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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Product number
- PP-E5415A-0C-100 - Provider product page
- Provider
- Perseus Proteomics Inc.
- Product name
- Anti mouse AQP4-ECD mouse monoclonal antibody (M1 & M23 isoforms) / E5415A
- Antibody type
- Monoclonal
- Description
- Protein A-purified. Generated by baculovirus display to target the native conformation (ECD) of mouse AQP4. In addition to surface binding, this antibody acts as a potent inducer of endocytosis and NMOSD-like pathology in validated models.
- Reactivity
- Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- E5415A
- Vial size
- 100µL (also 25µL is available)
- Concentration
- 1 mg/mL
- Storage
- 100µL (also 25µL is available)
Submitted references Early neuromyelitis optica antibody-induced molecular changes in aquaporin 4 and associated proteins at astrocyte endfeet in murine brain tissues.
Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats.
The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis.
Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.
Yoshikawa Y, Tomioka M, Abe Y, Yasui M, Nuriya M
Journal of pharmacological sciences 2025 Jul;158(3):212-218
Journal of pharmacological sciences 2025 Jul;158(3):212-218
Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats.
Katsu M, Sekine-Tanaka M, Tanaka M, Horai Y, Akatsuka A, Suga M, Kiyohara K, Fujita T, Sasaki A, Yamashita T
Journal of neuroimmunology 2024 Mar 15;388:578297
Journal of neuroimmunology 2024 Mar 15;388:578297
The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis.
Huang P, Takai Y, Kusano-Arai O, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, Han JY, Aoki M, Hamakubo T, Fujihara K, Yasui M, Abe Y
Biochemistry and biophysics reports 2016 Sep;7:77-83
Biochemistry and biophysics reports 2016 Sep;7:77-83
Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.
Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M
Acta neuropathologica communications 2015 Dec 4;3:82
Acta neuropathologica communications 2015 Dec 4;3:82
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