Antibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations [0]
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- Product number
- 26312-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- MCU/CCDC109A antibody
- Antibody type
- Polyclonal
- Description
- MCU/CCDC109A antibody (Cat. #26312-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sequential-targeting nanomedicine protects against acute kidney injury by modulating calcium influx and scavenging reactive oxygen species.
Redox switch C674 in SERCA2 triggers Ca(2+)-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
VPS13A Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of VPS13A Disease Patients.
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer's disease.
Peroxynitrite regulates ER stress-mediated Ca(2+) flux to mitochondria characterizing cardiac microvascular ischemia-reperfusion injury associated with hyperhomocysteinemia.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis.
MICU1 alleviates hypobaric hypoxia-induced myocardial injury through regulating Ca(2+) uptake to inhibit mitochondria-dependent apoptosis.
Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage.
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance.
Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells.
Dimethyl fumarate improves non-alcoholic fatty liver disease by regulating SIRT1 signal to inhibit MAMs over-enrichment.
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Mitotic ER-mitochondria contact enhances mitochondrial Ca(2+) influx to promote cell division.
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca(2+) uptake and oxidative metabolism.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer.
Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids.
Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model.
EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement.
A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease.
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.
CD137 Signal Mediates Cardiac Ischemia-Reperfusion Injury by Regulating the Necrosis of Cardiomyocytes.
Ca(2+)-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak.
Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes.
MICU3 regulates mitochondrial Ca(2+)-dependent antioxidant response in skeletal muscle aging.
PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca(2+) efflux.
Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Huang L, Yang P, Zhang C, Tan L, Zhao L, Yang L, Zhang L, Zhang Z, Deng J, Liao X
Biomaterials 2026 Jun;329:123933
Biomaterials 2026 Jun;329:123933
Redox switch C674 in SERCA2 triggers Ca(2+)-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
Chen H, Qiu YX, Xie YF, Chen X, Xiang YY, Zhang HL, Yu WM, Hu PP, Wang LT, Wu FH, Tong XY
Free radical biology & medicine 2026 Feb 16;244:380-394
Free radical biology & medicine 2026 Feb 16;244:380-394
VPS13A Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of VPS13A Disease Patients.
Grossmann D, Spranger A, Fischer E, Schubarth JW, Leopold J, Glaß H, Klicker S, Thi MUD, Bartalis AE, Hermann A, Peikert K
Movement disorders : official journal of the Movement Disorder Society 2026 Apr;41(4):856-869
Movement disorders : official journal of the Movement Disorder Society 2026 Apr;41(4):856-869
Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca(2+) flux through MAMs.
Li Y, Du T, Zhang Y, Lu Y, Li X, Xie W, Guo S
Frontiers in cardiovascular medicine 2025;12:1596757
Frontiers in cardiovascular medicine 2025;12:1596757
Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer's disease.
Shukla S, Kadam AA, Goyani S, Jaiswal N, Samantaray K, Raghav D, Kashyap S, Tomar D, Jadiya P
Cell communication and signaling : CCS 2025 Nov 3;23(1):472
Cell communication and signaling : CCS 2025 Nov 3;23(1):472
Peroxynitrite regulates ER stress-mediated Ca(2+) flux to mitochondria characterizing cardiac microvascular ischemia-reperfusion injury associated with hyperhomocysteinemia.
Liu H, Yu S, Gao S, Liu X, Qiu C, Wang N, Tan X, Zhao K, He Q, Zhang W
Journal of translational medicine 2025 Nov 10;23(1):1254
Journal of translational medicine 2025 Nov 10;23(1):1254
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis.
Promila L, Sarkar K, Guleria S, Rakshit A, Rathore M, Singh NC, Khan S, Tomar MS, Ammanathan V, Barthwal MK, Kumaravelu J, Shrivastava A, Mitra K, Guha R, Aggarwal A, Lahiri A
Free radical biology & medicine 2025 Jul;234:55-71
Free radical biology & medicine 2025 Jul;234:55-71
MICU1 alleviates hypobaric hypoxia-induced myocardial injury through regulating Ca(2+) uptake to inhibit mitochondria-dependent apoptosis.
Li Y, Liu F, Chen D, Tian Y, Liu C, Li F
Cellular signalling 2025 Jan;125:111524
Cellular signalling 2025 Jan;125:111524
Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).
Zhang X, Liu S, Su Y, Zhang L, Guo T, Wang X
Life (Basel, Switzerland) 2025 Jan 25;15(2)
Life (Basel, Switzerland) 2025 Jan 25;15(2)
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage.
Wang J, Cui Y, Ding PF, Zhang JT, Liu XZ, Gao S, Chen XX, Peng Z, Li XJ, Wu LY, Gao YY, Hang CH, Li W
Cell calcium 2025 Dec;132:103080
Cell calcium 2025 Dec;132:103080
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance.
Wang D, Zhang J, Yang X, Zhang Q, Hu X, Lu X, Li H, Bai X, Zhang K, Sack MN, Chang Y, Wang Y, Wang L, Zhu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e08991
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e08991
Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells.
Zhang Z, Yang F, Wang W, Cao Q, Zhang L, Zhang Y, Ma D, Zhang X, Wen J, Zheng B
Molecular biomedicine 2025 Dec 2;6(1):129
Molecular biomedicine 2025 Dec 2;6(1):129
Dimethyl fumarate improves non-alcoholic fatty liver disease by regulating SIRT1 signal to inhibit MAMs over-enrichment.
Zhang R, Zhang Q, Cui Z, Huang B, Wang Y, Ma H
European journal of pharmacology 2025 Aug 5;1000:177693
European journal of pharmacology 2025 Aug 5;1000:177693
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Cong J, Liu L, Shi R, He M, An Y, Feng X, Yin X, Li Y, Cong B, Shi W
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.
Bao H, Chen X, Hu X, Cao Z, Zhou W, Chen B, Liao F, Wei F, Huang R, Li W, Chen Z
Scientific reports 2025 Aug 12;15(1):29469
Scientific reports 2025 Aug 12;15(1):29469
Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Raby A, Missiroli S, Sanatine P, Langui D, Pansiot J, Beaude N, Vezzana L, Saleh R, Marinello M, Laforge M, Pinton P, Buj-Bello A, Burgo A
iScience 2024 Sep 20;27(9):110683
iScience 2024 Sep 20;27(9):110683
Mitotic ER-mitochondria contact enhances mitochondrial Ca(2+) influx to promote cell division.
Zhao G, Jia M, Zhu S, Ren H, Wang G, Xin G, Sun M, Wang X, Lin Q, Jiang Q, Zhang C
Cell reports 2024 Oct 22;43(10):114794
Cell reports 2024 Oct 22;43(10):114794
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca(2+) uptake and oxidative metabolism.
Dematteis G, Tapella L, Casali C, Talmon M, Tonelli E, Reano S, Ariotti A, Pessolano E, Malecka J, Chrostek G, Kulkovienė G, Umbrasas D, Distasi C, Grilli M, Ladds G, Filigheddu N, Fresu LG, Mikoshiba K, Matute C, Ramos-Gonzalez P, Jekabsone A, Calì T, Brini M, Biggiogera M, Cavaliere F, Miggiano R, Genazzani AA, Lim D
Communications biology 2024 Oct 10;7(1):1294
Communications biology 2024 Oct 10;7(1):1294
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
Zhai DS, Wang XS, Yang L, Jiang YL, Jin YC, Yan YX, Song DK, Zhang K, Han ZK, Liu MY, Wu YM, Ma X, Qi JY, Yang F, Tian F, Li XB, Liu SB
Journal of affective disorders 2024 Mar 1;348:283-296
Journal of affective disorders 2024 Mar 1;348:283-296
CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.
Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709
Nature chemical biology 2024 Jun;20(6):699-709
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Wang YS, Li BY, Xing YF, Huang JC, Chen ZS, Yue L, Zou YG, Guo B
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure.
Liang P, Tian K, Yang W, Feng R, Li Y, Hu L, Wang K, Qiu T, Zhang J, Sun X, Yao X
The Science of the total environment 2024 Dec 20;957:177679
The Science of the total environment 2024 Dec 20;957:177679
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer.
Chen S, Ma J, Xiao Y, Zhou D, He P, Chen Y, Zheng X, Lin H, Qiu F, Yuan Y, Zhong J, Li X, Pan X, Fang Z, Wang C
Molecular pharmaceutics 2023 Oct 2;20(10):5214-5225
Molecular pharmaceutics 2023 Oct 2;20(10):5214-5225
Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids.
Ghosheh M, Ehrlich A, Ioannidis K, Ayyash M, Goldfracht I, Cohen M, Fischer A, Mintz Y, Gepstein L, Nahmias Y
Nature biomedical engineering 2023 Nov;7(11):1493-1513
Nature biomedical engineering 2023 Nov;7(11):1493-1513
Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model.
Lu N, Zhu JF, Lv HF, Zhang HP, Wang PL, Yang JJ, Wang XW
Immunology letters 2023 Nov;263:14-24
Immunology letters 2023 Nov;263:14-24
EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma.
Meng K, Hu Y, Wang D, Li Y, Shi F, Lu J, Wang Y, Cao Y, Zhang CZ, He QY
Cancer science 2023 May;114(5):2029-2040
Cancer science 2023 May;114(5):2029-2040
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement.
Bulthuis EP, Adjobo-Hermans MJW, de Potter B, Hoogstraten S, Wezendonk LHT, Tutakhel OAZ, Wintjes LT, van den Heuvel B, Willems PHGM, Kamsteeg EJ, Gozalbo MER, Sallevelt SCEH, Koudijs SM, Nicolai J, de Bie CI, Hoogendijk JE, Koopman WJH, Rodenburg RJ
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166808
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166808
A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease.
Bharat V, Durairaj AS, Vanhauwaert R, Li L, Muir CM, Chandra S, Kwak CS, Le Guen Y, Nandakishore P, Hsieh CH, Rensi SE, Altman RB, Greicius MD, Feng L, Wang X
Cell reports 2023 Dec 26;42(12):113544
Cell reports 2023 Dec 26;42(12):113544
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Jiang C, Shen J, Wang C, Huang Y, Wang L, Yang Y, Hu W, Li P, Wu H
Toxicology letters 2023 Aug 1;384:86-95
Toxicology letters 2023 Aug 1;384:86-95
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome.
Geng J, Khaket TP, Pan J, Li W, Zhang Y, Ping Y, Cobos Sillero MI, Lu B
Developmental cell 2023 Apr 10;58(7):597-615.e10
Developmental cell 2023 Apr 10;58(7):597-615.e10
CD137 Signal Mediates Cardiac Ischemia-Reperfusion Injury by Regulating the Necrosis of Cardiomyocytes.
Xu Y, Chen R, Yan J, Zang G, Shao C, Wang Z
Journal of cardiovascular translational research 2022 Oct;15(5):1163-1175
Journal of cardiovascular translational research 2022 Oct;15(5):1163-1175
Ca(2+)-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak.
Quarato G, Llambi F, Guy CS, Min J, Actis M, Sun H, Narina S, Pruett-Miller SM, Peng J, Rankovic Z, Green DR
Cell death and differentiation 2022 Jul;29(7):1318-1334
Cell death and differentiation 2022 Jul;29(7):1318-1334
Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes.
Lan T, Zhang K, Lin F, He Q, Wu S, Xu Z, Zhang Y, Quan F
International journal of molecular sciences 2022 Aug 3;23(15)
International journal of molecular sciences 2022 Aug 3;23(15)
MICU3 regulates mitochondrial Ca(2+)-dependent antioxidant response in skeletal muscle aging.
Yang YF, Yang W, Liao ZY, Wu YX, Fan Z, Guo A, Yu J, Chen QN, Wu JH, Zhou J, Xiao Q
Cell death & disease 2021 Nov 29;12(12):1115
Cell death & disease 2021 Nov 29;12(12):1115
PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca(2+) efflux.
Zhou Q, Xie M, Zhu J, Yi Q, Tan B, Li Y, Ye L, Zhang X, Zhang Y, Tian J, Xu H
Stem cell research & therapy 2021 May 6;12(1):269
Stem cell research & therapy 2021 May 6;12(1):269
Sulforaphane Balances Ca(2+) Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
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