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- Antibody Data
- Antigen structure
- References [146]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10906-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10906-1-AP, RRID:AB_2147453
- Product name
- Myosin Light Chain 2/MLC-2V antibody
- Antibody type
- Polyclonal
- Description
- Myosin Light Chain 2/MLC-2V antibody (Cat. #10906-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, zebrafish and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation.
High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias.
Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.
E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells.
Cardiotoxicity assessment using 3D vascularized cardiac tissue consisting of human iPSC-derived cardiomyocytes and fibroblasts.
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment.
Generation of Functional Cardiomyocytes from Human Gastric Fibroblast-Derived Induced Pluripotent Stem Cells.
Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform.
Modeling Hypoxic Stress In Vitro Using Human Embryonic Stem Cells Derived Cardiomyocytes Matured by FGF4 and Ascorbic Acid Treatment.
LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.
Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation.
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction.
Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism.
Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.
Chamber-Specific Protein Expression during Direct Cardiac Reprogramming.
Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells.
Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart.
Therapeutic Hypothermia Mitigates the Sepsis-Increased Permeability in EA. hy926 Cells by Preserving Rap1 Expression.
The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats.
Derivation of iPSC lines from two patients with autism spectrum disorder carrying NRXN1α deletion (NUIGi041-A, NUIG041-B; NUIGi045-A) and one sibling control (NUIGi042-A, NUIGi042-B).
Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.
Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.
3D Microwell Platform for Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.
Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes.
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
Intrinsic Color Sensing System Allows for Real-Time Observable Functional Changes on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Generation of Ventricular-Like HiPSC-Derived Cardiomyocytes and High-Quality Cell Preparations for Calcium Handling Characterization.
Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis.
β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance.
Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice.
Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.
Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias.
Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes.
A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.
Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity.
Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy.
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.
Rare non-coding Desmoglein-2 variant contributes to Arrhythmogenic right ventricular cardiomyopathy.
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.
The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes.
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds.
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.
Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming.
Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.
Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells.
Generation of MLC-2v-tdTomato knock-in reporter mouse line.
Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.
Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes.
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Embryos and embryonic stem cells from the white rhinoceros.
Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells.
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.
Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue.
Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.
Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.
Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift.
Phenotypically silent Cre recombination within the postnatal ventricular conduction system.
Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes.
hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen.
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue.
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research.
Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes.
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.
Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.
Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency.
Nanopillar Surface Topology Promotes Cardiomyocyte Differentiation through Cofilin-Mediated Cytoskeleton Rearrangement.
Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.
Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Development of a human cardiac organoid injury model reveals innate regenerative potential.
Differentiation of cardiomyocytes and generation of human engineered heart tissue.
Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes.
Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.
Purification of small molecule-induced cardiomyocytes from human induced pluripotent stem cells using a reporter system.
Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation.
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.
Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.
Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers.
Simultaneous imaging of local calcium and single sarcomere length in rat neonatal cardiomyocytes using yellow Cameleon-Nano140.
In vivo myosin step-size from zebrafish skeletal muscle.
Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Human Engineered Heart Tissue: Analysis of Contractile Force.
Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.
Human Cardiomyocytes Prior to Birth by Integration-Free Reprogramming of Amniotic Fluid Cells.
Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells.
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.
Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells.
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome.
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.
Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway.
In vitro and in vivo single myosin step-sizes in striated muscle.
Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.
Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes.
Rho-associated protein kinases play an important role in the differentiation of rat adipose-derived stromal cells into cardiomyocytes in vitro.
Induced pluripotent stem cells from human placental chorion for perinatal tissue engineering applications.
Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes.
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Chemically defined generation of human cardiomyocytes.
Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF.
Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.
Effect of exogenous Oct4 overexpression on cardiomyocyte differentiation of human amniotic mesenchymal cells.
Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes.
Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes.
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions.
Establishment and characterization of immortalized human amniotic epithelial cells.
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets.
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method.
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers.
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.
Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals.
Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2.
Functional cardiomyocytes derived from human induced pluripotent stem cells.
Wang Y, Jiang T, Xu J, Gu Y, Zhou Y, Lin Y, Wu Y, Li W, Wang C, Shen B, Mo X, Wang X, Zhou B, Ding C, Hu Z
Frontiers in cell and developmental biology 2021;9:623394
Frontiers in cell and developmental biology 2021;9:623394
High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias.
Honda Y, Li J, Hino A, Tsujimoto S, Lee JK
Frontiers in pharmacology 2021;12:680618
Frontiers in pharmacology 2021;12:680618
Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.
Tan SH, Loo SJ, Gao Y, Tao ZH, Su LP, Wang CX, Zhang SL, Mu YH, Cui YH, Abdurrachim D, Wang WH, Lalic J, Lim KC, Bu J, Tan RS, Lee TH, Zhang J, Ye L
Theranostics 2021;11(16):7879-7895
Theranostics 2021;11(16):7879-7895
E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells.
Li X, Gao F, Wang X, Liang Q, Bai A, Liu Z, Chen X, Li E, Chen S, Lu C, Qian R, Sun N, Liang P, Xu C
EBioMedicine 2021 Sep;71:103575
EBioMedicine 2021 Sep;71:103575
Cardiotoxicity assessment using 3D vascularized cardiac tissue consisting of human iPSC-derived cardiomyocytes and fibroblasts.
Tadano K, Miyagawa S, Takeda M, Tsukamoto Y, Kazusa K, Takamatsu K, Akashi M, Sawa Y
Molecular therapy. Methods & clinical development 2021 Sep 10;22:338-349
Molecular therapy. Methods & clinical development 2021 Sep 10;22:338-349
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.
Lu J, Xu S, Huo Y, Sun D, Hu Y, Wang J, Zhang X, Wang P, Li Z, Liang M, Wu Z, Liu P
Cell death and differentiation 2021 Oct;28(10):2871-2887
Cell death and differentiation 2021 Oct;28(10):2871-2887
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment.
Soepriatna AH, Kim TY, Daley MC, Song E, Choi BR, Coulombe KLK
Cellular and molecular bioengineering 2021 Oct;14(5):441-457
Cellular and molecular bioengineering 2021 Oct;14(5):441-457
Generation of Functional Cardiomyocytes from Human Gastric Fibroblast-Derived Induced Pluripotent Stem Cells.
Wu CH, Lin HH, Wu YY, Chiu YL, Huang LY, Cheng CC, Yang CC, Tsai TN
Biomedicines 2021 Oct 29;9(11)
Biomedicines 2021 Oct 29;9(11)
Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform.
Tsan YC, DePalma SJ, Zhao YT, Capilnasiu A, Wu YW, Elder B, Panse I, Ufford K, Matera DL, Friedline S, O'Leary TS, Wubshet N, Ho KKY, Previs MJ, Nordsletten D, Isom LL, Baker BM, Liu AP, Helms AS
Nature communications 2021 Oct 25;12(1):6167
Nature communications 2021 Oct 25;12(1):6167
Modeling Hypoxic Stress In Vitro Using Human Embryonic Stem Cells Derived Cardiomyocytes Matured by FGF4 and Ascorbic Acid Treatment.
Choi SC, Seo HR, Cui LH, Song MH, Noh JM, Kim KS, Choi JH, Kim JH, Park CY, Joo HJ, Hong SJ, Ko TH, Choi JI, Kim HJ, Kim JH, Paek SH, Park JN, Kim DH, Jang Y, Park Y, Lim DS
Cells 2021 Oct 14;10(10)
Cells 2021 Oct 14;10(10)
LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.
Song MH, Choi SC, Noh JM, Joo HJ, Park CY, Cha JJ, Ahn TH, Ko TH, Choi JI, Na JE, Rhyu IJ, Jang Y, Park Y, Gim JA, Kim JH, Lim DS
Biomaterials 2021 Nov;278:121133
Biomaterials 2021 Nov;278:121133
Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Gong Y, Yang L, Tang J, Zheng J, Witman N, Jakob P, Tan Y, Liu M, Chen Y, Wang H, Fu W, Wang W
Cardiovascular toxicology 2021 Nov 24;
Cardiovascular toxicology 2021 Nov 24;
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation.
Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao ZA, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L
Cell research 2021 May;31(5):526-541
Cell research 2021 May;31(5):526-541
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R
Cell stem cell 2021 May 6;28(5):938-954.e9
Cell stem cell 2021 May 6;28(5):938-954.e9
Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction.
Tao Z, Loo S, Su L, Tan S, Tee G, Gan SU, Zhang J, Chen X, Ye L
Cardiovascular research 2021 May 25;117(6):1578-1591
Cardiovascular research 2021 May 25;117(6):1578-1591
Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism.
Yang L, Gong Y, Tan Y, Wu L, Witman N, Zheng J, Zhang J, Fu W, Wang W
Annals of translational medicine 2021 Mar;9(5):399
Annals of translational medicine 2021 Mar;9(5):399
Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.
Rozier R, Paul R, Madji Hounoum B, Villa E, Mhaidly R, Chiche J, Verhoeyen E, Marchetti S, Vandenberghe A, Raucoules M, Carles M, Ricci JE
The FEBS journal 2021 Jun;288(11):3547-3569
The FEBS journal 2021 Jun;288(11):3547-3569
Chamber-Specific Protein Expression during Direct Cardiac Reprogramming.
Zhang Z, Villalpando J, Zhang W, Nam YJ
Cells 2021 Jun 16;10(6)
Cells 2021 Jun 16;10(6)
Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells.
Takashima S, Usui S, Inoue O, Goten C, Yamaguchi K, Takeda Y, Cui S, Sakai Y, Hayashi K, Sakata K, Kawashiri MA, Takamura M
Scientific reports 2021 Jan 15;11(1):1520
Scientific reports 2021 Jan 15;11(1):1520
Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart.
Guan G, Huo D, Li Y, Zhao X, Li Y, Qin Z, Sun D, Yang G, Yang M, Tan J, Zeng W, Zhu C
Bioactive materials 2021 Dec;6(12):4415-4429
Bioactive materials 2021 Dec;6(12):4415-4429
Therapeutic Hypothermia Mitigates the Sepsis-Increased Permeability in EA. hy926 Cells by Preserving Rap1 Expression.
Shen Y, Ding W
Therapeutic hypothermia and temperature management 2021 Dec;11(4):201-207
Therapeutic hypothermia and temperature management 2021 Dec;11(4):201-207
The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats.
Chang S, Cao Y
Brain research 2021 Dec 15;1773:147684
Brain research 2021 Dec 15;1773:147684
Derivation of iPSC lines from two patients with autism spectrum disorder carrying NRXN1α deletion (NUIGi041-A, NUIG041-B; NUIGi045-A) and one sibling control (NUIGi042-A, NUIGi042-B).
Ding Y, O'Brien A, de la Cruz BM, Yang M, Fitzgerald J, Yang G, Li W, McInerney V, Krawczyk J, Lynch SA, Howard L, Allen NM, O'Brien T, Gallagher L, Shen S
Stem cell research 2021 Apr;52:102222
Stem cell research 2021 Apr;52:102222
Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.
Fukushima H, Yoshioka M, Kawatou M, López-Dávila V, Takeda M, Kanda Y, Sekino Y, Yoshida Y, Yamashita JK
PloS one 2020;15(11):e0241287
PloS one 2020;15(11):e0241287
Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.
Lam YY, Keung W, Chan CH, Geng L, Wong N, Brenière-Letuffe D, Li RA, Cheung YF
Journal of the American Heart Association 2020 Oct 20;9(20):e016528
Journal of the American Heart Association 2020 Oct 20;9(20):e016528
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.
Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R
eLife 2020 Oct 2;9
eLife 2020 Oct 2;9
3D Microwell Platform for Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.
Branco MA, Dias TP, Cotovio JP, Rodrigues CAV, Fernandes TG, Cabral JMS, Diogo MM
Methods in molecular biology (Clifton, N.J.) 2020 Nov 4;
Methods in molecular biology (Clifton, N.J.) 2020 Nov 4;
Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.
Li C, Liu F, Liu S, Pan H, Du H, Huang J, Xie Y, Li Y, Zhao R, Wei Y
EBioMedicine 2020 Mar;53:102695
EBioMedicine 2020 Mar;53:102695
Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes.
Kleinsorge M, Cyganek L
STAR protocols 2020 Jun 19;1(1):100026
STAR protocols 2020 Jun 19;1(1):100026
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
Zhou W, Liu Y, Gao Y, Cheng Y, Chang R, Li X, Zhou Y, Wang S, Liang L, Duan C, Zhang C
Cancer letters 2020 Jul 28;483:75-86
Cancer letters 2020 Jul 28;483:75-86
Intrinsic Color Sensing System Allows for Real-Time Observable Functional Changes on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Gong Y, Chen Z, Yang L, Ai X, Yan B, Wang H, Qiu L, Tan Y, Witman N, Wang W, Zhao Y, Fu W
ACS nano 2020 Jul 28;14(7):8232-8246
ACS nano 2020 Jul 28;14(7):8232-8246
Generation of Ventricular-Like HiPSC-Derived Cardiomyocytes and High-Quality Cell Preparations for Calcium Handling Characterization.
Oh JG, Dave J, Kho C, Stillitano F
Journal of visualized experiments : JoVE 2020 Jan 17;(155)
Journal of visualized experiments : JoVE 2020 Jan 17;(155)
Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system.
Kolanowski TJ, Busek M, Schubert M, Dmitrieva A, Binnewerg B, Pöche J, Fisher K, Schmieder F, Grünzner S, Hansen S, Richter A, El-Armouche A, Sonntag F, Guan K
Acta biomaterialia 2020 Jan 15;102:273-286
Acta biomaterialia 2020 Jan 15;102:273-286
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis.
Sun H, Zhao A, Li M, Dong H, Sun Y, Zhang X, Zhu Q, Bukhari AA, Cao C, Su D, Liu Y, Liang X
Cell death & disease 2020 Feb 24;11(2):146
Cell death & disease 2020 Feb 24;11(2):146
β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance.
Liu Y, Wu J, Chen L, Wu X, Gan Y, Xu N, Li M, Luo H, Guan F, Su Z, Chen J, Li Y
Biochemical pharmacology 2020 Dec;182:114260
Biochemical pharmacology 2020 Dec;182:114260
Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice.
Cheng Y, Wu T, Tang S, Liang F, Fang Y, Cao W, Pan S, Xu X
Food & function 2020 Apr 1;11(4):3167-3179
Food & function 2020 Apr 1;11(4):3167-3179
Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.
Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, Li B, Hu X, Zhang Z, Ruan Y
Oxidative medicine and cellular longevity 2019;2019:7064319
Oxidative medicine and cellular longevity 2019;2019:7064319
Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias.
Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S, Hidaka K, Miyagawa S, Sawa Y, Komuro I, Sakata Y
Frontiers in physiology 2019;10:818
Frontiers in physiology 2019;10:818
Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes.
Horikoshi Y, Yan Y, Terashvili M, Wells C, Horikoshi H, Fujita S, Bosnjak ZJ, Bai X
Cells 2019 Sep 17;8(9)
Cells 2019 Sep 17;8(9)
A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.
El-Battrawy I, Albers S, Cyganek L, Zhao Z, Lan H, Li X, Xu Q, Kleinsorge M, Huang M, Liao Z, Zhong R, Rudic B, Müller J, Dinkel H, Lang S, Diecke S, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X, Akin I
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2019 Sep 1;21(9):1410-1421
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2019 Sep 1;21(9):1410-1421
Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity.
Atmanli A, Hu D, Deiman FE, van de Vrugt AM, Cherbonneau F, Black LD 3rd, Domian IJ
eLife 2019 Oct 8;8
eLife 2019 Oct 8;8
Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy.
Nagai-Okatani C, Nishigori M, Sato T, Minamino N, Kaji H, Kuno A
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1749-1765
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1749-1765
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK
Cell systems 2019 May 22;8(5):412-426.e7
Cell systems 2019 May 22;8(5):412-426.e7
Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.
Fernandez-Perez A, Sathe AA, Bhakta M, Leggett K, Xing C, Munshi NV
Cell reports 2019 May 21;27(8):2354-2369.e7
Cell reports 2019 May 21;27(8):2354-2369.e7
Rare non-coding Desmoglein-2 variant contributes to Arrhythmogenic right ventricular cardiomyopathy.
Christensen AH, Andersen CB, Wassilew K, Svendsen JH, Bundgaard H, Brand SM, Schmitz B
Journal of molecular and cellular cardiology 2019 Jun;131:164-170
Journal of molecular and cellular cardiology 2019 Jun;131:164-170
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.
Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, Ding M, Andersson H, Polla M, Elliott DA, Drowley L, Clausen M, Plowright AT, Barrett IP, Wang QD, James DE, Porrello ER, Hudson JE
Cell stem cell 2019 Jun 6;24(6):895-907.e6
Cell stem cell 2019 Jun 6;24(6):895-907.e6
The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J
Toxicology letters 2019 Jun 1;307:26-40
Toxicology letters 2019 Jun 1;307:26-40
Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes.
Tang L, Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J, Wang L, Liang P
Journal of molecular and cellular cardiology 2019 Jan;126:143-154
Journal of molecular and cellular cardiology 2019 Jan;126:143-154
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, Li B, Wang Z
Bioscience reports 2019 Jan 31;39(1)
Bioscience reports 2019 Jan 31;39(1)
Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.
Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV
Scientific reports 2019 Feb 14;9(1):2106
Scientific reports 2019 Feb 14;9(1):2106
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.
Birket MJ, Raibaud S, Lettieri M, Adamson AD, Letang V, Cervello P, Redon N, Ret G, Viale S, Wang B, Biton B, Guillemot JC, Mikol V, Leonard JP, Hanley NA, Orsini C, Itier JM
Stem cell reports 2019 Aug 13;13(2):380-393
Stem cell reports 2019 Aug 13;13(2):380-393
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L
EMBO reports 2019 Apr;20(4)
EMBO reports 2019 Apr;20(4)
Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds.
Yang H, Wei L, Liu C, Zhong W, Li B, Chen Y, Han R, Zhuang J, Qu J, Tao H, Chen H, Xu C, Liang Q, Lu C, Qian R, Chen S, Wang W, Sun N
Acta biomaterialia 2019 Apr 1;88:540-553
Acta biomaterialia 2019 Apr 1;88:540-553
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35
Biomaterials 2018 Sep;178:23-35
Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.
Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I
International heart journal 2018 Sep 26;59(5):1096-1105
International heart journal 2018 Sep 26;59(5):1096-1105
Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming.
Gaignerie A, Lefort N, Rousselle M, Forest-Choquet V, Flippe L, Francois-Campion V, Girardeau A, Caillaud A, Chariau C, Francheteau Q, Derevier A, Chaubron F, Knöbel S, Gaborit N, Si-Tayeb K, David L
Scientific reports 2018 Sep 25;8(1):14363
Scientific reports 2018 Sep 25;8(1):14363
Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.
Geng L, Kong CW, Wong AOT, Shum AM, Chow MZY, Che H, Zhang C, Yau KL, Chan CW, Keung W, Li RA
Toxicology letters 2018 Sep 15;294:61-72
Toxicology letters 2018 Sep 15;294:61-72
Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells.
Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM
Stem cell reports 2018 Sep 11;11(3):828-841
Stem cell reports 2018 Sep 11;11(3):828-841
Generation of MLC-2v-tdTomato knock-in reporter mouse line.
Zhang Z, Nam YJ
Genesis (New York, N.Y. : 2000) 2018 Oct;56(10):e23256
Genesis (New York, N.Y. : 2000) 2018 Oct;56(10):e23256
Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.
Ju X, Xue D, Wang T, Ge B, Zhang Y, Li Z
Cardiovascular toxicology 2018 Oct;18(5):471-481
Cardiovascular toxicology 2018 Oct;18(5):471-481
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.
Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C, Concordet JP
Nature communications 2018 Mar 19;9(1):1133
Nature communications 2018 Mar 19;9(1):1133
Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes.
Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, Henze S, Stauske M, Salinas G, Zimmermann WH, Hasenfuss G, Guan K
JCI insight 2018 Jun 21;3(12)
JCI insight 2018 Jun 21;3(12)
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Jul 5;26(7):1644-1659
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Jul 5;26(7):1644-1659
Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt TB, Hermes R, Colleoni S, Diecke S, Holtze S, Renfree MB, Stejskal J, Hayashi K, Drukker M, Loi P, Göritz F, Lazzari G, Galli C
Nature communications 2018 Jul 4;9(1):2589
Nature communications 2018 Jul 4;9(1):2589
Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells.
Takeda M, Miyagawa S, Fukushima S, Saito A, Ito E, Harada A, Matsuura R, Iseoka H, Sougawa N, Mochizuki-Oda N, Matsusaki M, Akashi M, Sawa Y
Tissue engineering. Part C, Methods 2018 Jan;24(1):56-67
Tissue engineering. Part C, Methods 2018 Jan;24(1):56-67
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, Seebohm G, Greber B
Nature communications 2018 Jan 30;9(1):440
Nature communications 2018 Jan 30;9(1):440
High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.
Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ
Scientific reports 2018 Jan 19;8(1):1258
Scientific reports 2018 Jan 19;8(1):1258
Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue.
Iseoka H, Miyagawa S, Fukushima S, Saito A, Masuda S, Yajima S, Ito E, Sougawa N, Takeda M, Harada A, Lee JK, Sawa Y
Tissue engineering. Part A 2018 Feb;24(3-4):287-300
Tissue engineering. Part A 2018 Feb;24(3-4):287-300
Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.
Lin Y, Liu H, Klein M, Ostrominski J, Hong SG, Yada RC, Chen G, Navarengom K, Schwartzbeck R, San H, Yu ZX, Liu C, Linask K, Beers J, Qiu L, Dunbar CE, Boehm M, Zou J
Scientific reports 2018 Apr 12;8(1):5907
Scientific reports 2018 Apr 12;8(1):5907
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.
Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA
Nature communications 2018 Apr 10;9(1):1373
Nature communications 2018 Apr 10;9(1):1373
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M
Frontiers in physiology 2017;8:766
Frontiers in physiology 2017;8:766
Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.
Marczenke M, Piccini I, Mengarelli I, Fell J, Röpke A, Seebohm G, Verkerk AO, Greber B
Frontiers in physiology 2017;8:469
Frontiers in physiology 2017;8:469
Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.
Wang Y, Wang SQ, Wang LP, Yao YH, Ma CY, Ding JF, Ye J, Meng XM, Li JJ, Xu RX
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(1):381-398
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(1):381-398
Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift.
Burghardt TP, Sun X, Wang Y, Ajtai K
PloS one 2017;12(4):e0174690
PloS one 2017;12(4):e0174690
Phenotypically silent Cre recombination within the postnatal ventricular conduction system.
Bhattacharyya S, Bhakta M, Munshi NV
PloS one 2017;12(3):e0174517
PloS one 2017;12(3):e0174517
Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes.
Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N
Stem cell research & therapy 2017 Sep 29;8(1):202
Stem cell research & therapy 2017 Sep 29;8(1):202
hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen.
da Rocha AM, Campbell K, Mironov S, Jiang J, Mundada L, Guerrero-Serna G, Jalife J, Herron TJ
Scientific reports 2017 Oct 23;7(1):13834
Scientific reports 2017 Oct 23;7(1):13834
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue.
Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK
Nature communications 2017 Oct 20;8(1):1078
Nature communications 2017 Oct 20;8(1):1078
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research.
Kroll K, Chabria M, Wang K, Häusermann F, Schuler F, Polonchuk L
Progress in biophysics and molecular biology 2017 Nov;130(Pt B):212-222
Progress in biophysics and molecular biology 2017 Nov;130(Pt B):212-222
Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes.
Tohyama S, Fujita J, Fujita C, Yamaguchi M, Kanaami S, Ohno R, Sakamoto K, Kodama M, Kurokawa J, Kanazawa H, Seki T, Kishino Y, Okada M, Nakajima K, Tanosaki S, Someya S, Hirano A, Kawaguchi S, Kobayashi E, Fukuda K
Stem cell reports 2017 Nov 14;9(5):1406-1414
Stem cell reports 2017 Nov 14;9(5):1406-1414
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.
Vestergaard ML, Grubb S, Koefoed K, Anderson-Jenkins Z, Grunnet-Lauridsen K, Calloe K, Clausen C, Christensen ST, Møllgård K, Andersen CY
Stem cells and development 2017 Nov 1;26(21):1566-1577
Stem cells and development 2017 Nov 1;26(21):1566-1577
Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.
Marczenke M, Fell J, Piccini I, Röpke A, Seebohm G, Greber B
Stem cell research 2017 May;21:26-28
Stem cell research 2017 May;21:26-28
Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.
Lalit PA, Rodriguez AM, Downs KM, Kamp TJ
Nature protocols 2017 May;12(5):1029-1054
Nature protocols 2017 May;12(5):1029-1054
Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency.
Crombie DE, Curl CL, Raaijmakers AJ, Sivakumaran P, Kulkarni T, Wong RC, Minami I, Evans-Galea MV, Lim SY, Delbridge L, Corben LA, Dottori M, Nakatsuji N, Trounce IA, Hewitt AW, Delatycki MB, Pera MF, Pébay A
Aging 2017 May 30;9(5):1440-1452
Aging 2017 May 30;9(5):1440-1452
Nanopillar Surface Topology Promotes Cardiomyocyte Differentiation through Cofilin-Mediated Cytoskeleton Rearrangement.
Seo HR, Joo HJ, Kim DH, Cui LH, Choi SC, Kim JH, Cho SW, Lee KB, Lim DS
ACS applied materials & interfaces 2017 May 24;9(20):16803-16812
ACS applied materials & interfaces 2017 May 24;9(20):16803-16812
Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, Yang C, Dong H, Ma Y
Stem cell research 2017 Mar;19:94-103
Stem cell research 2017 Mar;19:94-103
Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.
Gao Y, Wang Z, Hao Q, Li W, Xu Y, Zhang J, Zhang W, Wang S, Liu S, Li M, Xue X, Zhang W, Zhang C, Zhang Y
Nature communications 2017 Mar 7;8:14483
Nature communications 2017 Mar 7;8:14483
Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.
Fernandez-Perez A, Munshi NV
Journal of visualized experiments : JoVE 2017 Mar 22;(121)
Journal of visualized experiments : JoVE 2017 Mar 22;(121)
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798
Scientific reports 2017 Mar 2;7:43798
Development of a human cardiac organoid injury model reveals innate regenerative potential.
Voges HK, Mills RJ, Elliott DA, Parton RG, Porrello ER, Hudson JE
Development (Cambridge, England) 2017 Mar 15;144(6):1118-1127
Development (Cambridge, England) 2017 Mar 15;144(6):1118-1127
Differentiation of cardiomyocytes and generation of human engineered heart tissue.
Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A
Nature protocols 2017 Jun;12(6):1177-1197
Nature protocols 2017 Jun;12(6):1177-1197
Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes.
Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G
Stem cells translational medicine 2017 Feb;6(2):527-538
Stem cells translational medicine 2017 Feb;6(2):527-538
Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.
Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC
Nature communications 2017 Feb 14;8:14428
Nature communications 2017 Feb 14;8:14428
Purification of small molecule-induced cardiomyocytes from human induced pluripotent stem cells using a reporter system.
Hwang GH, Park SM, Han HJ, Kim JS, Yun SP, Ryu JM, Lee HJ, Chang W, Lee SJ, Choi JH, Choi JS, Lee MY
Journal of cellular physiology 2017 Dec;232(12):3384-3395
Journal of cellular physiology 2017 Dec;232(12):3384-3395
Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation.
Cao Q, Shen Y, Liu X, Yu X, Yuan P, Wan R, Liu X, Peng X, He W, Pu J, Hong K
International heart journal 2017 Dec 12;58(6):939-947
International heart journal 2017 Dec 12;58(6):939-947
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.
Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C
Journal of molecular and cellular cardiology 2017 Aug;109:48-56
Journal of molecular and cellular cardiology 2017 Aug;109:48-56
Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.
Zhang X, Cao H, Bai S, Huo W, Ma Y
Stem cell research 2017 Apr;20:21-29
Stem cell research 2017 Apr;20:21-29
Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers.
Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y
Stem cells international 2016;2016:2634013
Stem cells international 2016;2016:2634013
Simultaneous imaging of local calcium and single sarcomere length in rat neonatal cardiomyocytes using yellow Cameleon-Nano140.
Tsukamoto S, Fujii T, Oyama K, Shintani SA, Shimozawa T, Kobirumaki-Shimozawa F, Ishiwata S, Fukuda N
The Journal of general physiology 2016 Oct;148(4):341-55
The Journal of general physiology 2016 Oct;148(4):341-55
In vivo myosin step-size from zebrafish skeletal muscle.
Burghardt TP, Ajtai K, Sun X, Takubo N, Wang Y
Open biology 2016 May;6(5)
Open biology 2016 May;6(5)
Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S
Cell stem cell 2016 Mar 3;18(3):368-81
Cell stem cell 2016 Mar 3;18(3):368-81
Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.
Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ
Cell stem cell 2016 Mar 3;18(3):354-67
Cell stem cell 2016 Mar 3;18(3):354-67
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S
Science (New York, N.Y.) 2016 Jun 3;352(6290):1216-20
Science (New York, N.Y.) 2016 Jun 3;352(6290):1216-20
Human Engineered Heart Tissue: Analysis of Contractile Force.
Mannhardt I, Breckwoldt K, Letuffe-Brenière D, Schaaf S, Schulz H, Neuber C, Benzin A, Werner T, Eder A, Schulze T, Klampe B, Christ T, Hirt MN, Huebner N, Moretti A, Eschenhagen T, Hansen A
Stem cell reports 2016 Jul 12;7(1):29-42
Stem cell reports 2016 Jul 12;7(1):29-42
Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.
Passer D, van de Vrugt A, Atmanli A, Domian IJ
Cell reports 2016 Feb 23;14(7):1662-1672
Cell reports 2016 Feb 23;14(7):1662-1672
Human Cardiomyocytes Prior to Birth by Integration-Free Reprogramming of Amniotic Fluid Cells.
Jiang G, Herron TJ, Di Bernardo J, Walker KA, O'Shea KS, Kunisaki SM
Stem cells translational medicine 2016 Dec;5(12):1595-1606
Stem cells translational medicine 2016 Dec;5(12):1595-1606
Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC
Tissue engineering. Part A 2016 Aug;22(15-16):1016-25
Tissue engineering. Part A 2016 Aug;22(15-16):1016-25
MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells.
Zeng Y, Zhang X, Kang K, Chen J, Wu Z, Huang J, Lu W, Chen Y, Zhang J, Wang Z, Zhai Y, Qu J, Ramchandran R, Raj JU, Wang J, Gou D
Scientific reports 2016 Apr 28;6:24900
Scientific reports 2016 Apr 28;6:24900
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.
Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K
Cell metabolism 2016 Apr 12;23(4):663-74
Cell metabolism 2016 Apr 12;23(4):663-74
Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H
PloS one 2015;10(9):e0138193
PloS one 2015;10(9):e0138193
Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells.
Fuerstenau-Sharp M, Zimmermann ME, Stark K, Jentsch N, Klingenstein M, Drzymalski M, Wagner S, Maier LS, Hehr U, Baessler A, Fischer M, Hengstenberg C
PloS one 2015;10(5):e0126596
PloS one 2015;10(5):e0126596
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K
Nature communications 2015 Sep 10;6:8243
Nature communications 2015 Sep 10;6:8243
Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome.
Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N
Journal of the American Heart Association 2015 Sep 1;4(9):e002159
Journal of the American Heart Association 2015 Sep 1;4(9):e002159
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.
Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD
Journal of molecular and cellular cardiology 2015 Oct;87:204-13
Journal of molecular and cellular cardiology 2015 Oct;87:204-13
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
Wang Y, Li ZC, Zhang P, Poon E, Kong CW, Boheler KR, Huang Y, Li RA, Yao X
Stem cells (Dayton, Ohio) 2015 Oct;33(10):2973-84
Stem cells (Dayton, Ohio) 2015 Oct;33(10):2973-84
Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.
Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B
Stem cells (Dayton, Ohio) 2015 May;33(5):1456-69
Stem cells (Dayton, Ohio) 2015 May;33(5):1456-69
Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway.
Connell JP, Ruano R, Jacot JG
Biomedical materials (Bristol, England) 2015 Mar 18;10(3):034103
Biomedical materials (Bristol, England) 2015 Mar 18;10(3):034103
In vitro and in vivo single myosin step-sizes in striated muscle.
Burghardt TP, Sun X, Wang Y, Ajtai K
Journal of muscle research and cell motility 2015 Dec;36(6):463-77
Journal of muscle research and cell motility 2015 Dec;36(6):463-77
Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.
Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A
Stem cells (Dayton, Ohio) 2015 Apr;33(4):1113-29
Stem cells (Dayton, Ohio) 2015 Apr;33(4):1113-29
Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes.
Ifkovits JL, Addis RC, Epstein JA, Gearhart JD
PloS one 2014;9(2):e89678
PloS one 2014;9(2):e89678
Rho-associated protein kinases play an important role in the differentiation of rat adipose-derived stromal cells into cardiomyocytes in vitro.
Zhao L, Yang G, Zhao X
PloS one 2014;9(12):e115191
PloS one 2014;9(12):e115191
Induced pluripotent stem cells from human placental chorion for perinatal tissue engineering applications.
Jiang G, Di Bernardo J, DeLong CJ, Monteiro da Rocha A, O'Shea KS, Kunisaki SM
Tissue engineering. Part C, Methods 2014 Sep;20(9):731-40
Tissue engineering. Part C, Methods 2014 Sep;20(9):731-40
Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes.
Tanaka A, Yuasa S, Mearini G, Egashira T, Seki T, Kodaira M, Kusumoto D, Kuroda Y, Okata S, Suzuki T, Inohara T, Arimura T, Makino S, Kimura K, Kimura A, Furukawa T, Carrier L, Node K, Fukuda K
Journal of the American Heart Association 2014 Nov 11;3(6):e001263
Journal of the American Heart Association 2014 Nov 11;3(6):e001263
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Izpisua Belmonte JC
Protein & cell 2014 Jan;5(1):59-68
Protein & cell 2014 Jan;5(1):59-68
Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.
Ye L, Chang YH, Xiong Q, Zhang P, Zhang L, Somasundaram P, Lepley M, Swingen C, Su L, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang J, Kamp TJ, Kaufman DS, Ge Y, Zhang J
Cell stem cell 2014 Dec 4;15(6):750-61
Cell stem cell 2014 Dec 4;15(6):750-61
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5383-92
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5383-92
Chemically defined generation of human cardiomyocytes.
Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC
Nature methods 2014 Aug;11(8):855-60
Nature methods 2014 Aug;11(8):855-60
Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF.
Ye L, Zhang S, Greder L, Dutton J, Keirstead SA, Lepley M, Zhang L, Kaufman D, Zhang J
PloS one 2013;8(1):e53764
PloS one 2013;8(1):e53764
Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.
Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T
Circulation journal : official journal of the Japanese Circulation Society 2013;77(5):1307-14
Circulation journal : official journal of the Japanese Circulation Society 2013;77(5):1307-14
Effect of exogenous Oct4 overexpression on cardiomyocyte differentiation of human amniotic mesenchymal cells.
Nagura S, Otaka S, Koike C, Okabe M, Yoshida T, Fathy M, Fukahara K, Yoshimura N, Misaki T, Nikaido T
Cellular reprogramming 2013 Oct;15(5):471-80
Cellular reprogramming 2013 Oct;15(5):471-80
Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes.
Frampton JP, Shi H, Kao A, Parent JM, Takayama S
Advanced healthcare materials 2013 Nov;2(11):1440-4
Advanced healthcare materials 2013 Nov;2(11):1440-4
Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes.
Bizy A, Guerrero-Serna G, Hu B, Ponce-Balbuena D, Willis BC, Zarzoso M, Ramirez RJ, Sener MF, Mundada LV, Klos M, Devaney EJ, Vikstrom KL, Herron TJ, Jalife J
Stem cell research 2013 Nov;11(3):1335-47
Stem cell research 2013 Nov;11(3):1335-47
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions.
Lian X, Zhang J, Azarin SM, Zhu K, Hazeltine LB, Bao X, Hsiao C, Kamp TJ, Palecek SP
Nature protocols 2013 Jan;8(1):162-75
Nature protocols 2013 Jan;8(1):162-75
Establishment and characterization of immortalized human amniotic epithelial cells.
Zhou K, Koike C, Yoshida T, Okabe M, Fathy M, Kyo S, Kiyono T, Saito S, Nikaido T
Cellular reprogramming 2013 Feb;15(1):55-67
Cellular reprogramming 2013 Feb;15(1):55-67
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.
Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Belmonte JC
Protein & cell 2013 Aug 27;
Protein & cell 2013 Aug 27;
Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets.
Kadota S, Minami I, Morone N, Heuser JE, Agladze K, Nakatsuji N
European heart journal 2013 Apr;34(15):1147-56
European heart journal 2013 Apr;34(15):1147-56
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method.
Zhang J, Klos M, Wilson GF, Herman AM, Lian X, Raval KK, Barron MR, Hou L, Soerens AG, Yu J, Palecek SP, Lyons GE, Thomson JA, Herron TJ, Jalife J, Kamp TJ
Circulation research 2012 Oct 12;111(9):1125-36
Circulation research 2012 Oct 12;111(9):1125-36
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N
Cell reports 2012 Nov 29;2(5):1448-60
Cell reports 2012 Nov 29;2(5):1448-60
Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.
Koka S, Xi L, Kukreja RC
Basic research in cardiology 2012 Mar;107(2):249
Basic research in cardiology 2012 Mar;107(2):249
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers.
Lee P, Klos M, Bollensdorff C, Hou L, Ewart P, Kamp TJ, Zhang J, Bizy A, Guerrero-Serna G, Kohl P, Jalife J, Herron TJ
Circulation research 2012 Jun 8;110(12):1556-63
Circulation research 2012 Jun 8;110(12):1556-63
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, Raval KK, Zhang J, Kamp TJ, Palecek SP
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 3;109(27):E1848-57
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 3;109(27):E1848-57
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.
Xi L, Zhu SG, Hobbs DC, Kukreja RC
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24
Journal of cellular and molecular medicine 2011 Nov;15(11):2512-24
Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals.
Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y
Cell research 2011 Apr;21(4):579-87
Cell research 2011 Apr;21(4):579-87
Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2.
Xu Y, Wang H, Zhou J, Lei Y, Zhou Y, Yang Q, Ye D, Li W, Deng F
Biochimie 2010 Dec;92(12):1812-7
Biochimie 2010 Dec;92(12):1812-7
Functional cardiomyocytes derived from human induced pluripotent stem cells.
Zhang J, Wilson GF, Soerens AG, Koonce CH, Yu J, Palecek SP, Thomson JA, Kamp TJ
Circulation research 2009 Feb 27;104(4):e30-41
Circulation research 2009 Feb 27;104(4):e30-41
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 10906-1-AP(MYL2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MYL2 (IP:10906-1-AP, 3ug; Detection:10906-1-AP 1:500) with mouse heart tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skin cancer using 10906-1-AP(MYL2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Myosin Light Chain 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Myosin Light Chain 2. This antibody recognizes human,mouse,rat,zebrafish antigen. The Myosin Light Chain 2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
