BS8304

antibody from Bioworld Technology, Inc

Targeting: HYAL2 LuCa-2, LUCA2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8304

Provider

Bioworld Technology, Inc

Product name

HYAL2 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human HYAL2.

Description

Hyaluronidases (HAases or HYALs) are a family of lysosomal enzymes that are crucial for the spread of bacterial infections and of toxins present in a variety of venoms. HYALs may also be involved in the progression of cancer. In humans, six HYAL proteins have been identified. HYAL proteins use hydrolysis to degrade hyaluronic acid (HA), which is present in body fluids, tissues and the extracellular matrix of vertebrate tissues. HA keeps tissues hydrated, maintains osmotic balance and promotes cell proliferation, differentiation and metastasis. HA is also an important structural component of cartilage and other tissues and acts as a lubricant in joints. HYAL2 is a 452 amino acid peptide that localizes to the lysosomes of mammalian cells. The hyaluronidase activity of HYAL2 is most efficient at a pH below 4, and it only hydrolyzes HAs of high molecular mass. HYAL2 is also the receptor for two exogenous oncogenic viruses, Jaagsiekte sheep retrovirus (JSRV) and Enzootic nasal tumor virus. The viral envelope of JSRV physically associates with and activates HYAL2, consequently activating the Akt1 and mitogen-activated protein kinase-1 pathways, leading to oncogenic transformation.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.