24744-1-AP

antibody from Proteintech Group

Targeting: YTHDF2 CAHL, HGRG8, NY-REN-2

Provider product page for 24744-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [268]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 24744-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#24744-1-AP, RRID:AB_2687435
Product name: YTHDF2 antibody
Antibody type: Polyclonal
Description: KD/KO validated YTHDF2 antibody (Cat. #24744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

YTHDF2 protein structure - 24744-1-AP shown in red.

Submitted references Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.

Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
International journal of biological sciences 2024;20(6):2092-2110

N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.

Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232

Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism.

Chen X, Lu T, Ding M, Cai Y, Yu Z, Zhou X, Wang X
Journal of advanced research 2024 Sep;63:17-33

Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.

Song J, Wang Y, Zhu Z, Wang W, Yang H, Shan Z
Advanced biology 2024 May;8(5):e2300642

Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.

Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226

Molecular characterization of m6A RNA methylation regulators with features of immune dysregulation in IgA nephropathy.

Wang Y, Sun N, He R, Wang Z, Jin J, Gao T, Qu J
Clinical and experimental medicine 2024 May 2;24(1):92

METTL3 Promotes OSCC Progression by Down-Regulating WEE1 in a m6A-YTHDF2-Dependent Manner.

Su Y, Hu Y, Qu B, Lei R, Guo G
Molecular biotechnology 2024 May 14;

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.

Wang K, Bhattacharya A, Haratake N, Daimon T, Nakashoji A, Ozawa H, Peng B, Li W, Kufe D
Cell death & disease 2024 May 13;15(5):330

METTL3 enhances E. coli F18 resistance by targeting IKBKG/NF-κB signaling via an m(6)A-YTHDF1-dependent manner in IPEC-J2 cells.

Jin J, Liu M, Yu F, Sun MA, Wu Z
International journal of biological macromolecules 2024 Mar;262(Pt 2):130101

METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038

Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.

Qu H, Liu X, Zhu J, Xiong X, Li L, He Q, Wang Y, Yang G, Zhang L, Yang Q, Luo G, Zheng Y, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365

Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.

Zheng W, Fu Z, Tan X, Liang X, Cao L
Biochemical genetics 2024 Mar 7;

Dynamics of N6-methyladenosine modification during Alzheimer's disease development.

Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan TF, Tian H, Peng B, Rao Y
Heliyon 2024 Mar 30;10(6):e26911

Mycobacterium tuberculosis inhibits METTL14-mediated m(6)A methylation of Nox2 mRNA and suppresses anti-TB immunity.

Ma M, Duan Y, Peng C, Wu Y, Zhang X, Chang B, Wang F, Yang H, Zheng R, Cheng H, Cheng Y, He Y, Huang J, Lei J, Ma H, Li L, Wang J, Huang X, Tang F, Liu J, Li J, Ying R, Wang P, Sha W, Gao Y, Wang L, Ge B
Cell discovery 2024 Mar 29;10(1):36

METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging.

Wang Y, Chen Y, Xiao H, Liu Z, Liu X, Feng Z, Sheng X, Peng B, Ren X, Xu L, Teng F, Yi Z, Niu Y, Xiang D, Xia Y, Geng B
Cell death discovery 2024 Mar 27;10(1):155

CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension.

Hu X, Sun Y, Wang S, Zhao H, Wei Y, Fu J, Huang Y, Wu W, Li J, Liu J, Gong S, Zhao Q, Wang L, Jiang R, Song X, Yuan P
Journal of the American Heart Association 2024 Mar 19;13(6):e031867

YTHDF2 governs muscle size through a targeted modulation of proteostasis.

Gilbert CJ, Rabolli CP, Golubeva VA, Sattler KM, Wang M, Ketabforoush A, Arnold WD, Lepper C, Accornero F
Nature communications 2024 Mar 11;15(1):2176

FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.

Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29

miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner.

Yang H, Wang W, Liu H, Zhang C, Cao Y, Long L, Han X, Wang Y, Yan F, Li G, Zhu M, Jin L, Fan Z
Cell proliferation 2024 Jun;57(6):e13607

YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.

Pang P, Si W, Wu H, Ju J, Liu K, Wang C, Jia Y, Diao H, Zeng L, Jiang W, Yang Y, Xiong Y, Kong X, Zhang Z, Zhang F, Song J, Wang N, Yang B, Bian Y
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905

lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.

Luo D, Tang H, Tan L, Zhang L, Wang L, Cheng Q, Lei X, Wu J
Molecular cancer research : MCR 2024 Jun 4;22(6):524-537

FTO elicits tumor neovascularization in cancer-associated fibroblasts through eliminating m(6)A modifications of multiple pro-angiogenic factors.

Liao Q, Shi H, Yang J, Ge S, Jia R, Song X, Chai P, Jia R
Cancer letters 2024 Jun 28;592:216911

m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.

Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962

BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.

Zhang P, Zhang W, Wang X, Li L, Lin Y, Wu N, Mao R, Lin J, Kang M, Ding C
Cancer letters 2024 Jun 1;591:216874

N(6)-methyladenosine (m(6)A) reader YTHDF2 accelerates endothelial cells ferroptosis in cerebrovascular atherosclerosis.

Li J, Zou C, Zhang Z, Xue F
Molecular and cellular biochemistry 2024 Jul;479(7):1853-1861

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

RNA m(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression.

Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, Weng H, Su R, Tan B, Shen C, Li W, Zhao Z, Qing Y, Qin X, Wang K, Leung K, Boldin M, Chen CW, Ann D, Qian Z, Deng X, Chen J, Chen Z
Genes & diseases 2024 Jan;11(1):382-396

Epitranscriptomic Reader YTHDF2 Regulates SEK1( MAP2K4 )-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress.

Malovic E, Ealy A, Hsu PJ, Sarkar S, Miller C, Rokad D, Goeser C, Hartman AK, Zhu A, Palanisamy B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, He C, Kanthasamy AG
bioRxiv : the preprint server for biology 2024 Jan 26;

METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.

Zhang Y, Kong Y, Zhang W, He J, Zhang Z, Cai Y, Zhao Y, Xu Q
Clinical epigenetics 2024 Jan 24;16(1):18

A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia.

Zhou W, Li S, Wang H, Zhou J, Li S, Chen G, Guan W, Fu X, Nervi C, Yu L, Li Y
Experimental hematology & oncology 2024 Jan 24;13(1):9

YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.

Huang R, Sun M, Wang W, Yu X, Liu F
Journal of neuroimmunology 2024 Feb 15;387:578265

Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.

Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H
Nature communications 2024 Feb 14;15(1):1353

YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation.

Zhao X, Lv S, Li N, Zou Q, Sun L, Song T
The Journal of biological chemistry 2024 Apr;300(4):107152

RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.

Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122

Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.

Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, Wei Q, He Z, Zhang W, Yang X
International immunopharmacology 2024 Apr 20;131:111820

PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt-β-catenin pathway.

Yu P, Xu T, Ma W, Fang X, Bao Y, Xu C, Huang J, Sun Y, Li G
Journal of experimental & clinical cancer research : CR 2024 Apr 18;43(1):116

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.

Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108

Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.

Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, Shu Y, Ma P
Molecular biomedicine 2024 Apr 1;5(1):11

Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.

Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396

Comprehensive analysis of m6A RNA methylation modification patterns and the immune microenvironment in osteoarthritis.

Liu Z, Liu H, Li D, Ma L, Lu T, Sun H, Zhang Y, Yang H
Frontiers in immunology 2023;14:1128459

Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.

Yu PL, Wu R, Cao SJ, Wen YP, Huang XB, Zhao S, Lang YF, Zhao Q, Lin JC, Du SY, Yu SM, Yan QG
Frontiers in microbiology 2023;14:1087484

Loss of YTHDF2 Alters the Expression of m(6)A-Modified Myzap and Causes Adverse Cardiac Remodeling.

Golubeva VA, Dorn LE, Gilbert CJ, Rabolli CP, Das AS, Wanasinghe VS, Veress R, Terentyev D, Accornero F
JACC. Basic to translational science 2023 Sep;8(9):1180-1194

Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.

Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687

Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.

Zhou X, Jin L, Li Y, Wang Y, Li W, Shen X
BMC genomics 2023 Sep 27;24(1):577

Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei.

Lei Y, Yuan Z, Zeng Q, Wan B, Liu J, Wang W
Journal of hazardous materials 2023 Sep 15;458:131996

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

m(6)A governs length-dependent enrichment of mRNAs in stress granules.

Ries RJ, Pickering BF, Poh HX, Namkoong S, Jaffrey SR
Nature structural & molecular biology 2023 Oct;30(10):1525-1535

YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.

Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248

WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.

Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931

YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.

Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.

Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206

RNA methylation reading protein YTHDF2 relieves myocardial ischemia-reperfusion injury by downregulating BNIP3 via m(6)A modification.

Cai X, Zou P, Hong L, Chen Y, Zhan Y, Liu Y, Shao L
Human cell 2023 Nov;36(6):1948-1964

O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.

Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690

Comprehensive analysis of m(6)A subtype classification for immune microenvironment of pituitary adenomas.

Yuan F, Cai X, Wang Y, Du C, Cong Z, Zeng X, Tang C, Ma C
International immunopharmacology 2023 Nov;124(Pt A):110784

FTO facilitates cancer metastasis by modifying the m(6)A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer.

Gao L, Wang A, Chen Y, Cai X, Li Y, Zhao J, Zhang Y, Zhang W, Zhu J, Zeng Y, Liu Z, Huang JA
Cell communication and signaling : CCS 2023 Nov 2;21(1):311

N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.

Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005

RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner.

Shen D, Lin J, Xie Y, Zhuang Z, Xu G, Peng S, Tang G, Bai L, Zhu M, Zhang Y, Huang Z, Wang P, Liu X, Huang M, Luo Y, Wang X, Yu H
Clinical and translational medicine 2023 May;13(5):e1279

Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI.

Liu C, Sun H, Yi Y, Shen W, Li K, Xiao Y, Li F, Li Y, Hou Y, Lu B, Liu W, Meng H, Peng J, Yi C, Wang J
Nature biotechnology 2023 Mar;41(3):355-366

Fibroblast-Derived Extracellular Vesicle-Packaged Long Noncoding RNA Upregulated in Diabetic Skin Enhances Keratinocyte MMP-9 Expression and Delays Diabetic Wound Healing.

Wu Y, Wu X, Wang J, Chen S, Chen H, Liu J, Zeng T, Hu M, Liang Y, Sun K, Yang C, Yan L, Ren M
Laboratory investigation; a journal of technical methods and pathology 2023 Mar;103(3):100019

YTHDF2 exerts tumor-suppressor roles in gastric cancer via up-regulating PPP2CA independently of m(6)A modification.

Zhou Y, Fan K, Dou N, Li L, Wang J, Chen J, Li Y, Gao Y
Biological procedures online 2023 Mar 4;25(1):6

YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.

Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822

Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation.

Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF
Nature communications 2023 Mar 27;14(1):1694

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.

Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y
Toxicology letters 2023 Mar 15;377:38-50

Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.

Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822

Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.

Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747

METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.

Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151

The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I-Mediated Immune Response.

Zhang L, Li Y, Zhou L, Zhou H, Ye L, Ou T, Hong H, Zheng S, Zhou Z, Wu K, Yan Z, Thiery JP, Cui J, Wu S
Cancer research 2023 Jun 2;83(11):1834-1850

Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization.

Liu P, Chen Y, Zhang Z, Yuan Z, Sun JG, Xia S, Cao X, Chen J, Zhang CJ, Chen Y, Zhan H, Jin Y, Bao X, Gu Y, Zhang M, Xu Y
PLoS biology 2023 Jul;21(7):e3002199

ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway.

Sun RX, Zhu HJ, Zhang YR, Wang JN, Wang Y, Cao QC, Ji JD, Jiang C, Yuan ST, Chen X, Liu QH
Cell reports 2023 Jul 25;42(7):112779

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.

Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467

TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.

Wang YQ, Wu DH, Wei D, Shen JY, Huang ZW, Liang XY, Cho WCS, Ma J, Lv J, Chen YP
Science advances 2023 Jan 6;9(1):eadd0960

Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.

Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H
Cell stem cell 2023 Jan 5;30(1):69-85.e7

METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance.

Zhang Y, Qiu JG, Jia XY, Ke Y, Zhang MK, Stieg D, Liu WJ, Liu LZ, Wang L, Jiang BH
Cancer letters 2023 Jan 28;553:215971

RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.

McMillan M, Gomez N, Hsieh C, Bekier M, Li X, Miguez R, Tank EMH, Barmada SJ
Molecular cell 2023 Jan 19;83(2):219-236.e7

Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis.

Wang X, Zhao X, Wang J, Wu H, Cheng Y, Guo Q, Liang T, Zhang G
International journal of molecular sciences 2023 Jan 14;24(2)

METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.

Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)

Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.

Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells.

Lyu Z, Huang B, Zhang J, Qian Q, Pu X, Cui N, Ou Y, Li B, You Z, Lian M, Tang R, Chen W, Zhao Z, Hou J, Gershwin ME, Zhang H, Xia Q, Ma X
Journal of autoimmunity 2023 Feb;135:102993

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19

Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.

Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122

Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability.

Cai Y, Yu R, Zhang Z, Li D, Yi B, Feng Z, Xu Q
Immunology letters 2023 Dec;264:64-73

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.

Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503

EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7

SON is an essential m(6)A target for hematopoietic stem cell fate.

Luo H, Cortés-López M, Tam CL, Xiao M, Wakiro I, Chu KL, Pierson A, Chan M, Chang K, Yang X, Fecko D, Han G, Ahn EE, Morris QD, Landau DA, Kharas MG
Cell stem cell 2023 Dec 7;30(12):1658-1673.e10

Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.

Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7

High Temperature-Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs.

Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Guo J, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2174-2183

m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.

Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202

Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.

Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821

Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.

Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310

METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.

Li W, Tan M, Wang H, Wang Z, Pang Y, Yang R, Zhong S, Pan X, Chen S, Wang Q, Li D, Xiao Y, Chen W, Chen L
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887

LncRNA CACClnc promotes chemoresistance of colorectal cancer by modulating alternative splicing of RAD51.

Zhang X, Ma D, Xuan B, Shi D, He J, Yu M, Xiong H, Ma Y, Shen C, Guo F, Cao Y, Yan Y, Gao Z, Tong T, Zhu X, Fang JY, Chen H, Hong J
Oncogene 2023 Apr;42(17):1374-1391

YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.

Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W, Ji SJ
Molecular psychiatry 2023 Apr;28(4):1679-1691

N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication.

Zhu Y, Wang R, Zou J, Tian S, Yu L, Zhou Y, Ran Y, Jin M, Chen H, Zhou H
PLoS pathogens 2023 Apr;19(4):e1011305

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.

Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755

Effects on the Cell Barrier Function of L-Met and DL-HMTBA Is Related to Metabolic Characteristics and m(6)A Modification.

Zuo F, Wei H, Peng J, Li S, Zhou Y
Frontiers in nutrition 2022;9:836069

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.

Wang L, Yu P, Wang J, Xu G, Wang T, Feng J, Bei Y, Xu J, Wang H, Das S, Xiao J
Research (Washington, D.C.) 2022;2022:9825916

M(6)A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.

Liu F, Zhang X, Liu Z, Cai W, Song C, Jiang Y, Yin J, Liu Z, Huang C
Journal of oncology 2022;2022:2513813

Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation.

Gao X, Li H, Wang X, Ren Z, Tian Y, Zhao J, Qi W, Wang H, Yu Y, Gong R, Chen H, Ji H, Yang F, Ma W, Liu Y
International journal of medical sciences 2022;19(8):1254-1264

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.

Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y
International journal of biological sciences 2022;18(15):5753-5769

Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.

Koh YW, Han JH, Haam S, Lee HW
Frontiers in oncology 2022;12:996634

m(1)A and m(6)A modifications function cooperatively to facilitate rapid mRNA degradation.

Boo SH, Ha H, Kim YK
Cell reports 2022 Sep 6;40(10):111317

M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.

Xu M, Zhuo R, Tao S, Liang Y, Liu C, Liu Q, Wang T, Zhong X
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)

m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.

Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji SJ
iScience 2022 Sep 16;25(9):104908

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350

m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.

Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333

Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.

Jiang FQ, Liu K, Chen JX, Cao Y, Chen WY, Zhao WL, Song GH, Liang CQ, Zhou YM, Huang HL, Huang RJ, Zhao H, Park KS, Ju Z, Cai D, Qi XF
eLife 2022 Nov 18;11

Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.

Xiong YW, Tan LL, Zhang J, Zhu HL, Zheng XM, Chang W, Gao L, Wei T, Xu DX, Wang H
Environmental pollution (Barking, Essex : 1987) 2022 Nov 15;313:120112

Functional and molecular dissection of HCMV long non-coding RNAs.

Lee S, Kim H, Hong A, Song J, Lee S, Kim M, Hwang SY, Jeong D, Kim J, Son A, Lee YS, Kim VN, Kim JS, Chang H, Ahn K
Scientific reports 2022 Nov 11;12(1):19303

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.

Cai Y, Yu R, Kong Y, Feng Z, Xu Q
Cellular signalling 2022 May;93:110283

PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner.

Sun S, Liu Y, Zhou M, Wen J, Xue L, Han S, Liang J, Wang Y, Wei Y, Yu J, Long X, Chen X, Liang H, Huang Z, Zhang B
Cell & bioscience 2022 May 7;12(1):55

CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.

Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
European journal of pharmacology 2022 May 5;922:174915

UPF1 promotes rapid degradation of m(6)A-containing RNAs.

Boo SH, Ha H, Lee Y, Shin MK, Lee S, Kim YK
Cell reports 2022 May 24;39(8):110861

METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner.

Xu QC, Tien YC, Shi YH, Chen S, Zhu YQ, Huang XT, Huang CS, Zhao W, Yin XY
Oncogene 2022 Mar;41(11):1622-1633

YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.

Hua Z, Wei R, Guo M, Lin Z, Yu X, Li X, Gu C, Yang Y
Oncogene 2022 Mar;41(10):1482-1491

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.

Ganan-Gomez I, Yang H, Ma F, Montalban-Bravo G, Thongon N, Marchica V, Richard-Carpentier G, Chien K, Manyam G, Wang F, Alfonso A, Chen S, Class C, Kanagal-Shamanna R, Ingram JP, Ogoti Y, Rose A, Loghavi S, Lockyer P, Cambo B, Muftuoglu M, Schneider S, Adema V, McLellan M, Garza J, Marchesini M, Giuliani N, Pellegrini M, Wang J, Walker J, Li Z, Takahashi K, Leverson JD, Bueso-Ramos C, Andreeff M, Clise-Dwyer K, Garcia-Manero G, Colla S
Nature medicine 2022 Mar;28(3):557-567

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism.

Wang Y, Chen J, Gao WQ, Yang R
Cell death discovery 2022 Mar 30;8(1):143

Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.

Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation.

Huang CS, Zhu YQ, Xu QC, Chen S, Huang Y, Zhao G, Ni X, Liu B, Zhao W, Yin XY
Clinical and translational medicine 2022 Jun;12(6):e848

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822

Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma.

Zhang C, Sun Q, Zhang X, Qin N, Pu Z, Gu Y, Yan C, Zhu M, Dai J, Wang C, Li N, Jin G, Ma H, Hu Z, Zhang E, Tan F, Shen H
Cancer communications (London, England) 2022 Jul;42(7):609-626

N(6)-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis.

Ma X, Cao J, Zhou Z, Lu Y, Li Q, Jin Y, Chen G, Wang W, Ge W, Chen X, Hu Z, Shu X, Deng Q, Pu J, Liang C, Fu J, Liu J, Zhu S
Nature communications 2022 Jul 18;13(1):4148

m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.

Qi M, Sun H, Guo Y, Zhou Y, Gu X, Jin J, Chen X, Wang F, Ma H, Guo X, Chen H, Shen B
Cell proliferation 2022 Jan;55(1):e13164

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.

Zhu Y, Zhou B, Hu X, Ying S, Zhou Q, Xu W, Feng L, Hou T, Wang X, Zhu L, Jin H
Clinical and translational medicine 2022 Jan;12(1):e703

Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.

Xu P, Hu K, Zhang P, Sun ZG, Zhang N
Cancer cell international 2022 Jan 7;22(1):13

Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens.

Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, Ma Y, Cao N, Wang J
Nature communications 2022 Jan 25;13(1):478

N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.

Ning J, Du H, Zhang Y, Liu Q, Jiang T, Pang Y, Tian X, Yan L, Niu Y, Zhang R
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.

Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F
Nature communications 2022 Jan 10;13(1):66

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563

RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.

Pan J, Wang J, Fang K, Hou W, Li B, Zhao J, Ma X
Nanoscale research letters 2022 Feb 5;17(1):23

The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

Niu F, Han P, Zhang J, She Y, Yang L, Yu J, Zhuang M, Tang K, Shi Y, Yang B, Liu C, Peng B, Ji SJ
eLife 2022 Feb 18;11

Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.

Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142

The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.

Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V
Nature immunology 2022 Aug;23(8):1208-1221

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.

Li J, Yao H, Huang J, Li C, Zhang Y, Xu R, Wang Z, Long Z, Tang J, Wang L
Cell death & disease 2022 Aug 19;13(8):723

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Zhang L, Cheng Y, Xue Z, Li J, Wu N, Yan J, Wang J, Wang C, Chen W, Zhou T, Qiu Z, Jiang H
Cell biology and toxicology 2022 Apr;38(2):347-369

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.

Shan HJ, Gu WX, Duan G, Chen HL
Bioengineered 2022 Apr;13(4):8038-8050

Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA.

Li J, Chen J, Zhao M, Li Z, Liu N, Fang H, Fang M, Zhu P, Lei L, Chen C
Annals of translational medicine 2022 Apr;10(7):417

The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m(6)A RNA methylation reading protein Ythdf2.

Yang Y, Mbikyo MB, Zhang J, Zhang Y, Zhang N, Li Z
Cell death discovery 2022 Apr 5;8(1):167

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.

Jiang J, Fan Q, Qu H, Liu C, Liang T, Chen L, Huang S, Sun X, Chen J, Chen T, Li H, Yao Y, Zhan X
Scientific reports 2022 Apr 29;12(1):7041

GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling.

Ren Y, Yang B, Guo G, Zhang J, Sun Y, Liu D, Guo S, Wu Y, Wang X, Wang S, Zhang W, Guo X, Li X, Li R, He J, Zhou Z
Cell death discovery 2022 Apr 18;8(1):208

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.

Zhou X, Yang Y, Li Y, Liang G, Kang D, Zhou B, Li Q
Frontiers in cell and developmental biology 2021;9:784719

N6-methyladenosine regulates ATM expression and downstream signaling.

Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051

Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition.

Han S, Zhu L, Zhu Y, Meng Y, Li J, Song P, Yousafzai NA, Feng L, Chen M, Wang Y, Jin H, Wang X
Theranostics 2021;11(17):8464-8479

YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.

Fang C, He M, Li D, Xu Q
Cellular signalling 2021 Sep;85:110060

Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206

METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70

LncAY controls BMI1 expression and activates BMI1/Wnt/β-catenin signaling axis in hepatocellular carcinoma.

Chen MH, Fu LS, Zhang F, Yang Y, Wu XZ
Life sciences 2021 Sep 1;280:119748

Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β.

Li H, Zhang N, Jiao X, Wang C, Sun W, He Y, Ren G, Huang S, Li M, Chang Y, Jin Z, Xie Q, Zhang X, Huang H, Jin H
Clinical and translational medicine 2021 Oct;11(10):e602

Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.

Jin M, Li G, Liu W, Wu X, Zhu J, Zhao D, Zeng Z, Xiong M, Song Y, He X, Zhang Q, Hu K
Cancer letters 2021 Oct 10;518:214-229

The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329

YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect.

Hou Y, Zhang Q, Pang W, Hou L, Liang Y, Han X, Luo X, Wang P, Zhang X, Li L, Meng X
Cell death and differentiation 2021 Nov;28(11):3105-3124

Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.

He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616

RNA m(6)A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling.

Li Y, Sheng H, Ma F, Wu Q, Huang J, Chen Q, Sheng L, Zhu X, Zhu X, Xu M
Cell death & disease 2021 May 13;12(5):479

Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.

Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jürgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gür K, Ölschläger J, Kühl F, Martin J, Ramirez-Pedraza M, Fernandez M, Doroudgar S, Méndez R, Katus HA, Hentze MW, Völkers M
Cell reports 2021 May 11;35(6):109100

m(6)A RNA methylation regulates the fate of endogenous retroviruses.

Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, Dossin F, Fouassier C, Lameiras S, Bourc'his D
Nature 2021 Mar;591(7849):312-316

Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.

Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361

miRNA-mediated loss of m6A increases nascent translation in glioblastoma.

Zepecki JP, Karambizi D, Fajardo JE, Snyder KM, Guetta-Terrier C, Tang OY, Chen JS, Sarkar A, Fiser A, Toms SA, Tapinos N
PLoS genetics 2021 Mar;17(3):e1009086

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis.

Qing Y, Dong L, Gao L, Li C, Li Y, Han L, Prince E, Tan B, Deng X, Wetzel C, Shen C, Gao M, Chen Z, Li W, Zhang B, Braas D, Ten Hoeve J, Sanchez GJ, Chen H, Chan LN, Chen CW, Ann D, Jiang L, Müschen M, Marcucci G, Plas DR, Li Z, Su R, Chen J
Molecular cell 2021 Mar 4;81(5):922-939.e9

MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.

Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519

FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.

Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X
Molecular cancer 2021 Mar 3;20(1):45

SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs.

Hou G, Zhao X, Li L, Yang Q, Liu X, Huang C, Lu R, Chen R, Wang Y, Jiang B, Yu J
Nucleic acids research 2021 Mar 18;49(5):2859-2877

Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma.

Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X, Jia R
Genome biology 2021 Mar 16;22(1):85

N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.

Wang F, Liao Y, Zhang M, Zhu Y, Wang W, Cai H, Liang J, Song F, Hou C, Huang S, Zhang Y, Wang C, Hou J
Oncogene 2021 Jun;40(22):3885-3898

PBRM1 Cooperates with YTHDF2 to Control HIF-1α Protein Translation.

Shmakova A, Frost M, Batie M, Kenneth NS, Rocha S
Cells 2021 Jun 8;10(6)

A heat shock-responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m(6)A modification.

Ji Q, Zong X, Mao Y, Qian SB
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.

Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803

Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).

Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.

Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C
PLoS biology 2021 Jul;19(7):e3001292

Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu Q, Liu N, Xiao Y
Aging 2021 Jul 26;13(14):18238-18256

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374

Epitranscriptomic addition of m(6)A regulates HIV-1 RNA stability and alternative splicing.

Tsai K, Bogerd HP, Kennedy EM, Emery A, Swanstrom R, Cullen BR
Genes & development 2021 Jul 1;35(13-14):992-1004

DNA methylation of FTO promotes renal inflammation by enhancing m(6)A of PPAR-α in alcohol-induced kidney injury.

Yu JT, Hu XW, Chen HY, Yang Q, Li HD, Dong YH, Zhang Y, Wang JN, Jin J, Wu YG, Li J, Ge JF, Meng XM
Pharmacological research 2021 Jan;163:105286

Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.

Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma.

Fang R, Chen X, Zhang S, Shi H, Ye Y, Shi H, Zou Z, Li P, Guo Q, Ma L, He C, Huang S
Nature communications 2021 Jan 8;12(1):177

ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.

Yuan Y, Yan G, He M, Lei H, Li L, Wang Y, He X, Li G, Wang Q, Gao Y, Qu Z, Mei Z, Shen Z, Pu J, Wang A, Zhao W, Jiang H, Du W, Yang L
Cell death & disease 2021 Jan 11;12(1):60

Relaxed initiation pausing of ribosomes drives oncogenic translation.

Dong L, Mao Y, Zhou A, Liu XM, Zhou J, Wan J, Qian SB
Science advances 2021 Feb;7(8)

m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475

The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.

Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, Qiu Z, Kidwell RL, Kim LJY, Xie Q, Vitting-Seerup K, Bhargava S, Dong Z, Jiang L, Zhu Z, Hamerlik P, Jaffrey SR, Zhao JC, Wang X, Rich JN
Cancer discovery 2021 Feb;11(2):480-499

Local translation in nuclear condensate amyloid bodies.

Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)

METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.

Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)

YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells.

Zhao X, Lin Z, Fan Y, Li W, Zhang Y, Li F, Hong T, Feng H, Tong M, Wang N, Kuang Y, Lyu Q
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1702-1712

GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.

Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3

m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.

Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

Sanderson MR, Fahlman RP, Wevrick R
The Journal of biological chemistry 2021 Aug;297(2):100959

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.

Zhou D, Tang W, Xu Y, Xu Y, Xu B, Fu S, Wang Y, Chen F, Chen Y, Han Y, Wang G
Molecular oncology 2021 Aug;15(8):2172-2184

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.

Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW
Molecular cell 2021 Aug 5;81(15):3048-3064.e9

Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus.

Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R
mBio 2021 Aug 31;12(4):e0170621

Transcriptome-wide m(6)A profiling reveals mRNA post-transcriptional modification of boar sperm during cryopreservation.

Qin Z, Wang W, Ali MA, Wang Y, Zhang Y, Zhang M, Zhou G, Yang JD, Zeng C
BMC genomics 2021 Aug 3;22(1):588

EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.

Bearss JJ, Padi SK, Singh N, Cardo-Vila M, Song JH, Mouneimne G, Fernandes N, Li Y, Harter MR, Gard JM, Cress AE, Peti W, Nelson AD, Buchan JR, Kraft AS, Okumura K
EMBO reports 2021 Apr 7;22(4):e50835

Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.

Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)

EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.

Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940

Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression.

Yang J, Han Q, Li C, Yang H, Chen X, Wang X
OncoTargets and therapy 2020;13:1723-1736

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m(6)A RNA Methylation.

Wu J, Li Y, Yu J, Gan Z, Wei W, Wang C, Zhang L, Wang T, Zhong X
Frontiers in pharmacology 2020;11:568006

m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.

He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.

Li J, Xie H, Ying Y, Chen H, Yan H, He L, Xu M, Xu X, Liang Z, Liu B, Wang X, Zheng X, Xie L
Molecular cancer 2020 Oct 29;19(1):152

m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.

Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514

Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing.

Price AM, Hayer KE, McIntyre ABR, Gokhale NS, Abebe JS, Della Fera AN, Mason CE, Horner SM, Wilson AC, Depledge DP, Weitzman MD
Nature communications 2020 Nov 26;11(1):6016

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;

Modulation of circRNA Metabolism by m(6)A Modification.

Di Timoteo G, Dattilo D, Centrón-Broco A, Colantoni A, Guarnacci M, Rossi F, Incarnato D, Oliviero S, Fatica A, Morlando M, Bozzoni I
Cell reports 2020 May 12;31(6):107641

N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.

Li Y, Guo X, Sun L, Xiao J, Su S, Du S, Li Z, Wu S, Liu W, Mo K, Xia S, Chang YJ, Denis D, Tao YX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Jul;7(13):1902402

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550

N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A
Nature genetics 2020 Jan;52(1):48-55

Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.

Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.

Li G, Song Y, Liao Z, Wang K, Luo R, Lu S, Zhao K, Feng X, Liang H, Ma L, Wang B, Ke W, Yin H, Zhan S, Li S, Wu X, Zhang Y, Yang C
Cell death & disease 2020 Feb 6;11(2):103

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.

Li D, Cai L, Meng R, Feng Z, Xu Q
International journal of molecular sciences 2020 Feb 28;21(5)

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.

Du J, Liao W, Liu W, Deb DK, He L, Hsu PJ, Nguyen T, Zhang L, Bissonnette M, He C, Li YC
Developmental cell 2020 Dec 21;55(6):737-753.e7

Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.

Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597

Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.

Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.

Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9

A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.

Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z
Cell death & disease 2020 Aug 13;11(8):613

AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.

Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869

METTL3/YTHDF2 m(6) A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, He L, Xu X, Liu B, Wang X, Zheng X, Xie L
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.

Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648

Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.

Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28

Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.

Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)

Multivalent m(6)A motifs promote phase separation of YTHDF proteins.

Gao Y, Pei G, Li D, Li R, Shao Y, Zhang QC, Li P
Cell research 2019 Sep;29(9):767-769

Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m(6)A RNA Methylation in the Intestine of Weaning Piglets.

Gan Z, Wei W, Wu J, Zhao Y, Zhang L, Wang T, Zhong X
ACS omega 2019 Oct 22;4(17):17438-17446

m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2.

Mao Y, Dong L, Liu XM, Guo J, Ma H, Shen B, Qian SB
Nature communications 2019 Nov 25;10(1):5332

Loss of m(6) A on FAM134B promotes adipogenesis in porcine adipocytes through m(6) A-YTHDF2-dependent way.

Cai M, Liu Q, Jiang Q, Wu R, Wang X, Wang Y
IUBMB life 2019 May;71(5):580-586

Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.

Park OH, Ha H, Lee Y, Boo SH, Kwon DH, Song HK, Kim YK
Molecular cell 2019 May 2;74(3):494-507.e8

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.

Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15

m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response.

Yu R, Li Q, Feng Z, Cai L, Xu Q
International journal of molecular sciences 2019 Mar 15;20(6)

Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.

Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES
PLoS pathogens 2019 Jun;15(6):e1007796

m(6)A enhances the phase separation potential of mRNA.

Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR
Nature 2019 Jul;571(7765):424-428

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.

Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, Peng J, Zhou Y, Jiang S, Peng J
Nucleic acids research 2019 Jul 9;47(12):6130-6144

Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR
Cell stem cell 2019 Jul 3;25(1):137-148.e6

A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination.

Wu R, Li A, Sun B, Sun JG, Zhang J, Zhang T, Chen Y, Xiao Y, Gao Y, Zhang Q, Ma J, Yang X, Liao Y, Lai WY, Qi X, Wang S, Shu Y, Wang HL, Wang F, Yang YG, Yuan Z
Cell research 2019 Jan;29(1):23-41

Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.

Woo HH, Chambers SK
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):35-46

N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.

Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374

Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.

Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C
Nature 2019 Feb;566(7743):270-274

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma.

Zhong L, Liao D, Zhang M, Zeng C, Li X, Zhang R, Ma H, Kang T
Cancer letters 2019 Feb 1;442:252-261

METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.

Zhang Y, Gu X, Li D, Cai L, Xu Q
International journal of molecular sciences 2019 Dec 27;21(1)

Modification of N6-methyladenosine RNA methylation on heat shock protein expression.

Yu J, Li Y, Wang T, Zhong X
PloS one 2018;13(6):e0198604

m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.

Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T
Nature 2018 Nov;563(7730):249-253

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m(6)A mRNA Methylation.

Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V
Cell reports 2018 Nov 13;25(7):1816-1828.e4

Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.

Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO
Nature neuroscience 2018 Jul;21(7):1004-1014

Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.

Tan B, Liu H, Zhang S, da Silva SR, Zhang L, Meng J, Cui X, Yuan H, Sorel O, Zhang SW, Huang Y, Gao SJ
Nature microbiology 2018 Jan;3(1):108-120

Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels.

Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L
Oncotarget 2018 Jan 9;9(3):3752-3764

Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.

Tsai K, Courtney DG, Cullen BR
PLoS pathogens 2018 Feb;14(2):e1006919

RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.

Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484

YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.

Chen J, Sun Y, Xu X, Wang D, He J, Zhou H, Lu Y, Zeng J, Du F, Gong A, Xu M
Cell cycle (Georgetown, Tex.) 2017;16(23):2259-2271

Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication.

Courtney DG, Kennedy EM, Dumm RE, Bogerd HP, Tsai K, Heaton NS, Cullen BR
Cell host & microbe 2017 Sep 13;22(3):377-386.e5

m(6)A Facilitates eIF4F-Independent mRNA Translation.

Coots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB
Molecular cell 2017 Nov 2;68(3):504-514.e7

YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.

Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C
Cell research 2017 Mar;27(3):315-328

MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein.

Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y, Zhang X
The Journal of biological chemistry 2017 Mar 3;292(9):3614-3623

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.

Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willer J, Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM
Cell host & microbe 2016 Nov 9;20(5):654-665

The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

Lin S, Choe J, Du P, Triboulet R, Gregory RI
Molecular cell 2016 May 5;62(3):335-345

Dynamic m(6)A mRNA methylation directs translational control of heat shock response.

Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR, Qian SB
Nature 2015 Oct 22;526(7574):591-4

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 24744-1-AP( YTHDF2 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The YTHDF2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YTHDF2. This antibody recognizes human antigen. The YTHDF2 antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
Appendix: 24744-1-AP.pdf

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