CBFA2T3

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Description

CBFA2/RUNX1 partner transcriptional co-repressor 3

Tissue specificity

Tissue enhanced (brain, lymphoid tissue, pancreas)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (88874858 - 88977207)

Ensembl ID

ENSG00000129993  (ver. 103.38)

Orthologs

Mouse Cbfa2t3: ENSMUSG00000006362

UniProt

O75081

neXtProt

NX_O75081

Human splice variants
Mouse splice variants

Protein structure