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- Antigen structure
- References [15]
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- Western blot [1]
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- Product number
- 16654-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- COQ4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COQ4 antibody (Cat. #16654-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references β-Resorcylic acid prevents MASLD in ob/ob mice by modulating lipid metabolism and inflammation in the liver.
Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise.
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking.
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
4-Hydroxybenzoic acid rescues multisystemic disease and perinatal lethality in a mouse model of mitochondrial disease.
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis.
Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes.
The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.
Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q(10) levels and each other's stability.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Detection of 6-demethoxyubiquinone in CoQ(10) deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.
4-Hydroxybenzoic acid restores CoQ(10) biosynthesis in human COQ2 deficiency.
López-Herrador S, Torres-Rusillo S, González-García P, Jiménez-Sánchez L, Corral-Sarasa J, Bakkali M, Díaz-Casado ME, López LC
Pharmacological research 2025 Sep;219:107906
Pharmacological research 2025 Sep;219:107906
Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise.
Meza-Torres C, Reyes-Torres I, Bui Thanh T, Campos-Silva C, Rodriguez-Bies E, Navas P, López-Lluch G
Antioxidants (Basel, Switzerland) 2025 Jun 27;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 27;14(7)
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
González-García P, Jiménez-Sánchez L, Corral-Sarasa J, López-Herrador S, Torres-Rusillo S, Díaz-Casado ME, López LC
Communications medicine 2025 Jul 10;5(1):286
Communications medicine 2025 Jul 10;5(1):286
Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking.
Wang Y, Hekimi S
The Journal of biological chemistry 2025 Dec;301(12):110878
The Journal of biological chemistry 2025 Dec;301(12):110878
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
Yen HC, Hsu CT, Wu SY, Kan CC, Chang CW, Chang HM, Chien YA, Wei YH, Wu CY
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
4-Hydroxybenzoic acid rescues multisystemic disease and perinatal lethality in a mouse model of mitochondrial disease.
Corral-Sarasa J, Martínez-Gálvez JM, González-García P, Wendling O, Jiménez-Sánchez L, López-Herrador S, Quinzii CM, Díaz-Casado ME, López LC
Cell reports 2024 May 28;43(5):114148
Cell reports 2024 May 28;43(5):114148
Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis.
Radaelli E, Assenmacher CA, Verrelle J, Banerjee E, Manero F, Khiati S, Girona A, Lopez-Lluch G, Navas P, Spinazzi M
eLife 2023 Jul 28;12
eLife 2023 Jul 28;12
Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes.
Laugwitz L, Seibt A, Herebian D, Peralta S, Kienzle I, Buchert R, Falb R, Gauck D, Müller A, Grimmel M, Beck-Woedel S, Kern J, Daliri K, Katibeh P, Danhauser K, Leiz S, Alesi V, Baertling F, Vasco G, Steinfeld R, Wagner M, Caglayan AO, Gumus H, Burmeister M, Mayatepek E, Martinelli D, Tamhankar PM, Tamhankar V, Joset P, Steindl K, Rauch A, Bonnen PE, Froukh T, Groeschel S, Krägeloh-Mann I, Haack TB, Distelmaier F
Journal of medical genetics 2022 Sep;59(9):878-887
Journal of medical genetics 2022 Sep;59(9):878-887
The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.
González-García P, Díaz-Casado ME, Hidalgo-Gutiérrez A, Jiménez-Sánchez L, Bakkali M, Barriocanal-Casado E, Escames G, Chiozzi RZ, Völlmy F, Zaal EA, Berkers CR, Heck AJR, López LC
Redox biology 2022 Sep;55:102403
Redox biology 2022 Sep;55:102403
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S
Autophagy 2022 Aug;18(8):1864-1878
Autophagy 2022 Aug;18(8):1864-1878
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.
Meza-Torres C, Hernández-Camacho JD, Cortés-Rodríguez AB, Fang L, Bui Thanh T, Rodríguez-Bies E, Navas P, López-Lluch G
Antioxidants (Basel, Switzerland) 2020 May 15;9(5)
Antioxidants (Basel, Switzerland) 2020 May 15;9(5)
Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q(10) levels and each other's stability.
Yen HC, Yeh WY, Lee SH, Feng YH, Yang SL
Biochimica et biophysica acta. Bioenergetics 2020 Jul 1;1861(7):148192
Biochimica et biophysica acta. Bioenergetics 2020 Jul 1;1861(7):148192
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9(R239X) mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Detection of 6-demethoxyubiquinone in CoQ(10) deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.
Herebian D, Seibt A, Smits SHJ, Bünning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, López LC, Mayatepek E, Distelmaier F
Molecular genetics and metabolism 2017 Jul;121(3):216-223
Molecular genetics and metabolism 2017 Jul;121(3):216-223
4-Hydroxybenzoic acid restores CoQ(10) biosynthesis in human COQ2 deficiency.
Herebian D, Seibt A, Smits SHJ, Rodenburg RJ, Mayatepek E, Distelmaier F
Annals of clinical and translational neurology 2017 Dec;4(12):902-908
Annals of clinical and translational neurology 2017 Dec;4(12):902-908
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COQ4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COQ4. This antibody recognizes human,mouse,rat antigen. The COQ4 antibody has been validated for the following applications: ELISA, WB analysis.
