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- Antigen structure
- References [87]
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- Product number
- 13363-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13363-1-AP, RRID:AB_2088552
- Product name
- CYP11A1 antibody
- Antibody type
- Polyclonal
- Description
- CYP11A1 antibody (Cat. #13363-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cholecystokinin (CCK) mediates CCKBR to regulate androgen secretion via the steroid pathway in Bactrian camel Sertoli cells.
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Alpha-ketoglutarate enhances the proliferation and steroidogenic capacities of Tan sheep granulosa cells through autophagy pathway regulation.
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.
Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro.
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.
Long-term dietary restriction changes lipid homeostasis and consequently impairs testosterone production in aged Wistar rats.
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
The β2-adrenoceptor agonist formoterol reverses metabolic dysfunction in the diabetic proximal tubule.
Spatiotemporal mapping reveals Ccl8(hi) macrophages as key drivers of testicular inflammaging.
circ_0000132 Regulates Chicken Granulosa Cell Proliferation Apoptosis and E2/P4 Synthesis via miR-206 E2F5 Signaling.
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
Identification and isolation of human testicular peritubular myoid cells and Leydig cells by a combination of ITGA9 and NGFR.
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis.
Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women.
Tandem mass tag-based proteomic analysis of granulosa and theca interna cells of the porcine ovarian follicle following in vitro treatment with vitamin D(3) and insulin alone or in combination.
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
Lactational high weight loss impairs follicular development by causing mitochondrial dysfunction of ovarian cells in sows and mitigated by butyrate supplement.
Inulin attenuates reproductive toxicity caused by prenatal and lactation GenX exposure through modulating the hypothalamic-pituitary-testicular (HPT) axis via the LH/cAMP/StAR pathway in male mice.
Glucose-dependent insulinotropic peptide (GIP) suppresses androgen biosynthesis in PCOS mouse models and cellular systems.
Bioactive Peptide C248 of PRDX4 Ameliorates the Function of Testicular Leydig Cells via Mitochondrial Protection.
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Lactylation drives hCG-triggered luteinization in hypoxic granulosa cells.
Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells.
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
Integrated RNA sequencing and biochemical studies reveal endoplasmic reticulum stress and autophagy dysregulation contribute to Tri (2-Ethylhexyl) phosphate (TEHP)-induced cell injury in Sertoli cells.
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism.
Cyclophosphamide activates ferroptosis-induced dysfunction of Leydig cells via SMAD2 pathway†.
Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation.
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.
Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice.
Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention.
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.
Apigenin improves testosterone synthesis by regulating endoplasmic reticulum stress.
Alterations in the Hypothalamic-Pituitary-Adrenal Axis as a Response to Experimental Autoimmune Encephalomyelitis in Dark Agouti Rats of Both Sexes.
Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens.
Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period.
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Melatonin Inhibits Testosterone Synthesis in Rooster Leydig Cells by Targeting CXCL14 through miR-7481-3p.
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis.
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells.
Impacts of elevated temperature on morphology, oxidative stress levels, and testosterone synthesis in ex vivo cultured porcine testicular tissue.
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Androgens improve ovarian follicle function impaired by glucocorticoids through an androgen-IGF1-FSH synergistic effect.
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells.
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Low-Intensity Pulsed Ultrasound Alleviates Human Testicular Leydig Cell Senescence In Vitro.
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
An integrated RNA-Seq and network study reveals that valproate inhibited progesterone production in human granulosa cells.
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Proteomics analysis reveals the effect of 1α,25(OH)(2)VD(3)-glycosides on development of early testes in piglets.
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
PRMT5 regulates ovarian follicle development by facilitating Wt1 translation.
CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Bisphenol A decreases progesterone synthesis in human ovarian granulosa cells.
Genipin improves reproductive health problems caused by circadian disruption in male mice.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Proteomic analysis of mouse ovaries during the prepubertal stages.
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression.
Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction.
Pregnenolone can protect the brain from cannabis intoxication.
Immunohistochemical Characterization of S100A6 in the Murine Ovary.
Wang Q, Wang W, Nan J, Zhang Y, Zhao X
The Journal of steroid biochemistry and molecular biology 2026 Mar;257:106922
The Journal of steroid biochemistry and molecular biology 2026 Mar;257:106922
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Shin C, Chen LW, Hossain MN, Li X, Islam S, Kou Z, Cui Q, de Avila JM, Zhu MJ, Du M
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
Alpha-ketoglutarate enhances the proliferation and steroidogenic capacities of Tan sheep granulosa cells through autophagy pathway regulation.
Wang J, Wang L, Zhao M, Min S, Yan Y, He J, Song H, Liu X, Chen Q
The Journal of steroid biochemistry and molecular biology 2026 Jun;260:106991
The Journal of steroid biochemistry and molecular biology 2026 Jun;260:106991
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.
Li N, Huang E, Wang R, Li J, Yuan X
Stem cell research & therapy 2026 Jan 17;17(1):83
Stem cell research & therapy 2026 Jan 17;17(1):83
Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro.
Liu K, Chi R, Zhang R, Liu Q, Xing F, Liu Y, Chu M
Biological research 2026 Jan 13;59(1):9
Biological research 2026 Jan 13;59(1):9
NMN/NAD(+)/SIRT1 axis activates NAMPT to ameliorate H(2)O(2)-triggered the impairment of progesterone synthesis in ovarian granulosa cells.
Wang Y, Li Q, Li Y, Ma Z, Xu H, Chen K, Li J, Lan D, Fu W
Journal of ovarian research 2026 Feb 28;19(1)
Journal of ovarian research 2026 Feb 28;19(1)
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Wang S, Ma G, Qi C, Cheng S, Lai H, Zhou L, Wu G, Chen Z, Mao X, Jing T, He Y, Zhou H
Free radical biology & medicine 2026 Feb 1;243:452-465
Free radical biology & medicine 2026 Feb 1;243:452-465
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Wang X, Dong W, Zhao J, Chen N, Zheng T, Liu Y, Li Q, Ye H, Li H, Xie L
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Molecular mechanism of testicular oxidative stress-induced ferroptosis in Leydig cells caused by cryptorchidism in yak.
Zeng J, Yuan L, Qi Y, Chen G, Chen Y, Li H, Song Y, Zhang Y
Theriogenology 2026 Apr 15;261:117946
Theriogenology 2026 Apr 15;261:117946
The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.
Faludi P, Barabás K, Lengyel F, Udvarácz I, Pham D, Kisjós O, Nagy Z, Reglődi D, Kovács G
Frontiers in endocrinology 2025;16:1677085
Frontiers in endocrinology 2025;16:1677085
Long-term dietary restriction changes lipid homeostasis and consequently impairs testosterone production in aged Wistar rats.
Sokanovic S, Prvulovic M, Simeunovic V, Pracer S, Mladenovic A
Frontiers in nutrition 2025;12:1665682
Frontiers in nutrition 2025;12:1665682
Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice.
Li X, Ye T, Zhu W, Gu J, Zheng Z, Wang C, Zhang X, Geng H, Zhou W, Tan X, Ma Y, Zhang H, Wang X
Biochemical pharmacology 2025 Sep;239:117083
Biochemical pharmacology 2025 Sep;239:117083
Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Li H, Zhang M, Ma J, Li W, Liu X, Li Y, Ma J, Yang D, Tie Y, Bai H, Wang S
Biological trace element research 2025 Sep;203(9):4659-4670
Biological trace element research 2025 Sep;203(9):4659-4670
The β2-adrenoceptor agonist formoterol reverses metabolic dysfunction in the diabetic proximal tubule.
Cleveland KH, Scholpa NE, Schnellmann RG
The Journal of pharmacology and experimental therapeutics 2025 Oct;392(10):103698
The Journal of pharmacology and experimental therapeutics 2025 Oct;392(10):103698
Spatiotemporal mapping reveals Ccl8(hi) macrophages as key drivers of testicular inflammaging.
Huang Y, Yao J, Zhang Z, Ouyang B, Zhuang J, Sha X, Qu C, Mo C, Lu M, Lin N, Sun X, Yang Q, Xie Y
Clinical and translational medicine 2025 Nov;15(11):e70527
Clinical and translational medicine 2025 Nov;15(11):e70527
circ_0000132 Regulates Chicken Granulosa Cell Proliferation Apoptosis and E2/P4 Synthesis via miR-206 E2F5 Signaling.
Yang H, Li W, Fu G, Liu S, Ma T
International journal of molecular sciences 2025 Nov 5;26(21)
International journal of molecular sciences 2025 Nov 5;26(21)
The ferroptosis of sertoli cells inducing blood-testis barrier damage is produced by oxidative stress in cryptorchidism.
Zeng J, Yuan L, Chen G, Qi Y, Qie X, Jin Y, Chen Y, Li H
Free radical biology & medicine 2025 May;232:97-106
Free radical biology & medicine 2025 May;232:97-106
Identification and isolation of human testicular peritubular myoid cells and Leydig cells by a combination of ITGA9 and NGFR.
Han S, Zhao L, Luo J, Shi C, Yao C, Ji Z, Xu J, Xu S, Tian R, Zhi E, Huang Y, Liu X, Zhou Y, Zhou Z, Li Z, Li P
Reproductive biology and endocrinology : RB&E 2025 May 31;23(1):82
Reproductive biology and endocrinology : RB&E 2025 May 31;23(1):82
Polydatin, a derivative of resveratrol, ameliorates busulfan-induced oligozoospermia in mice by inhibiting NF-κB pathway activation and suppressing ferroptosis.
Wang C, Li X, Ye T, Gu J, Zheng Z, Chen G, Dong J, Zhou W, Shi J, Zhang L
Bioorganic chemistry 2025 Mar;156:108170
Bioorganic chemistry 2025 Mar;156:108170
Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women.
Delgouffe E, Silva SM, Chalmel F, Cools W, Raets C, Tilleman K, T'Sjoen G, Baert Y, Goossens E
eLife 2025 Jan 7;13
eLife 2025 Jan 7;13
Tandem mass tag-based proteomic analysis of granulosa and theca interna cells of the porcine ovarian follicle following in vitro treatment with vitamin D(3) and insulin alone or in combination.
Kamińska K, Świderska B, Malinowska A, Grzesiak M
Journal of proteomics 2025 Jan 6;310:105318
Journal of proteomics 2025 Jan 6;310:105318
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
Luo J, Zhang J, Zhang Y, Li M, Yu L, Song D, Sun Z
Molecular and cellular endocrinology 2025 Feb 1;597:112440
Molecular and cellular endocrinology 2025 Feb 1;597:112440
Lactational high weight loss impairs follicular development by causing mitochondrial dysfunction of ovarian cells in sows and mitigated by butyrate supplement.
Liu K, Zhang L, Xu X, Song M, Ding H, Xiao L, Wen J, Zhou C, Bai J, Liu Y
Journal of advanced research 2025 Dec;78:11-28
Journal of advanced research 2025 Dec;78:11-28
Inulin attenuates reproductive toxicity caused by prenatal and lactation GenX exposure through modulating the hypothalamic-pituitary-testicular (HPT) axis via the LH/cAMP/StAR pathway in male mice.
Chen YQ, Chen YK, Zhang JJ, Zhang QY, Liu Y, Wang JH, Wang Q, Xie XL
Reproductive toxicology (Elmsford, N.Y.) 2025 Dec;138:109065
Reproductive toxicology (Elmsford, N.Y.) 2025 Dec;138:109065
Glucose-dependent insulinotropic peptide (GIP) suppresses androgen biosynthesis in PCOS mouse models and cellular systems.
Pan M, Qian Y, Jiang L, Cao C, Li L
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec 31;41(1):2582506
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec 31;41(1):2582506
Bioactive Peptide C248 of PRDX4 Ameliorates the Function of Testicular Leydig Cells via Mitochondrial Protection.
Wei N, Yuan S, Gao L, Zhang B, Yan Z, Gao C, Meng Y, Cui Y
Antioxidants (Basel, Switzerland) 2025 Dec 22;15(1)
Antioxidants (Basel, Switzerland) 2025 Dec 22;15(1)
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition.
Lv ZM, Liu C, Wang P, Chen YH
Journal of lipid research 2024 Oct;65(10):100639
Journal of lipid research 2024 Oct;65(10):100639
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Yin H, Zhang J, Chen Y, Guo J, Li Q, Dinnyes A, Sun Q, Liu X, He G, Zhu B, Liu Y, Xu P, Xu W, Xie J
Brain, behavior, and immunity 2024 Oct;121:13-25
Brain, behavior, and immunity 2024 Oct;121:13-25
Lactylation drives hCG-triggered luteinization in hypoxic granulosa cells.
Wu G, Pan Y, Chen M, Liu Z, Li C, Sheng Y, Li H, Shen M, Liu H
International journal of biological macromolecules 2024 Nov;280(Pt 4):135580
International journal of biological macromolecules 2024 Nov;280(Pt 4):135580
Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells.
Kwon HY, Lee H, Choi JS, Lim SH, Kim T, Bae K, Jang YA, Lee JY, Choung SY, Min DS
Nutrients 2024 Nov 30;16(23)
Nutrients 2024 Nov 30;16(23)
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
Chiang YF, Chen YT, Huang KC, Hung WL, Chung CP, Shieh TM, Huang YJ, Ali M, Hsia SM
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
Integrated RNA sequencing and biochemical studies reveal endoplasmic reticulum stress and autophagy dysregulation contribute to Tri (2-Ethylhexyl) phosphate (TEHP)-induced cell injury in Sertoli cells.
Chen P, Song Y, Tang L, Qiu Z, Chen J, Xia S, Iyaswamy A, Cai J, Sun Y, Yang C, Wang J
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124536
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124536
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism.
Deng Z, Zhao L, Li S, Chen X, Ling X, Zheng J, Yu K, Xu J, Yao C, Han S, Liang J, Feng H, Wu L, Li P, Tian R, Jing T, Tang Y, Dai Y, Yan M, Wang C, Li Z, Zhou Z
Nature aging 2024 May;4(5):647-663
Nature aging 2024 May;4(5):647-663
Cyclophosphamide activates ferroptosis-induced dysfunction of Leydig cells via SMAD2 pathway†.
Liao S, Wei C, Wei G, Liang H, Peng F, Zhao L, Li Z, Liu C, Zhou Q
Biology of reproduction 2024 May 9;110(5):1012-1024
Biology of reproduction 2024 May 9;110(5):1012-1024
Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation.
Wang TT, Zhu HL, Ouyang KW, Wang H, Luo YX, Zheng XM, Ling Q, Wang KW, Zhang J, Chang W, Lu Q, Zhang YF, Yuan Z, Li H, Xiong YW, Wei T, Wang H
Journal of hazardous materials 2024 May 15;470:134142
Journal of hazardous materials 2024 May 15;470:134142
Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis.
Dong J, Dong Y, Chen H, Ye T, Chen G, Fan B, Wang X, Shi J, Wang C
Bioorganic chemistry 2024 Mar;144:107174
Bioorganic chemistry 2024 Mar;144:107174
Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.
Zhao X, Fan C, Qie T, Fu X, Chen X, Wang Y, Wu Y, Fu X, Shi K, Yan W, Yu H
Reproductive biology and endocrinology : RB&E 2024 Jul 15;22(1):82
Reproductive biology and endocrinology : RB&E 2024 Jul 15;22(1):82
Ascorbic Acid Protects Bone Marrow from Oxidative Stress and Transient Elevation of Corticosterone Caused by X-ray Exposure in Akr1a-Knockout Mice.
Bo T, Nohara H, Yamada KI, Miyata S, Fujii J
Antioxidants (Basel, Switzerland) 2024 Jan 25;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 25;13(2)
Alleviating 3-MCPD-induced male reproductive toxicity: Mechanistic insights and resveratrol intervention.
Wang KL, Chiang YF, Huang KC, Chen HY, Ali M, Hsia SM
Ecotoxicology and environmental safety 2024 Feb;271:115978
Ecotoxicology and environmental safety 2024 Feb;271:115978
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.
Zhang Y, Yu L, He Y, Liu C, Abouelfetouh MM, Ju S, Zhou Z, Li Q
Theriogenology 2024 Dec;230:130-141
Theriogenology 2024 Dec;230:130-141
Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.
Ou K, Zhang S, Lei X, Liu X, Zhang N, Wang C, Yuan X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124914
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124914
Apigenin improves testosterone synthesis by regulating endoplasmic reticulum stress.
Wu L, Qu J, Mou L, Liu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117075
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117075
Alterations in the Hypothalamic-Pituitary-Adrenal Axis as a Response to Experimental Autoimmune Encephalomyelitis in Dark Agouti Rats of Both Sexes.
Milosevic A, Milosevic K, Zivkovic A, Lavrnja I, Savic D, Bjelobaba I, Janjic MM
Biomolecules 2024 Aug 17;14(8)
Biomolecules 2024 Aug 17;14(8)
Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens.
Wang D, Tan L, Zhi Y, Bu L, Wang Y, Wang Z, Guo Y, Tian W, Xu C, Li D, Li Z, Jiang R, Han R, Li G, Wang Y, Xia D, Tian Y, Dunn IC, Hu X, Li H, Zhao Y, Kang X, Liu X
Nature communications 2024 Aug 16;15(1):7069
Nature communications 2024 Aug 16;15(1):7069
Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period.
Knapczyk-Stwora K, Kozlowska A, Jastrzabek D, Grzesiak M, Slomczynska M, Koziorowski M
Environmental toxicology and pharmacology 2024 Apr;107:104435
Environmental toxicology and pharmacology 2024 Apr;107:104435
Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.
Liang HY, Peng F, Pan MJ, Liao SL, Wei C, Wei GY, Xie X, Xue KY, Chen MK, Yang JK, Guo WB, Liu CD, Zhou QZ
Asian journal of andrology 2023;25(4):474-483
Asian journal of andrology 2023;25(4):474-483
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Zhang Y, Zhou J, Zeng L, Xiong Y, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Chiang YF, Lin IC, Huang KC, Chen HY, Ali M, Huang YJ, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115327
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115327
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Jing YX, Li HX, Yue F, Li YM, Yu X, He JJ, Zhang XH
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Melatonin Inhibits Testosterone Synthesis in Rooster Leydig Cells by Targeting CXCL14 through miR-7481-3p.
Xu H, Pu J, Teng Y, Zhu Q, Guo L, Zhao J, Ding H, Fang Y, Ma X, Liu H, Guo J, Lu W, Wang J
International journal of molecular sciences 2023 Nov 21;24(23)
International journal of molecular sciences 2023 Nov 21;24(23)
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Wang YX, Dai W, Li YZ, Wu ZY, Kan YQ, Zeng HC, He QZ
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis.
Milosevic A, Lavrnja I, Savic D, Milosevic K, Skuljec J, Bjelobaba I, Janjic MM
Cells 2023 Mar 30;12(7)
Cells 2023 Mar 30;12(7)
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Deng CM, Zhang GG, Liu QW, Xu JJ, Liu ZC, Yang J, Xu TY, Li ZG, Zhang F, Li B
Cancer research 2023 Jun 2;83(11):1851-1865
Cancer research 2023 Jun 2;83(11):1851-1865
Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.
Li Z, Zhao Y, Zong Q, Hu P, Bao W, Liu HY, Cai D
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 9;12(1)
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells.
Liu W, Chen M, Liu C, Wang L, Wei H, Zhang R, Ren Z, Chen Y, Luo M, Zhao J, Jiang H, Gao F, Li W
Autophagy 2023 Feb;19(2):644-659
Autophagy 2023 Feb;19(2):644-659
Impacts of elevated temperature on morphology, oxidative stress levels, and testosterone synthesis in ex vivo cultured porcine testicular tissue.
Wang K, Li Z, Li Y, Li X, Suo Y, Li C
Theriogenology 2023 Dec;212:181-188
Theriogenology 2023 Dec;212:181-188
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G, Wu S
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Androgens improve ovarian follicle function impaired by glucocorticoids through an androgen-IGF1-FSH synergistic effect.
Gao L, Gao H, Wang W
Frontiers in endocrinology 2022;13:951928
Frontiers in endocrinology 2022;13:951928
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Zhou J, Zhang Y, Zeng L, Wang X, Mu H, Wang M, Pan H, Su P
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.
Abobaker H, Omer NA, Hu Y, Idriss AA, Zhao R
Poultry science 2022 Jun;101(6):101871
Poultry science 2022 Jun;101(6):101871
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells.
Lin YC, Cheung G, Porter E, Papadopoulos V
The Journal of biological chemistry 2022 Jul;298(7):102110
The Journal of biological chemistry 2022 Jul;298(7):102110
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway.
Jin H, Yan M, Pan C, Liu Z, Sha X, Jiang C, Li L, Pan M, Li D, Han X, Ding J
Particle and fibre toxicology 2022 Feb 17;19(1):13
Particle and fibre toxicology 2022 Feb 17;19(1):13
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Wang Y, Peng X, Zhou Z, Tang C, Liu W
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Low-Intensity Pulsed Ultrasound Alleviates Human Testicular Leydig Cell Senescence In Vitro.
Han S, Luo J, Xu S, Zhao L, Yao C, Xu J, Tian R, Zhi E, Huang Y, Xia S, Li Z, Li P
International journal of molecular sciences 2022 Dec 27;24(1)
International journal of molecular sciences 2022 Dec 27;24(1)
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Yan W, Li M, Guo Q, Li X, Zhou S, Dai J, Zhang J, Wu M, Tang W, Wen J, Xue L, Jin Y, Luo A, Wang S
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Li M, Zhou S, Wu Y, Li Y, Yan W, Guo Q, Xi Y, Chen Y, Li Y, Wu M, Zhang J, Wei J, Wang S
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
An integrated RNA-Seq and network study reveals that valproate inhibited progesterone production in human granulosa cells.
Li S, Qi J, Sun Y, Gao X, Ma J, Zhao S
The Journal of steroid biochemistry and molecular biology 2021 Nov;214:105991
The Journal of steroid biochemistry and molecular biology 2021 Nov;214:105991
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Zeng L, Zhou J, Wang X, Zhang Y, Wang M, Su P
Free radical biology & medicine 2021 Nov 20;176:176-188
Free radical biology & medicine 2021 Nov 20;176:176-188
Proteomics analysis reveals the effect of 1α,25(OH)(2)VD(3)-glycosides on development of early testes in piglets.
Chen H, Bühler K, Zhu Y, Nie X, Liu W
Scientific reports 2021 May 31;11(1):11341
Scientific reports 2021 May 31;11(1):11341
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K
Clinical and translational medicine 2021 Jun;11(6):e449
Clinical and translational medicine 2021 Jun;11(6):e449
PRMT5 regulates ovarian follicle development by facilitating Wt1 translation.
Chen M, Dong F, Chen M, Shen Z, Wu H, Cen C, Cui X, Bao S, Gao F
eLife 2021 Aug 27;10
eLife 2021 Aug 27;10
CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D.
Wang X, Li M, Zhang X, Li Y, He G, Dinnyés A, Sun Q, Xu W
Frontiers in molecular biosciences 2020;7:608447
Frontiers in molecular biosciences 2020;7:608447
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Bisphenol A decreases progesterone synthesis in human ovarian granulosa cells.
Qi J, Liu L, Yang J, Gao X, Zhang W
Birth defects research 2020 Dec;112(20):1843-1849
Birth defects research 2020 Dec;112(20):1843-1849
Genipin improves reproductive health problems caused by circadian disruption in male mice.
Xu Y, Wang L, Cao S, Hu R, Liu R, Hua K, Guo Z, Di HJ, Hu Z
Reproductive biology and endocrinology : RB&E 2020 Dec 11;18(1):122
Reproductive biology and endocrinology : RB&E 2020 Dec 11;18(1):122
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
Proteomic analysis of mouse ovaries during the prepubertal stages.
Xiong J, Wu M, Zhang Q, Zhang C, Xiong G, Ma L, Lu Z, Wang S
Experimental cell research 2019 Apr 15;377(1-2):36-46
Experimental cell research 2019 Apr 15;377(1-2):36-46
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Tu X, Liu M, Tang J, Zhang Y, Shi Y, Yu L, Sun Z
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
Reproductive biology and endocrinology : RB&E 2018 May 4;16(1):44
Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
Liu XM, Zhang YL, Ji SY, Zhao LW, Shang WN, Li D, Chen Z, Tong C, Fan HY
Endocrinology 2017 Nov 1;158(11):3988-3999
Endocrinology 2017 Nov 1;158(11):3988-3999
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Rajapaksha M, Kaur J, Prasad M, Pawlak KJ, Marshall B, Perry EW, Whittal RM, Bose HS
Molecular and cellular biology 2016 Jan 19;36(6):1032-47
Molecular and cellular biology 2016 Jan 19;36(6):1032-47
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O'Connor BP, Gelfand EW
Nature communications 2016 Jan 11;7:10213
Nature communications 2016 Jan 11;7:10213
Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression.
Fouquet B, Santulli P, Noel JC, Misrahi M
BBA clinical 2016 Dec;6:143-152
BBA clinical 2016 Dec;6:143-152
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Prasad M, Kaur J, Pawlak KJ, Bose M, Whittal RM, Bose HS
The Journal of biological chemistry 2015 Jan 30;290(5):2604-16
The Journal of biological chemistry 2015 Jan 30;290(5):2604-16
Pregnenolone can protect the brain from cannabis intoxication.
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Science (New York, N.Y.) 2014 Jan 3;343(6166):94-8
Science (New York, N.Y.) 2014 Jan 3;343(6166):94-8
Immunohistochemical Characterization of S100A6 in the Murine Ovary.
Hanaue M, Miwa N, Takamatsu K
Acta histochemica et cytochemica 2012 Feb 29;45(1):9-14
Acta histochemica et cytochemica 2012 Feb 29;45(1):9-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human placenta tissue were subjected to SDS PAGE followed by western blot with 13363-1-AP(CYP11A1 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 13363-1-AP(CYP11A1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP11A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP11A1. This antibody recognizes human antigen. The CYP11A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
