11081-1-AP

antibody from Proteintech Group

Targeting: UCP2 BMIQ4, SLC25A8

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

11081-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11081-1-AP, RRID:AB_2213793

Product name

UCP2 antibody

Antibody type

Polyclonal

Description

UCP2 antibody (Cat. #11081-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.

Shi L, Li LJ, Sun XY, Chen YY, Luo D, He LP, Ji HJ, Gao WP, Shen HX
Journal of ethnopharmacology 2024 Oct 28;333:118484

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Rasd1 is involved in white matter injury through neuron-oligodendrocyte communication after subarachnoid hemorrhage.

Fu W, Che X, Tan J, Cui S, Ma Y, Xu D, Long H, Yang X, Wen T, He Z
CNS neuroscience & therapeutics 2024 Mar;30(3):e14452

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Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.

Zou R, Wang S, Cai H, Wang Y, Wang C
Cardiovascular therapeutics 2023;2023:2108584

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Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro.

Han J, Wu J, Liu H, Huang Y, Ju W, Xing Y, Zhang X, Yang J
Open life sciences 2023;18(1):20220647

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Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy.

Paar V, Haslinger M, Krombholz-Reindl P, Pittner S, Neuner M, Jirak P, Kolbitsch T, Minnich B, Schrödl F, Kaser-Eichberger A, Kopp K, Koller A, Steinwender C, Lichtenauer M, Monticelli FC, Seitelberger R, Hoppe UC, Dinges C, Motloch LJ
Frontiers in pharmacology 2023;14:1264216

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Astragaloside IV-mediated inhibition of oxidative stress by upregulation of ghrelin in type 2 diabetes-induced cognitive impairment.

Zhang RH, Cao SS, Shi Y, Wang X, Shi LL, Zhang YH, Han CJ, Wang B, Feng L, Liu JP
Naunyn-Schmiedeberg's archives of pharmacology 2023 Oct;396(10):2637-2650

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Transgenic mice producing the trans 10, cis 12-conjugated linoleic acid present reduced adiposity and increased thermogenesis and fibroblast growth factor 21 (FGF21).

Rao Y, Li SL, Li MJ, Wang BZ, Wang YY, Liang LW, Yu S, Liu ZP, Cui S, Gou KM
The Journal of nutritional biochemistry 2023 Oct;120:109419

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A very high-carbohydrate diet differentially affects whole-body glucose tolerance and hepatic insulin resistance in rats.

Karasawa T, Koike A, Terada S
Nutrition (Burbank, Los Angeles County, Calif.) 2023 Oct;114:112113

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Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK/PGC1α Pathway.

Gong M, Jia J
Molecular neurobiology 2023 Nov;60(11):6598-6612

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5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.

Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703

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Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system.

Yoon H, Park SG, Kim HJ, Shin HR, Kim KT, Cho YD, Moon JI, Park MS, Kim WJ, Ryoo HM
Experimental & molecular medicine 2023 Jul;55(7):1531-1543

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Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy.

Chen W, Xu Z, You W, Zhou Y, Wang L, Huang Y, Shan T
BMC biology 2023 Feb 8;21(1):27

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Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.

Li P, Dai S, Gao X, Li W
Journal of physiology and biochemistry 2023 Aug;79(3):569-582

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Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.

Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288

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The effects of gut microbiota colonizing on the porcine hypothalamus revealed by whole transcriptome analysis.

Qi R, Wang J, Sun J, Qiu X, Liu X, Wang Q, Yang F, Ge L, Liu Z
Frontiers in microbiology 2022;13:970470

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Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.

Wu H, Lu C, Li X, Xu X, Wu S
Annals of translational medicine 2022 Nov;10(22):1241

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The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis.

Samad F, Bai H, Baik N, Haider P, Zhang Y, Rega-Kaun G, Kaun C, Prager M, Wojta J, Bui Q, Chakrabarty S, Wang J, Parmer RJ, Miles LA
Journal of thrombosis and haemostasis : JTH 2022 Mar;20(3):742-754

---

Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch During Brain Development.

Wang W, Su L, Wang Y, Li C, Ji F, Jiao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jun;9(18):e2105208

---

High glucose induces apoptosis, glycogen accumulation and suppresses protein synthesis in muscle cells of olive flounder Paralichthys olivaceus.

Liu J, Pan M, Huang D, Wu J, Liu Y, Guo Y, Zhang W, Mai K
The British journal of nutrition 2022 Jun 14;127(11):1601-1612

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Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder.

Gao L, Zhang Y, Liu J, Li X, Sang Y, Zhou G, Xue J, Jing L, Shi Z, Wei J, Lu X, Zhou X
Ecotoxicology and environmental safety 2022 Jun 1;237:113534

---

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca(2+) release from the ER.

Inoue R, Tsuno T, Togashi Y, Okuyama T, Sato A, Nishiyama K, Kyohara M, Li J, Fukushima S, Kin T, Miyashita D, Shiba Y, Atobe Y, Kiyonari H, Bando K, Shapiro AMJ, Funakoshi K, Kulkarni RN, Terauchi Y, Shirakawa J
iScience 2022 Jul 15;25(7):104603

---

Mito-Q promotes porcine oocytes maturation by maintaining mitochondrial thermogenesis via UCP2 downregulation.

Zhou D, Zhuan Q, Luo Y, Liu H, Meng L, Du X, Wu G, Hou Y, Li J, Fu X
Theriogenology 2022 Jul 15;187:205-214

---

Levosimendan protects from sepsis-inducing cardiac dysfunction by suppressing inflammation, oxidative stress and regulating cardiac mitophagy via the PINK-1-Parkin pathway in mice.

Shi J, Chen Y, Zhi H, An H, Hu Z
Annals of translational medicine 2022 Feb;10(4):212

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Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns.

Liu X, Li D, Liu Z, Song Y, Zhang B, Zang Y, Zhang W, Niu Y, Shen C
Burns : journal of the International Society for Burn Injuries 2022 Dec;48(8):1922-1932

---

Multidrug resistance genes screening of pancreatic ductal adenocarcinoma based on sensitivity profile to chemotherapeutic drugs.

Zhao B, Qin C, Li Z, Wang Y, Li T, Cao H, Yang X, Li T, Wang W
Cancer cell international 2022 Dec 1;22(1):374

---

ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway.

Sun C, Liu M, Liu J, Zhang T, Zhang L, Li H, Luo Z
Neuropsychiatric disease and treatment 2021;17:1937-1951

---

Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage.

Tu T, Yin S, Pang J, Zhang X, Zhang L, Zhang Y, Xie Y, Guo K, Chen L, Peng J, Jiang Y
Frontiers in aging neuroscience 2021;13:640215

---

Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.

Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82

---

Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.

Fan G, Li Y, Ma F, Zhao R, Yang X
Endocrine journal 2021 Jan 28;68(1):53-62

---

Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.

Zheng X, Liu D
Life sciences 2021 Jan 15;265:118825

---

Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.

Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542

---

Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.

Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124

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Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.

Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA
EMBO molecular medicine 2020 Oct 7;12(10):e12146

---

Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway.

Hsu YH, Chen YC, Chen YW, Chiu TH, Kuo YT, Chen CH
Metabolism: clinical and experimental 2020 Mar;104:154143

---

Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats.

Busceti CL, Cotugno M, Bianchi F, Forte M, Stanzione R, Marchitti S, Battaglia G, Nicoletti F, Fornai F, Rubattu S
International journal of molecular sciences 2020 Jun 16;21(12)

---

Role and mechanism of FLNa and UCP2 in the development of cervical cancer.

Wang A, Liu L, Yuan M, Han S, You X, Zhang H, Lei F, Zhang Y
Oncology reports 2020 Dec;44(6):2656-2668

---

Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.

Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679

---

Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome.

Zhang H, Ma Y, Cao R, Wang G, Li S, Cao Y, Zhang H, Liu M, Liu G, Zhang J, Li S, Wang Y, Ma Y
Journal of cellular and molecular medicine 2020 Aug;24(15):8849-8861

---

Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes.

Huang J, Peng W, Zheng Y, Hao H, Li S, Yao Y, Ding Y, Zhang J, Lyu J, Zeng Q
Oxidative medicine and cellular longevity 2019;2019:2758262

---

Different impacts on brain function depending on the mode of delivery.

Ikeda K, Onimaru H, Matsuura T, Kawakami K
Brain research 2019 Oct 1;1720:146289

---

Insulin-like growth factor-1 directly mediates expression of mitochondrial uncoupling protein 3 via forkhead box O4.

Watamoto Y, Futawaka K, Hayashi M, Matsushita M, Mitsutani M, Murakami K, Song Z, Koyama R, Fukuda Y, Nushida A, Nezu S, Kuwahara A, Kataoka K, Tagami T, Moriyama K
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2019 Jun-Aug;46-47:24-35

---

G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.

Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL, Yu J
Behavioural brain research 2019 Feb 1;359:845-852

---

IGF-1 regulate the expression of uncoupling protein 2 via FOXO1.

Watamoto Y, Futawaka K, Hayashi M, Matsushita M, Mitsutani M, Song Z, Koyama R, Fukuda Y, Nushida A, Nezu S, Kuwahara A, Kataoka K, Tagami T, Moriyama K
Growth factors (Chur, Switzerland) 2019 Dec;37(5-6):247-256

---

Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.

Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C
Journal of translational medicine 2019 Dec 17;17(1):422

---

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.

Zhong H, Liu M, Ji Y, Ma M, Chen K, Liang T, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897

---

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC
Scientific reports 2018 Sep 18;8(1):14013

---

mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924

---

Insulin alleviates mitochondrial oxidative stress involving upregulation of superoxide dismutase 2 and uncoupling protein 2 in septic acute kidney injury.

Chen GD, Zhang JL, Chen YT, Zhang JX, Wang T, Zeng QY
Experimental and therapeutic medicine 2018 Apr;15(4):3967-3975

---

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.

Chen K, Xu Z, Liu Y, Wang Z, Li Y, Xu X, Chen C, Xia T, Liao Q, Yao Y, Zeng C, He D, Yang Y, Tan T, Yi J, Zhou J, Zhu H, Ma J, Zeng C
Science translational medicine 2017 Nov 29;9(418)

---

UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex.

Ji F, Shen T, Zou W, Jiao J
Stem cells (Dayton, Ohio) 2017 Jun;35(6):1479-1492

---

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709

---

[Correlation between uncoupling protein 2 expression and myocardial mitochondrial injury in rats with sepsis induced by lipopolysaccharide].

Huang JD, Chen SL, Lyu JJ, Liu C, Zeng QY
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 2016 Feb;18(2):159-64

---

Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.

Chen GG, Yan JB, Wang XM, Zheng MZ, Jiang JP, Zhou XM, Cai B, Shen YL
Molecular medicine reports 2016 Aug;14(2):1857-64

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Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15

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Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.

Xie X, Zhang J, Chen D, Pan H, Wu Z, Ge D, Yang G
Shock (Augusta, Ga.) 2015 May;43(5):490-6

---

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.

Yu SX, Du CT, Chen W, Lei QQ, Li N, Qi S, Zhang XJ, Hu GQ, Deng XM, Han WY, Yang YJ
Scientific reports 2015 Dec 11;5:17935

---

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.

Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
PloS one 2014;9(4):e94930

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PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.

Li P, Guo X, Lei P, Shi S, Luo S, Cheng X
Molecular biology reports 2014 Oct;41(10):6931-7

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Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome.

Liu Y, Jiang H, Xing FQ, Huang WJ, Mao LH, He LY
Endocrine 2013 Jun;43(3):714-23

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Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.

Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F
Cell cycle (Georgetown, Tex.) 2013 Jan 1;12(1):172-82

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Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Liu Y, Jiang H, He LY, Huang WJ, He XY, Xing FQ
Reproduction, fertility, and development 2011;23(4):520-6

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11081-1-AP(UCP2 antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 11081-1-AP(UCP2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The UCP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCP2. This antibody recognizes human,mouse,rat antigen. The UCP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

11081-1-AP.pdf

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