10906-1-AP

antibody from Proteintech Group

Targeting: MYL2 CMH10

Provider product page for 10906-1-AP

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ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [199]
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Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 10906-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10906-1-AP, RRID:AB_2147453
Product name: Myosin Light Chain 2/MLC-2V antibody
Antibody type: Polyclonal
Description: Myosin Light Chain 2/MLC-2V antibody (Cat. #10906-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, zebrafish and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Zebrafish
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MYL2 protein structure - 10906-1-AP shown in red.

Submitted references Optical redox imaging to screen synthetic hydrogels for stem cell-derived cardiomyocyte differentiation and maturation.

Desa DE, Amitrano MJ, Murphy WL, Skala MC
Biophotonics discovery 2024 May;1(1)

Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy.

Wang R, Hasegawa M, Suginobe H, Yoshihara C, Ishii Y, Ueyama A, Ueda K, Hashimoto K, Hirose M, Ishii R, Narita J, Watanabe T, Kawamura T, Taira M, Ueno T, Miyagawa S, Ishida H
Journal of the American Heart Association 2024 Mar 19;13(6):e032375

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM.

Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW
American journal of physiology. Heart and circulatory physiology 2024 Mar 1;326(3):H599-H611

Multi-omic approaches provide insights into the molecular mechanisms of Sojae semen germinatum water extract against overactive bladder.

Cheng M, Qiang Y, Wu Y, Tong X, Tie Y, Sun Z, Guan S, Xu L, Xu P, Li X, Xue M, Zhou X
Food research international (Ottawa, Ont.) 2024 Jan;175:113746

Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats.

Tie Y, Sun Z, Tong X, Cheng M, Wu Y, Shi Z, Xu P, Xue M, Xu L, Zhou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155154

Multi-omics approaches revealed the therapeutic mechanisms of Suo-Quan-Wan for treating overactive bladder in spontaneously hypertensive rats.

Sun Z, Tie Y, Tong X, Cheng M, Wu Y, Xu P, Xue M, Xu L, Zhou X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117066

HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells.

Guo H, Hang C, Lin B, Lin Z, Xiong H, Zhang M, Lu R, Liu J, Shi D, Xie D, Liu Y, Liang D, Yang J, Chen YH
Stem cell research & therapy 2024 Feb 5;15(1):31

CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.

Nakanishi-Koakutsu M, Miki K, Naka Y, Sasaki M, Wakimizu T, Napier SC, Okubo C, Narita M, Nishikawa M, Hata R, Chonabayashi K, Hotta A, Imahashi K, Nishimoto T, Yoshida Y
Communications biology 2024 Feb 28;7(1):231

Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy.

Hu S, Meng K, Wang T, Qu R, Wang B, Xi Y, Yu T, Yuan Z, Cai Z, Tian Y, Zeng C, Wang X, Zou W, Fu X, Li L
Biomarker research 2024 Apr 19;12(1):40

Ascorbic acid induces MLC2v protein expression and promotes ventricular-like cardiomyocyte subtype in human induced pluripotent stem cells derived cardiomyocytes.

Gao Y, Su L, Wei Y, Tan S, Hu Z, Tao Z, Kovalik JP, Soong TW, Zhang J, Pu J, Ye L
Theranostics 2023;13(11):3872-3896

Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models.

Rawat H, Kornherr J, Zawada D, Bakhshiyeva S, Kupatt C, Laugwitz KL, Bähr A, Dorn T, Moretti A, Nowak-Imialek M
Frontiers in cell and developmental biology 2023;11:1111684

Chlorogenic Acid Ameliorates Post-Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes.

Zheng C, Zhong Y, Zhang W, Wang Z, Xiao H, Zhang W, Xie J, Peng X, Luo J, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(28):e2302798

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues.

DePalma SJ, Jillberto J, Stis AE, Huang DD, Lo J, Davidson CD, Chowdhury A, Jewett ME, Kobeissi H, Chen CS, Lejeune E, Helms AS, Nordsletten DA, Baker BM
bioRxiv : the preprint server for biology 2023 Oct 23;

Using Ribonucleoprotein-based CRISPR/Cas9 to Edit Single Nucleotide on Human Induced Pluripotent Stem Cells to Model Type 3 Long QT Syndrome (SCN5A(±)).

Ge N, Liu M, Li R, Allen NM, Galvin J, Shen S, O'Brien T, Prendiville TW
Stem cell reviews and reports 2023 Nov;19(8):2774-2789

ZC3H4 governs epithelial cell migration through ROCK/p-PYK2/p-MLC2 pathway in silica-induced pulmonary fibrosis.

Jiang R, Zhou Y, Gao Q, Han L, Hong Z
Environmental toxicology and pharmacology 2023 Nov;104:104301

Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.

Lingli C, Hongmei N, Penghuan J, Hongli Z, Yuye L, Rui W, Fei R, Zhihong Y, Dongfang H, Yaming G
Ecotoxicology and environmental safety 2023 Nov 1;266:115554

Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.

Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, Klaiman JM, Blakely LP, Karbassi E, Fields PA, Fenix AM, Beussman KM, Jayabalu A, Kalucki FA, Potter JC, Futakuchi-Tsuchida A, Weber GJ, Dupras S, Tsuchida H, Pabon L, Wang L, Knollmann BC, Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A, Murry CE
Cell stem cell 2023 May 4;30(5):741

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.

Reilly L, Semenza ER, Koshkaryan G, Mishra S, Chatterjee S, Abramson E, Mishra P, Sei Y, Wank SA, Donowitz M, Snyder SH, Guha P
iScience 2023 May 19;26(5):106623

Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V.

Busley AV, Cyganek L
Stem cell research 2023 Jun;69:103108

Establishment of a protocol to administer immunosuppressive drugs for iPS cell-derived cardiomyocyte patch transplantation in a rat myocardial infarction model.

Ito E, Kawamura A, Kawamura T, Takeda M, Harada A, Mochizuki-Oda N, Sawa Y, Miyagawa S
Scientific reports 2023 Jun 29;13(1):10530

Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.

Zou J, Wang W, Lu Y, Ayala J, Dong K, Zhou H, Wang J, Chen W, Weintraub NL, Zhou J, Li J, Su H
Cell reports 2023 Jan 31;42(1):112018

Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.

Song J, Xu R, Zhang H, Xue X, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Gastroenterology 2023 Dec;165(6):1505-1521.e20

The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain.

Sun YH, Kao HKJ, Thai PN, Smithers R, Chang CW, Pretto D, Yechikov S, Oppenheimer S, Bedolla A, Chalker BA, Ghobashy R, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK
Cell reports 2023 Dec 26;42(12):113505

JAK2 as a surface marker for enrichment of human pluripotent stem cells-derived ventricular cardiomyocytes.

Liew LC, Poh BM, An O, Ho BX, Lim CYY, Pang JKS, Beh LY, Yang HH, Soh BS
Stem cell research & therapy 2023 Dec 13;14(1):367

Single-Cell Analysis of Contractile Forces in iPSC-Derived Cardiomyocytes: Paving the Way for Precision Medicine in Cardiovascular Disease.

Turnbull IC, Bajpai A, Jankowski KB, Gaitas A
International journal of molecular sciences 2023 Aug 30;24(17)

Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.

Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation.

Xie Z, Zhang G, Liu R, Wang Y, Tsapieva AN, Zhang L, Han J
Nutrients 2023 Apr 4;15(7)

Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.

Dark N, Cosson MV, Tsansizi LI, Owen TJ, Ferraro E, Francis AJ, Tsai S, Bouissou C, Weston A, Collinson L, Abi-Gerges N, Miller PE, MacLeod KT, Ehler E, Mitter R, Harding SE, Smith JC, Bernardo AS
Cell reports methods 2023 Apr 24;3(4):100456

Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes.

Tsoi C, Deng R, Kwok M, Yan B, Lee C, Li HS, Ma CHY, Luo R, Leung KT, Chan GC, Chow LM, Poon EN
Frontiers in molecular biosciences 2022;9:714008

3D Microwell Platform for Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.

Branco MA, Dias TP, Cotovio JP, Rodrigues CAV, Fernandes TG, Cabral JMS, Diogo MM
Methods in molecular biology (Clifton, N.J.) 2022;2454:127-143

Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.

Lazzarini E, Lodrini AM, Arici M, Bolis S, Vagni S, Panella S, Rendon-Angel A, Saibene M, Metallo A, Torre T, Vassalli G, Ameri P, Altomare C, Rocchetti M, Barile L
Theranostics 2022;12(11):5237-5257

CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK.

Fu Y, Zhang X, Liang X, Chen Y, Chen Z, Xiao Z
World journal of surgical oncology 2022 Oct 19;20(1):347

The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.

Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y
Nature communications 2022 Oct 13;13(1):6030

Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes.

Hinata Y, Kagawa Y, Kubo H, Kato E, Baba A, Sasaki D, Matsuura K, Sawada K, Shimizu T
Journal of pharmacological and toxicological methods 2022 Nov-Dec;118:107228

Oxycodone relieves permeability damage and apoptosis of oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cells through ras homolog family member A (RhoA)/ Rho-associated coiled-coil containing kinases (ROCK)/ myosin light chain 2 (MLC2) signal.

Shao F, Han D, Shen Y, Bian W, Zou L, Hu Y, Sun W
Bioengineered 2022 Mar;13(3):5205-5215

Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1).

Khosravi F, Ahmadvand N, Wartenberg M, Sauer H
Biology 2022 Mar 30;11(4)

Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes.

Schade D, Drowley L, Wang QD, Plowright AT, Greber B
Bioorganic & medicinal chemistry 2022 Jul 1;65:116782

Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells.

Ng WH, Johnston EK, Tan JJ, Bliley JM, Feinberg AW, Stolz DB, Sun M, Wijesekara P, Hawkins F, Kotton DN, Ren X
eLife 2022 Jan 12;11

MicroRNA-365 regulates human cardiac action potential duration.

Esfandyari D, Idrissou BMG, Hennis K, Avramopoulos P, Dueck A, El-Battrawy I, Grüter L, Meier MA, Näger AC, Ramanujam D, Dorn T, Meitinger T, Hagl C, Milting H, Borggrefe M, Fenske S, Biel M, Dendorfer A, Sassi Y, Moretti A, Engelhardt S
Nature communications 2022 Jan 11;13(1):220

Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Gong Y, Yang L, Tang J, Zheng J, Witman N, Jakob P, Tan Y, Liu M, Chen Y, Wang H, Fu W, Wang W
Cardiovascular toxicology 2022 Feb;22(2):141-151

Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota.

Li X, Xu S, Zhang Y, Li K, Gao XJ, Guo MY
Microbiology spectrum 2022 Dec 21;10(6):e0320722

Cyclic Stretching Induces Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Nuclear-Mechanotransduction.

Song M, Jang Y, Kim SJ, Park Y
Tissue engineering and regenerative medicine 2022 Aug;19(4):781-792

Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions.

Wang J, Gu S, Liu F, Chen Z, Xu H, Liu Z, Cheng W, Wu L, Xu T, Chen Z, Chen D, Chen X, Zeng F, Zhao Z, Zhang M, Cao N
Nature biomedical engineering 2022 Apr;6(4):403-420

Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips.

Huebsch N, Charrez B, Neiman G, Siemons B, Boggess SC, Wall S, Charwat V, Jæger KH, Cleres D, Telle Å, Lee-Montiel FT, Jeffreys NC, Deveshwar N, Edwards AG, Serrano J, Snuderl M, Stahl A, Tveito A, Miller EW, Healy KE
Nature biomedical engineering 2022 Apr;6(4):372-388

Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction.

Kim YS, Yoon JW, Kim D, Choi S, Kim HK, Youm JB, Han J, Heo SC, Hyun SA, Seo JW, Kim DH, Kim JH
Experimental & molecular medicine 2022 Apr;54(4):493-502

Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways.

Song L, Wu T, Zhang L, Wan J, Ruan Z
Food & function 2022 Apr 20;13(8):4562-4575

The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.

Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP
Nature communications 2022 Apr 13;13(1):1991

Mutations in RNA Methyltransferase Gene NSUN5 Confer High Risk of Outflow Tract Malformation.

Wang Y, Jiang T, Xu J, Gu Y, Zhou Y, Lin Y, Wu Y, Li W, Wang C, Shen B, Mo X, Wang X, Zhou B, Ding C, Hu Z
Frontiers in cell and developmental biology 2021;9:623394

High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias.

Honda Y, Li J, Hino A, Tsujimoto S, Lee JK
Frontiers in pharmacology 2021;12:680618

Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.

Tan SH, Loo SJ, Gao Y, Tao ZH, Su LP, Wang CX, Zhang SL, Mu YH, Cui YH, Abdurrachim D, Wang WH, Lalic J, Lim KC, Bu J, Tan RS, Lee TH, Zhang J, Ye L
Theranostics 2021;11(16):7879-7895

E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells.

Li X, Gao F, Wang X, Liang Q, Bai A, Liu Z, Chen X, Li E, Chen S, Lu C, Qian R, Sun N, Liang P, Xu C
EBioMedicine 2021 Sep;71:103575

Cardiotoxicity assessment using 3D vascularized cardiac tissue consisting of human iPSC-derived cardiomyocytes and fibroblasts.

Tadano K, Miyagawa S, Takeda M, Tsukamoto Y, Kazusa K, Takamatsu K, Akashi M, Sawa Y
Molecular therapy. Methods & clinical development 2021 Sep 10;22:338-349

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Lu J, Xu S, Huo Y, Sun D, Hu Y, Wang J, Zhang X, Wang P, Li Z, Liang M, Wu Z, Liu P
Cell death and differentiation 2021 Oct;28(10):2871-2887

Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment.

Soepriatna AH, Kim TY, Daley MC, Song E, Choi BR, Coulombe KLK
Cellular and molecular bioengineering 2021 Oct;14(5):441-457

Generation of Functional Cardiomyocytes from Human Gastric Fibroblast-Derived Induced Pluripotent Stem Cells.

Wu CH, Lin HH, Wu YY, Chiu YL, Huang LY, Cheng CC, Yang CC, Tsai TN
Biomedicines 2021 Oct 29;9(11)

Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform.

Tsan YC, DePalma SJ, Zhao YT, Capilnasiu A, Wu YW, Elder B, Panse I, Ufford K, Matera DL, Friedline S, O'Leary TS, Wubshet N, Ho KKY, Previs MJ, Nordsletten D, Isom LL, Baker BM, Liu AP, Helms AS
Nature communications 2021 Oct 25;12(1):6167

Modeling Hypoxic Stress In Vitro Using Human Embryonic Stem Cells Derived Cardiomyocytes Matured by FGF4 and Ascorbic Acid Treatment.

Choi SC, Seo HR, Cui LH, Song MH, Noh JM, Kim KS, Choi JH, Kim JH, Park CY, Joo HJ, Hong SJ, Ko TH, Choi JI, Kim HJ, Kim JH, Paek SH, Park JN, Kim DH, Jang Y, Park Y, Lim DS
Cells 2021 Oct 14;10(10)

LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.

Song MH, Choi SC, Noh JM, Joo HJ, Park CY, Cha JJ, Ahn TH, Ko TH, Choi JI, Na JE, Rhyu IJ, Jang Y, Park Y, Gim JA, Kim JH, Lim DS
Biomaterials 2021 Nov;278:121133

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation.

Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao ZA, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L
Cell research 2021 May;31(5):526-541

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R
Cell stem cell 2021 May 6;28(5):938-954.e9

Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction.

Tao Z, Loo S, Su L, Tan S, Tee G, Gan SU, Zhang J, Chen X, Ye L
Cardiovascular research 2021 May 25;117(6):1578-1591

Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism.

Yang L, Gong Y, Tan Y, Wu L, Witman N, Zheng J, Zhang J, Fu W, Wang W
Annals of translational medicine 2021 Mar;9(5):399

Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.

Rozier R, Paul R, Madji Hounoum B, Villa E, Mhaidly R, Chiche J, Verhoeyen E, Marchetti S, Vandenberghe A, Raucoules M, Carles M, Ricci JE
The FEBS journal 2021 Jun;288(11):3547-3569

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.

Jang JH, Kim MS, Antao AM, Jo WJ, Kim HJ, Kim SJ, Choi MJ, Ramakrishna S, Kim KS
International journal of molecular sciences 2021 Jun 29;22(13)

Chamber-Specific Protein Expression during Direct Cardiac Reprogramming.

Zhang Z, Villalpando J, Zhang W, Nam YJ
Cells 2021 Jun 16;10(6)

Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells.

Takashima S, Usui S, Inoue O, Goten C, Yamaguchi K, Takeda Y, Cui S, Sakai Y, Hayashi K, Sakata K, Kawashiri MA, Takamura M
Scientific reports 2021 Jan 15;11(1):1520

Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart.

Guan G, Huo D, Li Y, Zhao X, Li Y, Qin Z, Sun D, Yang G, Yang M, Tan J, Zeng W, Zhu C
Bioactive materials 2021 Dec;6(12):4415-4429

Therapeutic Hypothermia Mitigates the Sepsis-Increased Permeability in EA. hy926 Cells by Preserving Rap1 Expression.

Shen Y, Ding W
Therapeutic hypothermia and temperature management 2021 Dec;11(4):201-207

Most myopathic lamin variants aggregate: a functional genomics approach for assessing variants of uncertain significance.

Anderson CL, Langer ER, Routes TC, McWilliams SF, Bereslavskyy I, Kamp TJ, Eckhardt LL
NPJ genomic medicine 2021 Dec 3;6(1):103

The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats.

Chang S, Cao Y
Brain research 2021 Dec 15;1773:147684

Derivation of iPSC lines from two patients with autism spectrum disorder carrying NRXN1α deletion (NUIGi041-A, NUIG041-B; NUIGi045-A) and one sibling control (NUIGi042-A, NUIGi042-B).

Ding Y, O'Brien A, de la Cruz BM, Yang M, Fitzgerald J, Yang G, Li W, McInerney V, Krawczyk J, Lynch SA, Howard L, Allen NM, O'Brien T, Gallagher L, Shen S
Stem cell research 2021 Apr;52:102222

Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.

Fukushima H, Yoshioka M, Kawatou M, López-Dávila V, Takeda M, Kanda Y, Sekino Y, Yoshida Y, Yamashita JK
PloS one 2020;15(11):e0241287

In vitro Differentiation of Human iPSC-derived Cardiovascular Progenitor Cells (iPSC-CVPCs).

D'Antonio-Chronowska A, D'Antonio M, Frazer KA
Bio-protocol 2020 Sep 20;10(18):e3755

Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.

Lam YY, Keung W, Chan CH, Geng L, Wong N, Brenière-Letuffe D, Li RA, Cheung YF
Journal of the American Heart Association 2020 Oct 20;9(20):e016528

Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.

Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R
eLife 2020 Oct 2;9

Multidimensional assembly using layer-by-layer deposition for synchronized cardiac macro tissues.

Jang Y, Jung DJ, Choi SC, Lim DS, Kim JH, Jeoung GS, Kim J, Park Y
RSC advances 2020 May 14;10(32):18806-18815

Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.

Li C, Liu F, Liu S, Pan H, Du H, Huang J, Xie Y, Li Y, Zhao R, Wei Y
EBioMedicine 2020 Mar;53:102695

Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes.

Kleinsorge M, Cyganek L
STAR protocols 2020 Jun 19;1(1):100026

MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.

Zhou W, Liu Y, Gao Y, Cheng Y, Chang R, Li X, Zhou Y, Wang S, Liang L, Duan C, Zhang C
Cancer letters 2020 Jul 28;483:75-86

Intrinsic Color Sensing System Allows for Real-Time Observable Functional Changes on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Gong Y, Chen Z, Yang L, Ai X, Yan B, Wang H, Qiu L, Tan Y, Witman N, Wang W, Zhao Y, Fu W
ACS nano 2020 Jul 28;14(7):8232-8246

Modulating cardiomyocyte and fibroblast interaction using layer-by-layer deposition facilitates synchronisation of cardiac macro tissues.

Jang Y, Choi SC, Lim DS, Kim JH, Kim J, Park Y
Soft matter 2020 Jan 2;16(2):428-434

Generation of Ventricular-Like HiPSC-Derived Cardiomyocytes and High-Quality Cell Preparations for Calcium Handling Characterization.

Oh JG, Dave J, Kho C, Stillitano F
Journal of visualized experiments : JoVE 2020 Jan 17;(155)

Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system.

Kolanowski TJ, Busek M, Schubert M, Dmitrieva A, Binnewerg B, Pöche J, Fisher K, Schmieder F, Grünzner S, Hansen S, Richter A, El-Armouche A, Sonntag F, Guan K
Acta biomaterialia 2020 Jan 15;102:273-286

Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.

Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856

Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis.

Sun H, Zhao A, Li M, Dong H, Sun Y, Zhang X, Zhu Q, Bukhari AA, Cao C, Su D, Liu Y, Liang X
Cell death & disease 2020 Feb 24;11(2):146

β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance.

Liu Y, Wu J, Chen L, Wu X, Gan Y, Xu N, Li M, Luo H, Guan F, Su Z, Chen J, Li Y
Biochemical pharmacology 2020 Dec;182:114260

Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice.

Cheng Y, Wu T, Tang S, Liang F, Fang Y, Cao W, Pan S, Xu X
Food & function 2020 Apr 1;11(4):3167-3179

Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.

Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, Li B, Hu X, Zhang Z, Ruan Y
Oxidative medicine and cellular longevity 2019;2019:7064319

Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias.

Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S, Hidaka K, Miyagawa S, Sawa Y, Komuro I, Sakata Y
Frontiers in physiology 2019;10:818

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes.

Horikoshi Y, Yan Y, Terashvili M, Wells C, Horikoshi H, Fujita S, Bosnjak ZJ, Bai X
Cells 2019 Sep 17;8(9)

A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.

El-Battrawy I, Albers S, Cyganek L, Zhao Z, Lan H, Li X, Xu Q, Kleinsorge M, Huang M, Liao Z, Zhong R, Rudic B, Müller J, Dinkel H, Lang S, Diecke S, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X, Akin I
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2019 Sep 1;21(9):1410-1421

Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity.

Atmanli A, Hu D, Deiman FE, van de Vrugt AM, Cherbonneau F, Black LD 3rd, Domian IJ
eLife 2019 Oct 8;8

Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy.

Nagai-Okatani C, Nishigori M, Sato T, Minamino N, Kaji H, Kuno A
Laboratory investigation; a journal of technical methods and pathology 2019 Nov;99(11):1749-1765

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.

Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK
Cell systems 2019 May 22;8(5):412-426.e7

Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.

Fernandez-Perez A, Sathe AA, Bhakta M, Leggett K, Xing C, Munshi NV
Cell reports 2019 May 21;27(8):2354-2369.e7

Rare non-coding Desmoglein-2 variant contributes to Arrhythmogenic right ventricular cardiomyopathy.

Christensen AH, Andersen CB, Wassilew K, Svendsen JH, Bundgaard H, Brand SM, Schmitz B
Journal of molecular and cellular cardiology 2019 Jun;131:164-170

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.

Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, Ding M, Andersson H, Polla M, Elliott DA, Drowley L, Clausen M, Plowright AT, Barrett IP, Wang QD, James DE, Porrello ER, Hudson JE
Cell stem cell 2019 Jun 6;24(6):895-907.e6

The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.

Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J
Toxicology letters 2019 Jun 1;307:26-40

Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes.

Tang L, Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J, Wang L, Liang P
Journal of molecular and cellular cardiology 2019 Jan;126:143-154

The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.

Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, Li B, Wang Z
Bioscience reports 2019 Jan 31;39(1)

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.

Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV
Scientific reports 2019 Feb 14;9(1):2106

A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.

Birket MJ, Raibaud S, Lettieri M, Adamson AD, Letang V, Cervello P, Redon N, Ret G, Viale S, Wang B, Biton B, Guillemot JC, Mikol V, Leonard JP, Hanley NA, Orsini C, Itier JM
Stem cell reports 2019 Aug 13;13(2):380-393

Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.

Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L
EMBO reports 2019 Apr;20(4)

Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds.

Yang H, Wei L, Liu C, Zhong W, Li B, Chen Y, Han R, Zhuang J, Qu J, Tao H, Chen H, Xu C, Liang Q, Lu C, Qian R, Chen S, Wang W, Sun N
Acta biomaterialia 2019 Apr 1;88:540-553

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35

Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.

Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I
International heart journal 2018 Sep 26;59(5):1096-1105

Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming.

Gaignerie A, Lefort N, Rousselle M, Forest-Choquet V, Flippe L, Francois-Campion V, Girardeau A, Caillaud A, Chariau C, Francheteau Q, Derevier A, Chaubron F, Knöbel S, Gaborit N, Si-Tayeb K, David L
Scientific reports 2018 Sep 25;8(1):14363

Probing flecainide block of I(Na) using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.

Geng L, Kong CW, Wong AOT, Shum AM, Chow MZY, Che H, Zhang C, Yau KL, Chan CW, Keung W, Li RA
Toxicology letters 2018 Sep 15;294:61-72

Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells.

Veevers J, Farah EN, Corselli M, Witty AD, Palomares K, Vidal JG, Emre N, Carson CT, Ouyang K, Liu C, van Vliet P, Zhu M, Hegarty JM, Deacon DC, Grinstein JD, Dirschinger RJ, Frazer KA, Adler ED, Knowlton KU, Chi NC, Martin JC, Chen J, Evans SM
Stem cell reports 2018 Sep 11;11(3):828-841

Generation of MLC-2v-tdTomato knock-in reporter mouse line.

Zhang Z, Nam YJ
Genesis (New York, N.Y. : 2000) 2018 Oct;56(10):e23256

Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.

Ju X, Xue D, Wang T, Ge B, Zhang Y, Li Z
Cardiovascular toxicology 2018 Oct;18(5):471-481

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair.

Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C, Concordet JP
Nature communications 2018 Mar 19;9(1):1133

Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes.

Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, Henze S, Stauske M, Salinas G, Zimmermann WH, Hasenfuss G, Guan K
JCI insight 2018 Jun 21;3(12)

Human ISL1(+) Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Jul 5;26(7):1644-1659

Embryos and embryonic stem cells from the white rhinoceros.

Hildebrandt TB, Hermes R, Colleoni S, Diecke S, Holtze S, Renfree MB, Stejskal J, Hayashi K, Drukker M, Loi P, Göritz F, Lazzari G, Galli C
Nature communications 2018 Jul 4;9(1):2589

Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells.

Takeda M, Miyagawa S, Fukushima S, Saito A, Ito E, Harada A, Matsuura R, Iseoka H, Sougawa N, Mochizuki-Oda N, Matsusaki M, Akashi M, Sawa Y
Tissue engineering. Part C, Methods 2018 Jan;24(1):56-67

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.

Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, Seebohm G, Greber B
Nature communications 2018 Jan 30;9(1):440

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ
Scientific reports 2018 Jan 19;8(1):1258

Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue.

Iseoka H, Miyagawa S, Fukushima S, Saito A, Masuda S, Yajima S, Ito E, Sougawa N, Takeda M, Harada A, Lee JK, Sawa Y
Tissue engineering. Part A 2018 Feb;24(3-4):287-300

Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice.

Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin AV, Zhang J
American journal of physiology. Heart and circulatory physiology 2018 Aug 1;315(2):H327-H339

Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.

Lin Y, Liu H, Klein M, Ostrominski J, Hong SG, Yada RC, Chen G, Navarengom K, Schwartzbeck R, San H, Yu ZX, Liu C, Linask K, Beers J, Qiu L, Dunbar CE, Boehm M, Zou J
Scientific reports 2018 Apr 12;8(1):5907

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA
Nature communications 2018 Apr 10;9(1):1373

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.

McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M
Frontiers in physiology 2017;8:766

Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.

Marczenke M, Piccini I, Mengarelli I, Fell J, Röpke A, Seebohm G, Verkerk AO, Greber B
Frontiers in physiology 2017;8:469

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.

Wang Y, Wang SQ, Wang LP, Yao YH, Ma CY, Ding JF, Ye J, Meng XM, Li JJ, Xu RX
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(1):381-398

Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift.

Burghardt TP, Sun X, Wang Y, Ajtai K
PloS one 2017;12(4):e0174690

Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

Bhattacharyya S, Bhakta M, Munshi NV
PloS one 2017;12(3):e0174517

Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N
Stem cell research & therapy 2017 Sep 29;8(1):202

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE
Proceedings of the National Academy of Sciences of the United States of America 2017 Oct 3;114(40):E8372-E8381

hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen.

da Rocha AM, Campbell K, Mironov S, Jiang J, Mundada L, Guerrero-Serna G, Jalife J, Herron TJ
Scientific reports 2017 Oct 23;7(1):13834

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue.

Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK
Nature communications 2017 Oct 20;8(1):1078

Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research.

Kroll K, Chabria M, Wang K, Häusermann F, Schuler F, Polonchuk L
Progress in biophysics and molecular biology 2017 Nov;130(Pt B):212-222

Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes.

Tohyama S, Fujita J, Fujita C, Yamaguchi M, Kanaami S, Ohno R, Sakamoto K, Kodama M, Kurokawa J, Kanazawa H, Seki T, Kishino Y, Okada M, Nakajima K, Tanosaki S, Someya S, Hirano A, Kawaguchi S, Kobayashi E, Fukuda K
Stem cell reports 2017 Nov 14;9(5):1406-1414

Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.

Vestergaard ML, Grubb S, Koefoed K, Anderson-Jenkins Z, Grunnet-Lauridsen K, Calloe K, Clausen C, Christensen ST, Møllgård K, Andersen CY
Stem cells and development 2017 Nov 1;26(21):1566-1577

Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.

Marczenke M, Fell J, Piccini I, Röpke A, Seebohm G, Greber B
Stem cell research 2017 May;21:26-28

Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.

Lalit PA, Rodriguez AM, Downs KM, Kamp TJ
Nature protocols 2017 May;12(5):1029-1054

Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency.

Crombie DE, Curl CL, Raaijmakers AJ, Sivakumaran P, Kulkarni T, Wong RC, Minami I, Evans-Galea MV, Lim SY, Delbridge L, Corben LA, Dottori M, Nakatsuji N, Trounce IA, Hewitt AW, Delatycki MB, Pera MF, Pébay A
Aging 2017 May 30;9(5):1440-1452

Nanopillar Surface Topology Promotes Cardiomyocyte Differentiation through Cofilin-Mediated Cytoskeleton Rearrangement.

Seo HR, Joo HJ, Kim DH, Cui LH, Choi SC, Kim JH, Cho SW, Lee KB, Lim DS
ACS applied materials & interfaces 2017 May 24;9(20):16803-16812

Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.

Pei F, Jiang J, Bai S, Cao H, Tian L, Zhao Y, Yang C, Dong H, Ma Y
Stem cell research 2017 Mar;19:94-103

Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.

Gao Y, Wang Z, Hao Q, Li W, Xu Y, Zhang J, Zhang W, Wang S, Liu S, Li M, Xue X, Zhang W, Zhang C, Zhang Y
Nature communications 2017 Mar 7;8:14483

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.

Fernandez-Perez A, Munshi NV
Journal of visualized experiments : JoVE 2017 Mar 22;(121)

Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.

Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798

Development of a human cardiac organoid injury model reveals innate regenerative potential.

Voges HK, Mills RJ, Elliott DA, Parton RG, Porrello ER, Hudson JE
Development (Cambridge, England) 2017 Mar 15;144(6):1118-1127

Differentiation of cardiomyocytes and generation of human engineered heart tissue.

Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A
Nature protocols 2017 Jun;12(6):1177-1197

Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes.

Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G
Stem cells translational medicine 2017 Feb;6(2):527-538

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC
Nature communications 2017 Feb 14;8:14428

Purification of small molecule-induced cardiomyocytes from human induced pluripotent stem cells using a reporter system.

Hwang GH, Park SM, Han HJ, Kim JS, Yun SP, Ryu JM, Lee HJ, Chang W, Lee SJ, Choi JH, Choi JS, Lee MY
Journal of cellular physiology 2017 Dec;232(12):3384-3395

Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation.

Cao Q, Shen Y, Liu X, Yu X, Yuan P, Wan R, Liu X, Peng X, He W, Pu J, Hong K
International heart journal 2017 Dec 12;58(6):939-947

Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.

Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C
Journal of molecular and cellular cardiology 2017 Aug;109:48-56

Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.

Zhang X, Cao H, Bai S, Huo W, Ma Y
Stem cell research 2017 Apr;20:21-29

Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes.

Hashimoto A, Naito AT, Lee JK, Kitazume-Taneike R, Ito M, Yamaguchi T, Nakata R, Sumida T, Okada K, Nakagawa A, Higo T, Kuramoto Y, Sakai T, Tominaga K, Okinaga T, Kogaki S, Ozono K, Miyagawa S, Sawa Y, Sakata Y, Morita H, Umezawa A, Komuro I
International heart journal 2016;57(1):112-7

Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers.

Li J, Minami I, Yu L, Tsuji K, Nakajima M, Qiao J, Suzuki M, Shimono K, Nakatsuji N, Kotera H, Liu L, Chen Y
Stem cells international 2016;2016:2634013

Simultaneous imaging of local calcium and single sarcomere length in rat neonatal cardiomyocytes using yellow Cameleon-Nano140.

Tsukamoto S, Fujii T, Oyama K, Shintani SA, Shimozawa T, Kobirumaki-Shimozawa F, Ishiwata S, Fukuda N
The Journal of general physiology 2016 Oct;148(4):341-55

In vivo myosin step-size from zebrafish skeletal muscle.

Burghardt TP, Ajtai K, Sun X, Takubo N, Wang Y
Open biology 2016 May;6(5)

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.

Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S
Cell stem cell 2016 Mar 3;18(3):368-81

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.

Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ
Cell stem cell 2016 Mar 3;18(3):354-67

Conversion of human fibroblasts into functional cardiomyocytes by small molecules.

Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S
Science (New York, N.Y.) 2016 Jun 3;352(6290):1216-20

Human Engineered Heart Tissue: Analysis of Contractile Force.

Mannhardt I, Breckwoldt K, Letuffe-Brenière D, Schaaf S, Schulz H, Neuber C, Benzin A, Werner T, Eder A, Schulze T, Klampe B, Christ T, Hirt MN, Huebner N, Moretti A, Eschenhagen T, Hansen A
Stem cell reports 2016 Jul 12;7(1):29-42

Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.

Passer D, van de Vrugt A, Atmanli A, Domian IJ
Cell reports 2016 Feb 23;14(7):1662-1672

Human Cardiomyocytes Prior to Birth by Integration-Free Reprogramming of Amniotic Fluid Cells.

Jiang G, Herron TJ, Di Bernardo J, Walker KA, O'Shea KS, Kunisaki SM
Stem cells translational medicine 2016 Dec;5(12):1595-1606

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC
Tissue engineering. Part A 2016 Aug;22(15-16):1016-25

MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells.

Zeng Y, Zhang X, Kang K, Chen J, Wu Z, Huang J, Lu W, Chen Y, Zhang J, Wang Z, Zhai Y, Qu J, Ramchandran R, Raj JU, Wang J, Gou D
Scientific reports 2016 Apr 28;6:24900

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.

Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K
Cell metabolism 2016 Apr 12;23(4):663-74

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.

Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H
PloS one 2015;10(9):e0138193

Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells.

Fuerstenau-Sharp M, Zimmermann ME, Stark K, Jentsch N, Klingenstein M, Drzymalski M, Wagner S, Maier LS, Hehr U, Baessler A, Fischer M, Hengstenberg C
PloS one 2015;10(5):e0126596

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.

Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K
Nature communications 2015 Sep 10;6:8243

Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome.

Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N
Journal of the American Heart Association 2015 Sep 1;4(9):e002159

Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD
Journal of molecular and cellular cardiology 2015 Oct;87:204-13

Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.

Wang Y, Li ZC, Zhang P, Poon E, Kong CW, Boheler KR, Huang Y, Li RA, Yao X
Stem cells (Dayton, Ohio) 2015 Oct;33(10):2973-84

Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B
Stem cells (Dayton, Ohio) 2015 May;33(5):1456-69

Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway.

Connell JP, Ruano R, Jacot JG
Biomedical materials (Bristol, England) 2015 Mar 18;10(3):034103

In vitro and in vivo single myosin step-sizes in striated muscle.

Burghardt TP, Sun X, Wang Y, Ajtai K
Journal of muscle research and cell motility 2015 Dec;36(6):463-77

Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A
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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse heart tissue were subjected to SDS PAGE followed by western blot with 10906-1-AP(MYL2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-MYL2 (IP:10906-1-AP, 3ug; Detection:10906-1-AP 1:500) with mouse heart tissue lysate 6000ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skin cancer using 10906-1-AP(MYL2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Myosin Light Chain 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Myosin Light Chain 2. This antibody recognizes human,mouse,rat,zebrafish antigen. The Myosin Light Chain 2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 10906-1-AP.pdf

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