Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 628801 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#628801, RRID:AB_2077385
- Product name
- Purified anti-Centrin 2 (Caltractin)
- Antibody type
- Polyclonal
- Antigen
- Recombinant centrin 2 protein
- Description
- Centrin 2, also known as caltractin, EF-hand protein 2, and 20 kD calcium-binding protein, is a calcium-binding protein that contains 4 EF-hand domains. Centrin 2 is highly expressed in the retina and testis, also expressed in liver, skeletal muscle and cardiac muscle. The centrin-2 protein plays a critical function in normal cell division,and is known to associate with the centrosomes, mitotic spindle poles, and basal bodies. Centrin 2 has a fundamental role in the structure and function of the microtubule-organizing center and has been shown to associate with the RAD23B, SFI1, and Xeroderma pigmentosum group C complementing proteins. The Poly6288 antibody recognizes human centrin 2 and has been shown to be useful for Western blotting.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 50 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins.
Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG
The Journal of cell biology 2011 Apr 18;193(2):307-18
The Journal of cell biology 2011 Apr 18;193(2):307-18
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-centrin 2 antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system.
- Conjugate
- Unconjugated