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- Product number
- 24744-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#24744-1-AP, RRID:AB_2687435
- Product name
- YTHDF2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated YTHDF2 antibody (Cat. #24744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references YTHDF2 promotes m6A-modified HSPA2 translation to restrict Newcastle Disease Virus.
CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage.
CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.
The m(6)A modification mediates the imbalance of mitochondrial homeostasis and apoptosis induced by Benzo[b]fluoranthene in mouse spermatocytes: mitophagy versus mitochondrial damage.
Bisphenol A disrupts circadian locomotor rhythms via m(6)A-dependent nr1d1 destabilization in zebrafish larvae.
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
A novel METTL3 inhibitor nimbolide ameliorates osteoporosis via orchestrating osteoclastogenesis in an m6A-dependent manner.
HucMSC-sEV-derived miR-320d alleviates IBD by inhibiting macrophage ferroptosis through m6A-mediated BCAT2 upregulation.
ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m(6)A-dependent STAT1 restoration.
RBM15/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia.
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis.
YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
A Novel YTHDF2/SIGMAR1 Axis in Astrocytes Regulates Neuroinflammation and Cognitive Impairment in Diabetic Encephalopathy.
Periprosthetic osteolysis is mediated by the m6A-dependent regulation of CEMIP via YTHDF2.
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
YTH Domain Family 2 Promotes Tubal Factor Infertility through Reducing H3K4me1 Methylation of CYLD by KMT2D.
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
METTL14 Promotes Proliferation, Migration, and Invasion in Endometriotic Stromal Cell Growth by Activating the ZEB1/MEK/ERK Pathway.
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
YTHDF2-mediated m(6)A modification regulates mRNA stability of Immediate early response gene 3 to modulate cell death in Staphylococcus aureus-induced bovine mastitis.
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma.
YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.
Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation.
YTHDF2 alleviates the radioresistance of rectal cancer cells by targeting methylated MYC.
YTHDF proteins and m(6)A-RNA clients undergo autophagic turnover during contact inhibition.
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
WTAP Promotes the Excessive Proliferation of Airway Smooth Muscle Cells in Asthma by Enhancing AXIN1 Levels Through the Recognition of YTHDF2.
METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
METTL3-mediated MSRB3 m6A modification accelerates hypoxia-induced cardiomyocyte ferroptosis by inhibiting mitochondrial oxidative phosphorylation.
miR-150-5p Regulates Merkel Cell Carcinoma Progression by Targeting FTO That Stabilizes CTNNB1 via m(6)A Modification.
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1.
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
m(6)A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis.
YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis.
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3.
METTL3 Promotes OSCC Progression by Down-Regulating WEE1 in a m6A-YTHDF2-Dependent Manner.
Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
FTO-mediated m6A modification elevates the MFN2 mRNA stability to suppress ovarian granulosa cell senescence.
YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit.
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling.
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia.
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation.
YTHDF2-mediated m(6)A modification of ONECUT2 promotes stemness and oxaliplatin resistance in gastric cancer through transcriptionally activating TFPI.
m(6)A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation.
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
METTL3-mediated m(6)A modification regulates muscle development by promoting TM4SF1 mRNA degradation in P-body via YTHDF2.
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
RNA N(6)-methyladenosine demethylase FTO promotes diabetic wound healing through TRIB3-mediated autophagy in an m(6)A-YTHDF2-dependent manner.
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer.
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy.
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
The cardiac METTL3/m6A pathway regulates the systemic response to Western diet.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
CRM1 mediates the nuclear export of YTHDF2.
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
m(6)A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development.
Transcriptomic analysis of the m6A reader YTHDF2 in the maintenance and differentiation of human embryonic stem cells.
CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance.
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Melatonin mitigates ovarian aging through regulation of the YTHDF2/m (6)A/UBE3C axis.
O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer.
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
RNA m(6)A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers.
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Role of m(6)A methyltransferase METTL3 in keratoconus pathogenesis.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Discovery of a Novel Selective and Cell-Active N(6)-Methyladenosine RNA Demethylase ALKBH5 Inhibitor.
Phenylpyrazoles as Inhibitors of the m(6)A RNA-Binding Protein YTHDF2.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m(6)A-YTHDF2-dependent mechanism.
YTHDF2 drives oral squamous cell carcinoma progression via m(6)A-dependent degradation of MTUS1/ATIP1 mRNA and mitochondrial dysregulation.
Enhanced Protein Synthesis and Hippocampus-Dependent Memory via Inhibition of YTHDF2-Mediated m(6)A mRNA Degradation.
YTHDF2 enhances proliferation and metastasis of nasopharyngeal carcinoma by mediating m6A modification in destabilizing FOXO1 mRNA.
TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers.
DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer.
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
ALKBH5 mediates FGF21 m6A demethylation in human bone marrow mesenchymal stem cells under high glucose conditions.
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
YTHDF2 regulates ACSL4-dependent ferroptosis of keratinocytes in diabetic wound healing.
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.
Interleukin-37 attenuates aortic valve lesions by inhibiting N6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation.
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism.
m(6)A modification of lipoyltransferase 1 inhibits bladder cancer progression by activating cuproptosis.
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition.
METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence.
Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.
Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N(6)-methyladenosine (m(6)A) mediated silencing of SLC7A11.
N(6)-Methyladenosine Modification-Related Genes Express Differentially in Sterile Male Cattle-Yaks.
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m(6)A modification.
C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes.
Coxsackievirus B3-Induced m(6)A Modification of RNA Enhances Viral Replication via Suppression of YTHDF-Mediated Stress Granule Formation.
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation.
Functional screen for mediators of onco-mRNA translation specificity.
Profiling Cellular Morphological Changes Induced by Dual-Targeting PROTACs of Aurora Kinase and RNA-Binding Protein YTHDF2.
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Fat Mass and Obesity-Associated Protein Regulates Granulosa Cell Aging by Targeting Matrix Metalloproteinase-2 Gene Via an N6-Methyladenosine-YT521-B Homology Domain Family Member 2-Dependent Pathway in Aged Mice.
RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells.
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
YTHDF2 promotes anaplastic thyroid cancer progression by activating the DDIT4/AKT/mTOR signaling pathway.
METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.
circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.
RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.
Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking.
Molecular characterization of m6A RNA methylation regulators with features of immune dysregulation in IgA nephropathy.
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
METTL3 enhances E. coli F18 resistance by targeting IKBKG/NF-κB signaling via an m(6)A-YTHDF1-dependent manner in IPEC-J2 cells.
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
Mycobacterium tuberculosis inhibits METTL14-mediated m(6)A methylation of Nox2 mRNA and suppresses anti-TB immunity.
METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging.
CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension.
YTHDF2 governs muscle size through a targeted modulation of proteostasis.
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner.
YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.
lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
FTO elicits tumor neovascularization in cancer-associated fibroblasts through eliminating m(6)A modifications of multiple pro-angiogenic factors.
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
N(6)-methyladenosine (m(6)A) reader YTHDF2 accelerates endothelial cells ferroptosis in cerebrovascular atherosclerosis.
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
RNA m(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression.
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA.
Epitranscriptomic Reader YTHDF2 Regulates SEK1( MAP2K4 )-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress.
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.
A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia.
YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
Tumor-derived CCL15 regulates RNA m(6)A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth.
Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis.
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Differentiation and Growth-Arrest-Related lncRNA (DAGAR): Initial Characterization in Human Smooth Muscle and Fibroblast Cells.
METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m(6)A-YTHDF2-dependent manner.
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation.
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt-β-catenin pathway.
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Comprehensive analysis of m6A RNA methylation modification patterns and the immune microenvironment in osteoarthritis.
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
Loss of YTHDF2 Alters the Expression of m(6)A-Modified Myzap and Causes Adverse Cardiac Remodeling.
Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei.
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
m(6)A governs length-dependent enrichment of mRNAs in stress granules.
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
RNA methylation reading protein YTHDF2 relieves myocardial ischemia-reperfusion injury by downregulating BNIP3 via m(6)A modification.
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Comprehensive analysis of m(6)A subtype classification for immune microenvironment of pituitary adenomas.
FTO facilitates cancer metastasis by modifying the m(6)A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer.
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner.
Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI.
Fibroblast-Derived Extracellular Vesicle-Packaged Long Noncoding RNA Upregulated in Diabetic Skin Enhances Keratinocyte MMP-9 Expression and Delays Diabetic Wound Healing.
YTHDF2 exerts tumor-suppressor roles in gastric cancer via up-regulating PPP2CA independently of m(6)A modification.
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation.
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I-Mediated Immune Response.
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization.
ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway.
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.
Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.
METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance.
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis.
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells.
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
SON is an essential m(6)A target for hematopoietic stem cell fate.
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
High Temperature-Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs.
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.
LncRNA CACClnc promotes chemoresistance of colorectal cancer by modulating alternative splicing of RAD51.
YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Effects on the Cell Barrier Function of L-Met and DL-HMTBA Is Related to Metabolic Characteristics and m(6)A Modification.
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
M(6)A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.
Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation.
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.
m(1)A and m(6)A modifications function cooperatively to facilitate rapid mRNA degradation.
M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.
m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.
Functional and molecular dissection of HCMV long non-coding RNAs.
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner.
CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner.
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism.
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation.
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma.
N(6)-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis.
m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.
Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.
Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens.
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.
The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.
Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA.
The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m(6)A RNA methylation reading protein Ythdf2.
Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.
GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling.
METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.
N6-methyladenosine regulates ATM expression and downstream signaling.
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition.
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
LncAY controls BMI1 expression and activates BMI1/Wnt/β-catenin signaling axis in hepatocellular carcinoma.
Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β.
Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect.
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
RNA m(6)A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling.
Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.
m(6)A RNA methylation regulates the fate of endogenous retroviruses.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
miRNA-mediated loss of m6A increases nascent translation in glioblastoma.
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis.
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.
SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs.
Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
PBRM1 Cooperates with YTHDF2 to Control HIF-1α Protein Translation.
A heat shock-responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m(6)A modification.
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).
N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Epitranscriptomic addition of m(6)A regulates HIV-1 RNA stability and alternative splicing.
DNA methylation of FTO promotes renal inflammation by enhancing m(6)A of PPAR-α in alcohol-induced kidney injury.
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma.
ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Relaxed initiation pausing of ribosomes drives oncogenic translation.
m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.
Local translation in nuclear condensate amyloid bodies.
METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells.
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.
METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus.
Transcriptome-wide m(6)A profiling reveals mRNA post-transcriptional modification of boar sperm during cryopreservation.
EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression.
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m(6)A RNA Methylation.
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Modulation of circRNA Metabolism by m(6)A Modification.
N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
METTL3/YTHDF2 m(6) A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Multivalent m(6)A motifs promote phase separation of YTHDF proteins.
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m(6)A RNA Methylation in the Intestine of Weaning Piglets.
m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2.
Loss of m(6) A on FAM134B promotes adipogenesis in porcine adipocytes through m(6) A-YTHDF2-dependent way.
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response.
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.
m(6)A enhances the phase separation potential of mRNA.
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination.
Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma.
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
Modification of N6-methyladenosine RNA methylation on heat shock protein expression.
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m(6)A mRNA Methylation.
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.
Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels.
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Dynamic m6A modification regulates local translation of mRNA in axons.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.
Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication.
m(6)A Facilitates eIF4F-Independent mRNA Translation.
YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein.
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.
Wang Z, Yin B, Hou Y, Zhao Y, Chen L, Ren T, Yuan W
Veterinary microbiology 2026 May;316:110960
Veterinary microbiology 2026 May;316:110960
CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage.
Huang J, Shi M, Zhang Z, Xu Z, Xi X
Pathology, research and practice 2026 May;281:156384
Pathology, research and practice 2026 May;281:156384
CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.
Sun Q, Chi R, Zhang X, Chen T, Xu X, Ma L, Tian X, Miao Y, Yu Y, Kang R, Kroemer G, Shi Y, Tang D, Wang J
Developmental cell 2026 May 13;61(5):1092-1110.e12
Developmental cell 2026 May 13;61(5):1092-1110.e12
The m(6)A modification mediates the imbalance of mitochondrial homeostasis and apoptosis induced by Benzo[b]fluoranthene in mouse spermatocytes: mitophagy versus mitochondrial damage.
Shi CF, Han F, Jiang X, Sun L, Liu KL, Sun SQ, Li YQ, Wang JK, Ao L, Cao J, Chen Q, Liu JY
Journal of advanced research 2026 Mar 17;
Journal of advanced research 2026 Mar 17;
Bisphenol A disrupts circadian locomotor rhythms via m(6)A-dependent nr1d1 destabilization in zebrafish larvae.
Kong WY, Chen PY, Shen O, Cai YN, Liu WX, Li XJ, Lu SZ, Bian W, Wang H, Wang YH, Wu LJ, Ji C, Song XY, Zhang J
Ecotoxicology and environmental safety 2026 Mar 15;313:119887
Ecotoxicology and environmental safety 2026 Mar 15;313:119887
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
Inamoto T, Nakano M, Fukami T, Nakajima M
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
A novel METTL3 inhibitor nimbolide ameliorates osteoporosis via orchestrating osteoclastogenesis in an m6A-dependent manner.
Cai C, Zhang Z, Zhao X, Yang C, Huang X, Tang C, Qiu H, Yang S, Zhang Y, Hu X, Zuo R, Zhang C, Chen Y, Chu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158048
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158048
HucMSC-sEV-derived miR-320d alleviates IBD by inhibiting macrophage ferroptosis through m6A-mediated BCAT2 upregulation.
Wang N, Yuan J, Wang X, Yao D, Ocansey DKW, Mao F
Bioorganic chemistry 2026 Jul 5;175:109817
Bioorganic chemistry 2026 Jul 5;175:109817
ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m(6)A-dependent STAT1 restoration.
Wang KT, Yang S, Zhao ZH, Rui CH, Shen SY, Cao D, Guo LN, Tang SH, Chen L, Wang HY, Qiu XY
Acta pharmacologica Sinica 2026 Jan;47(1):209-221
Acta pharmacologica Sinica 2026 Jan;47(1):209-221
RBM15/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia.
Yu B, Gong H, Zhang S, Zhao M, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):1079-1090
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):1079-1090
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis.
Wang Q, Wang Y, Liu T, Wang H, Yuan M, Zhang T, Ji Z, Shen H
International journal of biological macromolecules 2026 Jan;335(Pt 1):149287
International journal of biological macromolecules 2026 Jan;335(Pt 1):149287
YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.
Cheng X, Wang S, Yu Y, Xu J, Wang Q, Wei Y, Jin Z, Qi X, Jian D, Shi Y, Li Z, Ma Z, Wang W, Xia T, Xing J, Gu X, Tang H
Aging cell 2026 Jan;25(1):e70332
Aging cell 2026 Jan;25(1):e70332
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Du J, Li C, Zhang J, Luo J, Zhang H, Chen H, Li X, Qian P
Cell & bioscience 2026 Jan 4;16(1):13
Cell & bioscience 2026 Jan 4;16(1):13
A Novel YTHDF2/SIGMAR1 Axis in Astrocytes Regulates Neuroinflammation and Cognitive Impairment in Diabetic Encephalopathy.
Xu F, Zhang H, Chen X, Duan C, Gu Q, Hu J
Inflammation 2026 Jan 16;49(1):55
Inflammation 2026 Jan 16;49(1):55
Periprosthetic osteolysis is mediated by the m6A-dependent regulation of CEMIP via YTHDF2.
Lei Z, Wang Y, Yin L, Wang Z, Bai L
International immunopharmacology 2026 Jan 1;168(Pt 2):115895
International immunopharmacology 2026 Jan 1;168(Pt 2):115895
N6-methyladenosine (m(6)A) modification of TXNIP in 3'UTR instigates abdominal aorta aneurysm in mice.
Hantelys F, Yin W, Zou MH
iScience 2026 Feb 20;29(2):114630
iScience 2026 Feb 20;29(2):114630
YTH Domain Family 2 Promotes Tubal Factor Infertility through Reducing H3K4me1 Methylation of CYLD by KMT2D.
Shao L, Wang N, Yan Y, Tan Y, Huang Y, Wu Q, Tan Q, Liu L
Applied biochemistry and biotechnology 2026 Apr;198(4):3250-3267
Applied biochemistry and biotechnology 2026 Apr;198(4):3250-3267
m(6)A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis.
Gong W, Yang X, Fan N, Wang H, Fu S, Tian Y, Li L
Scientific reports 2026 Apr 18;
Scientific reports 2026 Apr 18;
METTL14 Promotes Proliferation, Migration, and Invasion in Endometriotic Stromal Cell Growth by Activating the ZEB1/MEK/ERK Pathway.
Lv X, Li F
Gynecologic and obstetric investigation 2025;90(1):42-54
Gynecologic and obstetric investigation 2025;90(1):42-54
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Li J, Luo Q, Lu M, Lu C, Xu C, Ding J, Zhan T, Zhu J, Qian M, Lin S, Chang L, Li J, Wang K
International journal of biological sciences 2025;21(11):4782-4797
International journal of biological sciences 2025;21(11):4782-4797
Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression.
He HF, Hou S, Ma XY, Huang SS, Yang B, Wang JK, Xu Y, Tan L, Li HY
PloS one 2025;20(4):e0319605
PloS one 2025;20(4):e0319605
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
YTHDF2-mediated m(6)A modification regulates mRNA stability of Immediate early response gene 3 to modulate cell death in Staphylococcus aureus-induced bovine mastitis.
Xing Y, Mi S, Chen S, Tao X, Zhang Z, Shi Y, Wang X, Yu Y
Frontiers in cellular and infection microbiology 2025;15:1542647
Frontiers in cellular and infection microbiology 2025;15:1542647
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.
Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172
Toxicology 2025 Sep;516:154172
O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma.
Li J, Zhou W, Zhang J, Ma L, Lv Z, Geng Y, Chen X, Li J
Fundamental research 2025 Sep;5(5):2388-2396
Fundamental research 2025 Sep;5(5):2388-2396
YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.
Chen XH, Wang ZL, Yang J, Chen M, Zhao SY, Guo KX, Zheng X, Zhao Z, Chen X, Li J, Zhang MM, Ran L, Zhu H, Gu XF, Yan GR
The EMBO journal 2025 Sep;44(17):4899-4917
The EMBO journal 2025 Sep;44(17):4899-4917
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.
Wang J, Yu Y, Xiong Z, Wang P, Wang Z, Du A, Han S, Wang X, Zhang L
Biochemical pharmacology 2025 Sep;239:117016
Biochemical pharmacology 2025 Sep;239:117016
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.
Cheng QX, Xie G, Zhang X, Wang J, Ding S, Wu YX, Shi M, Duan FF, Wan ZL, Wei JJ, Xiao J, Wang Y
Nature methods 2025 Sep;22(9):1824-1835
Nature methods 2025 Sep;22(9):1824-1835
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.
Li X, Li X, Liu C, Li Z, Ding K, Wang Y, Gu N, Xie L, Chen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e05725
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e05725
Fine particulate matter exacerbates asthma by activating STC2-mediated mitophagy through METTL3/YTHDF2-dependent m6A methylation.
Liu Y, Li G, Xiong A, Liu J, Zeng R, Zhang L, Wang J, Jiang M, Gao J, Xiong Y, He X
Journal of hazardous materials 2025 Sep 5;495:138854
Journal of hazardous materials 2025 Sep 5;495:138854
YTHDF2 alleviates the radioresistance of rectal cancer cells by targeting methylated MYC.
Fang Y, Shang S, Chen G, Chen D, Yu J
Journal of radiation research 2025 Sep 23;66(5):459-472
Journal of radiation research 2025 Sep 23;66(5):459-472
YTHDF proteins and m(6)A-RNA clients undergo autophagic turnover during contact inhibition.
Ho-Xuan H, Bruckmann A, Natali L, Prieto-Garcia C, Stuke JFM, Brunello L, Vicente A, Pfab A, Wesseling H, Cano-Franco S, Khatri A, Larivera S, Sanz-Martinez P, de la Cruz-Thea B, Jacomin AC, Prochazka J, Feederle R, Dötsch V, Sedlacek R, Hummer G, Kaiser S, Dikic I, Musri MM, Meister G, Stolz A
Cell reports 2025 Sep 23;44(9):116188
Cell reports 2025 Sep 23;44(9):116188
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141
International immunopharmacology 2025 Sep 23;162:115141
WTAP Promotes the Excessive Proliferation of Airway Smooth Muscle Cells in Asthma by Enhancing AXIN1 Levels Through the Recognition of YTHDF2.
Chen X, Dai L
Biochemical genetics 2025 Oct;63(5):4612-4629
Biochemical genetics 2025 Oct;63(5):4612-4629
METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.
Yang N, Lai Y, Yu G, Zhang X, Shi J, Xiang L, Zhang J, Wu Y, Jiang X, Zhang X, Yang L, Gao W, Ding J, Wang X, Xiao J, Zhou K
Autophagy 2025 Oct;21(10):2168-2191
Autophagy 2025 Oct;21(10):2168-2191
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Chen Y, Wang Y, Xiao H, Teng F, Yang A, Liu J, Liu Z, Sheng X, Zhang C, Zhang S, Geng B, Xia Y
Chemico-biological interactions 2025 Oct 22;420:111672
Chemico-biological interactions 2025 Oct 22;420:111672
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
METTL3-mediated MSRB3 m6A modification accelerates hypoxia-induced cardiomyocyte ferroptosis by inhibiting mitochondrial oxidative phosphorylation.
Li Y, Xia J, Wei Y, He M, He G, Zhu Y
International immunopharmacology 2025 Oct 10;163:115268
International immunopharmacology 2025 Oct 10;163:115268
miR-150-5p Regulates Merkel Cell Carcinoma Progression by Targeting FTO That Stabilizes CTNNB1 via m(6)A Modification.
Zheng B, Li M, Gao Z, Yang Y, Guo K, Gao H, Zhao Y, Lui WO, Xie H
Molecular carcinogenesis 2025 Nov;64(11):1899-1912
Molecular carcinogenesis 2025 Nov;64(11):1899-1912
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1.
Si W, Wang CL, Zeng LH, Zhao QY, Xie YT, Yang Y, Diao HT, Song JL, Wu H, Zhang F, Wang Z, Kong X, Jiang WT, Zhang XY, Lin KY, Yao FT, Xiong YT, Pan TF, Pang P, Yang BF, Bian Y
Acta pharmacologica Sinica 2025 Nov;46(11):2924-2937
Acta pharmacologica Sinica 2025 Nov;46(11):2924-2937
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024
Cellular signalling 2025 Nov;135:112024
m(6)A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis.
Tan Z, Yang J, Chen Y, Zhu H, Liu X, Xu H, Meng Q, Xiao M, Tang R, Rong Z, Yu X, Liang C, Xu J
Cell death & disease 2025 Nov 3;16(1):784
Cell death & disease 2025 Nov 3;16(1):784
YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis.
Yang S, Cui YH, Li H, Wei J, Park G, Sun M, Verghese M, Wilkinson E, Nam T, Lungstrom LL, Cui X, Ryu TY, Chen J, Bissonnette M, He C, He YY
Nature communications 2025 Nov 12;16(1):9946
Nature communications 2025 Nov 12;16(1):9946
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3.
Xu X, Zhang Y, Wu S, Wu Y, Lin X, Chen K, Lin X
Journal of medical virology 2025 May;97(5):e70356
Journal of medical virology 2025 May;97(5):e70356
METTL3 Promotes OSCC Progression by Down-Regulating WEE1 in a m6A-YTHDF2-Dependent Manner.
Su Y, Hu Y, Qu B, Lei R, Guo G
Molecular biotechnology 2025 May;67(5):1867-1879
Molecular biotechnology 2025 May;67(5):1867-1879
Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm.
He B, Hu Y, Wu Y, Wang C, Gao L, Gong C, Li Z, Gao N, Yang H, Xiao Y, Yang S
Cancer communications (London, England) 2025 May;45(5):608-631
Cancer communications (London, England) 2025 May;45(5):608-631
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
FTO-mediated m6A modification elevates the MFN2 mRNA stability to suppress ovarian granulosa cell senescence.
Li Q, Shen H, Liu A, Yu L, Wang L, Zhang X
International journal of biological macromolecules 2025 May;307(Pt 4):142181
International journal of biological macromolecules 2025 May;307(Pt 4):142181
YTHDF2 suppresses the 2C-like state in mouse embryonic stem cells via the DUX-ZSCAN4 molecular circuit.
Wu X, Cai W, He J, Zhang S, Wang S, Huang L, Zhang H, Sun X, Zhou J, Liu XM
The Journal of biological chemistry 2025 May;301(5):108479
The Journal of biological chemistry 2025 May;301(5):108479
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819
Biochemical pharmacology 2025 May;235:116819
METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling.
Chen Z, Zhong M, Lin Y, Zhang W, Zhu Y, Chen L, Huang Z, Luo K, Lu Z, Huang Z, Yan Y
Journal of molecular and cellular cardiology 2025 May;202:64-80
Journal of molecular and cellular cardiology 2025 May;202:64-80
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.
Kim JS, Cho S, Jeong MY, Rivera-Piza A, Kim Y, Wu C, Yoon YE, Lee I, Choi JW, Lee HL, Shin SW, Shin J, Gil H, Lee MG, Keum N, Kim JA, Lee D, Jung YH, Chung S, Shin MJ, Hong S, Chi SG, Lee SJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156599
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia.
Huang H, Li X, Luo J, Gao C, Yang M, Xu J, Xie T, Chen Z, Wang D, Wang Y, Li HB, Huang J, Liu Y, Zhang H, Ntziachristos P, Zhao Y, Qing G, Liu H
Science advances 2025 May 30;11(22):eadq3052
Science advances 2025 May 30;11(22):eadq3052
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618
Cell reports 2025 May 27;44(5):115618
H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation.
Wu Y, Xu B, Peng Y, Lin S, Du W, Liu R, Zhang S, Wu J, Zou K, Zhao X
Clinical epigenetics 2025 May 27;17(1):84
Clinical epigenetics 2025 May 27;17(1):84
YTHDF2-mediated m(6)A modification of ONECUT2 promotes stemness and oxaliplatin resistance in gastric cancer through transcriptionally activating TFPI.
Fan X, Han F, Wang H, Shu Z, Qiu B, Zeng F, Chen H, Wu Z, Lin Y, Lan Z, Ye Z, Ying Y, Geng T, Xian Z, Niu X, Wu J, Mo K, Zheng K, Ye Y, Cui C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Mar;79:101200
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Mar;79:101200
m(6)A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation.
Chen C, Wang G, Zou Q, Xiong K, Chen Z, Shao B, Liu Y, Xie D, Ji Y
Science China. Life sciences 2025 Mar;68(3):706-721
Science China. Life sciences 2025 Mar;68(3):706-721
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
Wen L, Lin X, Hu D, Li J, Xie K, Li S, Su S, Duan X, Zhong G, Lin Y, Chen Y, Xu T, Zeng Q
Atherosclerosis 2025 Mar;402:119109
Atherosclerosis 2025 Mar;402:119109
METTL3-mediated m(6)A modification regulates muscle development by promoting TM4SF1 mRNA degradation in P-body via YTHDF2.
Ru W, Cheng J, Gao Y, Yang K, Qi A, Zhang X, Qi X, Lan X, Liu W, Huang B, Chen H
International journal of biological macromolecules 2025 Mar;295:139576
International journal of biological macromolecules 2025 Mar;295:139576
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
Nature cell biology 2025 Mar;27(3):518-529
Nature cell biology 2025 Mar;27(3):518-529
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249
Clinical and translational medicine 2025 Mar;15(3):e70249
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
RNA N(6)-methyladenosine demethylase FTO promotes diabetic wound healing through TRIB3-mediated autophagy in an m(6)A-YTHDF2-dependent manner.
Dong Z, Li S, Huang Y, Chen T, Ding Y, Tan Q
Cell death & disease 2025 Mar 29;16(1):222
Cell death & disease 2025 Mar 29;16(1):222
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
Tsao N, Lombardi PM, Park A, Olabode J, Rodell R, Sun H, Padmanaban S, Brickner JR, Tsai MS, Pollina EA, Chen CK, Mosammaparast N
Molecular cell 2025 Mar 20;85(6):1085-1100.e9
Molecular cell 2025 Mar 20;85(6):1085-1100.e9
FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer.
Wang Z, Liu XC, Gao ZG, Shi WD, Wang WC
Acta pharmaceutica (Zagreb, Croatia) 2025 Mar 1;75(1):69-86
Acta pharmaceutica (Zagreb, Croatia) 2025 Mar 1;75(1):69-86
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.
Zhou SM, Shi Y, Li JY, Wang N, Zeng Y, Chen HQ, Tan YP, Deng SW, Liu QQ, Huang XQ, Wang YQ, Zhou ZY, Liu WB
Free radical biology & medicine 2025 Mar 1;229:364-373
Free radical biology & medicine 2025 Mar 1;229:364-373
Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy.
Wang J, Ran Y, Li Z, Zhao T, Zhang F, Wang J, Liu Z, Chen X
Neural regeneration research 2025 Mar 1;20(3):887-899
Neural regeneration research 2025 Mar 1;20(3):887-899
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
Luo T, Chen Z, Zhang F, Liu H, Huang F, Zhang X, Feng J, Ding S, Liu L, Guan W, Zeng A, Hao H
Viruses 2025 Jun 9;17(6)
Viruses 2025 Jun 9;17(6)
The cardiac METTL3/m6A pathway regulates the systemic response to Western diet.
Rabolli C, Longenecker JZ, Naarmann-de Vries IS, Serrano J, Petrosino JM, Kyriazis GA, Dieterich C, Accornero F
JCI insight 2025 Jun 9;10(11)
JCI insight 2025 Jun 9;10(11)
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
CRM1 mediates the nuclear export of YTHDF2.
Wei S, Wang Y, Cao J, Hou J, Xie C, Gao XW
Biochemical and biophysical research communications 2025 Jun 30;767:151899
Biochemical and biophysical research communications 2025 Jun 30;767:151899
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T
Science advances 2025 Jun 27;11(26):eadq9643
Science advances 2025 Jun 27;11(26):eadq9643
m(6)A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development.
Broix L, Roy R, Shohayeb B, Oomoto I, Umeshima H, Wang DO
Cell reports 2025 Jun 24;44(6):115727
Cell reports 2025 Jun 24;44(6):115727
Transcriptomic analysis of the m6A reader YTHDF2 in the maintenance and differentiation of human embryonic stem cells.
Feng B, Chen Y, Tu H, Zhang J, Tong L, Lyu X, Irving AT, Chen D
Stem cells (Dayton, Ohio) 2025 Jun 24;43(7)
Stem cells (Dayton, Ohio) 2025 Jun 24;43(7)
CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance.
Wang M, Zou F, Wang S, Yang Y, Xia C, Chen L, Liu B, Li L, Li MJ, Li H, Song W, Niu R, Yuan Z, Yang J, Li X, Chen K, Wu Z, Mi Z
Cancer research 2025 Jun 2;85(11):2046-2066
Cancer research 2025 Jun 2;85(11):2046-2066
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Zhu C, Li R, You X, Xu J, Wang J, Dong D, Chen X, Wang K
NPJ precision oncology 2025 Jun 17;9(1):193
NPJ precision oncology 2025 Jun 17;9(1):193
Melatonin mitigates ovarian aging through regulation of the YTHDF2/m (6)A/UBE3C axis.
Xia W, Wang X, Li J, Zhang M, Lu J, Li H, He Q, Meng Q, Huang B
Acta biochimica et biophysica Sinica 2025 Jun 11;57(9):1529-1538
Acta biochimica et biophysica Sinica 2025 Jun 11;57(9):1529-1538
O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer.
Wang Q, Wei D, Li C, Yang X, Su K, Wang T, Zou R, Wang L, Cun D, Tang B, Wu T
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):228
Molecular medicine (Cambridge, Mass.) 2025 Jun 10;31(1):228
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
Wang F, Zhou L, Zhong Y, Cai Y, Meng X, Chen M, Mao R, Xiao X, Yi C, Guo Y, Xie H, Zhang Y, Li J
MedComm 2025 Jul;6(7):e70205
MedComm 2025 Jul;6(7):e70205
The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.
Qin M, Gao N, Sun J, Lin S, Hu T, Liu X, Zhang R, Wang Y, Qiu J
PLoS neglected tropical diseases 2025 Jul;19(7):e0013289
PLoS neglected tropical diseases 2025 Jul;19(7):e0013289
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392
Clinical and translational medicine 2025 Jul;15(7):e70392
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388
Clinical and translational medicine 2025 Jul;15(7):e70388
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910
Mutation research 2025 Jul-Dec;831:111910
Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer.
Zhang C, Zhang Z, Wu Y, Wu Y, Cheng J, Luo K, Li Z, Zhang M, Wang J, Zhang X, Li Y
eLife 2025 Jul 24;13
eLife 2025 Jul 24;13
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer.
Fang M, Li Y, Wang P, Wang Y, Wang X, Wa X, Zhang Y, He Z, Li J, Li L, Su Y, Zhou H, He J, Liu Y
Cancer immunology research 2025 Jul 2;13(7):1037-1052
Cancer immunology research 2025 Jul 2;13(7):1037-1052
ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.
Wan P, Ren Y, Li HT
Functional & integrative genomics 2025 Jul 19;25(1):158
Functional & integrative genomics 2025 Jul 19;25(1):158
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
Li S, Jiang Z, Wei W, Deng S, Duan T
Journal of translational medicine 2025 Jul 1;23(1):703
Journal of translational medicine 2025 Jul 1;23(1):703
N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.
Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488
RNA m(6)A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers.
Zhao Y, Jiang Y, Feng Y, Zhao R
Poultry science 2025 Jan;104(1):104393
Poultry science 2025 Jan;104(1):104393
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC.
Zhi Y, Liu S, Chang X, Guan W, Li R, Liu Q, Chen J, Ling J, Zhao X, Liu A, Chen J, Zhang X, Huang Y
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
Cancer control : journal of the Moffitt Cancer Center 2025 Jan-Dec;32:10732748251342685
Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.
Mu SQ, Lin JJ, Wang Y, Yang LY, Wang S, Wang ZY, Zhao AQ, Luo WJ, Dong ZQ, Cao YG, Jiang ZA, Wang SF, Cao SH, Meng L, Li Y, Yang SY, Sun SG
Communications biology 2025 Jan 30;8(1):146
Communications biology 2025 Jan 30;8(1):146
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.
Chen Z, Zeng C, Yang L, Che Y, Chen M, Sau L, Wang B, Zhou K, Chen Y, Qing Y, Shen C, Zhang T, Wunderlich M, Wu D, Li W, Wang K, Leung K, Sun M, Tang T, He X, Zhang L, Swaminathan S, Mulloy JC, Müschen M, Huang H, Weng H, Xiao G, Deng X, Chen J
Cell 2025 Jan 23;188(2):331-351.e30
Cell 2025 Jan 23;188(2):331-351.e30
YTH N(6)-methyladenosine RNA Binding Protein 1 Inhibits Smooth Muscle Cell Phenotypic Modulation and Neointimal Hyperplasia.
Tian K, Cai D, Yang S, Zhao W, Mei X, Chen SY
Cells 2025 Jan 22;14(3)
Cells 2025 Jan 22;14(3)
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95
Diabetes 2025 Jan 1;74(1):82-95
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.
Zheng W, Fu Z, Tan X, Liang X, Cao L
Biochemical genetics 2025 Feb;63(1):433-464
Biochemical genetics 2025 Feb;63(1):433-464
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Wei X, Su Y, Tian W, Cheng L, Yin L, He X
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
Role of m(6)A methyltransferase METTL3 in keratoconus pathogenesis.
Yu H, Dou S, Wang H, Sun Y, Qu J, Liu T, Liu X, Wei C, Gao H
Experimental eye research 2025 Feb;251:110207
Experimental eye research 2025 Feb;251:110207
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Discovery of a Novel Selective and Cell-Active N(6)-Methyladenosine RNA Demethylase ALKBH5 Inhibitor.
Yang X, Huang K, Wu XN, Zhang C, Sun Y, Gao Y, Zhou J, Tao L, Zhang H, Wu Y, Luo HB, Wang H
Journal of medicinal chemistry 2025 Feb 27;68(4):4133-4147
Journal of medicinal chemistry 2025 Feb 27;68(4):4133-4147
Phenylpyrazoles as Inhibitors of the m(6)A RNA-Binding Protein YTHDF2.
Qiu X, Kemker C, Goebel GL, Lampe P, Wallis N, Schiller D, Bigler K, Jiang M, Sievers S, Yeo GW, Wu P
JACS Au 2025 Feb 24;5(2):618-630
JACS Au 2025 Feb 24;5(2):618-630
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m(6)A-YTHDF2-dependent mechanism.
Liu TT, Chen LT, Pei XY, Hu SN, Zhuo FF, Chen ZK, Liu Y, Wang JK, Zhang JC, Cao Q, Li L, Wang J, Wei TT, Han B, Tu PF, Zhao XY, Xue R, Zeng KW
iMeta 2025 Dec;4(6):e70089
iMeta 2025 Dec;4(6):e70089
YTHDF2 drives oral squamous cell carcinoma progression via m(6)A-dependent degradation of MTUS1/ATIP1 mRNA and mitochondrial dysregulation.
Tang D, Cao C, Huang S, He Q, Wang A
Cellular signalling 2025 Dec;136:112145
Cellular signalling 2025 Dec;136:112145
Enhanced Protein Synthesis and Hippocampus-Dependent Memory via Inhibition of YTHDF2-Mediated m(6)A mRNA Degradation.
Li K, Guo C, Wu X, Wu C, Wu S, Su S, Wu M, Zhou X, Li S, Cui Y, Zhou T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e14926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e14926
YTHDF2 enhances proliferation and metastasis of nasopharyngeal carcinoma by mediating m6A modification in destabilizing FOXO1 mRNA.
Yu P, Wei W, Peng X, Ye J, Ji Y, Zhang B, Cai Y
Cancer biology & therapy 2025 Dec 31;26(1):2582349
Cancer biology & therapy 2025 Dec 31;26(1):2582349
TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers.
Zhang W, Lin J, Zhou Y, Wu C, Li Q, Chen J, Zeng Y, Xiao Z, Shen H, Wu Y, Su Z, Yu W, Xie Z
Cell death & disease 2025 Dec 23;16(1):902
Cell death & disease 2025 Dec 23;16(1):902
DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer.
Zhang P, Ma L, Wei Y, Peng Q, Xiang H, Fang X, Weng C, Wu Y, Lu L
Cell biology and toxicology 2025 Dec 2;42(1):7
Cell biology and toxicology 2025 Dec 2;42(1):7
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
Liang C, Fu R, Chen D, Tian G, He J, Zheng P, Yu J, Pu J, Yu B
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
Wang C, Feng L, Fang W, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W, Xia X
International journal of surgery (London, England) 2025 Dec 1;111(12):9147-9165
International journal of surgery (London, England) 2025 Dec 1;111(12):9147-9165
ALKBH5 mediates FGF21 m6A demethylation in human bone marrow mesenchymal stem cells under high glucose conditions.
Wang Z, Tang Y, Liu Y, Zeng Y, Zhang M
Biochemical and biophysical research communications 2025 Aug 8;774:152042
Biochemical and biophysical research communications 2025 Aug 8;774:152042
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
Cao Q, Zhou X, Zou F, He R, He L, Chen J, Li Y, Cao T, Li Y, Lan X, Liu S
Journal of leukocyte biology 2025 Aug 5;117(8)
Journal of leukocyte biology 2025 Aug 5;117(8)
YTHDF2 regulates ACSL4-dependent ferroptosis of keratinocytes in diabetic wound healing.
Wu L, Li L, Wang W, Chen S, Saw PE, Hong X, Liang D, Yang C, Yan L, Lin WJ, Ren M
Clinical science (London, England : 1979) 2025 Aug 20;139(16):860-79
Clinical science (London, England : 1979) 2025 Aug 20;139(16):860-79
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230
Free radical biology & medicine 2025 Aug 1;235:213-230
Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.
Zheng Y, Wang K, Mao W, Zhang G, Han X, Li H, Wang Y
International journal of oncology 2025 Apr;66(4)
International journal of oncology 2025 Apr;66(4)
Interleukin-37 attenuates aortic valve lesions by inhibiting N6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation.
Xian G, Huang R, Hu D, Xu M, Chen Y, Ren H, Xu D, Zeng Q
Cardiovascular research 2025 Apr 29;121(3):492-506
Cardiovascular research 2025 Apr 29;121(3):492-506
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
Hou J, Gao Y, Han B, Yan S, Wei S, Gao X
Science advances 2025 Apr 18;11(16):eado7660
Science advances 2025 Apr 18;11(16):eado7660
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
Hu Y, Yang L, Huang L, Zeng C, Ren S
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection.
Wu M, Nie Q, Zhang Y, Qin J, Ye L, Zhao R, Dai M, Wu M
ACS infectious diseases 2025 Apr 11;11(4):905-916
ACS infectious diseases 2025 Apr 11;11(4):905-916
Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.
An D, Han J, Fang P, Bu Y, Ji G, Liu M, Deng J, Song X
CytoJournal 2024;21:33
CytoJournal 2024;21:33
Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.
Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
International journal of biological sciences 2024;20(6):2092-2110
International journal of biological sciences 2024;20(6):2092-2110
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232
Frontiers in cell and developmental biology 2024;12:1383232
Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism.
Chen X, Lu T, Ding M, Cai Y, Yu Z, Zhou X, Wang X
Journal of advanced research 2024 Sep;63:17-33
Journal of advanced research 2024 Sep;63:17-33
m(6)A modification of lipoyltransferase 1 inhibits bladder cancer progression by activating cuproptosis.
Du K, Luo Y, Zhang L, Zeng Y, Dai Y, Ren M, Pan W, Liu Y, Tian F, Zhou L, Gu C
Oncogene 2024 Sep;43(40):2971-2985
Oncogene 2024 Sep;43(40):2971-2985
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598
The Journal of biological chemistry 2024 Sep;300(9):107598
Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition.
Zhang J, Xiong YW, Zhu HL, Tan LL, Zhou H, Zheng XM, Zhang YF, Chang W, Xu DX, Wei T, Guan SZ, Wang H
Journal of hazardous materials 2024 Sep 5;476:135159
Journal of hazardous materials 2024 Sep 5;476:135159
METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence.
Dong S, Zhang J, Fu Y, Tang G, Chen J, Sun D, Qi Y, Zhou N
Journal of translational medicine 2024 Sep 27;22(1):865
Journal of translational medicine 2024 Sep 27;22(1):865
Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.
Malovic E, Ealy A, Miller C, Jang A, Hsu PJ, Sarkar S, Rokad D, Goeser C, Hartman AK, Zhu A, Palanisamy B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, He C, Kanthasamy AG
iScience 2024 Sep 20;27(9):110619
iScience 2024 Sep 20;27(9):110619
Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N(6)-methyladenosine (m(6)A) mediated silencing of SLC7A11.
Huang H, Lin Y, Xin J, Sun N, Zhao Z, Wang H, Duan L, Zhou Y, Liu X, Fang J, Jing B, Pan K, Zeng Y, Zeng D, Li H, Ma H, Bai Y, Wei L, Ni X
Ecotoxicology and environmental safety 2024 Sep 15;283:116816
Ecotoxicology and environmental safety 2024 Sep 15;283:116816
N(6)-Methyladenosine Modification-Related Genes Express Differentially in Sterile Male Cattle-Yaks.
Liu Y, Chen L, Jiang H, Wang H, Zhang Y, Yuan Z, Ma Y
Life (Basel, Switzerland) 2024 Sep 12;14(9)
Life (Basel, Switzerland) 2024 Sep 12;14(9)
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)
Viruses 2024 Sep 11;16(9)
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m(6)A modification.
Hu J, Wang S, Zhang X, Yan W, Liu H, Chen X, Nie Y, Liu F, Zheng Y, Lu Y, Jin H
Archives of toxicology 2024 Oct;98(10):3425-3438
Archives of toxicology 2024 Oct;98(10):3425-3438
C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes.
Nabeel-Shah S, Pu S, Burns JD, Braunschweig U, Ahmed N, Burke GL, Lee H, Radovani E, Zhong G, Tang H, Marcon E, Zhang Z, Hughes TR, Blencowe BJ, Greenblatt JF
Molecular cell 2024 Oct 3;84(19):3810-3825.e10
Molecular cell 2024 Oct 3;84(19):3810-3825.e10
Coxsackievirus B3-Induced m(6)A Modification of RNA Enhances Viral Replication via Suppression of YTHDF-Mediated Stress Granule Formation.
Zhao G, Zhang HM, Chen YT, Shi K, Aghakeshmiri S, Yip F, Luo H, McManus B, Yang D
Microorganisms 2024 Oct 26;12(11)
Microorganisms 2024 Oct 26;12(11)
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation.
Liang Z, Huang T, Li W, Ma Z, Wang K, Zhai Z, Fan Y, Fu Y, Wang X, Qin Y, Wang B, Zhao C, Kuang J, Pei D
Nucleic acids research 2024 Oct 14;52(18):10879-10896
Nucleic acids research 2024 Oct 14;52(18):10879-10896
Functional screen for mediators of onco-mRNA translation specificity.
Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
bioRxiv : the preprint server for biology 2024 Oct 11;
bioRxiv : the preprint server for biology 2024 Oct 11;
Profiling Cellular Morphological Changes Induced by Dual-Targeting PROTACs of Aurora Kinase and RNA-Binding Protein YTHDF2.
Goebel GL, Giannino N, Lampe P, Qiu X, Schloßhauer JL, Imig J, Sievers S, Wu P
Chembiochem : a European journal of chemical biology 2024 Oct 1;25(19):e202400183
Chembiochem : a European journal of chemical biology 2024 Oct 1;25(19):e202400183
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
Zhang H, Han B, Tian S, Gong Y, Liu L
International journal of oncology 2024 Nov;65(5)
International journal of oncology 2024 Nov;65(5)
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.
Xu X, Wu S, Zhang Y, Fan W, Lin X, Chen K, Lin X
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Molecular carcinogenesis 2024 Nov;63(11):2174-2189
Fat Mass and Obesity-Associated Protein Regulates Granulosa Cell Aging by Targeting Matrix Metalloproteinase-2 Gene Via an N6-Methyladenosine-YT521-B Homology Domain Family Member 2-Dependent Pathway in Aged Mice.
Li L, Yang L, Shen L, Zhao Y, Wang L, Zhang H
Reproductive sciences (Thousand Oaks, Calif.) 2024 Nov;31(11):3498-3511
Reproductive sciences (Thousand Oaks, Calif.) 2024 Nov;31(11):3498-3511
RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells.
Zhang X, Zhu C, Zhang L, Tan L, Cheng W, Li M, Zhang X, Zhang W, Zhang W
Food science & nutrition 2024 Nov;12(11):9238-9251
Food science & nutrition 2024 Nov;12(11):9238-9251
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
Deng K, Su Y, Liu Z, Hu S, Ren C, Wei W, Fan Y, Zhang Y, Wang F
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity.
Zhang H, Luo X, Yang W, Wu Z, Zhao Z, Pei X, Zhang X, Chen C, Lei JH, Shi Q, Zhao Q, Chen Y, Wu W, Zeng Z, Ju HQ, Qiu M, Liu J, Shen B, Chen M, Chen J, Deng CX, Xu RH, Hou J
Nature communications 2024 Nov 5;15(1):9559
Nature communications 2024 Nov 5;15(1):9559
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
YTHDF2 promotes anaplastic thyroid cancer progression by activating the DDIT4/AKT/mTOR signaling pathway.
Dai B, Xu L, Rong S, Song M, Lan Z, Chen W, Zhang L, Liu Y, Wang L, Li J, Chen J, Wu Z
Biology direct 2024 Nov 26;19(1):122
Biology direct 2024 Nov 26;19(1):122
METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.
Bai X, Liu J, Zhou S, Wu L, Feng X, Zhang P
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307
circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.
Shen Y, Liang Y, Yuan Z, Qiao L, Liu J, Pan Y, Yang K, Liu W
International journal of molecular sciences 2024 Nov 18;25(22)
International journal of molecular sciences 2024 Nov 18;25(22)
RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.
Li YW, Wang DD, Chen HQ, Zeng Y, Wang N, Shi Y, Li JY, Zhou NY, Wang DP, Chen Q, Han X, Cao J, Liu WB
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124889
Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide.
Song J, Wang Y, Zhu Z, Wang W, Yang H, Shan Z
Advanced biology 2024 May;8(5):e2300642
Advanced biology 2024 May;8(5):e2300642
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226
The Journal of biological chemistry 2024 May;300(5):107226
Identifying cellular RNA-binding proteins during infection uncovers a role for MKRN2 in influenza mRNA trafficking.
Bonazza S, Coutts HL, Sukumar S, Turkington HL, Courtney DG
PLoS pathogens 2024 May;20(5):e1012231
PLoS pathogens 2024 May;20(5):e1012231
Molecular characterization of m6A RNA methylation regulators with features of immune dysregulation in IgA nephropathy.
Wang Y, Sun N, He R, Wang Z, Jin J, Gao T, Qu J
Clinical and experimental medicine 2024 May 2;24(1):92
Clinical and experimental medicine 2024 May 2;24(1):92
Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3'UTR to decrease the expression of CD82.
You G, Li Z, Li L, Xu C
Heliyon 2024 May 15;10(9):e30702
Heliyon 2024 May 15;10(9):e30702
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
Wang K, Bhattacharya A, Haratake N, Daimon T, Nakashoji A, Ozawa H, Peng B, Li W, Kufe D
Cell death & disease 2024 May 13;15(5):330
Cell death & disease 2024 May 13;15(5):330
METTL3 enhances E. coli F18 resistance by targeting IKBKG/NF-κB signaling via an m(6)A-YTHDF1-dependent manner in IPEC-J2 cells.
Jin J, Liu M, Yu F, Sun MA, Wu Z
International journal of biological macromolecules 2024 Mar;262(Pt 2):130101
International journal of biological macromolecules 2024 Mar;262(Pt 2):130101
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038
Cellular signalling 2024 Mar;115:111038
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Qu H, Liu X, Zhu J, Xiong X, Li L, He Q, Wang Y, Yang G, Zhang L, Yang Q, Luo G, Zheng Y, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Dynamics of N6-methyladenosine modification during Alzheimer's disease development.
Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan TF, Tian H, Peng B, Rao Y
Heliyon 2024 Mar 30;10(6):e26911
Heliyon 2024 Mar 30;10(6):e26911
Mycobacterium tuberculosis inhibits METTL14-mediated m(6)A methylation of Nox2 mRNA and suppresses anti-TB immunity.
Ma M, Duan Y, Peng C, Wu Y, Zhang X, Chang B, Wang F, Yang H, Zheng R, Cheng H, Cheng Y, He Y, Huang J, Lei J, Ma H, Li L, Wang J, Huang X, Tang F, Liu J, Li J, Ying R, Wang P, Sha W, Gao Y, Wang L, Ge B
Cell discovery 2024 Mar 29;10(1):36
Cell discovery 2024 Mar 29;10(1):36
METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging.
Wang Y, Chen Y, Xiao H, Liu Z, Liu X, Feng Z, Sheng X, Peng B, Ren X, Xu L, Teng F, Yi Z, Niu Y, Xiang D, Xia Y, Geng B
Cell death discovery 2024 Mar 27;10(1):155
Cell death discovery 2024 Mar 27;10(1):155
CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension.
Hu X, Sun Y, Wang S, Zhao H, Wei Y, Fu J, Huang Y, Wu W, Li J, Liu J, Gong S, Zhao Q, Wang L, Jiang R, Song X, Yuan P
Journal of the American Heart Association 2024 Mar 19;13(6):e031867
Journal of the American Heart Association 2024 Mar 19;13(6):e031867
YTHDF2 governs muscle size through a targeted modulation of proteostasis.
Gilbert CJ, Rabolli CP, Golubeva VA, Sattler KM, Wang M, Ketabforoush A, Arnold WD, Lepper C, Accornero F
Nature communications 2024 Mar 11;15(1):2176
Nature communications 2024 Mar 11;15(1):2176
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29
Theriogenology 2024 Mar 1;216:20-29
miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner.
Yang H, Wang W, Liu H, Zhang C, Cao Y, Long L, Han X, Wang Y, Yan F, Li G, Zhu M, Jin L, Fan Z
Cell proliferation 2024 Jun;57(6):e13607
Cell proliferation 2024 Jun;57(6):e13607
YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.
Pang P, Si W, Wu H, Ju J, Liu K, Wang C, Jia Y, Diao H, Zeng L, Jiang W, Yang Y, Xiong Y, Kong X, Zhang Z, Zhang F, Song J, Wang N, Yang B, Bian Y
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905
lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
Luo D, Tang H, Tan L, Zhang L, Wang L, Cheng Q, Lei X, Wu J
Molecular cancer research : MCR 2024 Jun 4;22(6):524-537
Molecular cancer research : MCR 2024 Jun 4;22(6):524-537
FTO elicits tumor neovascularization in cancer-associated fibroblasts through eliminating m(6)A modifications of multiple pro-angiogenic factors.
Liao Q, Shi H, Yang J, Ge S, Jia R, Song X, Chai P, Jia R
Cancer letters 2024 Jun 28;592:216911
Cancer letters 2024 Jun 28;592:216911
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962
Cancer research 2024 Jun 14;84(12):1947-1962
BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.
Zhang P, Zhang W, Wang X, Li L, Lin Y, Wu N, Mao R, Lin J, Kang M, Ding C
Cancer letters 2024 Jun 1;591:216874
Cancer letters 2024 Jun 1;591:216874
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
Xian G, Huang R, Xu M, Zhao H, Xu X, Chen Y, Ren H, Xu D, Zeng Q
Experimental & molecular medicine 2024 Jul;56(7):1560-1573
Experimental & molecular medicine 2024 Jul;56(7):1560-1573
N(6)-methyladenosine (m(6)A) reader YTHDF2 accelerates endothelial cells ferroptosis in cerebrovascular atherosclerosis.
Li J, Zou C, Zhang Z, Xue F
Molecular and cellular biochemistry 2024 Jul;479(7):1853-1861
Molecular and cellular biochemistry 2024 Jul;479(7):1853-1861
BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.
Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811
Cancer medicine 2024 Jan;13(1):e6811
RNA m(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression.
Zhang Z, Zhou K, Han L, Small A, Xue J, Huang H, Weng H, Su R, Tan B, Shen C, Li W, Zhao Z, Qing Y, Qin X, Wang K, Leung K, Boldin M, Chen CW, Ann D, Qian Z, Deng X, Chen J, Chen Z
Genes & diseases 2024 Jan;11(1):382-396
Genes & diseases 2024 Jan;11(1):382-396
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA.
Liu B, Meng D, Luo M, Xu L, Yao M
Molecular pain 2024 Jan-Dec;20:17448069241295987
Molecular pain 2024 Jan-Dec;20:17448069241295987
Epitranscriptomic Reader YTHDF2 Regulates SEK1( MAP2K4 )-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress.
Malovic E, Ealy A, Hsu PJ, Sarkar S, Miller C, Rokad D, Goeser C, Hartman AK, Zhu A, Palanisamy B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, He C, Kanthasamy AG
bioRxiv : the preprint server for biology 2024 Jan 26;
bioRxiv : the preprint server for biology 2024 Jan 26;
METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis.
Zhang Y, Kong Y, Zhang W, He J, Zhang Z, Cai Y, Zhao Y, Xu Q
Clinical epigenetics 2024 Jan 24;16(1):18
Clinical epigenetics 2024 Jan 24;16(1):18
A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia.
Zhou W, Li S, Wang H, Zhou J, Li S, Chen G, Guan W, Fu X, Nervi C, Yu L, Li Y
Experimental hematology & oncology 2024 Jan 24;13(1):9
Experimental hematology & oncology 2024 Jan 24;13(1):9
YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.
Huang R, Sun M, Wang W, Yu X, Liu F
Journal of neuroimmunology 2024 Feb 15;387:578265
Journal of neuroimmunology 2024 Feb 15;387:578265
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H
Nature communications 2024 Feb 14;15(1):1353
Nature communications 2024 Feb 14;15(1):1353
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
Li Q, Liu J, Zeng C, Qin D, Zhang Z, Lv Q, Li J, Huang W
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.
Liu B, Tian X, Li L, Zhang R, Wu J, Jiang N, Yuan M, Chen D, Su A, Xu S, Wu Z
EMBO reports 2024 Dec;25(12):5599-5619
EMBO reports 2024 Dec;25(12):5599-5619
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L, Jiang P
Epigenetics 2024 Dec;19(1):2326868
Epigenetics 2024 Dec;19(1):2326868
Host RNA N(6)-methyladenosine and incoming DNA N(6)-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance.
Wang N, Liu Q, Wang B, Yang Z, Li S, Li R, Liang X, Fan J, Wang H, Sun Z, Dong L, Hou Y, Wang S, Song C, Wang Y, Quan C, Yang Q, Wang L
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4418-4434
Tumor-derived CCL15 regulates RNA m(6)A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth.
Wang C, Dong D, Zhao N, Liu Y, Bai C, Hua J, Cui R, Wei X, Zhao T, Ji N, Yang S, Zhao J, Li H, Li Y
Cancer letters 2024 Dec 27;611:217420
Cancer letters 2024 Dec 27;611:217420
Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis.
Li F, Tao H, Wei Y, Meng R, Li Y, Nie L, Zhang Y, Chang J
Frontiers in bioscience (Landmark edition) 2024 Dec 18;29(12):421
Frontiers in bioscience (Landmark edition) 2024 Dec 18;29(12):421
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272
Journal of affective disorders 2024 Dec 1;366:262-272
Differentiation and Growth-Arrest-Related lncRNA (DAGAR): Initial Characterization in Human Smooth Muscle and Fibroblast Cells.
de la Cruz-Thea B, Natali L, Ho-Xuan H, Bruckmann A, Coll-Bonfill N, Strieder N, Peinado VI, Meister G, Musri MM
International journal of molecular sciences 2024 Aug 31;25(17)
International journal of molecular sciences 2024 Aug 31;25(17)
METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m(6)A-YTHDF2-dependent manner.
Sheng R, Meng W, Zhang Z, Yin Q, Jiang S, Li Q, Gan X, Zhang D, Zhou Z, Lin S, Lyu M, Yang X, Yuan Q
Cell reports 2024 Aug 27;43(8):114535
Cell reports 2024 Aug 27;43(8):114535
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation.
Zhao X, Lv S, Li N, Zou Q, Sun L, Song T
The Journal of biological chemistry 2024 Apr;300(4):107152
The Journal of biological chemistry 2024 Apr;300(4):107152
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186
Cell death discovery 2024 Apr 22;10(1):186
Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification.
Cheng W, Tan L, Yu S, Song J, Li Z, Peng X, Wei Q, He Z, Zhang W, Yang X
International immunopharmacology 2024 Apr 20;131:111820
International immunopharmacology 2024 Apr 20;131:111820
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt-β-catenin pathway.
Yu P, Xu T, Ma W, Fang X, Bao Y, Xu C, Huang J, Sun Y, Li G
Journal of experimental & clinical cancer research : CR 2024 Apr 18;43(1):116
Journal of experimental & clinical cancer research : CR 2024 Apr 18;43(1):116
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.
Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, Shu Y, Ma P
Molecular biomedicine 2024 Apr 1;5(1):11
Molecular biomedicine 2024 Apr 1;5(1):11
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Comprehensive analysis of m6A RNA methylation modification patterns and the immune microenvironment in osteoarthritis.
Liu Z, Liu H, Li D, Ma L, Lu T, Sun H, Zhang Y, Yang H
Frontiers in immunology 2023;14:1128459
Frontiers in immunology 2023;14:1128459
Pseudorabies virus exploits N(6)-methyladenosine modification to promote viral replication.
Yu PL, Wu R, Cao SJ, Wen YP, Huang XB, Zhao S, Lang YF, Zhao Q, Lin JC, Du SY, Yu SM, Yan QG
Frontiers in microbiology 2023;14:1087484
Frontiers in microbiology 2023;14:1087484
Loss of YTHDF2 Alters the Expression of m(6)A-Modified Myzap and Causes Adverse Cardiac Remodeling.
Golubeva VA, Dorn LE, Gilbert CJ, Rabolli CP, Das AS, Wanasinghe VS, Veress R, Terentyev D, Accornero F
JACC. Basic to translational science 2023 Sep;8(9):1180-1194
JACC. Basic to translational science 2023 Sep;8(9):1180-1194
Comprehensive analysis of transcriptome-wide N6-methyladenosine methylomes in the Barrett's esophagus in rats.
Zou K, Dong H, Li M, Zhang Y, Zhang K, Song D, Chu C
Genomics 2023 Sep;115(5):110687
Genomics 2023 Sep;115(5):110687
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Zhou X, Jin L, Li Y, Wang Y, Li W, Shen X
BMC genomics 2023 Sep 27;24(1):577
BMC genomics 2023 Sep 27;24(1):577
Dynamic N6-methyladenosine RNA methylation landscapes reveal epi-transcriptomic modulation induced by ammonia nitrogen exposure in the Pacific whiteleg shrimp Litopenaeus vannamei.
Lei Y, Yuan Z, Zeng Q, Wan B, Liu J, Wang W
Journal of hazardous materials 2023 Sep 15;458:131996
Journal of hazardous materials 2023 Sep 15;458:131996
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Cell biology and toxicology 2023 Oct;39(5):2165-2181
m(6)A governs length-dependent enrichment of mRNAs in stress granules.
Ries RJ, Pickering BF, Poh HX, Namkoong S, Jaffrey SR
Nature structural & molecular biology 2023 Oct;30(10):1525-1535
Nature structural & molecular biology 2023 Oct;30(10):1525-1535
YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner.
Hwang HJ, Park TL, Kim HI, Park Y, Kim G, Song C, Cho WK, Kim YK
Nature communications 2023 Oct 6;14(1):6248
Nature communications 2023 Oct 6;14(1):6248
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
Cancer communications (London, England) 2023 Nov;43(11):1185-1206
RNA methylation reading protein YTHDF2 relieves myocardial ischemia-reperfusion injury by downregulating BNIP3 via m(6)A modification.
Cai X, Zou P, Hong L, Chen Y, Zhan Y, Liu Y, Shao L
Human cell 2023 Nov;36(6):1948-1964
Human cell 2023 Nov;36(6):1948-1964
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690
Nature cell biology 2023 Nov;25(11):1676-1690
Comprehensive analysis of m(6)A subtype classification for immune microenvironment of pituitary adenomas.
Yuan F, Cai X, Wang Y, Du C, Cong Z, Zeng X, Tang C, Ma C
International immunopharmacology 2023 Nov;124(Pt A):110784
International immunopharmacology 2023 Nov;124(Pt A):110784
FTO facilitates cancer metastasis by modifying the m(6)A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer.
Gao L, Wang A, Chen Y, Cai X, Li Y, Zhao J, Zhang Y, Zhang W, Zhu J, Zeng Y, Liu Z, Huang JA
Cell communication and signaling : CCS 2023 Nov 2;21(1):311
Cell communication and signaling : CCS 2023 Nov 2;21(1):311
N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, Jiang X, Li H, Yang P, Xiang D
Gastroenterology 2023 May;164(6):990-1005
Gastroenterology 2023 May;164(6):990-1005
RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner.
Shen D, Lin J, Xie Y, Zhuang Z, Xu G, Peng S, Tang G, Bai L, Zhu M, Zhang Y, Huang Z, Wang P, Liu X, Huang M, Luo Y, Wang X, Yu H
Clinical and translational medicine 2023 May;13(5):e1279
Clinical and translational medicine 2023 May;13(5):e1279
Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI.
Liu C, Sun H, Yi Y, Shen W, Li K, Xiao Y, Li F, Li Y, Hou Y, Lu B, Liu W, Meng H, Peng J, Yi C, Wang J
Nature biotechnology 2023 Mar;41(3):355-366
Nature biotechnology 2023 Mar;41(3):355-366
Fibroblast-Derived Extracellular Vesicle-Packaged Long Noncoding RNA Upregulated in Diabetic Skin Enhances Keratinocyte MMP-9 Expression and Delays Diabetic Wound Healing.
Wu Y, Wu X, Wang J, Chen S, Chen H, Liu J, Zeng T, Hu M, Liang Y, Sun K, Yang C, Yan L, Ren M
Laboratory investigation; a journal of technical methods and pathology 2023 Mar;103(3):100019
Laboratory investigation; a journal of technical methods and pathology 2023 Mar;103(3):100019
YTHDF2 exerts tumor-suppressor roles in gastric cancer via up-regulating PPP2CA independently of m(6)A modification.
Zhou Y, Fan K, Dou N, Li L, Wang J, Chen J, Li Y, Gao Y
Biological procedures online 2023 Mar 4;25(1):6
Biological procedures online 2023 Mar 4;25(1):6
YTHDF2 Is Downregulated in Response to Host Shutoff Induced by DNA Virus Infection and Regulates Interferon-Stimulated Gene Expression.
Hesser CR, Walsh D
Journal of virology 2023 Mar 30;97(3):e0175822
Journal of virology 2023 Mar 30;97(3):e0175822
Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation.
Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF
Nature communications 2023 Mar 27;14(1):1694
Nature communications 2023 Mar 27;14(1):1694
N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.
Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185
Nature communications 2023 Mar 2;14(1):1185
YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m(6)A/mRNA pathway in spermatogonial stem cells/progenitors.
Li T, Zheng Y, Wu Z, Guo M, Liu R, Zeng W, Lv Y
Toxicology letters 2023 Mar 15;377:38-50
Toxicology letters 2023 Mar 15;377:38-50
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice.
Yan S, Zhou X, Wu C, Gao Y, Qian Y, Hou J, Xie R, Han B, Chen Z, Wei S, Gao X
Nature communications 2023 Mar 13;14(1):1379
Nature communications 2023 Mar 13;14(1):1379
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747
Veterinary microbiology 2023 Jun;281:109747
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407
Journal of translational medicine 2023 Jun 23;21(1):407
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I-Mediated Immune Response.
Zhang L, Li Y, Zhou L, Zhou H, Ye L, Ou T, Hong H, Zheng S, Zhou Z, Wu K, Yan Z, Thiery JP, Cui J, Wu S
Cancer research 2023 Jun 2;83(11):1834-1850
Cancer research 2023 Jun 2;83(11):1834-1850
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization.
Liu P, Chen Y, Zhang Z, Yuan Z, Sun JG, Xia S, Cao X, Chen J, Zhang CJ, Chen Y, Zhan H, Jin Y, Bao X, Gu Y, Zhang M, Xu Y
PLoS biology 2023 Jul;21(7):e3002199
PLoS biology 2023 Jul;21(7):e3002199
ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway.
Sun RX, Zhu HJ, Zhang YR, Wang JN, Wang Y, Cao QC, Ji JD, Jiang C, Yuan ST, Chen X, Liu QH
Cell reports 2023 Jul 25;42(7):112779
Cell reports 2023 Jul 25;42(7):112779
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467
Nature communications 2023 Jul 25;14(1):4467
TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.
Wang YQ, Wu DH, Wei D, Shen JY, Huang ZW, Liang XY, Cho WCS, Ma J, Lv J, Chen YP
Science advances 2023 Jan 6;9(1):eadd0960
Science advances 2023 Jan 6;9(1):eadd0960
Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.
Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H
Cell stem cell 2023 Jan 5;30(1):69-85.e7
Cell stem cell 2023 Jan 5;30(1):69-85.e7
METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance.
Zhang Y, Qiu JG, Jia XY, Ke Y, Zhang MK, Stieg D, Liu WJ, Liu LZ, Wang L, Jiang BH
Cancer letters 2023 Jan 28;553:215971
Cancer letters 2023 Jan 28;553:215971
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.
McMillan M, Gomez N, Hsieh C, Bekier M, Li X, Miguez R, Tank EMH, Barmada SJ
Molecular cell 2023 Jan 19;83(2):219-236.e7
Molecular cell 2023 Jan 19;83(2):219-236.e7
Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis.
Wang X, Zhao X, Wang J, Wu H, Cheng Y, Guo Q, Liang T, Zhang G
International journal of molecular sciences 2023 Jan 14;24(2)
International journal of molecular sciences 2023 Jan 14;24(2)
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)
International journal of molecular sciences 2023 Jan 11;24(2)
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells.
Lyu Z, Huang B, Zhang J, Qian Q, Pu X, Cui N, Ou Y, Li B, You Z, Lian M, Tang R, Chen W, Zhao Z, Hou J, Gershwin ME, Zhang H, Xia Q, Ma X
Journal of autoimmunity 2023 Feb;135:102993
Journal of autoimmunity 2023 Feb;135:102993
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122
Journal of virology 2023 Feb 28;97(2):e0175122
Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability.
Cai Y, Yu R, Zhang Z, Li D, Yi B, Feng Z, Xu Q
Immunology letters 2023 Dec;264:64-73
Immunology letters 2023 Dec;264:64-73
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
SON is an essential m(6)A target for hematopoietic stem cell fate.
Luo H, Cortés-López M, Tam CL, Xiao M, Wakiro I, Chu KL, Pierson A, Chan M, Chang K, Yang X, Fecko D, Han G, Ahn EE, Morris QD, Landau DA, Kharas MG
Cell stem cell 2023 Dec 7;30(12):1658-1673.e10
Cell stem cell 2023 Dec 7;30(12):1658-1673.e10
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766
Journal of ethnopharmacology 2023 Dec 5;317:116766
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7
High Temperature-Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs.
Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Guo J, Cui XS
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2174-2183
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 Dec 21;29(6):2174-2183
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202
The Science of the total environment 2023 Dec 20;905:167202
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310
iScience 2023 Aug 18;26(8):107310
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.
Li W, Tan M, Wang H, Wang Z, Pang Y, Yang R, Zhong S, Pan X, Chen S, Wang Q, Li D, Xiao Y, Chen W, Chen L
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887
LncRNA CACClnc promotes chemoresistance of colorectal cancer by modulating alternative splicing of RAD51.
Zhang X, Ma D, Xuan B, Shi D, He J, Yu M, Xiong H, Ma Y, Shen C, Guo F, Cao Y, Yan Y, Gao Z, Tong T, Zhu X, Fang JY, Chen H, Hong J
Oncogene 2023 Apr;42(17):1374-1391
Oncogene 2023 Apr;42(17):1374-1391
YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory.
Zhuang M, Geng X, Han P, Che P, Liang F, Liu C, Yang L, Yu J, Zhang Z, Dong W, Ji SJ
Molecular psychiatry 2023 Apr;28(4):1679-1691
Molecular psychiatry 2023 Apr;28(4):1679-1691
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication.
Zhu Y, Wang R, Zou J, Tian S, Yu L, Zhou Y, Ran Y, Jin M, Chen H, Zhou H
PLoS pathogens 2023 Apr;19(4):e1011305
PLoS pathogens 2023 Apr;19(4):e1011305
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Effects on the Cell Barrier Function of L-Met and DL-HMTBA Is Related to Metabolic Characteristics and m(6)A Modification.
Zuo F, Wei H, Peng J, Li S, Zhou Y
Frontiers in nutrition 2022;9:836069
Frontiers in nutrition 2022;9:836069
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N(6)-Methyladenosine-Modified Yap Expression.
Wang L, Yu P, Wang J, Xu G, Wang T, Feng J, Bei Y, Xu J, Wang H, Das S, Xiao J
Research (Washington, D.C.) 2022;2022:9825916
Research (Washington, D.C.) 2022;2022:9825916
M(6)A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.
Liu F, Zhang X, Liu Z, Cai W, Song C, Jiang Y, Yin J, Liu Z, Huang C
Journal of oncology 2022;2022:2513813
Journal of oncology 2022;2022:2513813
Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation.
Gao X, Li H, Wang X, Ren Z, Tian Y, Zhao J, Qi W, Wang H, Yu Y, Gong R, Chen H, Ji H, Yang F, Ma W, Liu Y
International journal of medical sciences 2022;19(8):1254-1264
International journal of medical sciences 2022;19(8):1254-1264
N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.
Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y
International journal of biological sciences 2022;18(15):5753-5769
International journal of biological sciences 2022;18(15):5753-5769
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.
Koh YW, Han JH, Haam S, Lee HW
Frontiers in oncology 2022;12:996634
Frontiers in oncology 2022;12:996634
m(1)A and m(6)A modifications function cooperatively to facilitate rapid mRNA degradation.
Boo SH, Ha H, Kim YK
Cell reports 2022 Sep 6;40(10):111317
Cell reports 2022 Sep 6;40(10):111317
M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.
Xu M, Zhuo R, Tao S, Liang Y, Liu C, Liu Q, Wang T, Zhong X
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)
m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs.
Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji SJ
iScience 2022 Sep 16;25(9):104908
iScience 2022 Sep 16;25(9):104908
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.
Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546
Cell reports 2022 Oct 25;41(4):111546
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N (6)-Methyladenosine-Modified RNAs.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891
ACS pharmacology & translational science 2022 Oct 14;5(10):872-891
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554
The Journal of biological chemistry 2022 Nov;298(11):102554
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Mettl3-mediated m(6)A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Jiang FQ, Liu K, Chen JX, Cao Y, Chen WY, Zhao WL, Song GH, Liang CQ, Zhou YM, Huang HL, Huang RJ, Zhao H, Park KS, Ju Z, Cai D, Qi XF
eLife 2022 Nov 18;11
eLife 2022 Nov 18;11
Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner.
Xiong YW, Tan LL, Zhang J, Zhu HL, Zheng XM, Chang W, Gao L, Wei T, Xu DX, Wang H
Environmental pollution (Barking, Essex : 1987) 2022 Nov 15;313:120112
Environmental pollution (Barking, Essex : 1987) 2022 Nov 15;313:120112
Functional and molecular dissection of HCMV long non-coding RNAs.
Lee S, Kim H, Hong A, Song J, Lee S, Kim M, Hwang SY, Jeong D, Kim J, Son A, Lee YS, Kim VN, Kim JS, Chang H, Ahn K
Scientific reports 2022 Nov 11;12(1):19303
Scientific reports 2022 Nov 11;12(1):19303
METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.
Cai Y, Yu R, Kong Y, Feng Z, Xu Q
Cellular signalling 2022 May;93:110283
Cellular signalling 2022 May;93:110283
PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner.
Sun S, Liu Y, Zhou M, Wen J, Xue L, Han S, Liang J, Wang Y, Wei Y, Yu J, Long X, Chen X, Liang H, Huang Z, Zhang B
Cell & bioscience 2022 May 7;12(1):55
Cell & bioscience 2022 May 7;12(1):55
CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.
Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
European journal of pharmacology 2022 May 5;922:174915
European journal of pharmacology 2022 May 5;922:174915
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
Boo SH, Ha H, Lee Y, Shin MK, Lee S, Kim YK
Cell reports 2022 May 24;39(8):110861
Cell reports 2022 May 24;39(8):110861
METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner.
Xu QC, Tien YC, Shi YH, Chen S, Zhu YQ, Huang XT, Huang CS, Zhao W, Yin XY
Oncogene 2022 Mar;41(11):1622-1633
Oncogene 2022 Mar;41(11):1622-1633
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.
Hua Z, Wei R, Guo M, Lin Z, Yu X, Li X, Gu C, Yang Y
Oncogene 2022 Mar;41(10):1482-1491
Oncogene 2022 Mar;41(10):1482-1491
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
Ganan-Gomez I, Yang H, Ma F, Montalban-Bravo G, Thongon N, Marchica V, Richard-Carpentier G, Chien K, Manyam G, Wang F, Alfonso A, Chen S, Class C, Kanagal-Shamanna R, Ingram JP, Ogoti Y, Rose A, Loghavi S, Lockyer P, Cambo B, Muftuoglu M, Schneider S, Adema V, McLellan M, Garza J, Marchesini M, Giuliani N, Pellegrini M, Wang J, Walker J, Li Z, Takahashi K, Leverson JD, Bueso-Ramos C, Andreeff M, Clise-Dwyer K, Garcia-Manero G, Colla S
Nature medicine 2022 Mar;28(3):557-567
Nature medicine 2022 Mar;28(3):557-567
METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism.
Wang Y, Chen J, Gao WQ, Yang R
Cell death discovery 2022 Mar 30;8(1):143
Cell death discovery 2022 Mar 30;8(1):143
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.
Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099
Journal of hazardous materials 2022 Mar 15;426:128099
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248
Nature communications 2022 Mar 10;13(1):1248
YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation.
Huang CS, Zhu YQ, Xu QC, Chen S, Huang Y, Zhao G, Ni X, Liu B, Zhao W, Yin XY
Clinical and translational medicine 2022 Jun;12(6):e848
Clinical and translational medicine 2022 Jun;12(6):e848
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma.
Zhang C, Sun Q, Zhang X, Qin N, Pu Z, Gu Y, Yan C, Zhu M, Dai J, Wang C, Li N, Jin G, Ma H, Hu Z, Zhang E, Tan F, Shen H
Cancer communications (London, England) 2022 Jul;42(7):609-626
Cancer communications (London, England) 2022 Jul;42(7):609-626
N(6)-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis.
Ma X, Cao J, Zhou Z, Lu Y, Li Q, Jin Y, Chen G, Wang W, Ge W, Chen X, Hu Z, Shu X, Deng Q, Pu J, Liang C, Fu J, Liu J, Zhu S
Nature communications 2022 Jul 18;13(1):4148
Nature communications 2022 Jul 18;13(1):4148
m(6) A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts.
Qi M, Sun H, Guo Y, Zhou Y, Gu X, Jin J, Chen X, Wang F, Ma H, Guo X, Chen H, Shen B
Cell proliferation 2022 Jan;55(1):e13164
Cell proliferation 2022 Jan;55(1):e13164
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.
Zhu Y, Zhou B, Hu X, Ying S, Zhou Q, Xu W, Feng L, Hou T, Wang X, Zhu L, Jin H
Clinical and translational medicine 2022 Jan;12(1):e703
Clinical and translational medicine 2022 Jan;12(1):e703
Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.
Xu P, Hu K, Zhang P, Sun ZG, Zhang N
Cancer cell international 2022 Jan 7;22(1):13
Cancer cell international 2022 Jan 7;22(1):13
Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens.
Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, Ma Y, Cao N, Wang J
Nature communications 2022 Jan 25;13(1):478
Nature communications 2022 Jan 25;13(1):478
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
Ning J, Du H, Zhang Y, Liu Q, Jiang T, Pang Y, Tian X, Yan L, Niu Y, Zhang R
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F
Nature communications 2022 Jan 10;13(1):66
Nature communications 2022 Jan 10;13(1):66
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563
The Journal of biological chemistry 2022 Feb;298(2):101563
The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.
Li Y, Zhang X, Cai J, Ren L, Liu B, Wu M, Lu W, Li R, Zhang C, Huang C, Tong J, Liu A, Zheng Y, Ren D, Guo Y, Huang Y
The journal of gene medicine 2022 Feb;24(2):e3397
The journal of gene medicine 2022 Feb;24(2):e3397
RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.
Pan J, Wang J, Fang K, Hou W, Li B, Zhao J, Ma X
Nanoscale research letters 2022 Feb 5;17(1):23
Nanoscale research letters 2022 Feb 5;17(1):23
The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
Niu F, Han P, Zhang J, She Y, Yang L, Yu J, Zhuang M, Tang K, Shi Y, Yang B, Liu C, Peng B, Ji SJ
eLife 2022 Feb 18;11
eLife 2022 Feb 18;11
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766
Brain research 2022 Feb 15;1777:147766
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142
EBioMedicine 2022 Aug;82:104142
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.
Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V
Nature immunology 2022 Aug;23(8):1208-1221
Nature immunology 2022 Aug;23(8):1208-1221
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
Li J, Yao H, Huang J, Li C, Zhang Y, Xu R, Wang Z, Long Z, Tang J, Wang L
Cell death & disease 2022 Aug 19;13(8):723
Cell death & disease 2022 Aug 19;13(8):723
Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.
Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)
International journal of molecular sciences 2022 Aug 17;23(16)
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Zhang L, Cheng Y, Xue Z, Li J, Wu N, Yan J, Wang J, Wang C, Chen W, Zhou T, Qiu Z, Jiang H
Cell biology and toxicology 2022 Apr;38(2):347-369
Cell biology and toxicology 2022 Apr;38(2):347-369
Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.
Shan HJ, Gu WX, Duan G, Chen HL
Bioengineered 2022 Apr;13(4):8038-8050
Bioengineered 2022 Apr;13(4):8038-8050
Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA.
Li J, Chen J, Zhao M, Li Z, Liu N, Fang H, Fang M, Zhu P, Lei L, Chen C
Annals of translational medicine 2022 Apr;10(7):417
Annals of translational medicine 2022 Apr;10(7):417
The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m(6)A RNA methylation reading protein Ythdf2.
Yang Y, Mbikyo MB, Zhang J, Zhang Y, Zhang N, Li Z
Cell death discovery 2022 Apr 5;8(1):167
Cell death discovery 2022 Apr 5;8(1):167
Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.
Jiang J, Fan Q, Qu H, Liu C, Liang T, Chen L, Huang S, Sun X, Chen J, Chen T, Li H, Yao Y, Zhan X
Scientific reports 2022 Apr 29;12(1):7041
Scientific reports 2022 Apr 29;12(1):7041
GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling.
Ren Y, Yang B, Guo G, Zhang J, Sun Y, Liu D, Guo S, Wu Y, Wang X, Wang S, Zhang W, Guo X, Li X, Li R, He J, Zhou Z
Cell death discovery 2022 Apr 18;8(1):208
Cell death discovery 2022 Apr 18;8(1):208
METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.
Zhou X, Yang Y, Li Y, Liang G, Kang D, Zhou B, Li Q
Frontiers in cell and developmental biology 2021;9:784719
Frontiers in cell and developmental biology 2021;9:784719
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition.
Han S, Zhu L, Zhu Y, Meng Y, Li J, Song P, Yousafzai NA, Feng L, Chen M, Wang Y, Jin H, Wang X
Theranostics 2021;11(17):8464-8479
Theranostics 2021;11(17):8464-8479
YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.
Fang C, He M, Li D, Xu Q
Cellular signalling 2021 Sep;85:110060
Cellular signalling 2021 Sep;85:110060
Vitamin B(12) Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.
Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N
Molecular nutrition & food research 2021 Sep;65(17):e2100206
Molecular nutrition & food research 2021 Sep;65(17):e2100206
METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak SL, Pajdzik K, Dai Q, He C, Wang W, O'Donnell JM, Tang B, Zhu X
Molecular neurodegeneration 2021 Sep 30;16(1):70
Molecular neurodegeneration 2021 Sep 30;16(1):70
LncAY controls BMI1 expression and activates BMI1/Wnt/β-catenin signaling axis in hepatocellular carcinoma.
Chen MH, Fu LS, Zhang F, Yang Y, Wu XZ
Life sciences 2021 Sep 1;280:119748
Life sciences 2021 Sep 1;280:119748
Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β.
Li H, Zhang N, Jiao X, Wang C, Sun W, He Y, Ren G, Huang S, Li M, Chang Y, Jin Z, Xie Q, Zhang X, Huang H, Jin H
Clinical and translational medicine 2021 Oct;11(10):e602
Clinical and translational medicine 2021 Oct;11(10):e602
Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
Jin M, Li G, Liu W, Wu X, Zhu J, Zhao D, Zeng Z, Xiong M, Song Y, He X, Zhang Q, Hu K
Cancer letters 2021 Oct 10;518:214-229
Cancer letters 2021 Oct 10;518:214-229
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect.
Hou Y, Zhang Q, Pang W, Hou L, Liang Y, Han X, Luo X, Wang P, Zhang X, Li L, Meng X
Cell death and differentiation 2021 Nov;28(11):3105-3124
Cell death and differentiation 2021 Nov;28(11):3105-3124
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616
Cancer cell international 2021 Nov 22;21(1):616
RNA m(6)A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling.
Li Y, Sheng H, Ma F, Wu Q, Huang J, Chen Q, Sheng L, Zhu X, Zhu X, Xu M
Cell death & disease 2021 May 13;12(5):479
Cell death & disease 2021 May 13;12(5):479
Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes.
Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jürgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gür K, Ölschläger J, Kühl F, Martin J, Ramirez-Pedraza M, Fernandez M, Doroudgar S, Méndez R, Katus HA, Hentze MW, Völkers M
Cell reports 2021 May 11;35(6):109100
Cell reports 2021 May 11;35(6):109100
m(6)A RNA methylation regulates the fate of endogenous retroviruses.
Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, Dossin F, Fouassier C, Lameiras S, Bourc'his D
Nature 2021 Mar;591(7849):312-316
Nature 2021 Mar;591(7849):312-316
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
miRNA-mediated loss of m6A increases nascent translation in glioblastoma.
Zepecki JP, Karambizi D, Fajardo JE, Snyder KM, Guetta-Terrier C, Tang OY, Chen JS, Sarkar A, Fiser A, Toms SA, Tapinos N
PLoS genetics 2021 Mar;17(3):e1009086
PLoS genetics 2021 Mar;17(3):e1009086
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis.
Qing Y, Dong L, Gao L, Li C, Li Y, Han L, Prince E, Tan B, Deng X, Wetzel C, Shen C, Gao M, Chen Z, Li W, Zhang B, Braas D, Ten Hoeve J, Sanchez GJ, Chen H, Chan LN, Chen CW, Ann D, Jiang L, Müschen M, Marcucci G, Plas DR, Li Z, Su R, Chen J
Molecular cell 2021 Mar 4;81(5):922-939.e9
Molecular cell 2021 Mar 4;81(5):922-939.e9
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.
Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X
Molecular cancer 2021 Mar 3;20(1):45
Molecular cancer 2021 Mar 3;20(1):45
SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs.
Hou G, Zhao X, Li L, Yang Q, Liu X, Huang C, Lu R, Chen R, Wang Y, Jiang B, Yu J
Nucleic acids research 2021 Mar 18;49(5):2859-2877
Nucleic acids research 2021 Mar 18;49(5):2859-2877
Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma.
Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X, Jia R
Genome biology 2021 Mar 16;22(1):85
Genome biology 2021 Mar 16;22(1):85
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Wang F, Liao Y, Zhang M, Zhu Y, Wang W, Cai H, Liang J, Song F, Hou C, Huang S, Zhang Y, Wang C, Hou J
Oncogene 2021 Jun;40(22):3885-3898
Oncogene 2021 Jun;40(22):3885-3898
PBRM1 Cooperates with YTHDF2 to Control HIF-1α Protein Translation.
Shmakova A, Frost M, Batie M, Kenneth NS, Rocha S
Cells 2021 Jun 8;10(6)
Cells 2021 Jun 8;10(6)
A heat shock-responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m(6)A modification.
Ji Q, Zong X, Mao Y, Qian SB
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding.
Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y, He J, Lu Z
Nature communications 2021 Jun 21;12(1):3803
Nature communications 2021 Jun 21;12(1):3803
Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).
Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)
Science advances 2021 Jul;7(31)
N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.
Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C
PLoS biology 2021 Jul;19(7):e3001292
PLoS biology 2021 Jul;19(7):e3001292
Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.
Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu Q, Liu N, Xiao Y
Aging 2021 Jul 26;13(14):18238-18256
Aging 2021 Jul 26;13(14):18238-18256
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q
Nucleic acids research 2021 Jul 21;49(13):7361-7374
Nucleic acids research 2021 Jul 21;49(13):7361-7374
Epitranscriptomic addition of m(6)A regulates HIV-1 RNA stability and alternative splicing.
Tsai K, Bogerd HP, Kennedy EM, Emery A, Swanstrom R, Cullen BR
Genes & development 2021 Jul 1;35(13-14):992-1004
Genes & development 2021 Jul 1;35(13-14):992-1004
DNA methylation of FTO promotes renal inflammation by enhancing m(6)A of PPAR-α in alcohol-induced kidney injury.
Yu JT, Hu XW, Chen HY, Yang Q, Li HD, Dong YH, Zhang Y, Wang JN, Jin J, Wu YG, Li J, Ge JF, Meng XM
Pharmacological research 2021 Jan;163:105286
Pharmacological research 2021 Jan;163:105286
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547
The Journal of biological chemistry 2021 Jan-Jun;296:100547
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma.
Fang R, Chen X, Zhang S, Shi H, Ye Y, Shi H, Zou Z, Li P, Guo Q, Ma L, He C, Huang S
Nature communications 2021 Jan 8;12(1):177
Nature communications 2021 Jan 8;12(1):177
ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma.
Yuan Y, Yan G, He M, Lei H, Li L, Wang Y, He X, Li G, Wang Q, Gao Y, Qu Z, Mei Z, Shen Z, Pu J, Wang A, Zhao W, Jiang H, Du W, Yang L
Cell death & disease 2021 Jan 11;12(1):60
Cell death & disease 2021 Jan 11;12(1):60
Relaxed initiation pausing of ribosomes drives oncogenic translation.
Dong L, Mao Y, Zhou A, Liu XM, Zhou J, Wan J, Qian SB
Science advances 2021 Feb;7(8)
Science advances 2021 Feb;7(8)
m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475
Autophagy 2021 Feb;17(2):457-475
The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.
Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, Qiu Z, Kidwell RL, Kim LJY, Xie Q, Vitting-Seerup K, Bhargava S, Dong Z, Jiang L, Zhu Z, Hamerlik P, Jaffrey SR, Zhao JC, Wang X, Rich JN
Cancer discovery 2021 Feb;11(2):480-499
Cancer discovery 2021 Feb;11(2):480-499
Local translation in nuclear condensate amyloid bodies.
Theodoridis PR, Bokros M, Marijan D, Balukoff NC, Wang D, Kirk CC, Budine TD, Goldsmith HD, Wang M, Audas TE, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
Proceedings of the National Academy of Sciences of the United States of America 2021 Feb 16;118(7)
YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells.
Zhao X, Lin Z, Fan Y, Li W, Zhang Y, Li F, Hong T, Feng H, Tong M, Wang N, Kuang Y, Lyu Q
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1702-1712
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1702-1712
GR-mediated transcriptional regulation of m(6)A metabolic genes contributes to diet-induced fatty liver in hens.
Feng Y, Li Y, Jiang W, Hu Y, Jia Y, Zhao R
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
Journal of animal science and biotechnology 2021 Dec 7;12(1):117
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3
Cell death & disease 2021 Dec 17;13(1):3
m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation.
Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, Xie H, Wang RL
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3436-3448
The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.
Sanderson MR, Fahlman RP, Wevrick R
The Journal of biological chemistry 2021 Aug;297(2):100959
The Journal of biological chemistry 2021 Aug;297(2):100959
METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
Zhou D, Tang W, Xu Y, Xu Y, Xu B, Fu S, Wang Y, Chen F, Chen Y, Han Y, Wang G
Molecular oncology 2021 Aug;15(8):2172-2184
Molecular oncology 2021 Aug;15(8):2172-2184
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, Yee BA, Li H, Madrigal AA, Neill NJ, Shankar A, Tyagi S, Westbrook TF, Yeo GW
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
Molecular cell 2021 Aug 5;81(15):3048-3064.e9
Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus.
Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R
mBio 2021 Aug 31;12(4):e0170621
mBio 2021 Aug 31;12(4):e0170621
Transcriptome-wide m(6)A profiling reveals mRNA post-transcriptional modification of boar sperm during cryopreservation.
Qin Z, Wang W, Ali MA, Wang Y, Zhang Y, Zhang M, Zhou G, Yang JD, Zeng C
BMC genomics 2021 Aug 3;22(1):588
BMC genomics 2021 Aug 3;22(1):588
EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.
Bearss JJ, Padi SK, Singh N, Cardo-Vila M, Song JH, Mouneimne G, Fernandes N, Li Y, Harter MR, Gard JM, Cress AE, Peti W, Nelson AD, Buchan JR, Kraft AS, Okumura K
EMBO reports 2021 Apr 7;22(4):e50835
EMBO reports 2021 Apr 7;22(4):e50835
Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M
mBio 2021 Apr 13;12(2)
mBio 2021 Apr 13;12(2)
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940
Frontiers in cell and developmental biology 2020;8:574940
Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression.
Yang J, Han Q, Li C, Yang H, Chen X, Wang X
OncoTargets and therapy 2020;13:1723-1736
OncoTargets and therapy 2020;13:1723-1736
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m(6)A RNA Methylation.
Wu J, Li Y, Yu J, Gan Z, Wei W, Wang C, Zhang L, Wang T, Zhong X
Frontiers in pharmacology 2020;11:568006
Frontiers in pharmacology 2020;11:568006
m(6)A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.
He JJ, Li Z, Rong ZX, Gao J, Mu Y, Guan YD, Ren XX, Zi YY, Liu LY, Fan Q, Zhou M, Duan YM, Zhou Q, Deng YZ, Sun LQ
Frontiers in oncology 2020;10:1166
Frontiers in oncology 2020;10:1166
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.
Li J, Xie H, Ying Y, Chen H, Yan H, He L, Xu M, Xu X, Liang Z, Liu B, Wang X, Zheng X, Xie L
Molecular cancer 2020 Oct 29;19(1):152
Molecular cancer 2020 Oct 29;19(1):152
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
Direct RNA sequencing reveals m(6)A modifications on adenovirus RNA are necessary for efficient splicing.
Price AM, Hayer KE, McIntyre ABR, Gokhale NS, Abebe JS, Della Fera AN, Mason CE, Horner SM, Wilson AC, Depledge DP, Weitzman MD
Nature communications 2020 Nov 26;11(1):6016
Nature communications 2020 Nov 26;11(1):6016
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;
bioRxiv : the preprint server for biology 2020 Nov 16;
Modulation of circRNA Metabolism by m(6)A Modification.
Di Timoteo G, Dattilo D, Centrón-Broco A, Colantoni A, Guarnacci M, Rossi F, Incarnato D, Oliviero S, Fatica A, Morlando M, Bozzoni I
Cell reports 2020 May 12;31(6):107641
Cell reports 2020 May 12;31(6):107641
N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.
Li Y, Guo X, Sun L, Xiao J, Su S, Du S, Li Z, Wu S, Liu W, Mo K, Xia S, Chang YJ, Denis D, Tao YX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Jul;7(13):1902402
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Jul;7(13):1902402
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A
Nature genetics 2020 Jan;52(1):48-55
Nature genetics 2020 Jan;52(1):48-55
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8
Molecular cell 2020 Feb 6;77(3):542-555.e8
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
Li G, Song Y, Liao Z, Wang K, Luo R, Lu S, Zhao K, Feng X, Liang H, Ma L, Wang B, Ke W, Yin H, Zhan S, Li S, Wu X, Zhang Y, Yang C
Cell death & disease 2020 Feb 6;11(2):103
Cell death & disease 2020 Feb 6;11(2):103
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.
Li D, Cai L, Meng R, Feng Z, Xu Q
International journal of molecular sciences 2020 Feb 28;21(5)
International journal of molecular sciences 2020 Feb 28;21(5)
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
N(6)-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Du J, Liao W, Liu W, Deb DK, He L, Hsu PJ, Nguyen T, Zhang L, Bissonnette M, He C, Li YC
Developmental cell 2020 Dec 21;55(6):737-753.e7
Developmental cell 2020 Dec 21;55(6):737-753.e7
Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1.
Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML
Cancer cell international 2020 Dec 14;20(1):597
Cancer cell international 2020 Dec 14;20(1):597
Interplay of m(6)A and H3K27 trimethylation restrains inflammation during bacterial infection.
Wu C, Chen W, He J, Jin S, Liu Y, Yi Y, Gao Z, Yang J, Yang J, Cui J, Zhao W
Science advances 2020 Aug;6(34):eaba0647
Science advances 2020 Aug;6(34):eaba0647
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, Potts PR
Molecular cell 2020 Aug 20;79(4):645-659.e9
Molecular cell 2020 Aug 20;79(4):645-659.e9
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z
Cell death & disease 2020 Aug 13;11(8):613
Cell death & disease 2020 Aug 13;11(8):613
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
METTL3/YTHDF2 m(6) A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.
Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, He L, Xu X, Liu B, Wang X, Zheng X, Xie L
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z
Nature communications 2020 Apr 3;11(1):1648
Nature communications 2020 Apr 3;11(1):1648
Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification.
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
The Journal of biological chemistry 2020 Apr 24;295(17):5626-5639
G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.
Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP
Cell 2020 Apr 16;181(2):325-345.e28
Cell 2020 Apr 16;181(2):325-345.e28
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Multivalent m(6)A motifs promote phase separation of YTHDF proteins.
Gao Y, Pei G, Li D, Li R, Shao Y, Zhang QC, Li P
Cell research 2019 Sep;29(9):767-769
Cell research 2019 Sep;29(9):767-769
Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m(6)A RNA Methylation in the Intestine of Weaning Piglets.
Gan Z, Wei W, Wu J, Zhao Y, Zhang L, Wang T, Zhong X
ACS omega 2019 Oct 22;4(17):17438-17446
ACS omega 2019 Oct 22;4(17):17438-17446
m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2.
Mao Y, Dong L, Liu XM, Guo J, Ma H, Shen B, Qian SB
Nature communications 2019 Nov 25;10(1):5332
Nature communications 2019 Nov 25;10(1):5332
Loss of m(6) A on FAM134B promotes adipogenesis in porcine adipocytes through m(6) A-YTHDF2-dependent way.
Cai M, Liu Q, Jiang Q, Wu R, Wang X, Wang Y
IUBMB life 2019 May;71(5):580-586
IUBMB life 2019 May;71(5):580-586
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
Park OH, Ha H, Lee Y, Boo SH, Kwon DH, Song HK, Kim YK
Molecular cell 2019 May 2;74(3):494-507.e8
Molecular cell 2019 May 2;74(3):494-507.e8
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15
Immunity 2019 Mar 19;50(3):600-615.e15
m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response.
Yu R, Li Q, Feng Z, Cai L, Xu Q
International journal of molecular sciences 2019 Mar 15;20(6)
International journal of molecular sciences 2019 Mar 15;20(6)
Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis.
Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W
Oncogene 2019 Jun;38(24):4755-4772
Oncogene 2019 Jun;38(24):4755-4772
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.
Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES
PLoS pathogens 2019 Jun;15(6):e1007796
PLoS pathogens 2019 Jun;15(6):e1007796
m(6)A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR
Nature 2019 Jul;571(7765):424-428
Nature 2019 Jul;571(7765):424-428
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, Peng J, Zhou Y, Jiang S, Peng J
Nucleic acids research 2019 Jul 9;47(12):6130-6144
Nucleic acids research 2019 Jul 9;47(12):6130-6144
Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR
Cell stem cell 2019 Jul 3;25(1):137-148.e6
Cell stem cell 2019 Jul 3;25(1):137-148.e6
A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination.
Wu R, Li A, Sun B, Sun JG, Zhang J, Zhang T, Chen Y, Xiao Y, Gao Y, Zhang Q, Ma J, Yang X, Liao Y, Lai WY, Qi X, Wang S, Shu Y, Wang HL, Wang F, Yang YG, Yuan Z
Cell research 2019 Jan;29(1):23-41
Cell research 2019 Jan;29(1):23-41
Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.
Woo HH, Chambers SK
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):35-46
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):35-46
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W
Nucleic acids research 2019 Jan 10;47(1):362-374
Nucleic acids research 2019 Jan 10;47(1):362-374
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C
Nature 2019 Feb;566(7743):270-274
Nature 2019 Feb;566(7743):270-274
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma.
Zhong L, Liao D, Zhang M, Zeng C, Li X, Zhang R, Ma H, Kang T
Cancer letters 2019 Feb 1;442:252-261
Cancer letters 2019 Feb 1;442:252-261
METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.
Zhang Y, Gu X, Li D, Cai L, Xu Q
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
Modification of N6-methyladenosine RNA methylation on heat shock protein expression.
Yu J, Li Y, Wang T, Zhong X
PloS one 2018;13(6):e0198604
PloS one 2018;13(6):e0198604
m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1.
Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T
Nature 2018 Nov;563(7730):249-253
Nature 2018 Nov;563(7730):249-253
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m(6)A mRNA Methylation.
Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V
Cell reports 2018 Nov 13;25(7):1816-1828.e4
Cell reports 2018 Nov 13;25(7):1816-1828.e4
Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts.
Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO
Nature neuroscience 2018 Jul;21(7):1004-1014
Nature neuroscience 2018 Jul;21(7):1004-1014
Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.
Tan B, Liu H, Zhang S, da Silva SR, Zhang L, Meng J, Cui X, Yuan H, Sorel O, Zhang SW, Huang Y, Gao SJ
Nature microbiology 2018 Jan;3(1):108-120
Nature microbiology 2018 Jan;3(1):108-120
Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels.
Li J, Meng S, Xu M, Wang S, He L, Xu X, Wang X, Xie L
Oncotarget 2018 Jan 9;9(3):3752-3764
Oncotarget 2018 Jan 9;9(3):3752-3764
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Tsai K, Courtney DG, Cullen BR
PLoS pathogens 2018 Feb;14(2):e1006919
PLoS pathogens 2018 Feb;14(2):e1006919
Dynamic m6A modification regulates local translation of mRNA in axons.
Yu J, Chen M, Huang H, Zhu J, Song H, Zhu J, Park J, Ji SJ
Nucleic acids research 2018 Feb 16;46(3):1412-1423
Nucleic acids research 2018 Feb 16;46(3):1412-1423
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.
Chen J, Sun Y, Xu X, Wang D, He J, Zhou H, Lu Y, Zeng J, Du F, Gong A, Xu M
Cell cycle (Georgetown, Tex.) 2017;16(23):2259-2271
Cell cycle (Georgetown, Tex.) 2017;16(23):2259-2271
Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication.
Courtney DG, Kennedy EM, Dumm RE, Bogerd HP, Tsai K, Heaton NS, Cullen BR
Cell host & microbe 2017 Sep 13;22(3):377-386.e5
Cell host & microbe 2017 Sep 13;22(3):377-386.e5
m(6)A Facilitates eIF4F-Independent mRNA Translation.
Coots RA, Liu XM, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB
Molecular cell 2017 Nov 2;68(3):504-514.e7
Molecular cell 2017 Nov 2;68(3):504-514.e7
YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C
Cell research 2017 Mar;27(3):315-328
Cell research 2017 Mar;27(3):315-328
MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein.
Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y, Zhang X
The Journal of biological chemistry 2017 Mar 3;292(9):3614-3623
The Journal of biological chemistry 2017 Mar 3;292(9):3614-3623
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 24744-1-AP( YTHDF2 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The YTHDF2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human YTHDF2. This antibody recognizes human antigen. The YTHDF2 antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
