HPA014784

antibody from Atlas Antibodies

Targeting: AQP4 MIWC

Provider product page for HPA014784

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA014784 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA014784, RRID:AB_1844967
Product name: Anti-AQP4
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human AQP4, Gene description: aquaporin 4, Alternative Gene Names: MIWC, Validated applications: IHC, WB, Uniprot ID: P55087, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.3 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

AQP4 protein structure - HPA014784 shown in red.

Submitted references LRP10 and α-synuclein transmission in Lewy body diseases

Carreras Mascaro A, Grochowska M, Boumeester V, Dits N, Bilgiҫ E, Breedveld G, Vergouw L, de Jong F, van Royen M, Bonifati V, Mandemakers W
Cellular and Molecular Life Sciences 2024;81(1)

An epigenetic barrier sets the timing of human neuronal maturation

Ciceri G, Baggiolini A, Cho H, Kshirsagar M, Benito-Kwiecinski S, Walsh R, Aromolaran K, Gonzalez-Hernandez A, Munguba H, Koo S, Xu N, Sevilla K, Goldstein P, Levitz J, Leslie C, Koche R, Studer L
Nature 2024;626(8000):881-890

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids

Thomas R, Sirois J, Li S, Gestin A, Deyab G, Piscopo V, Lépine P, Mathur M, Chen C, Soubannier V, Goldsmith T, Fawaz L, Durcan T, Fon E
iScience 2024;27(9):110613

A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity

Clayton B, Kristell J, Allan K, Cohn E, Karl M, Jerome A, Garrison E, Maeno-Hikichi Y, Sturno A, Kerr A, Shick H, Sepeda J, Freundt E, Sas A, Segal B, Miller R, Tesar P
Nature Neuroscience 2024;27(4):656-665

Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids

Govaerts J, Van Breedam E, De Beuckeleer S, Goethals C, D’Incal C, Di Stefano J, Van Calster S, Buyle-Huybrecht T, Boeren M, De Reu H, Paludan S, Thiry M, Lebrun M, Sadzot-Delvaux C, Motaln H, Rogelj B, Van Weyenbergh J, De Vos W, Vanden Berghe W, Ogunjimi B, Delputte P, Ponsaerts P
Frontiers in Immunology 2024;15

Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma

De A, Lattier J, Morales J, Kelly J, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse J, Lang F, McCarty J
The Journal of Neuroscience 2023;43(47):8043-8057

Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood–Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation

Tapp Z, Ren C, Palmer K, Kumar J, Atluri R, Fitzgerald J, Velasquez J, Godbout J, Sheridan J, Kokiko-Cochran O
Neurotrauma Reports 2023;4(1):613-626

Direct association with the vascular basement membrane is a frequent feature of myelinating oligodendrocytes in the neocortex

Palhol J, Balia M, Sánchez-Román Terán F, Labarchède M, Gontier E, Battefeld A
Fluids and Barriers of the CNS 2023;20(1)

Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels

Khan S, Lokman N, Oehler M, Ricciardelli C, Yool A
Cancers 2023;15(18):4507

Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis

Ben-Nejma I, Keliris A, Vanreusel V, Ponsaerts P, Van der Linden A, Keliris G
Alzheimer's Research & Therapy 2023;15(1)

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Domingo-Muelas A, Duart-Abadia P, Morante-Redolat J, Jordán-Pla A, Belenguer G, Fabra-Beser J, Paniagua-Herranz L, Pérez-Villalba A, Álvarez-Varela A, Barriga F, Gil-Sanz C, Ortega F, Batlle E, Fariñas I
Nature Communications 2023;14(1)

Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models

Vasciaveo V, Iadarola A, Casile A, Dante D, Morello G, Minotta L, Tamagno E, Cicolin A, Guglielmotto M
Acta Neuropathologica Communications 2023;11(1)

Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.

Kameyama T, Miyata M, Shiotani H, Adachi J, Kakuta S, Uchiyama Y, Mizutani K, Takai Y
iScience 2023 Oct 20;26(10):108010

Kushwaha R, Li Y, Makarava N, Pandit N, Molesworth K, Birukov K, Baskakov I
2023

MS‐Driven Metabolic Alterations Are Recapitulated in iPSC‐Derived Astrocytes

Ghirotto B, Oliveira D, Cipelli M, Basso P, de Lima J, Breda C, Ribeiro H, Silva C, Sertié A, Oliveira A, Hiyane M, Caldini E, Sussulini A, Nakaya H, Kowaltowski A, Oliveira E, Zatz M, Câmara N
Annals of Neurology 2022;91(5):652-669

Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia

Xu T, Li X, Guo Y, Uhlin E, Holmberg L, Mitra S, Winn D, Falk A, Sundström E
eBioMedicine 2022;77

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection

Henao‐Restrepo J, López‐Murillo C, Valderrama‐Carmona P, Orozco‐Santa N, Gomez J, Gutiérrez‐Vargas J, Moraga R, Toledo J, Littau J, Härtel S, Arboleda‐Velásquez J, Sepulveda‐Falla D, Lopera F, Cardona‐Gómez G, Villegas A, Posada‐Duque R
Brain Pathology 2022;33(2)

Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

Littau J, Velilla L, Hase Y, Villalba‐Moreno N, Hagel C, Drexler D, Osorio Restrepo S, Villegas A, Lopera F, Vargas S, Glatzel M, Krasemann S, Quiroz Y, Arboleda‐Velasquez J, Kalaria R, Sepulveda‐Falla D
Brain Pathology 2022;32(6)

Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain

Rayaprolu S, Bitarafan S, Santiago J, Betarbet R, Sunna S, Cheng L, Xiao H, Nelson R, Kumar P, Bagchi P, Duong D, Goettemoeller A, Oláh V, Rowan M, Levey A, Wood L, Seyfried N, Rangaraju S
Nature Communications 2022;13(1)

An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms

Pandit K, Petrescu J, Cuevas M, Stephenson W, Smibert P, Phatnani H, Maniatis S
Scientific Reports 2022;12(1)

Thiocyanate Reduces Motor Impairment in the hMPO-A53T PD Mouse Model While Reducing MPO-Oxidation of Alpha Synuclein in Enlarged LYVE1/AQP4 Positive Periventricular Glymphatic Vessels

Reynolds W, Malle E, Maki R
Antioxidants 2022;11(12):2342

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

Wood J, Chidlow G, Halliday L, Casson R, Selva D, Sun M
Translational Vision Science & Technology 2022;11(11):10

The degree of astrocyte activation is predictive of the incubation time to prion disease

Makarava N, Mychko O, Chang J, Molesworth K, Baskakov I
Acta Neuropathologica Communications 2021;9(1)

Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol J, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka M, Bosch B, Sanchez‐Valle R, Månberg A, Svenningsson P, Nilsson P
Annals of Clinical and Translational Neurology 2021;8(7):1456-1470

A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

Bergström S, Öijerstedt L, Remnestål J, Olofsson J, Ullgren A, Seelaar H, van Swieten J, Synofzik M, Sanchez-Valle R, Moreno F, Finger E, Masellis M, Tartaglia C, Vandenberghe R, Laforce R, Galimberti D, Borroni B, Butler C, Gerhard A, Ducharme S, Rohrer J, Månberg A, Graff C, Nilsson P, Jiskoot L, Rowe J, de Mendonça A, Tagliavini F, Santana I, Le Ber I, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Pasquier F, Jelic V, Andersson C, Afonso S, Almeida M, Anderl-Straub S, Antonell A, Archetti S, Arighi A, Balasa M, Barandiaran M, Bargalló N, Bartha R, Bender B, Benussi A, Benussi L, Bessi V, Binetti G, Black S, Bocchetta M, Borrego-Ecija S, Bras J, Bruffaerts R, Cañada M, Cantoni V, Caroppo P, Cash D, Castelo-Branco M, Convery R, Cope T, Di Fede G, Díez A, Duro D, Fenoglio C, Ferrari C, Ferreira C, Fox N, Freedman M, Fumagalli G, Gabilondo A, Gasparotti R, Gauthier S, Gazzina S, Giaccone G, Gorostidi A, Greaves C, Guerreiro R, Heller C, Hoegen T, Indakoetxea B, Jiskoot L, Karnath H, Keren R, Langheinrich T, Leitão M, Lladó A, Lombardi G, Loosli S, Maruta C, Mead S, Meeter L, Miltenberger G, van Minkelen R, Mitchell S, Moore K, Nacmias B, Nicholas J, Olives J, Ourselin S, Padovani A, Panman J, Papma J, Peakman G, Pievani M, Pijnenburg Y, Polito C, Premi E, Prioni S, Prix C, Rademakers R, Redaelli V, Rittman T, Rogaeva E, Rosa-Neto P, Rossi G, Rosser M, Santiago B, Scarpini E, Schönecker S, Semler E, Shafei R, Shoesmith C, Tábuas-Pereira M, Tainta M, Taipa R, Tang-Wai D, Thomas D, Thompson P, Thonberg H, Timberlake C, Tiraboschi P, Todd E, Van Damme P, Vandenbulcke M, Veldsman M, Verdelho A, Villanua J, Warren J, Wilke C, Woollacott I, Wlasich E, Zetterberg H, Zulaica M
Molecular Neurodegeneration 2021;16(1)

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Rao W, Wang S, Duleba M, Niroula S, Goller K, Xie J, Mahalingam R, Neupane R, Liew A, Vincent M, Okuda K, O’Neal W, Boucher R, Dickey B, Wechsler M, Ibrahim O, Engelhardt J, Mertens T, Wang W, Jyothula S, Crum C, Karmouty-Quintana H, Parekh K, Metersky M, McKeon F, Xian W
Cell 2020;181(4):848-864.e18

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

Early A, Gorman A, Van Eldik L, Bachstetter A, Morganti J
Journal of Neuroinflammation 2020;17(1)

Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis

Paraiso H, Wang X, Kuo P, Furnas D, Scofield B, Chang F, Yen J, Yu I
Frontiers in Cellular Neuroscience 2020;14

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick J, Wang M, Kalpana K, Rose I, Burstein S, Rusielewicz T, Nijsure M, Guttenplan K, di Domenico A, Croft G, Zhang B, Nobuta H, Hébert J, Liddelow S, Fossati V
Neuron 2020;107(3):436-453.e12

Protocol for Cloning Epithelial Stem Cell Variants from Human Lung.

Rao W, Niroula S, Wang S, Vincent M, McKeon F, Xian W
STAR protocols 2020 Sep 18;1(2)

Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke

Howe M, Furr J, Munshi Y, Roy-O’Reilly M, Maniskas M, Koellhoffer E, d’Aigle J, Sansing L, McCullough L, Urayama A
GeroScience 2019;41(5):543-559

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

Diéguez-Hurtado R, Kato K, Giaimo B, Nieminen-Kelhä M, Arf H, Ferrante F, Bartkuhn M, Zimmermann T, Bixel M, Eilken H, Adams S, Borggrefe T, Vajkoczy P, Adams R
Nature Communications 2019;10(1)

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas

Rosenberg S, Simeonova I, Bielle F, Verreault M, Bance B, Le Roux I, Daniau M, Nadaradjane A, Gleize V, Paris S, Marie Y, Giry M, Polivka M, Figarella-Branger D, Aubriot-Lorton M, Villa C, Vasiljevic A, Lechapt-Zalcman E, Kalamarides M, Sharif A, Mokhtari K, Pagnotta S, Iavarone A, Lasorella A, Huillard E, Sanson M
Nature Communications 2018;9(1)

Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood–Brain Barrier Disruption after Ischemic Stroke

Li F, Geng X, Yip J, Ding Y
Cell Transplantation 2018;28(2):145-156

Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity

Eroglu C, Cerrato V, Parmigiani E, Figueres-Oñate M, Betizeau M, Aprato J, Nanavaty I, Berchialla P, Luzzati F, de’Sperati C, López-Mascaraque L, Buffo A
PLOS Biology 2018;16(9):e2005513

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow S, Guttenplan K, Clarke L, Bennett F, Bohlen C, Schirmer L, Bennett M, Münch A, Chung W, Peterson T, Wilton D, Frouin A, Napier B, Panicker N, Kumar M, Buckwalter M, Rowitch D, Dawson V, Dawson T, Stevens B, Barres B
Nature 2017;541(7638):481-487

A role for ErbB signaling in the induction of reactive astrogliosis

Chen J, He W, Hu X, Shen Y, Cao J, Wei Z, Luan Y, He L, Jiang F, Tao Y
Cell Discovery 2017;3(1)

Changes in Cannabinoid Receptors, Aquaporin 4 and Vimentin Expression after Traumatic Brain Injury in Adolescent Male Mice. Association with Edema and Neurological Deficit

Dehghani F, Lopez-Rodriguez A, Acaz-Fonseca E, Viveros M, Garcia-Segura L
PLOS ONE 2015;10(6):e0128782

Changes in Cannabinoid Receptors, Aquaporin 4 and Vimentin Expression after Traumatic Brain Injury in Adolescent Male Mice. Association with Edema and Neurological Deficit

Lopez-Rodriguez A, Acaz-Fonseca E, Viveros M, Garcia-Segura L, Dehghani F
PLOS ONE 2015 June;10(6)

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord

Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen C
Journal of Comparative Neurology 2014;522(12):2707-2728

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human cerebral cortex and liver tissues using HPA014784 antibody. Corresponding AQP4 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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