HPA016436

antibody from Atlas Antibodies

Targeting: CYP11A1 CYP11A, P450SCC

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA016436

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA016436, RRID:AB_1847423

Product name

Anti-CYP11A1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human CYP11A1, Gene description: cytochrome P450, family 11, subfamily A, polypeptide 1, Alternative Gene Names: CYP11A, P450SCC, Validated applications: IHC, Uniprot ID: P05108, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.05 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors

Allan F, Watson A, Syme H
Journal of Veterinary Internal Medicine 2024;38(6):3070-3078

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Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity.

Andreassen CH, Holt R, Juel Mortensen L, Knudsen NK, Nielsen JE, Poulsen NN, Yahyavi SK, Boisen IM, Cui Z, Ongaro L, Hjerresen JP, Toft BG, Hasselager T, Jørgensen NR, Bernard DJ, Juul A, O'Brien C, Jørgensen A, Blomberg Jensen M
Cell reports. Medicine 2024 Oct 15;5(10):101783

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Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis

Dochez-Arnault J, Desdoits-Lethimonier C, Matias I, Evrard B, Lagarrigue M, Toupin M, Lardenois A, Chalmel F, Mazaud-Guittot S, Dejucq-Rainsford N, Gely-Pernot A
BMC Medicine 2023;21(1)

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Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

Lundgaard Riis M, Matilionyte G, Nielsen J, Melau C, Greenald D, Juul Hare K, Langhoff Thuesen L, Dreisler E, Aaboe K, Brenøe P, Andersson A, Albrethsen J, Frederiksen H, Rajpert-De Meyts E, Juul A, Mitchell R, Jørgensen A
BMC Medicine 2022;20(1)

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Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model

Lecante L, Leverrier-Penna S, Gicquel T, Giton F, Costet N, Desdoits-Lethimonier C, Lesné L, Fromenty B, Lavoué V, Rolland A, Mazaud-Guittot S
The Journal of Clinical Endocrinology & Metabolism 2022;107(6):1647-1661

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Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment

Hutka M, Kadam P, Van Saen D, Homer N, Onofre J, Wallace W, Smith L, Stukenborg J, Goossens E, Mitchell R
Cancers 2020;12(10):2830

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The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty.

Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR
Cell stem cell 2020 Feb 6;26(2):262-276.e4

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Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes

Harpelunde Poulsen K, Nielsen J, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, Perlman S, Lundvall L, Mitchell R, Juul A, Rajpert-De Meyts E, Jørgensen A
Human Reproduction 2019;34(11):2228-2243

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Characterization of Human Adrenal Steroidogenesis During Fetal Development

Melau C, Nielsen J, Frederiksen H, Kilcoyne K, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Andersson A, Mitchell R, Juul A, Jørgensen A
The Journal of Clinical Endocrinology & Metabolism 2019;104(5):1802-1812

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Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants

Gaudriault P, Mazaud-Guittot S, Lavoué V, Coiffec I, Lesné L, Dejucq-Rainsford N, Scholze M, Kortenkamp A, Jégou B
Environmental Health Perspectives 2017;125(8)

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Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome

Arboleda V, Lee H, Parnaik R, Fleming A, Banerjee A, Ferraz-de-Souza B, Délot E, Rodriguez-Fernandez I, Braslavsky D, Bergadá I, Dell'Angelica E, Nelson S, Martinez-Agosto J, Achermann J, Vilain E
Nature Genetics 2012;44(7):788-792

Immunohistochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Enhanced method

Orthogonal validation

Main image

Experimental details

Immunohistochemistry analysis in human adrenal gland and cerebral cortex tissues using Anti-CYP11A1 antibody. Corresponding CYP11A1 RNA-seq data are presented for the same tissues.

Sample type

Human

Protocol

Protocol

Orthogonal method

Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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