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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 60250-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- HADHA antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated HADHA antibody (Cat. #60250-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3E9B1
- Vial size
- 20ul, 150ul
Submitted references Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts.
Knockdown of HOXD13 in Oral Squamous Cell Carcinoma Inhibited its Proliferation, Migration, and Influenced Fatty Acid Metabolism.
Very high-dose vitamin D₃ supplementation reduces the expression of genes and proteins engaged in β-oxidation in healthy pigs.
Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency.
Morphine induces HADHA succinylation, while HADHA desuccinylation alleviates morphine tolerance by influencing autophagy.
A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency.
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.
Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells.
Quantitative proteomic study of myocardial mitochondria in urea transporter B knockout mice.
Vieira Neto E, Wang M, Szuminsky AJ, Ferraro L, Basu S, Zhao X, Karunanidhi A, Wang Y, Vockley J
Journal of inherited metabolic disease 2026 Jan;49(1):e70132
Journal of inherited metabolic disease 2026 Jan;49(1):e70132
Knockdown of HOXD13 in Oral Squamous Cell Carcinoma Inhibited its Proliferation, Migration, and Influenced Fatty Acid Metabolism.
Ma X, Zhang X, Li H, Mei S, Wang B, Guan S, Wang Y, Li Y, Li S, Li X
Journal of Cancer 2025;16(1):214-226
Journal of Cancer 2025;16(1):214-226
Very high-dose vitamin D₃ supplementation reduces the expression of genes and proteins engaged in β-oxidation in healthy pigs.
Steg A, Smołucha G, Świątkiewicz M, Oczkowicz M
The Journal of steroid biochemistry and molecular biology 2025 Nov;254:106835
The Journal of steroid biochemistry and molecular biology 2025 Nov;254:106835
Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency.
Vieira Neto E, Wang M, Szuminsky AJ, Ferraro L, Koppes E, Wang Y, Van't Land C, Mohsen AW, Zanatta G, El-Gharbawy AH, Anthonymuthu TS, Tyurina YY, Tyurin VA, Kagan V, Bayır H, Vockley J
JCI insight 2024 Sep 10;9(17)
JCI insight 2024 Sep 10;9(17)
Morphine induces HADHA succinylation, while HADHA desuccinylation alleviates morphine tolerance by influencing autophagy.
Huang Y, Lu S, Chen Y, Feng Y, Lu W
Naunyn-Schmiedeberg's archives of pharmacology 2024 Mar;397(3):1589-1600
Naunyn-Schmiedeberg's archives of pharmacology 2024 Mar;397(3):1589-1600
A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency.
Gaston G, Babcock S, Ryals R, Elizondo G, DeVine T, Wafai D, Packwood W, Holden S, Raber J, Lindner JR, Pennesi ME, Harding CO, Gillingham MB
Communications biology 2023 Aug 29;6(1):890
Communications biology 2023 Aug 29;6(1):890
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, Nomura Y, Menzies R, Tajima M, Kitaoka K, Haku Y, Delghandi S, Yurimoto K, Matsuda F, Iwata S, Ogura T, Fagarasan S, Honjo T
Science (New York, N.Y.) 2022 Oct 28;378(6618):eabj3510
Science (New York, N.Y.) 2022 Oct 28;378(6618):eabj3510
Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.
Lu J, Zhang Y, Sun M, Ding C, Zhang L, Kong Y, Cai M, Miccoli P, Ma C, Yue X
Frontiers in oncology 2021;11:737127
Frontiers in oncology 2021;11:737127
Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.
Zhu X, Ji W, Guo S, Zhu D, Yang Y, Liu X
RSC advances 2020 May 27;10(35):21000-21008
RSC advances 2020 May 27;10(35):21000-21008
Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells.
Li S, Zhan JK, Wang YJ, Lin X, Zhong JY, Wang Y, Tan P, He JY, Cui XJ, Chen YY, Huang W, Liu YS
Cell & bioscience 2019;9:1
Cell & bioscience 2019;9:1
Quantitative proteomic study of myocardial mitochondria in urea transporter B knockout mice.
Du Y, Meng Y, Zhu J, Kang L, Jia X, Guo L, Zhang L, Ye M, Hu L, Zhao X, Gu J, Yang B, Zou H
Proteomics 2014 Sep;14(17-18):2072-83
Proteomics 2014 Sep;14(17-18):2072-83
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 60250-1-Ig(HADHA antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 60250-1-Ig(HADHA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HADHA antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human HADHA. This antibody recognizes human,mouse antigen. The HADHA antibody has been validated for the following applications: ELISA, WB, IHC analysis.
