Tissue expression
Cell line expression
Protein structure
DUSP7
Dual specificity phosphatase 7MKP-X, PYST2
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]). [supplied by OMIM, Dec 2009]
Top validated antibodies |
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Proteintech Group | 26910-1-AP | 4 references | Polyclonal |
WB
EL
IHC
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Abnova Corporation | PAB4132 | 3 references | Polyclonal |
WB
IHC |
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antibodies-online | ABIN2157240 | Polyclonal |
WB
ICC
IHC
|
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GeneTex | GTX109289 | Polyclonal |
WB
ICC
IHC
|
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LSBio | LS-C186060 | Polyclonal |
WB
ICC
IHC
|
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