CABT-B9242

antibody from Creative Diagnostics

Targeting: ATP1A3 DYT12

No application information provided.

Antibody Data

Product number

CABT-B9242

Provider

Creative Diagnostics

Product name

Mouse anti-Human Na+, K+ ATPase ÉÇ3 monoclonal antibody, clone 57

Antibody type

Monoclonal

Description

Na+, K+-ATPase is an integral plasma membrane protein that maintains the intracellular concentrations of Na+ and K+ ions. It is a P class pump that is composed of two Ï« and two ÉÇ transmembrane subunits. It is also thought to contain a ÎÛ subunit. The 120 kDa Ï« subunit represents the catalytic site. Although the 50 kDa ÉÇ subunit mediates proper folding of newly synthesized Ï« subunits, it is not directly involved in ion transfer. There are four known Ï« isoforms (Ï«1, Ï«2, Ï«3, and Ï«4) and three ÉÇ isoforms (ÉÇ1, ÉÇ2, and ÉÇ3). The Na+, K+-ATPase is ubiquitously expressed in the plasma membrane. However, the individual subunits have different tissue distributions: Ï«1 is ubiquitous