FPGS

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Description

Folylpolyglutamate synthase

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9:q34.11 (127794597 - 127814327)

Ensembl ID

ENSG00000136877  (ver. 103.38)

Orthologs

Mouse Fpgs: ENSMUSG00000009566

UniProt

Q05932

neXtProt

NX_Q05932

Human splice variants
Mouse splice variants