CYP2C19

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Description

Cytochrome P450 family 2 subfamily C member 19

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

10 (94762681 - 94855547)

Ensembl ID

ENSG00000165841  (ver. 103.38)

Orthologs

-

UniProt

P33261

neXtProt

NX_P33261

Human splice variants

Protein structure