M, Lin Z, Zhang Y
Biological trace element research 2013 Aug;154(2):268-74
Biological trace element research 2013 Aug;154(2):268-74
COMMD1-mediated ubiquitination regulates CFTR trafficking.
Drévillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelièvre A, Aissat A, Tarze A, Goossens M, Fanen P
PloS one 2011 Mar 31;6(3):e18334
PloS one 2011 Mar 31;6(3):e18334
Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.
Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y
The Biochemical journal 2010 Jul 1;429(1):53-61
The Biochemical journal 2010 Jul 1;429(1):53-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 11938-1-AP(COMMD1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-COMMD1 (IP:11938-1-AP, 3ug; Detection:11938-1-AP 1:500) with mouse brain tissue lysate 5200ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 11938-1-AP(COMMD1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COMMD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COMMD1. This antibody recognizes human,mouse,rat antigen. The COMMD1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.