BS60713

antibody from Bioworld Technology, Inc
Targeting: EPX EPO, EPP, EPX-PEN
Provider product page for BS60713

Antibody data

Product number
BS60713 - Provider product page
Provider
Bioworld Technology, Inc
Product name
EPX polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human EPX
Description
Eosinophil peroxidase (EPX) is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX-dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies, cancer, and parasitic/helminthic infections. Human EPX gene product can form a tetramer of two light chains and two heavy chains. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK-dependent manner. Other peroxidase family members include myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
EPX protein structure - BS60713 shown in red.