BS4685

antibody from Bioworld Technology, Inc
Targeting: FANCA FA-H, FAA, FACA, FAH, FANCH
Provider product page for BS4685
Western blot
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
BS4685 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FANCA (phospho S1149) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human FANCA around the phosphorylation site of Serine 1149.
Description
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least eight complementation groups (A-G) have been identified and six FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNFÏ« signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. FANCA, also known as FACA and FANCH, associates with the Brm-related gene 1 (BRG1) product, a subunit of the SWI/SNF complex which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA is mainly expressed in lymphoid tissues, testis and ovary. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization and functional activity of the complex.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FANCA protein structure - BS4685 shown in red.