10286-1-AP

antibody from Proteintech Group

Targeting: PLAUR CD87, UPAR, URKR

Provider product page for 10286-1-AP

Western blot

ELISA

Immunoprecipitation

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [31]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 10286-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10286-1-AP, RRID:AB_10667460
Product name: uPAR antibody
Antibody type: Polyclonal
Description: uPAR antibody (Cat. #10286-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PLAUR protein structure - 10286-1-AP shown in red.

Submitted references Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.

Lin Z, Wu C, Du Y, Zhao D, Li Y, Wang L, Kang Y, Li Z, Zuo R, Cui W, Zhao J
Advanced healthcare materials 2026 Feb;15(5):e04034

S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice From FOLFOX-Induced Liver Injury.

Gangi A, Li TWH, Lim Y, Chandla S, Floris A, Khangholi A, Tomasi ML, Lu SC
Cellular and molecular gastroenterology and hepatology 2025;19(8):101513

Characterization of hypoxia-related molecular clusters and prognostic riskScore for glioma.

Fang X, Wu X, Xu C
Frontiers in oncology 2025;15:1605949

Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.

Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818

Induction of epithelial cell senescence by SERPINE1 derived from fibroblasts in the amnion at parturition.

Ling LJ, Li MD, Lu JW, Zhang F, Pan F, Su Y, Myatt L, Wang WS, Sun K, Ying H
Mechanisms of ageing and development 2025 Jun;225:112053

Radiogenomics of intrahepatic cholangiocarcinoma predicts immunochemotherapy response and identifies therapeutic target.

Ji GW, Xu ZG, Liu SC, Cao SY, Jiao CY, Lu M, Zhang B, Yang Y, Xu Q, Wu XF, Wang K, Xia YX, Li XC, Wang XH
Clinical and molecular hepatology 2025 Jul;31(3):935-959

PLAUR, C3, and EMP3 coordinate tumor progression and immune evasion in clear cell renal cell carcinoma.

Zi SR, Feng ZY, Dong LS
Discover oncology 2025 Dec 19;17(1):130

Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells.

Zhang Y, Ding Y, Liang J, Zhang K, Su H, Wang D, Zhang M, Zhao F, Sun Z, Wu Z, Wang F, Cao G, Zhang Y
International journal of molecular sciences 2025 Apr 20;26(8)

A spatially resolved transcriptome landscape during thyroid cancer progression.

Liao T, Zeng Y, Xu W, Shi X, Shen C, Du Y, Zhang M, Zhang Y, Li L, Ding P, Hu W, Huang Z, Fung MHM, Ji Q, Wang Y, Li S, Wei W
Cell reports. Medicine 2025 Apr 15;6(4):102043

A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation.

Lyu X, Cui Y, Kong Y, Yang M, Shen H, Liao S, Li S, An C, Wang H, Zhang Z, Ong J, Li Y, Du P
Molecular cell 2024 Jul 25;84(14):2665-2681.e13

Clinical significance, molecular characterization, and immune microenvironment analysis of coagulation-related genes in clear cell renal cell carcinoma.

Chen W, Zhao X, Lu Y, Wang H, Wang X, Wang Y, Liang C, Jia Z, Ma W
Cancer innovation 2024 Feb;3(1):e105

Cell Sheets Formation Enhances Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells on Spinal Cord Injury.

Zhao Y, Wu Z, Zhou Y, Chen C, Lu Y, Wang H, Xu T, Yang C, Chen X
CNS neuroscience & therapeutics 2024 Dec;30(12):e70163

Plasminogen activator urokinase interacts with the fusion protein and antagonizes the growth of Peste des petits ruminants virus.

Wu J, Yang W, Li L, Wu J, He J, Ru Y, Ren J, Wang Y, Zheng H, Shang Y, Li D
Journal of virology 2024 Apr 16;98(4):e0014624

ICAM-1-suPAR-CD11b Axis Is a Novel Therapeutic Target for Metastatic Triple-Negative Breast Cancer.

Li D, Hemati H, Park Y, Taftaf R, Zhang Y, Liu J, Cristofanilli M, Liu X
Cancers 2023 May 12;15(10)

γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5.

Chen W, Yu H, Sun C, Dong M, Zhao N, Wang Y, Yu K, Zhang J, Xu N, Liu W
Toxicology letters 2023 Jul 1;383:177-191

YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR.

Zhang C, Chen S, Wang W, Gao Y
Functional & integrative genomics 2023 Aug 8;23(3):269

Endocytosis of Peptidase Inhibitor SerpinE2 promotes Myocardial Fibrosis through activating ERK1/2 and β-catenin Signaling Pathways.

Li C, Lv LF, Qi-Li MG, Yang R, Wang YJ, Chen SS, Zhang MX, Li TY, Yu T, Zhou YH, Liang HH, Shan HL, Li XL
International journal of biological sciences 2022;18(16):6008-6019

Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.

Ma M, Fan AY, Liu Z, Yang LQ, Huang JM, Pang ZY, Yin F
Frontiers in pharmacology 2022;13:874952

Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.

Sela Y, Li J, Maheswaran S, Norgard R, Yuan S, Hubbi M, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ
Cancer research 2022 May 16;82(10):1890-1908

A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles.

Kanada M, Linenfelser L, Cox E, Gilad AA
Pharmaceutics 2022 Feb 22;14(3)

PLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma.

Liu M, Chen S, Zhang A, Zheng Q, Fu J
Journal of inflammation research 2021;14:4629-4641

Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.

Miao Z, Ding Y, Bi Y, Chen M, Cao X, Wang F
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Su Z, Li Y, Lv H, Cui X, Liu M, Wang Z, Zhang Y, Zhen J, Tang W, Wang X, Yi F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21711

Identification of an immune-related signature indicating the dedifferentiation of thyroid cells.

Wang X, Peng W, Li C, Qin R, Zhong Z, Sun C
Cancer cell international 2021 Apr 23;21(1):231

The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis.

Huang F, Li Y, Xu R, Cheng A, Lv Y, Liu Q
Mediators of inflammation 2020;2020:7850179

Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.

Tang H, Zheng J, Bai X, Yue KL, Liang JH, Li DY, Wang LP, Wang JL, Guo Q
Frontiers in oncology 2020;10:564298

Ulinastatin Inhibits Osteoclastogenesis and Suppresses Ovariectomy-Induced Bone Loss by Downregulating uPAR.

Huang JM, Ren RY, Bao Y, Guo JC, Xiang W, Jing XZ, Shi J, Zhang GX, Li L, Tian Y, Kang H, Guo FJ
Frontiers in pharmacology 2018;9:1016

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413

High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses.

Xia J, Chen H, Yan J, Wu H, Wang H, Guo J, Zhang X, Zhang S, Zhao C, Chen Y
ACS applied materials & interfaces 2017 Mar 22;9(11):9506-9515

Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures.

Ge Y, Siegel AP, Jordan R, Naumann CA
Biophysical journal 2014 Nov 4;107(9):2101-11

Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.

Chauhan S, Boyd DD
Nucleic acids research 2012 Jan;40(2):600-13

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The uPAR antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human uPAR. This antibody recognizes human, mouse antigen. The uPAR antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10286-1-AP.pdf

: Show more